-
1
-
-
69149089036
-
Molecular pathogenesis of Parkinson disease: Insights from genetic studies
-
19631006
-
Gasser T. Molecular pathogenesis of Parkinson disease: insights from genetic studies. Expert Rev Mol Med. 2009;11:e22.
-
(2009)
Expert Rev Mol Med
, vol.11
, pp. e22
-
-
Gasser, T.1
-
2
-
-
33749247103
-
Novel pharmacological targets for the treatment of Parkinson's disease
-
1:CAS:528:DC%2BD28XhtVajsbnE 17016425
-
Schapira AH, Bezard E, Brotchie J, Calon F, Collingridge GL, Ferger B, Hengerer B, Hirsch E, Jenner P, Le Novere N, et al. Novel pharmacological targets for the treatment of Parkinson's disease. Nat Rev Drug Discov. 2006;5:845-54.
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 845-854
-
-
Schapira, A.H.1
Bezard, E.2
Brotchie, J.3
Calon, F.4
Collingridge, G.L.5
Ferger, B.6
Hengerer, B.7
Hirsch, E.8
Jenner, P.9
Le Novere, N.10
-
3
-
-
80055082804
-
Parkinson's disease and alpha-synuclein expression
-
21887711 4669565
-
Devine MJ, Gwinn K, Singleton A, Hardy J. Parkinson's disease and alpha-synuclein expression. Mov Disord. 2011;26:2160-8.
-
(2011)
Mov Disord
, vol.26
, pp. 2160-2168
-
-
Devine, M.J.1
Gwinn, K.2
Singleton, A.3
Hardy, J.4
-
4
-
-
20144389524
-
Aggregated alpha-synuclein activates microglia: A process leading to disease progression in Parkinson's disease
-
1:CAS:528:DC%2BD2MXjtFaqsrc%3D 15791003
-
Zhang W, Wang T, Pei Z, Miller DS, Wu X, Block ML, Wilson B, Zhou Y, Hong JS, Zhang J. Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease. FASEB J. 2005;19:533-42.
-
(2005)
FASEB J
, vol.19
, pp. 533-542
-
-
Zhang, W.1
Wang, T.2
Pei, Z.3
Miller, D.S.4
Wu, X.5
Block, M.L.6
Wilson, B.7
Zhou, Y.8
Hong, J.S.9
Zhang, J.10
-
5
-
-
0036316772
-
Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: Relevance to Parkinson's disease
-
1:CAS:528:DC%2BD38XltVWks7s%3D 12068076
-
Gao HM, Jiang J, Wilson B, Zhang W, Hong JS, Liu B. Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease. J Neurochem. 2002;81:1285-97.
-
(2002)
J Neurochem
, vol.81
, pp. 1285-1297
-
-
Gao, H.M.1
Jiang, J.2
Wilson, B.3
Zhang, W.4
Hong, J.S.5
Liu, B.6
-
6
-
-
84873123076
-
Triggering of inflammasome by aggregated alpha-synuclein, an inflammatory response in synucleinopathies
-
1:CAS:528:DC%2BC3sXis1yltrw%3D 23383169 3561263
-
Codolo G, Plotegher N, Pozzobon T, Brucale M, Tessari I, Bubacco L, de Bernard M. Triggering of inflammasome by aggregated alpha-synuclein, an inflammatory response in synucleinopathies. PLoS One. 2013;8:e55375.
-
(2013)
PLoS One
, vol.8
-
-
Codolo, G.1
Plotegher, N.2
Pozzobon, T.3
Brucale, M.4
Tessari, I.5
Bubacco, L.6
De Bernard, M.7
-
7
-
-
84903269246
-
Innate immune activation in neurodegenerative disease
-
1:CAS:528:DC%2BC2cXhtVemu7zJ 24962261
-
Heneka MT, Kummer MP, Latz E. Innate immune activation in neurodegenerative disease. Nat Rev Immunol. 2014;14:463-77.
-
(2014)
Nat Rev Immunol
, vol.14
, pp. 463-477
-
-
Heneka, M.T.1
Kummer, M.P.2
Latz, E.3
-
8
-
-
80053233055
-
Heterogeneity of CNS myeloid cells and their roles in neurodegeneration
-
1:CAS:528:DC%2BC3MXht1anu7vE 21952260
-
Prinz M, Priller J, Sisodia SS, Ransohoff RM. Heterogeneity of CNS myeloid cells and their roles in neurodegeneration. Nat Neurosci. 2011;14:1227-35.
-
(2011)
Nat Neurosci
, vol.14
, pp. 1227-1235
-
-
Prinz, M.1
Priller, J.2
Sisodia, S.S.3
Ransohoff, R.M.4
-
10
-
-
20444413356
-
Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease
-
1:CAS:528:DC%2BD2MXlvVWjtLg%3D 15953415
-
Masliah E, Rockenstein E, Adame A, Alford M, Crews L, Hashimoto M, Seubert P, Lee M, Goldstein J, Chilcote T, et al. Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease. Neuron. 2005;46:857-68.
-
(2005)
Neuron
, vol.46
, pp. 857-868
-
-
Masliah, E.1
Rockenstein, E.2
Adame, A.3
Alford, M.4
Crews, L.5
Hashimoto, M.6
Seubert, P.7
Lee, M.8
Goldstein, J.9
Chilcote, T.10
-
11
-
-
42249115877
-
Neuroinflammation mediated by IL-1beta increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease
-
18304357 2292163
-
Koprich JB, Reske-Nielsen C, Mithal P, Isacson O. Neuroinflammation mediated by IL-1beta increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease. J Neuroinflammation. 2008;5:8.
