Basigin (CD147), a multifunctional transmembrane glycoprotein with various binding partners

Journal of Biochemistry

Volumn 159, Issue 5, 2016, Pages 481-490

  Muramatsu, Takashi ^a  

^a NAGOYA UNIVERSITY   (Japan)

Author keywords

basigin; cyclophilins; glycoproteins; immunoglobulin superfamily; monocarboxylate transporters

Indexed keywords

APOLIPOPROTEIN D; CALGRANULIN B; CARBOHYDRATE; CASPASE RECRUITMENT DOMAIN PROTEIN 15; CD147 ANTIGEN; CD98 ANTIGEN; CYCLOPHILIN; EPIDERMAL GROWTH FACTOR RECEPTOR; GALECTIN 3; GAMMA SECRETASE; GLUCOSE TRANSPORTER 1; GLYCOPROTEIN VI; HERMES ANTIGEN; INTEGRIN; LEUKOSIALIN; MONOCARBOXYLATE TRANSPORTER; PLAKOGLOBIN; ROD DERIVED CONE VIABILITY FACTOR; BSG PROTEIN, HUMAN; CD44 PROTEIN, HUMAN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; FIBRINOGEN RECEPTOR; GALECTIN-3, HUMAN; ISOPROTEIN; NXNL1 PROTEIN, HUMAN; PLATELET MEMBRANE GLYCOPROTEIN VI; SLC2A1 PROTEIN, HUMAN; THIOREDOXIN; TUMOR PROTEIN;

DEVELOPMENT; DISEASE ASSOCIATION; HEART INFARCTION; HUMAN; IMMUNE RESPONSE; INFECTION; KIDNEY FIBROSIS; MALIGNANT NEOPLASTIC DISEASE; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; MULTIPLE SCLEROSIS; NERVOUS SYSTEM; NONHUMAN; PROTEIN BINDING; PROTEIN CARBOHYDRATE INTERACTION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REPRODUCTION; REVIEW; RHEUMATOID ARTHRITIS; SENSORY SYSTEM; ANIMAL; FEMALE; MALARIA; MALE; METABOLISM; NEOPLASM; SPERMATOGENESIS; VISION;

ANIMALS; ANTIGENS, CD147; ANTIGENS, CD44; ANTIGENS, CD98; CALGRANULIN B; CYCLOPHILINS; E-SELECTIN; FEMALE; GALECTIN 3; GLUCOSE TRANSPORTER TYPE 1; HUMANS; MALARIA; MALE; NEOPLASM PROTEINS; NEOPLASMS; PLATELET MEMBRANE GLYCOPROTEINS; PROTEIN ISOFORMS; SPERMATOGENESIS; THIOREDOXINS; VISION, OCULAR;

EID: 84966376458     PISSN: 0021924X     EISSN: 17562651     Source Type: Journal    
DOI: 10.1093/jb/mvv127     Document Type: Review

References (86)

