SCOPUS 정보 검색 플랫폼

ChemMedChem

Volumn 11, Issue 10, 2016, Pages 1060-1068

Pharmacokinetic Studies around the Mono- and Difunctionalization of a Bioavailable Cyclic Decapeptide Scaffold

(6) Fouché, Marianne a Schäfer, Michael a Blatter, Markus a Berghausen, Jörg a Desrayaud, Sandrine a Roth, Hans Jörg a

a NOVARTIS PHARMA AG (Switzerland)

Author keywords

amino acids; biological activity; macrocycles; metabolism; peptides

Indexed keywords

ALANINE; ASPARAGINE; ASPARTIC ACID; CARBOXYLIC ACID; CYCLIC DECAPEPTIDE; CYCLOPEPTIDE; HYDROXYL GROUP; LYSINE; METIROSINE; N METHYLASPARTIC ACID; PHENYLALANINE; PYRIDYLALANINE; THREONINE; TYROSINE; UNCLASSIFIED DRUG; AMINO ACID;

ACTIVE TRANSPORT; ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG PENETRATION; DRUG SOLUBILITY; DRUG SYNTHESIS; ENTROPY; HYDROGEN BOND; INTRINSIC CLEARANCE; LIPOPHILICITY; LIVER MICROSOME; MALE; METABOLIC STABILITY; METHYLATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN CONFORMATION; RAT; SURFACE AREA; VOLUME OF DISTRIBUTION; VOLUME OF DISTRIBUTION AT STEADY-STATE; ANIMAL; BIOAVAILABILITY; BLOOD; CELL MEMBRANE PERMEABILITY; CHEMISTRY; DOG; HALF LIFE TIME; HUMAN; MDCK CELL LINE; METABOLISM; ORAL DRUG ADMINISTRATION; PROTEIN SECONDARY STRUCTURE; SOLUBILITY; SPRAGUE DAWLEY RAT;

ADMINISTRATION, ORAL; AMINO ACIDS; ANIMALS; BIOLOGICAL AVAILABILITY; CELL MEMBRANE PERMEABILITY; DOGS; HALF-LIFE; HUMANS; MADIN DARBY CANINE KIDNEY CELLS; MALE; MICROSOMES, LIVER; PEPTIDES, CYCLIC; PROTEIN STRUCTURE, SECONDARY; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY;

EID: 84969195241 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.201600083 Document Type: Article

Times cited : (23)

References (33)

1
- 84920272791
- P. Thansandote, R. M. Harris, H. L. Dexter, G. L. Simpson, S. Pal, R. J. Upton, K. Valko, Bioorg. Med. Chem. 2015, 23, 322-327;
- (2015) Bioorg. Med. Chem. , vol.23 , pp. 322-327
- Thansandote, P.¹ Harris, R.M.² Dexter, H.L.³ Simpson, G.L.⁴ Pal, S.⁵ Upton, R.J.⁶ Valko, K.⁷

2
- 84975231508
- A. Tapeinou, M. T. Matsoukas, C. Simal, T. Tselios, Biopolymers 2015, 104, 453-461;
- (2015) Biopolymers , vol.104 , pp. 453-461
- Tapeinou, A.¹ Matsoukas, M.T.² Simal, C.³ Tselios, T.⁴

3
- 84945190129
- D. S. Nielsen, R. J. Lohman, H. N. Hoang, T. A. Hill, A. Jones, A. J. Lucke, D. P. Fairlie, ChemBioChem 2015, 16, 2289-2293;
- (2015) ChemBioChem , vol.16 , pp. 2289-2293
- Nielsen, D.S.¹ Lohman, R.J.² Hoang, H.N.³ Hill, T.A.⁴ Jones, A.⁵ Lucke, A.J.⁶ Fairlie, D.P.⁷

