Design of Ionizable Lipids to Overcome the Limiting Step of Endosomal Escape: Application in the Intracellular Delivery of mRNA, DNA, and siRNA

Journal of Medicinal Chemistry

Volumn 59, Issue 7, 2016, Pages 3046-3062

  Habrant, Damien ^a   Peuziat, Pauline ^b,c   Colombani, Thibault ^b,c   Dallet, Laurence ^d   Gehin, Johan ^a   Goudeau, Emilie ^a   Evrard, Bérangère ^a   Lambert, Olivier ^d   Haudebourg, Thomas ^b,c   Pitard, Bruno ^a,b,c  

^a In Cell Art   (France)

^b CNRS   (France)

^c UNIVERSITÉ DE NANTES   (France)

^d CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE DERIVATIVE; DNA; DRUG CARRIER; IONIZABLE LIPID; LIPID; LIPOSOME; LUCIFERASE; MESSENGER RNA; PLASMID DNA; SMALL INTERFERING RNA; TOBRAMYCIN; UNCLASSIFIED DRUG; 1,2-DIOLEOYLOXY-3-(TRIMETHYLAMMONIUM)PROPANE; MONOUNSATURATED FATTY ACID; N-(1-(2,3-DIOLEYLOXY)PROPYL)-N,N,N-TRIMETHYLAMMONIUM; QUATERNARY AMMONIUM DERIVATIVE;

AGAR GEL ELECTROPHORESIS; ANIMAL CELL; ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; COMPARATIVE STUDY; COMPLEX FORMATION; CONJUGATE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; ENDOSOME; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYDROGENATION; HYDROPHOBICITY; LUCIFERASE ASSAY; NONHUMAN; PH; PHOTON CORRELATION SPECTROSCOPY; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYNTHESIS; TRANSMISSION ELECTRON MICROSCOPY; ANIMAL; CHEMICAL PHENOMENA; CHEMISTRY; CRYOELECTRON MICROSCOPY; CYTOLOGY; HELA CELL LINE; METABOLISM; PROCEDURES; STRUCTURE ACTIVITY RELATION; VASCULAR SMOOTH MUSCLE;

ANIMALS; CHEMISTRY TECHNIQUES, SYNTHETIC; CRYOELECTRON MICROSCOPY; DNA; DRUG DELIVERY SYSTEMS; ENDOSOMES; FATTY ACIDS, MONOUNSATURATED; HELA CELLS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LIPIDS; LIPOSOMES; MICROSCOPY, ELECTRON, TRANSMISSION; MUSCLE, SMOOTH, VASCULAR; QUATERNARY AMMONIUM COMPOUNDS; RATS; RNA, MESSENGER; RNA, SMALL INTERFERING; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 84966393230     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b01679     Document Type: Article

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