1. Williams, A. F. And Barclay, A. N. (1988) The immunoglobulin superfamily-domains for cell surface recognition. Annu. Rev. Immunol. 6, 381-405
2. Miyauchi, T., Kanekura, T., Yamaoka, A., Ozawa, M., Miyazawa, S., and Muramatsu, T. (1990) Basigin, a new, broadly distributed member of the immunoglobulin superfamily, has strong homology with both the immunoglobulin V domain and the b-chain of major histocompatibility complex class II antigen. J. Biochem. 107, 316-323
3. Biswas, C., Zhang, Y., DeCastro, R., Guo, H., Nakamura, T., Kataoka, H., and Nabeshima, K. (1995) The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily. Cancer Res. 55, 434-439
4. Muramatsu, T. And Miyauchi, T. (2003) Basigin (CD147): A multifunctional transmembrane protein involved in reproduction, neural function, inflammation and tumor invasion. Histol. Histopathol. 18, 981-987
5. Yurchenko, V., Constant, S., Eisenmesser, E., and Bukrinsky, M. (2010) Cyclophilin-CD147 interactions: A new target for anti-inflammatory therapeutics. Clin. Exp. Immunol. 160, 305-317
6. Grass, G. D., Dai, L., Qin, Z., Parsons, C., and Toole, B. P. (2014) CD147: regulator of hyaluronan signaling in invasiveness and chemoresistance. Adv. Cancer Res. 123, 351-373
7. Muramatsu, T. (2012) Basigin: A multifunctional membrane protein with an emerging role in infections by malaria parasites. Expert Opin. Ther. Targets 16, 999-1011
8. Spring, F. A., Holmes, C. H., Simpson, K. L., Mawby, W. J., Mattes, M. J., Okubo, Y., and Parsons, S. F. (1997) The Oka blood group antigen is a marker for the M6 leukocyte activation antigen, the human homolog of OX-47 antigen, basigin and neurothelin, an immunoglobulin superfamily molecule that is widely expressed in human cells and tissues. Eur. J. Immunol. 27, 891-897
9. Ozawa, M., Huang, R. P., Furukawa, T., and Muramatsu, T. (1988) A teratocarcinoma glycoprotein carrying a developmentally regulated carbohydrate marker is a member of the immunoglobulin gene superfamily. J. Biol. Chem. 263, 3059-3062
10. Tachikui, H., Kurosawa, N., Kadomatsu, K., and Muramatsu, T. (1999) Genomic organization and promoter activity of embigin, a member of the immunoglobulin superfamily. Gene 240, 325-332
11. Beesley, P. W., Herrera-Molina, R., Smalla, K. H., and Seidenbecher, C. (2014) The Neuroplastin adhesion molecules: key regulators of neuronal plasticity and synaptic function. J. Neurochem. 131, 268-283
12. Kaname, T., Miyauchi, T., Kuwano, A., Matsuda, Y., Muramatsu, T., and Kajii, T. (1993) Mapping basigin (BSG), a member of the immunoglobulin superfamily, to 19p13. 3. Cytogenet. Cell Genet. 64, 195-197
13. Curtin, K. D., Meinertzhagen, I. A., and Wyman, R. J. (2005) Basigin (EMMPRIN/CD147) interacts with integrin to affect cellular architecture. J. Cell Sci. 118, 2649-2660
14. Belton, R. J. Jr., Chen, L., Mesquita, F. S., and Nowak, R. A. (2008) Basigin-2 is a cell surface receptor for soluble basigin ligand. J. Biol. Chem. 283, 17805-17814
15. Liao, C. G., Kong, L. M., Song, F., Xing, J. L., Wang, L. X., Sun, Z. J., Tang, H., Yao, H., Zhang, Y., Wang, L., Wang, Y., Yang, X. M., Li, Y., and Chen, Z. N. (2011) Characterization of basigin isoforms and the inhibitory function of basigin-3 in human hepatocellular carcinoma proliferation and invasion. Mol. Cell. Biol. 31, 2591-2604
16. Ochrietor, J. D., Moroz, T. P., van Ekeris, L., Clamp, M. F., Jefferson, S. C., deCarvalho, A. C., Fadool, J. M., Wistow, G., Muramatsu, T., and Linser, P. J. (2003) Retina-specific expression of 5A11/Basigin-2, a member of the immunoglobulin gene superfamily. Invest. Ophthalmol. Vis. Sci. 44, 4086-4096
