Cyclooxygenase-2 expression in gingival biopsies from periodontal patients is correlated with connective tissue loss

Journal of Periodontology

Volumn 83, Issue 12, 2012, Pages 1538-1545

  Mesa, Francisco ^a   Aguilar, Mariano ^a   Galindo Moreno, Pablo ^a,b   Bravo, Manuel ^a   Francisco O'Valle, ^a  

^a UNIVERSITY OF GRANADA   (Spain)

^b UNIVERSITY OF MICHIGAN SCHOOL OF DENTISTRY   (United States)

Author keywords

Biopsy; Chronic periodontitis; Cyclooxygenase 2; Gingivitis; Image processing computer assisted; Immunohistochemistry

Indexed keywords

CYCLOOXYGENASE 2;

ADULT; ARTICLE; BIOPSY; BIOSYNTHESIS; CASE CONTROL STUDY; CHRONIC PERIODONTITIS; CONNECTIVE TISSUE; CROSS-SECTIONAL STUDY; ENZYMOLOGY; FEMALE; GINGIVITIS; HUMAN; IMAGE PROCESSING; MALE; MIDDLE AGED; MOUTH MUCOSA; NONPARAMETRIC TEST; PERIODONTAL DISEASE; SIGNAL TRANSDUCTION;

ADULT; BIOPSY; CASE-CONTROL STUDIES; CHRONIC PERIODONTITIS; CONNECTIVE TISSUE; CROSS-SECTIONAL STUDIES; CYCLOOXYGENASE 2; FEMALE; GINGIVITIS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MALE; MIDDLE AGED; MOUTH MUCOSA; PERIODONTAL ATTACHMENT LOSS; SIGNAL TRANSDUCTION; STATISTICS, NONPARAMETRIC;

EID: 84871077326     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2012.110561     Document Type: Article

References (27)