4
- 84942288094
- A. T. Bockus, J. A. Schwochert, C. R. Pye, C. E. Townsend, V. Sok, M. A. Bednarek, R. S. Lokey, J. Med. Chem. 2015, 58, 7409-7418;
- (2015) J. Med. Chem. , vol.58 , pp. 7409-7418
- Bockus, A.T.¹ Schwochert, J.A.² Pye, C.R.³ Townsend, C.E.⁴ Sok, V.⁵ Bednarek, M.A.⁶ Lokey, R.S.⁷

5
- 84867025688
- A. C. Rand, S. S. F. Leung, H. Eng, C. J. Rotter, R. Sharma, A. S. Kalgutkar, Y. Zhang, M. V. Varma, K. A. Farley, B. Khunte, C. Limberakis, D. A. Price, S. Liras, A. M. Mathiowetz, M. P. Jacobson, R. S. Lokey, MedChemComm 2012, 3, 1282-1289;
- (2012) MedChemComm , vol.3 , pp. 1282-1289
- Rand, A.C.¹ Leung, S.S.F.² Eng, H.³ Rotter, C.J.⁴ Sharma, R.⁵ Kalgutkar, A.S.⁶ Zhang, Y.⁷ Varma, M.V.⁸ Farley, K.A.⁹ Khunte, B.¹⁰ Limberakis, C.¹¹ Price, D.A.¹² Liras, S.¹³ Mathiowetz, A.M.¹⁴ Jacobson, M.P.¹⁵ Lokey, R.S.¹⁶

6
- 84929175342
- A. Bhat, L R. Roberts, J. J. Dwyer, Eur. J. Med. Chem. 2015, 94, 471-479.
- (2015) Eur. J. Med. Chem. , vol.94 , pp. 471-479
- Bhat, A.¹ Roberts, L.R.² Dwyer, J.J.³

7
- 84939992928
- H. Hennemann, S. Wirths, C. Carl, Eur. J. Med. Chem. 2015, 94, 489-496;
- (2015) Eur. J. Med. Chem. , vol.94 , pp. 489-496
- Hennemann, H.¹ Wirths, S.² Carl, C.³

8
- 84945377050
- S. J. de Veer, C. K. Wang, J. M. Harris, D. J. Craik, J. E. Swedberg, J. Med. Chem. 2015, 58, 8257-8268;
- (2015) J. Med. Chem. , vol.58 , pp. 8257-8268
- De Veer, S.J.¹ Wang, C.K.² Harris, J.M.³ Craik, D.J.⁴ Swedberg, J.E.⁵

9
- 84906060855
- K. R. Lennard, A. Tavassoli, Chemistry 2014, 20, 10608-10614;
- (2014) Chemistry , vol.20 , pp. 10608-10614
- Lennard, K.R.¹ Tavassoli, A.²

10
- 0036942484
- D. A. Horton, G. T. Bourne, M. L. Smythe, Mol. Diversity 2000, 5, 289-304.
- (2000) Mol. Diversity , vol.5 , pp. 289-304
- Horton, D.A.¹ Bourne, G.T.² Smythe, M.L.³

11
- 84922005015
- L. Di, AAPS J. 2015, 17, 134-143;
- (2015) AAPS J. , vol.17 , pp. 134-143
- Di, L.¹

12
- 84885229737
- L. Diao, B. Meibohm, Clin. Pharmacokinet. 2013, 52, 855-868;
- (2013) Clin. Pharmacokinet. , vol.52 , pp. 855-868
- Diao, L.¹ Meibohm, B.²

13
- 84871394690
- D. J. Craik, D. P. Fairlie, S. Liras, D. Price, Chem. Biol. Drug Des. 2013, 81, 136-147;
- (2013) Chem. Biol. Drug Des. , vol.81 , pp. 136-147
- Craik, D.J.¹ Fairlie, D.P.² Liras, S.³ Price, D.⁴

14
- 84859720244
- E. S. Khafagy, M. Morishita, Adv. Drug Delivery Rev. 2012, 64, 531-539;
- (2012) Adv. Drug Delivery Rev. , vol.64 , pp. 531-539
- Khafagy, E.S.¹ Morishita, M.²