17. Yu, X. L., Hu, T., Du, J. M., Ding, J. P., Yang, X. M., Zhang, J., Yang, B., Shen, X., Zhang, Z., Zhong, W. D., Wen, N., Jiang, H., Zhu, P., and Chen, Z. N. (2008) Crystal structure of HAb18G/CD147: implications for immunoglobulin superfamily homophilic adhesion. J. Biol. Chem. 283, 18056-18065
18. Schlegel, J., Redzic, J. S., Porter, C. C., Yurchenko, V., Bukrinsky, M., Labeikovsky, W., Armstrong, G. S., Zhang, F., Isern, N. G., DeGregori, J., Hodges, R., and Eisenmesser, E. Z. (2009) Solution characterization of the extracellular region of CD147 and its interaction with its enzyme ligand cyclophilin A. J. Mol. Biol. 391, 518-535
19. Redzic, J. S., Armstrong, G. S., Isern, N. G., Jones, D. N., Kieft, J. S., and Eisenmesser, E. Z. (2011) The retinal specific CD147 Ig0 domain: from molecular structure to biological activity. J. Mol. Biol. 411, 68-82
20. Miyauchi, T., Masuzawa, Y., and Muramatsu, T. (1991) The basigin group of the immunoglobulin superfamily: complete conservation of a segment in and around transmembrane domains of human and mouse basigin and chicken HT7 antigen. J. Biochem. 110, 770-774
21. Halestrap, A. P. (2012) The monocarboxylate transporter family-structure and functional characterization. IUBMB Life 64, 1-9
22. Kirk, P., Wilson, M. C., Heddle, C., Brown, M. H., Barclay, A. N., and Halestrap, A. P. (2000) CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression. EMBO J. 19, 3896-3904
23. Wilson, M. C., Meredith, D., Fox, J. E., Manoharan, C., Davies, A. J., and Halestrap, A. P. (2005) Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: The ancillary protein for the insensitive MCT2 is EMBIGIN (gp70). J. Biol. Chem. 280, 27213-27221
24. Mannowetz, N., Wandernoth, P., and Wennemuth, G. (2012) Basigin interacts with both MCT1 and MCT2 in murine spermatozoa. J. Cell. Physiol. 227, 2154-2162
25. Poole, R. C. And Halestrap, A. P. (1997) Interaction of the erythrocyte lactate transporter (monocarboxylate transporter 1) with an integral 70-kDa membrane glycoprotein of the immunoglobulin superfamily. J. Biol. Chem. 272, 14624-14628
26. Wilson, M. C., Meredith, D., and Halestrap, A. P. (2002) Fluorescence resonance energy transfer studies on the interaction between the lactate transporter MCT1 and CD147 provide information on the topology and stoichiometry of the complex in situ. J. Biol. Chem. 277, 3666-3672
27. Hori, K., Katayama, N., Kachi, S., Kondo, M., Kadomatsu, K., Usukura, J., Muramatsu, T., Mori, S., and Miyake, Y. (2000) Retinal dysfunction in basigin deficiency. Invest. Ophthalmol. Vis. Sci. 41, 3128-3133
28. Philp, N. J., Ochrietor, J. D., Rudoy, C., Muramatsu, T., and Linser, P. J. (2003) Loss of MCT1, MCT3, and MCT4 expression in the retinal pigment epithelium and neural retina of the 5A11/basigin-null mouse. Invest. Ophthalmol. Vis. Sci. 44, 1305-1311
29. Ait-Ali, N., Fridlich, R., Millet-Puel, G., Clerin, E., Delalande, F., Jaillard, C., Blond, F., Perrocheau, L., Reichman, S., Byrne, L. C., Olivier-Bandini, A., Bellalou, J., Moyse, E., Bouillaud, F., Nicol, X., Dalkara, D., van Dorsselaer, A., Sahel, J. A., and Leveillard, T. (2015) Rod-derived cone viability factor promotes cone survival by stimulating aerobic glycolysis. Cell 161, 817-832
30. Slomiany, M. G., Grass, G. D., Robertson, A. D., Yang, X. Y., Maria, B. L., Beeson, C., and Toole, B. P. (2009) Hyaluronan, CD44, and emmprin regulate lactate efflux and membrane localization of monocarboxylate transporters in human breast carcinoma cells. Cancer Res. 69, 1293-1301
