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Volumn 21, Issue 4, 2016, Pages

Wild Bitter Melon Leaf Extract Inhibits Porphyromonas gingivalis-Induced Inflammation: Identification of Active Compounds through Bioassay-Guided Isolation

Author keywords

Anti inflammation; Cucurbitane triterpenoid; Porphyromonas gingivalis; Wild bitter melon

Indexed keywords

CUCURBITANE; GLYCOSIDE; PLANT EXTRACT; TRITERPENE;

EID: 84966340186     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules21040454     Document Type: Article
Times cited : (25)

References (49)
  • 1
    • 84971323731 scopus 로고    scopus 로고
    • Periodontitis: From microbial immune subversion to systemic inflammation
    • [CrossRef] PubMed
    • Hajishengallis, G. Periodontitis: From microbial immune subversion to systemic inflammation. Nat. Rev. Immunol. 2015, 15, 30-44. [CrossRef] [PubMed]
    • (2015) Nat. Rev. Immunol. , vol.15 , pp. 30-44
    • Hajishengallis, G.1
  • 2
    • 2542483789 scopus 로고    scopus 로고
    • Intracellular signaling and cytokine induction upon interactions of Porphyromonas gingivalis fimbriae with pattern-recognition receptors
    • CrossRef
    • Hajishengallis, G.; Sojar, H.; Genco, R.J.; DeNardin, E. Intracellular signaling and cytokine induction upon interactions of Porphyromonas gingivalis fimbriae with pattern-recognition receptors. Immunol. Investig. 2004, 33, 157-172. [CrossRef]
    • (2004) Immunol. Investig. , vol.33 , pp. 157-172
    • Hajishengallis, G.1    Sojar, H.2    Genco, R.J.3    DeNardin, E.4
  • 3
    • 0345059142 scopus 로고    scopus 로고
    • Porphyromonas gingivalis 67-kDa fimbriae induced cytokine production and osteoclast differentiation utilizing TLR2
    • CrossRef
    • Hiramine, H.; Watanabe, K.; Hamada, N.; Umemoto, T. Porphyromonas gingivalis 67-kDa fimbriae induced cytokine production and osteoclast differentiation utilizing TLR2. FEMS Microbiol. Lett. 2003, 229, 49-55. [CrossRef]
    • (2003) FEMS Microbiol. Lett. , vol.229 , pp. 49-55
    • Hiramine, H.1    Watanabe, K.2    Hamada, N.3    Umemoto, T.4
  • 4
    • 0035130525 scopus 로고    scopus 로고
    • Production of inflammatory cytokines by human gingival fibroblasts stimulated by cell-surface preparations of Porphyromonas gingivalis
    • [CrossRef] PubMed
    • Imatani, T.; Kato, T.; Okuda, K. Production of inflammatory cytokines by human gingival fibroblasts stimulated by cell-surface preparations of Porphyromonas gingivalis. Oral Microbiol. Immunol. 2001, 16, 65-72. [CrossRef] [PubMed]
    • (2001) Oral Microbiol. Immunol. , vol.16 , pp. 65-72
    • Imatani, T.1    Kato, T.2    Okuda, K.3
  • 5
    • 84907966105 scopus 로고    scopus 로고
    • TNF-α augmented Porphyromonas gingivalis invasion in human gingival epithelial cells through Rab5 and ICAM-1
    • CrossRef PubMed
    • Kato, Y.; Hagiwara, M.; Ishihara, Y.; Isoda, R.; Sugiura, S.; Komatsu, T.; Ishida, N.; Noguchi, T.; Matsushita, K. TNF-α augmented Porphyromonas gingivalis invasion in human gingival epithelial cells through Rab5 and ICAM-1. BMC Microbiol. 2014, 14, 229. [CrossRef] [PubMed]
    • (2014) BMC Microbiol. , vol.14 , pp. 229
    • Kato, Y.1    Hagiwara, M.2    Ishihara, Y.3    Isoda, R.4    Sugiura, S.5    Komatsu, T.6    Ishida, N.7    Noguchi, T.8    Matsushita, K.9
  • 7
    • 0027692326 scopus 로고
