The amorphous solid dispersion of the poorly soluble ABT-102 forms nano/microparticulate structures in aqueous medium: Impact on solubility

International Journal of Nanomedicine

Volumn 7, Issue , 2012, Pages 5757-5768

  Frank, Kerstin J ^a,c   Westedt, Ulrich ^b   Rosenblatt, Karin M ^b   Hölig, Peter ^b   Rosenberg, Jörg ^b   Mägerlein, Markus ^b   Fricker, Gert ^c   Brandl, Martin ^a  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b ABBOTT GMBH AND CO KG   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

AFlFFF; Micelles; Solid dispersion; Solubility; Supersaturation

Indexed keywords

(5 TERT BUTYL 2,3 DIHYDRO 1H INDEN 1 YL) 3 (1H INDAZOL 4 YL)UREA; NANOMATERIAL;

AQUEOUS SOLUTION; ARTICLE; CHEMICAL COMPOSITION; DRUG SOLUBILITY; DRUG STRUCTURE; EQUILIBRIUM DIALYSIS; FIELD FLOW FRACTIONATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHILICITY; INFRARED SPECTROSCOPY; MICELLE; NANOCHEMISTRY; PHYSICAL CHEMISTRY; RADIATION SCATTERING; SCANNING ELECTRON MICROSCOPY; STRUCTURE ANALYSIS;

COLLOIDS; DIFFUSION; INDAZOLES; MATERIALS TESTING; MICROSPHERES; NANOPARTICLES; PARTICLE SIZE; PARTICULATE MATTER; SOLUBILITY; UREA; WATER;

APIS;

EID: 84870356219     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S36571     Document Type: Article

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