31. Grass, G. D., Tolliver, L. B., Bratoeva, M., and Toole, B. P. (2013) CD147, CD44, and the epidermal growth factor receptor (EGFR) signaling pathway cooperate to regulate breast epithelial cell invasiveness. J. Biol. Chem. 288, 26089-26104
32. Berditchevski, F., Chang, S., Bodorova, J., and Hemler, M. E. (1997) Generation of monoclonal antibodies to integrin-associated proteins. Evidence that a3b1 complexes with EMMPRIN/basigin/OX47/M6. J. Biol. Chem. 272, 29174-29180
33. Li, Y., Wu, J., Song, F., Tang, J., Wang, S. J., Yu, X. L., Chen, Z. N., and Jiang, J. L. (2012) Extracellular membrane-proximal domain of HAb18G/CD147 binds to metal ion-dependent adhesion site (MIDAS) motif of integrin b1 to modulate malignant properties of hepatoma cells. J. Biol. Chem. 287, 4759-4772
34. Xu, D. And Hemler, M. E. (2005) Metabolic activationrelated CD147-CD98 complex. Mol. Cell. Proteomics 4, 1061-1071
35. Cho, J. Y., Fox, D. A., Horejsi, V., Sagawa, K., Skubitz, K. M., Katz, D. R., and Chain, B. (2001) The functional interactions between CD98, b1-integrins, and CD147 in the induction of U937 homotypic aggregation. Blood 98, 374-382
36. Khunkaewla, P., Schiller, H. B., Paster, W., Leksa, V., Cermak, L., Andera, L., Horejsi, V., and Stockinger, H. (2008) LFA-1-mediated leukocyte adhesion regulated by interaction of CD43 with LFA-1 and CD147. Mol. Immunol. 45, 1703-1711
37. Gallagher, S. M., Castorino, J. J., and Philp, N. J. (2009) Interaction of monocarboxylate transporter 4 with b1-integrin and its role in cell migration. Am. J. Physiol. Cell. Physiol. 296, C414-C421
38. Reed, B. H., Wilk, R., Schock, F., and Lipshitz, H. D. (2004) Integrin-dependent apposition of Drosophila extraembryonic membranes promotes morphogenesis and prevents anoikis. Curr. Biol. 14, 372-380
39. Zhou, S., Zhou, H., Walian, P. J., and Jap, B. K. (2005) CD147 is a regulatory subunit of the g-secretase complex in Alzheimer's disease amyloid b-peptide production. Proc. Natl Acad. Sci. U S A 102, 7499-7504
40. Till, A., Rosenstiel, P., Brautigam, K., Sina, C., Jacobs, G., Oberg, H. H., Seegert, D., Chakraborty, T., and Schreiber, S. (2008) A role for membrane-bound CD147 in NOD2-mediated recognition of bacterial cytoinvasion. J. Cell Sci. 121, 487-495
41. Moreno, V., Gonzalo, P., Gomez-Escudero, J., Pollan, A., Acin-Perez, R., Breckenridge, M., Yanez-Mo, M., Barreiro, O., Orsenigo, F., Kadomatsu, K., Chen, C. S., Enriquez, J. A., Dejana, E., Sanchez-Madrid, F., and Arroyo, A. G. (2014) An EMMPRIN-g-catenin-Nm23 complex drives ATP production and actomyosin contractility at endothelial junctions. J. Cell Sci. 127, 3768-3781
42. Yurchenko, V., Zybarth, G., O'Connor, M., Dai, W. W., Franchin, G., Hao, T., Guo, H., Hung, H. C., Toole, B., Gallay, P., Sherry, B., and Bukrinsky, M. (2002) Active site residues of cyclophilin A are crucial for its signaling activity via CD147. J. Biol. Chem. 277, 22959-22965
43. Pakula, R., Melchior, A., Denys, A., Vanpouille, C., Mazurier, J., and Allain, F. (2007) Syndecan-1/CD147 association is essential for cyclophilin B-induced activation of p44/42 mitogen-activated protein kinases and promotion of cell adhesion and chemotaxis. Glycobiology 17, 492-503
44. Seizer, P., Borst, O., Langer, H. F., Bultmann, A., Munch, G., Herouy, Y., Stellos, K., Kramer, B., Bigalke, B., Buchele, B., Bachem, M. G., Vestweber, D., Simmet, T., Gawaz, M., and May, A. E. (2009) EMMPRIN (CD147) is a novel receptor for platelet GPVI and mediates platelet rolling via GPVIEMMPRIN interaction. Thromb. Haemost. 101, 682-686
45. Hibino, T., Sakaguchi, M., Miyamoto, S., Yamamoto, M., Motoyama, A., Hosoi, J., Shimokata, T., Ito, T., Tsuboi, R., and Huh, N. H. (2013) S100A9 is a novel ligand of EMMPRIN that promotes melanoma metastasis. Cancer Res. 73, 172-183