15
- 22244488749
- J. H. Hamman, G. M. Enslin, A. F. Kotz, Biodrugs 2005, 19, 165-177;
- (2005) Biodrugs , vol.19 , pp. 165-177
- Hamman, J.H.¹ Enslin, G.M.² Kotz, A.F.³

16
- 0141997761
- R. I. Mahato, A. S. Narang, L. Thoma, Crit. Rev. Ther. Drug Carrier Syst. 2003, 20, 153-214.
- (2003) Crit. Rev. Ther. Drug Carrier Syst. , vol.20 , pp. 153-214
- Mahato, R.I.¹ Narang, A.S.² Thoma, L.³

17
- 84966389321
- M. Fouché, M. Schäfer, J. Berghausen, S. Desrayaud, M. Blatter, P. Piéchon, I. Dix, A. M. Garcia, H.-J. Roth, ChemMedChem 2016, DOI: 10.1002/cmdc.201600082.
- (2016) ChemMedChem
- Fouché, M.¹

18
- 80054853098
- T. R. White, C. M. Renzelman, A. C. Rand, T. Rezai, C. M. McEwen, V. M. Gelev, R. A. Turner, R. G. Linington, S. S. Leung, A. S. Kalgutkar, J. N. Bauman, Y. Zhang, S. Liras, D. A. Price, A. M. Mathiowetz, M. P. Jacobson, R. S. Lokey, Nat. Chem. Biol. 2011, 7, 810-817.
- (2011) Nat. Chem. Biol. , vol.7 , pp. 810-817
- White, T.R.¹ Renzelman, C.M.² Rand, A.C.³ Rezai, T.⁴ McEwen, C.M.⁵ Gelev, V.M.⁶ Turner, R.A.⁷ Linington, R.G.⁸ Leung, S.S.⁹ Kalgutkar, A.S.¹⁰ Bauman, J.N.¹¹ Zhang, Y.¹² Liras, S.¹³ Price, D.A.¹⁴ Mathiowetz, A.M.¹⁵ Jacobson, M.P.¹⁶ Lokey, R.S.¹⁷

19
- 84969125472
- MarinLit, University of Canterbury:; pubs.rsc.org/marinlit
- MarinLit, University of Canterbury: www.chem.canterbury.ac.nz/marinlit/marinlit.shtml; see also: pubs.rsc.org/marinlit.

20
- 84859788959
- S. B. Rafi, B. R. Hearn, P. Vedantham, M. P. Jacobson, A. R. Renslo, J. Med. Chem. 2012, 55, 3163-3169.
- (2012) J. Med. Chem. , vol.55 , pp. 3163-3169
- Rafi, S.B.¹ Hearn, B.R.² Vedantham, P.³ Jacobson, M.P.⁴ Renslo, A.R.⁵

21
- 81855206518
- D. A. Volpe, Future Med. Chem. 2011, 3, 2063-2077.
- (2011) Future Med. Chem. , vol.3 , pp. 2063-2077
- Volpe, D.A.¹

22
- 84938919255
- D. A. Smith, K. Beaumont, T. S. Maurer, L. Di, J. Med. Chem. 2015, 58, 5691-5698.
- (2015) J. Med. Chem. , vol.58 , pp. 5691-5698
- Smith, D.A.¹ Beaumont, K.² Maurer, T.S.³ Di, L.⁴

23
- 84928957792
- P. Upadhyaya, Z. Qian, N. G. Selner, S. R. Clippinger, Z. Wu, R. Briesewitz, D. Pei, Angew. Chem. Int. Ed. 2015, 54, 7602-7606;
- (2015) Angew. Chem. Int. Ed. , vol.54 , pp. 7602-7606
- Upadhyaya, P.¹ Qian, Z.² Selner, N.G.³ Clippinger, S.R.⁴ Wu, Z.⁵ Briesewitz, R.⁶ Pei, D.⁷