    • Role of cytokines and inflammatory mediators in tissue destruction
    • [CrossRef] PubMed
    • Birkedal-Hansen, H. Role of cytokines and inflammatory mediators in tissue destruction. J. Periodontal. Res. 1993, 28, 500-510. [CrossRef] [PubMed]
    • (1993) J. Periodontal. Res. , vol.28 , pp. 500-510
    • Birkedal-Hansen, H.1
  • 8
    • 0027601371 scopus 로고
    • The role of interleukin-8 in inflammation and mechanisms of regulation
    • [PubMed]
    • Bickel, M. The role of interleukin-8 in inflammation and mechanisms of regulation. J. Periodontol. 1993, 64 (Suppl. S5), 456-460. [PubMed]
    • (1993) J. Periodontol. , vol.64 , pp. 456-460
    • Bickel, M.1
  • 9
    • 0032468328 scopus 로고    scopus 로고
    • Cytokine expression in periodontal health and disease
    • [CrossRef] PubMed
    • Okada, H.; Murakami, S. Cytokine expression in periodontal health and disease. Crit. Rev. Oral Biol. Med. 1998, 9, 248-266. [CrossRef] [PubMed]
    • (1998) Crit. Rev. Oral Biol. Med. , vol.9 , pp. 248-266
    • Okada, H.1    Murakami, S.2
  • 11
    • 0031152178 scopus 로고    scopus 로고
    • Mechanisms of alveolar bone destruction in periodontitis
    • [CrossRef] [PubMed]
    • Schwartz, Z.; Goultschin, J.; Dean, D.D.; Boyan, B.D. Mechanisms of alveolar bone destruction in periodontitis. Periodontol. 2000 1997, 14, 158-172. [CrossRef] [PubMed]
    • (1997) Periodontol. 2000 , vol.14 , pp. 158-172
    • Schwartz, Z.1    Goultschin, J.2    Dean, D.D.3    Boyan, B.D.4
  • 12
    • 0024986636 scopus 로고
    • Tumour necrosis factor alpha in gingival crevicular fluid as a possible indicator of periodontal disease in humans
    • CrossRef
    • Rossomando, E.F.; Kennedy, J.E.; Hadjimichael, J. Tumour necrosis factor alpha in gingival crevicular fluid as a possible indicator of periodontal disease in humans. Arch. Oral Biol. 1990, 35, 431-434. [CrossRef]
    • (1990) Arch. Oral Biol. , vol.35 , pp. 431-434
    • Rossomando, E.F.1    Kennedy, J.E.2    Hadjimichael, J.3
  • 13
    • 84890065640 scopus 로고    scopus 로고
    • Porphyromonas gingivalis LPS inhibits osteoblastic differentiation and promotes pro-inflammatory cytokine production in human periodontal ligament stem cells
    • CrossRef PubMed
    • Kato, H.; Taguchi, Y.; Tominaga, K.; Umeda, M.; Tanaka, A. Porphyromonas gingivalis LPS inhibits osteoblastic differentiation and promotes pro-inflammatory cytokine production in human periodontal ligament stem cells. Arch. Oral Biol. 2014, 59, 167-175. [CrossRef] [PubMed]
    • (2014) Arch. Oral Biol. , vol.59 , pp. 167-175
    • Kato, H.1    Taguchi, Y.2    Tominaga, K.3    Umeda, M.4    Tanaka, A.5
  • 14
    • 84880485815 scopus 로고    scopus 로고
    • Assessment of IL-6, IL-8 and TNF-α levels in the gingival tissue of patients with periodontitis
    • PubMed
    • Noh, M.K.; Jung, M.; Kim, S.H.; Lee, S.; Park, K.H.; Kim, D.H.; Kim, H.H.; Park, Y.G. Assessment of IL-6, IL-8 and TNF-α levels in the gingival tissue of patients with periodontitis. Exp. Ther. Med. 2013, 6, 847-851. [PubMed]
    • (2013) Exp. Ther. Med. , vol.6 , pp. 847-851
    • Noh, M.K.1    Jung, M.2    Kim, S.H.3    Lee, S.4    Park, K.H.5    Kim, D.H.6    Kim, H.H.7    Park, Y.G.8
  • 15
    • 79958212501 scopus 로고    scopus 로고
    • Serum cytokine levels in periodontitis patients in relation to the bacterial load
    • CrossRef PubMed
