Mechanism of Dissolution-Induced Nanoparticle Formation from a Copovidone-Based Amorphous Solid Dispersion

Molecular Pharmaceutics

Volumn 13, Issue 5, 2016, Pages 1467-1481

  Harmon, Paul ^a   Galipeau, Kendra ^a   Xu, Wei ^a   Brown, Chad ^a   Wuelfing, W Peter ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

dissolution; hydrophobic capture; nanoparticles; scaffold particle; solid dispersion; solubility; surfactant

Indexed keywords

AMORPHOUS SOLID DISPERSION; ANACETRAPIB; NANOPARTICLE; POVIDONE DERIVATIVE; SUCCINIC ACID; SURFACTANT; UNCLASSIFIED DRUG; POLY(VINYLPYRROLIDONE-CO-VINYL-ACETATE); PYRROLIDINE DERIVATIVE; SOLUTION AND SOLUBILITY; VINYL DERIVATIVE;

ARTICLE; DISSOLUTION; DRUG FORMULATION; DRUG RELEASE; HYDROPHOBICITY; MICROSCOPY; MOLECULAR MECHANICS; PARTICLE SIZE; PHASE SEPARATION; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SOLUBILITY; TRANSMISSION ELECTRON MICROSCOPY; X RAY DIFFRACTION; CHEMICAL PHENOMENA; CHEMISTRY; MEDICINAL CHEMISTRY; PROCEDURES; SOLUTION AND SOLUBILITY;

CHEMISTRY, PHARMACEUTICAL; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; NANOPARTICLES; PARTICLE SIZE; PYRROLIDINES; SOLUBILITY; SOLUTIONS; SURFACE-ACTIVE AGENTS; VINYL COMPOUNDS;

EID: 84968763994     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/acs.molpharmaceut.5b00863     Document Type: Article

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