1. Yucel-Lindberg T, Ahola H, Carlstedt-Duke J, Modéer T. Involvement of tyrosine kinases on cyclooxygenase expression and prostaglandin E2 production in human gingival fibroblasts stimulated with interleukin-1beta and epidermal growth factor. Biochem Biophys Res Commun 1999;257:528-532.
2. Lohinai Z, Stachlewitz R, Székely AD, Fehér E, Dé zsi L, Szabó C. Evidence for the expression of cyclooxygenase- 2 enzyme in periodontitis. Life Sci 2001;70:279-290.
3. Miyauchi M, Hiraoka M, Oka H, et al. Immuno-localization of COX-1 and COX-2 in the rat molar periodontal tissue after topical application of lipopolysaccharide. Arch Oral Biol 2004;49:739-746.
4. Offenbacher S, Heasman PA, Collins JG. Modulation of host PGE2 secretion as a determinant of periodontal disease expression. J Periodontol 1993;64(Suppl. 5): 432-444.
5. Drisko CH. Non-surgical pocket therapy: Pharmacotherapeutics. Ann Periodontol 1996;1:491-566.
6. Smith WL, Garavito RM, DeWitt DL. Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2. J Biol Chem 1996;271:33157-33160.
7. DuBois RN, Awad J, Morrow J, Roberts LJ 2nd, Bishop PR. Regulation of eicosanoid production and mitogenesis in rat intestinal epithelial cells by transforming growth factor-alpha and phorbol ester. J Clin Invest 1994;93:493-498.
8. Morton RS, Dongari-Bagtzoglou AI. Cyclooxygenase-2 is upregulated in inflamed gingival tissues. J Periodontol 2001;72:461-469.
9. Ho YP, Lin YC, Yang YH, Ho KY, Wu YM, Tsai CC. Cyclooxygenase-2 Gene-765 single nucleotide polymorphism as a protective factor against periodontitis in Taiwanese. J Clin Periodontol 2008;35:1-8.
10. Xie CJ, Xiao LM, Fan WH, Xuan DY, Zhang JC. Common single nucleotide polymorphisms in cyclooxygenase- 2 and risk of severe chronic periodontitis in a Chinese population. J Clin Periodontol 2009;36:198-203.
11. Schaefer AS, Richter GM, Nothnagel M, et al. COX-2 is associated with periodontitis in Europeans. J Dent Res 2010;89:384-388.
12. Zhang F, Engebretson SP, Morton RS, Cavanaugh PF Jr, Subbaramaiah K, Dannenberg AJ. The overexpression of cyclo-oxygenase-2 in chronic periodontitis. J Am Dent Assoc 2003;134:861-867.
13. Arbes SJ Jr, Slade GD, Beck JD. Association between extent of periodontal attachment loss and self-reported history of heart attack: An analysis of NHANES III data. J Dent Res 1999;78:1777-1782.
14. Ainamo J, Bay I. Problems and proposal for recording gingivitis and plaque. Int Dent J 1975;25:229-235.
15. Sweat F, Puchtler H, Rosenthal SI. Sirius red F3BA as a stain for connective tissue. Arch Pathol 1964;78:69-72.
16. Masseroli M, O'Valle F, Andú jar M, et al. Design and validation of a new image analysis method for automatic quantification of interstitial fibrosis and glomerular morphometry. Lab Invest 1998;78:511-522.
17. Yen CA, Damoulis PD, Stark PC, Hibberd PL, Singh M, Papas AS. The effect of a selective cyclooxygenase-2 inhibitor (celecoxib) on chronic periodontitis. J Periodontol 2008;79:104-113.
18. Vardar S, Baylas H, Huseyinov A. Effects of selective cyclooxygenase-2 inhibition on gingival tissue levels of prostaglandin E2 and prostaglandin F2alpha and clinical parameters of chronic periodontitis. J Periodontol 2003;74:57-63.
19. Queiroz-Junior CM, Pacheco CM, Maltos KL, Caliari MV, Duarte ID, Francischi JN. Role of systemic and local administration of selective inhibitors of cyclooxygenase 1 and 2 in an experimental model of periodontal disease in rats. J Periodontal Res 2009;44:153-160.
20. Vardar-Sengul S, Buduneli E, Turkoglu O, et al. The effects of selective COX-2 inhibitor/celecoxib and omega-3 fatty acid on matrix metalloproteinases, TIMP-1, and laminin-5gamma2-chain immunolocalization in experimental periodontitis. J Periodontol 2008;79:1934-1941.
21. Holzhausen M, Spolidorio DM, Muscará MN, Hebling J, Spolidorio LC. Protective effects of etoricoxib, a selective inhibitor of cyclooxygenase-2, in experimental periodontitis in rats. J Periodontal Res 2005;40:208-211.
22. Tipton DA, Flynn JC, Stein SH, Dabbous MK. Cyclooxygenase- 2 inhibitors decrease interleukin-1betastimulated prostaglandin E2 and IL-6 production by human gingival fibroblasts. J Periodontol 2003;74: 1754-1763.
23. Loo WT, Wang M, Jin LJ, Cheung MN, Li GR. Association of matrix metalloproteinase (MMP-1, MMP-3 and MMP-9) and cyclooxygenase-2 gene polymorphisms and their proteins with chronic periodontitis. Arch Oral Biol 2011;56:1081-1090.
24. Noguchi K, Yanai M, Shitashige M, Nishihara T, Ishikawa I. Cyclooxygenase-2-dependent prostaglandin production by peripheral blood monocytes stimulated with lipopolysaccharides isolated from periodontopathogenic bacteria. J Periodontol 2000;71:1575-1582.
25. Zhong Y, Slade GD, Beck JD, Offenbacher S. Gingival crevicular fluid interleukin-1beta, prostaglandin E2 and periodontal status in a community population. J Clin Periodontol 2007;34:285-293.
26. Chan G, Boyle JO, Yang EK, et al. Cyclooxygenase-2 expression is up-regulated in squamous cell carcinoma of the head and neck. Cancer Res 1999;59:991-994.
27. Shimizu N, Ozawa Y, Yamaguchi M, Goseki T, Ohzeki K, Abiko Y. Induction of COX-2 expression by mechanical tension force in human periodontal ligament cells. J Periodontol 1998;69:670-677.