    • Andrukhov, O.; Ulm, C.; Reischl, H.; Nguyen, P.Q.; Matejka, M.; Rausch-Fan, X. Serum cytokine levels in periodontitis patients in relation to the bacterial load. J. Periodontaol. 2011, 82, 885-892. [CrossRef] [PubMed]
    • (2011) J. Periodontaol. , vol.82 , pp. 885-892
    • Andrukhov, O.1    Ulm, C.2    Reischl, H.3    Nguyen, P.Q.4    Matejka, M.5    Rausch-Fan, X.6
  • 17
    • 43849096918 scopus 로고    scopus 로고
    • Phenolic contents and antioxidant activities of bitter gourd (Momordica charantia L. ) leaf, stem and fruit fraction extracts in vitro
    • PubMed
    • Kubola, J.; Siriamornpun, S. Phenolic contents and antioxidant activities of bitter gourd (Momordica charantia L.) leaf, stem and fruit fraction extracts in vitro. Food Chem. 2008, 110, 881-890. [PubMed]
    • (2008) Food Chem. , vol.110 , pp. 881-890
    • Kubola, J.1    Siriamornpun, S.2
  • 18
    • 85068988237 scopus 로고    scopus 로고
    • Food prospects and nutraceutical attributes of Momordica species: A potential tropical bioresources-A review
    • CrossRef
    • Nagarani, G.; Abirami, A.; Siddhuraju, P. Food prospects and nutraceutical attributes of Momordica species: A potential tropical bioresources-A review. Food Sci. Hum. Wellness 2014, 3, 36-46. [CrossRef]
    • (2014) Food Sci. Hum. Wellness , vol.3 , pp. 36-46
    • Nagarani, G.1    Abirami, A.2    Siddhuraju, P.3
  • 19
    • 84928988424 scopus 로고    scopus 로고
    • Antioxidant, cell-protective, and anti-melanogenic activities of leaf extracts from wild bitter melon (Momordica charantia Linn. Var. Abbreviata Ser. ) cultivars
    • CrossRef
    • Tsai, T.H.; Huang, C.J.; Wu, W.H.; Huang, W.C.; Chyuan, J.H.; Tsai, P.J. Antioxidant, cell-protective, and anti-melanogenic activities of leaf extracts from wild bitter melon (Momordica charantia Linn. var. abbreviata Ser.) cultivars. Bot. Stud. 2014, 55, 78-88. [CrossRef]
    • (2014) Bot. Stud. , vol.55 , pp. 78-88
    • Tsai, T.H.1    Huang, C.J.2    Wu, W.H.3    Huang, W.C.4    Chyuan, J.H.5    Tsai, P.J.6
  • 20
    • 84938766194 scopus 로고    scopus 로고
    • Inhibitory effects of wild bitter melon leaf extract on Propionibacterium acnes-induced skin inflammation in mouse and cytokine production in vitro
    • CrossRef PubMed
    • Huang, W.C.; Tsai, T.H.; Huang, C.J.; Li, Y.Y.; Chyuan, J.H.; Chuang, L.T.; Tsai, P.J. Inhibitory effects of wild bitter melon leaf extract on Propionibacterium acnes-induced skin inflammation in mouse and cytokine production in vitro. Food Funct. 2015, 6, 2550-2560. [CrossRef] [PubMed]
    • (2015) Food Funct. , vol.6 , pp. 2550-2560
    • Huang, W.C.1    Tsai, T.H.2    Huang, C.J.3    Li, Y.Y.4    Chyuan, J.H.5    Chuang, L.T.6    Tsai, P.J.7
  • 23
    • 84857182203 scopus 로고    scopus 로고
    • Role of phytotherapy in gingivitis: A review
    • CrossRef
    • Jagan Rao, N.; Subash, K.R.; Sandeep Kumar, K. Role of phytotherapy in gingivitis: A review. Int. J. Pharmacol. 2012, 8, 1-5. [CrossRef]
    • (2012) Int. J. Pharmacol. , vol.8 , pp. 1-5
    • Jagan Rao, N.1    Subash, K.R.2    Kumar, S.K.3
  • 24
    • 60849121701 scopus 로고    scopus 로고
    • Suppressive effects of wild bitter gourd (Momordica charantia Linn. Var. Abbreviate ser. ) fruit extracts on inflammatory responses in RAW 264.7 macrophages
    • CrossRef PubMed
