Two distinct modes of metal ion binding in the nuclease active site of a viral DNA-packaging terminase: Insight into the two-metal-ion catalytic mechanism

Nucleic Acids Research

Volumn 43, Issue 22, 2015, Pages 11003-11016

  Zhao, Haiyan ^a   Lin, Zihan ^a   Lynn, Anna Y ^a   Varnado, Brittany ^a   Beutler, John A ^b   Murelli, Ryan P ^c   Le Grice, Stuart F J ^b   Tang, Liang ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA THUJAPLICINOL; CALCIUM ION; CHELATING AGENT; DNA PACKAGING TERMINASE; MAGNESIUM ION; MANGANESE; UNCLASSIFIED DRUG; VIRUS DNA; BETA-THUJAPLICINOL; DEOXYRIBONUCLEASE; LYSINE; MAGNESIUM; METAL; PROTEIN BINDING; TERMINASE; TROPOLONE; VIRAL PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; BACILLUS HALODURANS; BACTERIOPHAGE; CATALYSIS; DNA BINDING; DNA PACKAGING; ENZYME ACTIVE SITE; ENZYME SUBSTRATE COMPLEX; MOLECULAR INTERACTION; MOLECULAR PROBE; NONHUMAN; NUCLEOTIDE BINDING SITE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STATIC ELECTRICITY; ANALOGS AND DERIVATIVES; BIOCATALYSIS; CHEMISTRY; ENZYMOLOGY; GENETICS; METABOLISM; MOLECULAR MODEL; MUTATION; PODOVIRIDAE;

BIOCATALYSIS; CATALYTIC DOMAIN; DNA PACKAGING; ENDODEOXYRIBONUCLEASES; LYSINE; MAGNESIUM; MANGANESE; METALS; MODELS, MOLECULAR; MUTATION; PODOVIRIDAE; PROTEIN BINDING; TROPOLONE; VIRAL PROTEINS;

EID: 84968869376     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkv1018     Document Type: Article

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