46. Najyb, O., Brissette, L., and Rassart, E. (2015) Apolipoprotein D internalization is a basigin-dependent mechanism. J. Biol. Chem. 290, 16077-16087
47. Yoshida, S., Shibata, M., Yamamoto, S., Hagihara, M., Asai, N., Takahashi, M., Mizutani, S., Muramatsu, T., and Kadomatsu, K. (2000) Homo-oligomer formation by basigin, an immunoglobulin superfamily member, via its N-terminal immunoglobulin domain. Eur. J. Biochem. 267, 4372-4380
48. Besse, F., Mertel, S., Kittel, R. J., Wichmann, C., Rasse, T. M., Sigrist, S. J., and Ephrussi, A. (2007) The Ig cell adhesion molecule Basigin controls compartmentalization and vesicle release at Drosophila melanogaster synapses. J. Cell Biol. 177, 843-855
49. Hanna, S. M., Kirk, P., Holt, O. J., Puklavec, M. J., Brown, M. H., and Barclay, A. N. (2003) A novel form of the membrane protein CD147 that contains an extra Ig-like domain and interacts homophilically. BMC Biochem. 4, 17
50. Huang, W., Luo, W. J., Zhu, P., Tang, J., Yu, X. L., Cui, H. Y., Wang, B., Zhang, Y., Jiang, J. L., and Chen, Z. N. (2013) Modulation of CD147-induced matrix metalloproteinase activity: role of CD147 N-glycosylation. Biochem. J. 449, 437-448
51. Tang, W., Chang, S. B., and Hemler, M. E. (2004) Links between CD147 function, glycosylation, and caveolin-1. Mol. Biol. Cell 15, 4043-4050
52. Priglinger, C. S., Szober, C. M., Priglinger, S. G., Merl, J., Euler, K. N., Kernt, M., Gondi, G., Behler, J., Geerlof, A., Kampik, A., Ueffing, M., and Hauck, S. M. (2013) Galectin-3 induces clustering of CD147 and integrin-b1 transmembrane glycoprotein receptors on the RPE cell surface. PLoS One 8, e70011
53. Mauris, J., Woodward, A. M., Cao, Z., Panjwani, N., and Argueso, P. (2014) Molecular basis for MMP9 induction and disruption of epithelial cell-cell contacts by galectin-3. J. Cell Sci. 127, 3141-3148
54. Kato, N., Yuzawa, Y., Kosugi, T., Hobo, A., Sato, W., Miwa, Y., Sakamoto, K., Matsuo, S., and Kadomatsu, K. (2009) The E-selectin ligand basigin/CD147 is responsible for neutrophil recruitment in renal ischemia/reperfusion. J. Am. Soc. Nephrol. 20, 1565-1576
55. Bi, J., Li, Y., Sun, F., Saalbach, A., Klein, C., Miller, D. J., Hess, R., and Nowak, R. A. (2013) Basigin null mutant male mice are sterile and exhibit impaired interactions between germ cells and Sertoli cells. Dev. Biol. 380, 145-156
56. Rodriguez-Teja, M., Gronau, J. H., Minamidate, A., Darby, S., Gaughan, L., Robson, C., Mauri, F., Waxman, J., and Sturge, J. (2015) Survival outcome and EMT suppression mediated by a lectin domain interaction of Endo180 and CD147. Mol. Cancer Res. 13, 538-547
57. Igakura, T., Kadomatsu, K., Kaname, T., Muramatsu, H., Fan, Q. W., Miyauchi, T., Toyama, Y., Kuno, N., Yuasa, S., Takahashi, M., Senda, T., Taguchi, O., Yamamura, K., Arimura, K., and Muramatsu, T. (1998) A null mutation in basigin, an immunoglobulin superfamily member, indicates its important roles in periimplantation development and spermatogenesis. Dev. Biol. 194, 152-165
58. Kuno, N., Kadomatsu, K., Fan, Q. W., Hagihara, M., Senda, T., Mizutani, S., and Muramatsu, T. (1998) Female sterility in mice lacking the basigin gene, which encodes a transmembrane glycoprotein belonging to the immunoglobulin superfamily. FEBS Lett. 425, 191-194
59. Akama, T. O., Nakagawa, H., Sugihara, K., Narisawa, S., Ohyama, C., Nishimura, S., O'Brien, D. A., Moremen, K. W., Millan, J. L., and Fukuda, M. N. (2002) Germ cell survival through carbohydratemediated interaction with Sertoli cells. Science 295, 124-127