24
- 84946067240
- Angew. Chem. 2015, 127, 7712-7716;
- (2015) Angew. Chem. , vol.127 , pp. 7712-7716

25
- 84939950031
- P. Matsson, L A. Fenu, P. Lundquist, J. R. Wisniewski, M. Kansy, P. Artursson, Trends Pharmacol. Sci. 2015, 36, 255-262;
- (2015) Trends Pharmacol. Sci. , vol.36 , pp. 255-262
- Matsson, P.¹ Fenu, L.A.² Lundquist, P.³ Wisniewski, J.R.⁴ Kansy, M.⁵ Artursson, P.⁶

26
- 84944711138
- U. K. Marelli, O. Ovadia, A. O. Frank, J. Chatterjee, C. Gilon, A. Hoffman, H. Kessler, Chemistry 2015, 21, 15148-15152;
- (2015) Chemistry , vol.21 , pp. 15148-15152
- Marelli, U.K.¹ Ovadia, O.² Frank, A.O.³ Chatterjee, J.⁴ Gilon, C.⁵ Hoffman, A.⁶ Kessler, H.⁷

27
- 84929353606
- U. K. Marelli, J. Bezencon, E. Puig, B. Ernst, H. Kessler, Chemistry 2015, 21, 8023-8027;
- (2015) Chemistry , vol.21 , pp. 8023-8027
- Marelli, U.K.¹ Bezencon, J.² Puig, E.³ Ernst, B.⁴ Kessler, H.⁵

28
- 84920550526
- Q. Chu, R. E. Moellering, G. J. Hilinski, Y.-W. Kim, T. N. Grossmann, J. T. H. Yeh, G. L. Verdine, MedChemComm 2015, 6, 111-119;
- (2015) MedChemComm , vol.6 , pp. 111-119
- Chu, Q.¹ Moellering, R.E.² Hilinski, G.J.³ Kim, Y.-W.⁴ Grossmann, T.N.⁵ Yeh, J.T.H.⁶ Verdine, G.L.⁷

29
- 84864631153
- F. Milletti, Drug Discovery Today 2012, 17, 850-860;
- (2012) Drug Discovery Today , vol.17 , pp. 850-860
- Milletti, F.¹

30
- 84864182405
- J. G. Beck, J. Chatterjee, B. Laufer, M. U. Kiran, A. O. Frank, S. Neubauer, O. Ovadia, S. Greenberg, C. Gilon, A. Hoffman, H. Kessler, J. Am. Chem. Soc. 2012, 134, 12125-12133;
- (2012) J. Am. Chem. Soc. , vol.134 , pp. 12125-12133
- Beck, J.G.¹ Chatterjee, J.² Laufer, B.³ Kiran, M.U.⁴ Frank, A.O.⁵ Neubauer, S.⁶ Ovadia, O.⁷ Greenberg, S.⁸ Gilon, C.⁹ Hoffman, A.¹⁰ Kessler, H.¹¹

31
- 80054813491
- K. Lanthaler, E. Bilsland, P. D. Dobson, H. J. Moss, P. Pir, D. B. Kell, S. G. Oliver, BMC Biol. 2011, 9, 70;
- (2011) BMC Biol. , vol.9 , pp. 70
- Lanthaler, K.¹ Bilsland, E.² Dobson, P.D.³ Moss, H.J.⁴ Pir, P.⁵ Kell, D.B.⁶ Oliver, S.G.⁷

32
- 80051666394
- D. B. Kell, P. D. Dobson, S. G. Oliver, Drug Discovery Today 2011, 16, 704-714;
- (2011) Drug Discovery Today , vol.16 , pp. 704-714
- Kell, D.B.¹ Dobson, P.D.² Oliver, S.G.³

33
- 40049110714
- P. D. Dobson, D. B. Kell, Nat. Rev. Drug Discovery 2008, 7, 205-220.
- (2008) Nat. Rev. Drug Discovery , vol.7 , pp. 205-220
- Dobson, P.D.¹ Kell, D.B.²

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.