    • Lii, C.K.; Chen, H.W.; Yun, W.T.; Liu, K. Suppressive effects of wild bitter gourd (Momordica charantia Linn. var. abbreviate ser.) fruit extracts on inflammatory responses in RAW 264.7 macrophages. J. Ethnopharmacol. 2009, 122, 227-233. [CrossRef] [PubMed]
    • (2009) J. Ethnopharmacol. , vol.122 , pp. 227-233
    • Lii, C.K.1    Chen, H.W.2    Yun, W.T.3    Liu, K.4
  • 25
    • 84865762517 scopus 로고    scopus 로고
    • Wild bitter melon (Momordica charantia Linn. Var. Abbreviata Ser. ) extract and its bioactive components suppress Propionibacterium acnes-induced inflammation
    • CrossRef PubMed
    • Hsu, C.; Tsai, T.H.; Li, Y.Y.; Wu, W.H.; Huang, C.J.; Tsai, P.J. Wild bitter melon (Momordica charantia Linn. var. abbreviata Ser.) extract and its bioactive components suppress Propionibacterium acnes-induced inflammation. Food Chem. 2012, 135, 976-984. [CrossRef] [PubMed]
    • (2012) Food Chem. , vol.135 , pp. 976-984
    • Hsu, C.1    Tsai, T.H.2    Li, Y.Y.3    Wu, W.H.4    Huang, C.J.5    Tsai, P.J.6
  • 26
    • 84939433561 scopus 로고    scopus 로고
    • Effect of wild bitter gourd treatment on inflammatory responses in BALB/c mice with sepsis
    • CrossRef PubMed
    • Ciou, S.Y.; Hsu, C.C.; Kuo, Y.H.; Chao, C.Y. Effect of wild bitter gourd treatment on inflammatory responses in BALB/c mice with sepsis. Biomedicine 2014, 4, 7-13. [CrossRef] [PubMed]
    • (2014) Biomedicine , vol.4 , pp. 7-13
    • Ciou, S.Y.1    Hsu, C.C.2    Kuo, Y.H.3    Chao, C.Y.4
  • 28
    • 85038367570 scopus 로고    scopus 로고
    • Momordica charantia
    • Lim, T.K., Ed.; Springer: New York, NY, USA
    • Lim, T.K. Momordica charantia. In Edible Medicinal and Non-Medicinal Plants; Lim, T.K., Ed.; Springer: New York, NY, USA, 2012; Volume 2, pp. 331-368.
    • (2012) Edible Medicinal and Non-Medicinal Plants , vol.2 , pp. 331-368
    • Lim, T.K.1
  • 29
    • 79955679532 scopus 로고    scopus 로고
    • Isolation and identification of cucurbitane-type triterpenoids with partial agonist/antagonist potential for estrogen receptors from Momordica charantia
    • CrossRef PubMed
    • Hsu, C.; Hsieh, C.L.; Kuo, Y.H.; Huang, C.J. Isolation and identification of cucurbitane-type triterpenoids with partial agonist/antagonist potential for estrogen receptors from Momordica charantia. J. Agric. Food Chem. 2011, 59, 4553-4561. [CrossRef] [PubMed]
    • (2011) J. Agric. Food Chem. , vol.59 , pp. 4553-4561
    • Hsu, C.1    Hsieh, C.L.2    Kuo, Y.H.3    Huang, C.J.4
  • 30
    • 78649872740 scopus 로고    scopus 로고
    • Cucurbitane triterpenoids from Momordica charantia and their cytoprotective activity in tert-butyl hydroperoxide-induced hepatotoxicity of HepG2 cells
    • [CrossRef] PubMed
    • Chen, C.R.; Liao, Y.W.; Wang, L.; Kuo, Y.H.; Liu, H.J.; Shih, W.L.; Cheng, H.L.; Chang, C.I. Cucurbitane triterpenoids from Momordica charantia and their cytoprotective activity in tert-butyl hydroperoxide-induced hepatotoxicity of HepG2 cells. Chem. Pharm. Bull. 2010, 58, 1639-1642. [CrossRef] [PubMed]
    • (2010) Chem. Pharm. Bull. , vol.58 , pp. 1639-1642
    • Chen, C.R.1    Liao, Y.W.2    Wang, L.3    Kuo, Y.H.4    Liu, H.J.5    Shih, W.L.6    Cheng, H.L.7    Chang, C.I.8
  • 31
    • 84880170193 scopus 로고    scopus 로고
    • Cucurbitane triterpenoid from Momordica charantia induces apoptosis and autophagy in breast cancer cells, in part, through peroxisome proliferator-activated receptor ã activation