60. Chen, L., Belton, R. J. Jr., and Nowak, R. A. (2009) Basigin-mediated gene expression changes in mouse uterine stromal cells during implantation. Endocrinology 150, 966-976
61. Chen, S., Kadomatsu, K., Kondo, M., Toyama, Y., Toshimori, K., Ueno, S., Miyake, Y., and Muramatsu, T. (2004) Effects of flanking genes on the phenotypes of mice deficient in basigin/CD147. Biochem. Biophys. Res. Commun. 324, 147-153
62. Mauris, J., Dieckow, J., Schob, S., Pulli, B., Hatton, M. P., Jeong, S., Bauskar, A., Gabison, E., Nowak, R., and Argueso, P. (2015) Loss of CD147 results in impaired epithelial cell differentiation and malformation of the meibomian gland. Cell Death Dis. 6, e1726
63. Khaddam, M., Huet, E., Vallee, B., Bensidhoum, M., Le Denmat, D., Filatova, A., Jimenez-Rojo, L., Ribes, S., Lorenz, G., Morawietz, M., Rochefort, G. Y., Kiesow, A., Mitsiadis, T. A., Poliard, A., Petzold, M., Gabison, E. E., Menashi, S., and Chaussain, C. (2014) EMMPRIN/CD147 deficiency disturbs ameloblastodontoblast cross-talk and delays enamel mineralization. Bone 66, 256-266
64. Igakura, T., Kadomatsu, K., Taguchi, O., Muramatsu, H., Kaname, T., Miyauchi, T., Yamamura, K., Arimura, K., and Muramatsu, T. (1996) Roles of basigin, a member of the immunoglobulin superfamily, in behavior as to an irritating odor, lymphocyte response, and bloodbrain barrier. Biochem. Biophys. Res. Commun. 224, 33-36
65. Naruhashi, K., Kadomatsu, K., Igakura, T., Fan, Q. W., Kuno, N., Muramatsu, H., Miyauchi, T., Hasegawa, T., Itoh, A., Muramatsu, T., and Nabeshima, T. (1997) Abnormalities of sensory and memory functions in mice lacking BSG gene. Biochem. Biophys. Res. Commun. 236, 733-737
66. Fan, Q. W., Yuasa, S., Kuno, N., Senda, T., Kobayashi, M., Muramatsu, T., and Kadomatsu, K. (1998) Expression of basigin, a member of the immunoglobulin superfamily, in the mouse central nervous system. Neurosci. Res. 30, 53-63
67. Yao, H., Teng, Y., Sun, Q., Xu, J., Chen, Y. T., Hou, N., Cheng, X., Yang, X., and Chen, Z. N. (2014) Important functional roles of basigin in thymocyte development and T cell activation. Int. J. Biol. Sci. 10, 43-52
68. Ruiz, S., Castro-Castro, A., and Bustelo, X. R. (2008) CD147 inhibits the nuclear factor of activated T-cells by impairing Vav1 and Rac1 downstream signaling. J. Biol. Chem. 283, 5554-5566
69. Solstad, T., Bains, S. J., Landskron, J., Aandahl, E. M., Thiede, B., Tasken, K., and Torgersen, K. M. (2011) CD147 (Basigin/Emmprin) identifies FoxP3+CD45RO+CTLA4+-activated human regulatory T cells. Blood 118, 5141-5151
70. Kanekura, T. And Chen, X. (2010) CD147/basigin promotes progression of malignant melanoma and other cancers. J. Dermatol. Sci. 57, 149-154
71. Partridge, E. A., Le Roy, C., Di Guglielmo, G. M., Pawling, J., Cheung, P., Granovsky, M., Nabi, I. R., Wrana, J. L., and Dennis, J. W. (2004) Regulation of cytokine receptors by Golgi N-glycan processing and endocytosis. Science 306, 120-124
72. Baba, M., Inoue, M., Itoh, K., and Nishizawa, Y. (2008) Blocking CD147 induces cell death in cancer cells through impairment of glycolytic energy metabolism. Biochem. Biophys. Res. Commun. 374, 111-116
73. Le Floch, R., Chiche, J., Marchiq, I., Naiken, T., Ilc, K., Murray, C. M., Critchlow, S. E., Roux, D., Simon, M. P., and Pouyssegur, J. (2011) CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors. Proc. Natl. Acad. Sci. U S A 108, 16663-16668
74. Sun, J. And Hemler, M. E. (2001) Regulation of MMP-1 and MMP-2 production through CD147/extracellular matrix metalloproteinase inducer interactions. Cancer Res. 61, 2276-2281