    • CrossRef PubMed
    • Weng, J.R.; Bai, L.Y.; Chiu, C.F.; Hu, J.L.; Chiu, S.J.; Wu, C.Y. Cucurbitane triterpenoid from Momordica charantia induces apoptosis and autophagy in breast cancer cells, in part, through peroxisome proliferator-activated receptor ã activation. Evid. Based Complement. Altern. Med. 2013, 2013, 935675. [CrossRef] [PubMed]
    • (2013) Evid. Based Complement. Altern. Med. , vol.2013 , pp. 935675
    • Weng, J.R.1    Bai, L.Y.2    Chiu, C.F.3    Hu, J.L.4    Chiu, S.J.5    Wu, C.Y.6
  • 32
    • 51649085397 scopus 로고    scopus 로고
    • A cell-based screening identifies compounds from the stem of Momordica charantia that overcome insulin resistance and activate AMP-activated protein kinase
    • CrossRef PubMed
    • Cheng, H.L.; Huang, H.K.; Chang, C.I.; Tsai, C.P.; Chou, C.H. A cell-based screening identifies compounds from the stem of Momordica charantia that overcome insulin resistance and activate AMP-activated protein kinase. J. Agric. Food Chem. 2008, 56, 6835-6843. [CrossRef] [PubMed]
    • (2008) J. Agric. Food Chem. , vol.56 , pp. 6835-6843
    • Cheng, H.L.1    Huang, H.K.2    Chang, C.I.3    Tsai, C.P.4    Chou, C.H.5
  • 33
    • 84863118843 scopus 로고    scopus 로고
    • Cucurbitane triterpenoids from the leaves of Momordica charantia, and their cancer chemopreventive effects and cytotoxicities
    • CrossRef PubMed
    • Zhang, J.; Huang, Y.; Kikuchi, T.; Tokuda, H.; Suzuki, N.; Inafuku, K.; Miura, M.; Motohashi, S.; Suzuki, T.; Akihisa, T. Cucurbitane triterpenoids from the leaves of Momordica charantia, and their cancer chemopreventive effects and cytotoxicities. Chem. Biodivers. 2012, 9, 428-440. [CrossRef] [PubMed]
    • (2012) Chem. Biodivers. , vol.9 , pp. 428-440
    • Zhang, J.1    Huang, Y.2    Kikuchi, T.3    Tokuda, H.4    Suzuki, N.5    Inafuku, K.6    Miura, M.7    Motohashi, S.8    Suzuki, T.9    Akihisa, T.10
  • 34
    • 33745685683 scopus 로고    scopus 로고
    • Momordica charantia constituents and antidiabetic screening of the isolated major compounds
    • CrossRef PubMed
    • Harinantenaina, L.; Tanaka, M.; Takaoka, S.; Oda, M.; Mogami, O.; Uchida, M.; Asakawa, Y. Momordica charantia constituents and antidiabetic screening of the isolated major compounds. Chem. Pharm. Bull. 2006, 54, 1017-1021. [CrossRef] [PubMed]
    • (2006) Chem. Pharm. Bull. , vol.54 , pp. 1017-1021
    • Harinantenaina, L.1    Tanaka, M.2    Takaoka, S.3    Oda, M.4    Mogami, O.5    Uchida, M.6    Asakawa, Y.7
  • 35
    • 84897094456 scopus 로고    scopus 로고
    • Cucurbitane-type triterpenoids from the stems and leaves of Momordica charantia
    • CrossRef PubMed
    • Zhao, G.T.; Liu, J.Q.; Deng, Y.Y.; Li, H.Z.; Chen, J.C.; Zhang, Z.R.; Zhou, L.; Qiu, M.H. Cucurbitane-type triterpenoids from the stems and leaves of Momordica charantia. Fitoterapia 2014, 95, 75-82. [CrossRef] [PubMed]
    • (2014) Fitoterapia , vol.95 , pp. 75-82
    • Zhao, G.T.1    Liu, J.Q.2    Deng, Y.Y.3    Li, H.Z.4    Chen, J.C.5    Zhang, Z.R.6    Zhou, L.7    Qiu, M.H.8
  • 36
    • 33846604410 scopus 로고    scopus 로고
    • Study on colorimetric determination of oleanolic acid in Chinese quince
    • Xiang, Z.B.; Tang, C.H.; Chen, G.; Shi, Y.S. Study on colorimetric determination of oleanolic acid in Chinese quince. Nat. Prod. Res. Dev. 2001, 13, 23-26.
    • (2001) Nat. Prod. Res. Dev. , vol.13 , pp. 23-26
    • Xiang, Z.B.1    Tang, C.H.2    Chen, G.3    Shi, Y.S.4
  • 37
    • 38849092080 scopus 로고    scopus 로고
    • Identification of signaling pathways in macrophage exposed to Porphyromonas gingivalis or to its purified cell wall components
    • CrossRef PubMed
    • Zhou, Q.; Amar, S. Identification of signaling pathways in macrophage exposed to Porphyromonas gingivalis or to its purified cell wall components. J. Immunol. 2007, 179, 7777-7790. [CrossRef] [PubMed]
    • (2007) J. Immunol. , vol.179 , pp. 7777-7790
    • Zhou, Q.1    Amar, S.2
  • 38
    • 84896399883 scopus 로고    scopus 로고
    • Beyond toll-like receptors: Porphyromonas gingivalis induces IL-6, IL-8, and VCAM-1 expression through NOD-mediated NF-êB and ERK signaling pathways in periodontal fibroblasts
    • CrossRef PubMed
    • Liu, J.; Wang, Y.; Ouyang, X. Beyond toll-like receptors: Porphyromonas gingivalis induces IL-6, IL-8, and VCAM-1 expression through NOD-mediated NF-êB and ERK signaling pathways in periodontal fibroblasts. Inflammation 2014, 37, 522-533. [CrossRef] [PubMed]
    • (2014) Inflammation , vol.37 , pp. 522-533
    • Liu, J.1    Wang, Y.2    Ouyang, X.3
  • 39
    • 84861474688 scopus 로고    scopus 로고
    • Signaling in Innate Immunity and Inflammation
    • CrossRef PubMed
    • Newton, K.; Dixit, V.M. Signaling in Innate Immunity and Inflammation. Cold Spring Harb. Perspect. Biol. 2012, 4, a006049. [CrossRef] [PubMed]
    • (2012) Cold Spring Harb. Perspect. Biol. , vol.4 , pp. a006049
    • Newton, K.1    Dixit, V.M.2
  • 40
    • 84930006794 scopus 로고    scopus 로고
    • Mechanisms of bone resorption in periodontitis
    • CrossRef PubMed
    • Hienz, S.A.; Paliwal, S.; Ivanoki, S. Mechanisms of bone resorption in periodontitis. J. Immunol. Res. 2015, 2015, 615486. [CrossRef] [PubMed]
    • (2015) J. Immunol. Res. , vol.2015 , pp. 615486
    • Hienz, S.A.1    Paliwal, S.2    Ivanoki, S.3
  • 41
    • 49449113092 scopus 로고    scopus 로고
    • Inflammation and bone loss in periodontal disease
    • CrossRef PubMed
    • Cochran, D.L. Inflammation and bone loss in periodontal disease. J. Periodontol. 2008, 79, 1569-1576. [CrossRef] [PubMed]
    • (2008) J. Periodontol. , vol.79 , pp. 1569-1576
    • Cochran, D.L.1
  • 42
    • 84871077326 scopus 로고    scopus 로고
    • Cyclooxygenase-2 expression in gingival biopsies from periodontal patients is correlated with connective tissue loss
    • CrossRef PubMed
    • Mesa, F.; Aguilar, M.; Galindo-Moreno, P.; Bravo, M.; O'Valle, F. Cyclooxygenase-2 expression in gingival biopsies from periodontal patients is correlated with connective tissue loss. J. Periodontol. 2012, 83, 1538-1545. [CrossRef] [PubMed]
    • (2012) J. Periodontol. , vol.83 , pp. 1538-1545
    • Mesa, F.1    Aguilar, M.2    Galindo-Moreno, P.3    Bravo, M.4    O'Valle, F.5
  • 43
    • 84996867612 scopus 로고    scopus 로고
    • The significance of gingival crevicular fluid and IL-1β, TNF-α and PGE2 in periodontal disease: A literature review
    • Younis, M.N.; Machtei, E.E.; Oetlinger-Barak, O.; Peled, M. The significance of gingival crevicular fluid and IL-1β, TNF-α and PGE2 in periodontal disease: A literature review. Oral Biosci. Med. 2004, 1, 249-257.