75. Tang, Y., Nakada, M. T., Kesavan, P., McCabe, F., Millar, H., Rafferty, P., Bugelski, P., and Yan, L. (2005) Extracellular matrix metalloproteinase inducer stimulates tumor angiogenesis by elevating vascular endothelial cell growth factor and matrix metalloproteinases. Cancer Res. 65, 3193-3199
76. Zhu, D., Wang, Z., Zhao, J. J., Calimeri, T., Meng, J., Hideshima, T., Fulciniti, M., Kang, Y., Ficarro, S. B., Tai, Y. T., Hunter, Z., McMilin, D., Tong, H., Mitsiades, C. S., Wu, C. J., Treon, S. P., Dorfman, D. M., Pinkus, G., Munshi, N. C., Tassone, P., Marto, J. A., Anderson, K. C., and Carrasco, R. D. (2015) The Cyclophilin A-CD147 complex promotes the proliferation and homing of multiple myeloma cells. Nat. Med. 21, 572-580
77. Wang, W. J., Li, Q. Q., Xu, J. D., Cao, X. X., Li, H. X., Tang, F., Chen, Q., Yang, J. M., Xu, Z. D., and Liu, X. P. (2008) Interaction between CD147 and P-glycoprotein and their regulation by ubiquitination in breast cancer cells. Chemotherapy 54, 291-301
78. Bougatef, F., Quemener, C., Kellouche, S., Naimi, B., Podgorniak, M. P., Millot, G., Gabison, E. E., Calvo, F., Dosquet, C., Lebbe, C., Menashi, S., and Mourah, S. (2009) EMMPRIN promotes angiogenesis through hypoxia-inducible factor-2a-mediated regulation of soluble VEGF isoforms and their receptor VEGFR-2. Blood 114, 5547-5556
79. Hatanaka, M., Higashi, Y., Fukushige, T., Baba, N., Kawai, K., Hashiguchi, T., Su, J., Zeng, W., Chen, X., and Kanekura, T. (2014) Cleaved CD147 shed from the surface of malignant melanoma cells activates MMP2 produced by fibroblasts. Anticancer Res. 34, 7091-7096
80. Redzic, J. S., Kendrick, A. A., Bahmed, K., Dahl, K. D., Pearson, C. G., Robinson, W. A., Robinson, S. E., Graner, M. W., and Eisenmesser, E. Z. (2013) Extracellular vesicles secreted from cancer cell lines stimulate secretion of MMP-9, IL-6, TGF-b1 and EMMPRIN. PLoS One 8, e71225
81. Crosnier, C., Bustamante, L. Y., Bartholdson, S. J., Bei, A. K., Theron, M., Uchikawa, M., Mboup, S., Ndir, O., Kwiatkowski, D. P., Duraisingh, M. T., Rayner, J. C., and Wright, G. J. (2011) Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum. Nature 480, 534-537
82. Wright, K. E., Hjerrild, K. A., Bartlett, J., Douglas, A. D., Jin, J., Brown, R. E., Illingworth, J. J., Ashfield, R., Clemmensen, S. B., de Jongh, W. A., Draper, S. J., and Higgins, M. K. (2014) Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodies. Nature 515, 427-430
83. Zenonos, Z. A., Dummler, S. K., Muller-Sienerth, N., Chen, J., Preiser, P. R., Rayner, J. C., and Wright, G. J. (2015) Basigin is a druggable target for host-oriented antimalarial interventions. J. Exp. Med. 212, 1145-1151
84. Bernard, S. C., Simpson, N., Join-Lambert, O., Federici, C., Laran-Chich, M. P., Maissa, N., Bouzinba-Segard, H., Morand, P. C., Chretien, F., Taouji, S., Chevet, E., Janel, S., Lafont, F., Coureuil, M., Segura, A., Niedergang, F., Marullo, S., Couraud, P. O., Nassif, X., and Bourdoulous, S. (2014) Pathogenic Neisseria meningitidis utilizes CD147 for vascular colonization. Nat. Med. 20, 725-731
85. Kato, N., Kosugi, T., Sato, W., Ishimoto, T., Kojima, H., Sato, Y., Sakamoto, K., Maruyama, S., Yuzawa, Y., Matsuo, S., and Kadomatsu, K. (2011) Basigin/CD147 promotes renal fibrosis after unilateral ureteral obstruction. Am. J. Pathol. 178, 572-579
86. Maeda, K., Kosugi, T., Sato, W., Kojima, H., Sato, Y., Kamimura, D., Kato, N., Tsuboi, N., Yuzawa, Y., Matsuo, S., Murakami, M., Maruyama, S., and Kadomatsu, K. (2015) CD147/Basigin limits lupus nephritis and Th17 cell differentiation in mice by inhibiting the interleukin-6/STAT-3 pathway. Arthritis Rheum. 67, 2185-2195