    • (2004) Oral Biosci. Med. , vol.1 , pp. 249-257
    • Younis, M.N.1    Machtei, E.E.2    Oetlinger-Barak, O.3    Peled, M.4
  • 44
    • 0025639201 scopus 로고
    • New cucurbitane triterpenoids from Momordica charantia
    • CrossRef
    • Fatope, M.O.; Takeda, Y.; Yamashita, H.; Okabe, H.; Yamauchi, T. New cucurbitane triterpenoids from Momordica charantia. J. Nat. Prod. 1990, 53, 1491-1497. [CrossRef]
    • (1990) J. Nat. Prod. , vol.53 , pp. 1491-1497
    • Fatope, M.O.1    Takeda, Y.2    Yamashita, H.3    Okabe, H.4    Yamauchi, T.5
  • 46
    • 0033214799 scopus 로고    scopus 로고
    • Enhanced interleukin-8 production in THP-1 human monocytic cells by lipopolysaccharide from oral microorganisms and granulocyte-macrophage colony-stimulating factor
    • CrossRef PubMed
    • Baqui, A.A.M.A.; Meiller, T.F.; Falkler, W.A. Enhanced interleukin-8 production in THP-1 human monocytic cells by lipopolysaccharide from oral microorganisms and granulocyte-macrophage colony-stimulating factor. Oral Microbiol. Immunol. 1999, 14, 275-280. [CrossRef] [PubMed]
    • (1999) Oral Microbiol. Immunol. , vol.14 , pp. 275-280
    • Baqui, A.A.M.A.1    Meiller, T.F.2    Falkler, W.A.3
  • 47
    • 52449091206 scopus 로고    scopus 로고
    • Lipopolysaccharide (LPS) of Porphyromonas gingivalis induces IL-1β, TNF-α and IL-6 production by THP-1 cells in a way different from that of Escherichia coli LPS
    • CrossRef PubMed
    • Zhang, D.; Chen, L.; Li, S.; Gu, Z.; Yan, J. Lipopolysaccharide (LPS) of Porphyromonas gingivalis induces IL-1β, TNF-α and IL-6 production by THP-1 cells in a way different from that of Escherichia coli LPS. Innate Immun. 2008, 14, 99-107. [CrossRef] [PubMed]
    • (2008) Innate Immun. , vol.14 , pp. 99-107
    • Zhang, D.1    Chen, L.2    Li, S.3    Gu, Z.4    Yan, J.5
  • 48
    • 84871312627 scopus 로고    scopus 로고
    • Luteolin and fisetin inhibit the effects of lipopolysaccharide obtained from Porphyromonas gingivalis in human gingival fibroblasts
    • CrossRef PubMed
    • Gutiérrez-Venegas, G.; Contreras-Sa?nchez, A. Luteolin and fisetin inhibit the effects of lipopolysaccharide obtained from Porphyromonas gingivalis in human gingival fibroblasts. Mol. Biol. Rep. 2013, 40, 477-485. [CrossRef] [PubMed]
    • (2013) Mol. Biol. Rep. , vol.40 , pp. 477-485
    • Gutiérrez-Venegas, G.1    Contreras-Sanchez, A.2


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