-
(2008)
J Neuroinflammation
, vol.5
, pp. 8
-
-
Koprich, J.B.1
Reske-Nielsen, C.2
Mithal, P.3
Isacson, O.4
-
13
-
-
68249145501
-
Innate and adaptive immunity for the pathobiology of Parkinson's disease
-
1:CAS:528:DC%2BD1MXpvFaru7w%3D 19243239 2788126
-
Stone DK, Reynolds AD, Mosley RL, Gendelman HE. Innate and adaptive immunity for the pathobiology of Parkinson's disease. Antioxid Redox Signal. 2009;11:2151-66.
-
(2009)
Antioxid Redox Signal
, vol.11
, pp. 2151-2166
-
-
Stone, D.K.1
Reynolds, A.D.2
Mosley, R.L.3
Gendelman, H.E.4
-
14
-
-
34247174432
-
A signal for the caspase-1 inflammasome free of TLR
-
1:CAS:528:DC%2BD2sXltVGqu70%3D 17459804
-
Dinarello CA. A signal for the caspase-1 inflammasome free of TLR. Immunity. 2007;26:383-5.
-
(2007)
Immunity
, vol.26
, pp. 383-385
-
-
Dinarello, C.A.1
-
15
-
-
84873087532
-
NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice
-
1:CAS:528:DC%2BC38XhvV2ntLfM 23254930 3812809
-
Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, Griep A, Axt D, Remus A, Tzeng TC, et al. NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature. 2013;493:674-8.
-
(2013)
Nature
, vol.493
, pp. 674-678
-
-
Heneka, M.T.1
Kummer, M.P.2
Stutz, A.3
Delekate, A.4
Schwartz, S.5
Vieira-Saecker, A.6
Griep, A.7
Axt, D.8
Remus, A.9
Tzeng, T.C.10
-
16
-
-
32944468985
-
Gout-associated uric acid crystals activate the NALP3 inflammasome
-
1:CAS:528:DC%2BD28XitFGitLg%3D 16407889
-
Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature. 2006;440:237-41.
-
(2006)
Nature
, vol.440
, pp. 237-241
-
-
Martinon, F.1
Petrilli, V.2
Mayor, A.3
Tardivel, A.4
Tschopp, J.5
-
17
-
-
32944470765
-
Cryopyrin activates the inflammasome in response to toxins and ATP
-
1:CAS:528:DC%2BD28XitFGitLs%3D 16407890
-
Mariathasan S, Weiss DS, Newton K, McBride J, O'Rourke K, Roose-Girma M, Lee WP, Weinrauch Y, Monack DM, Dixit VM. Cryopyrin activates the inflammasome in response to toxins and ATP. Nature. 2006;440:228-32.
-
(2006)
Nature
, vol.440
, pp. 228-232
-
-
Mariathasan, S.1
Weiss, D.S.2
Newton, K.3
McBride, J.4
O'Rourke, K.5
Roose-Girma, M.6
Lee, W.P.7
Weinrauch, Y.8
Monack, D.M.9
Dixit, V.M.10
-
18
-
-
77954533073
-
On the role of P2X(7) receptors in dopamine nerve cell degeneration in a rat model of Parkinson's disease: Studies with the P2X(7) receptor antagonist A-438079
-
1:CAS:528:DC%2BC3cXmslOgtro%3D 20387084
-
Marcellino D, Suarez-Boomgaard D, Sanchez-Reina MD, Aguirre JA, Yoshitake T, Yoshitake S, Hagman B, Kehr J, Agnati LF, Fuxe K, Rivera A. On the role of P2X(7) receptors in dopamine nerve cell degeneration in a rat model of Parkinson's disease: studies with the P2X(7) receptor antagonist A-438079. J Neural Transm. 2010;117:681-7.
-
(2010)
J Neural Transm
, vol.117
, pp. 681-687
-
-
Marcellino, D.1
Suarez-Boomgaard, D.2
Sanchez-Reina, M.D.3
Aguirre, J.A.4
Yoshitake, T.5
Yoshitake, S.6
Hagman, B.7
Kehr, J.8
Agnati, L.F.9
Fuxe, K.10
Rivera, A.11
-
19
-
-
84876350807
-
The therapeutic potential of modifying inflammasomes and NOD-like receptors
-
23592611
-
Di Virgilio F. The therapeutic potential of modifying inflammasomes and NOD-like receptors. Pharmacol Rev. 2013;65:872-905.
-
(2013)
Pharmacol Rev
, vol.65
, pp. 872-905
-
-
Di Virgilio, F.1
-
20
-
-
69149102628
-
Repression of alpha-synuclein expression and toxicity by microRNA-7
-
1:CAS:528:DC%2BD1MXhtVKru7%2FL 19628698 2722353
-
Junn E, Lee KW, Jeong BS, Chan TW, Im JY, Mouradian MM. Repression of alpha-synuclein expression and toxicity by microRNA-7. Proc Natl Acad Sci U S A. 2009;106:13052-7.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 13052-13057
-
-
Junn, E.1
Lee, K.W.2
Jeong, B.S.3
Chan, T.W.4
Im, J.Y.5
Mouradian, M.M.6
-
21
-
-
69949140066
-
The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation
-
19565166
-
Henn A, Lund S, Hedtjarn M, Schrattenholz A, Porzgen P, Leist M. The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation. Altex. 2009;26:83-94.
-
(2009)
Altex
, vol.26
, pp. 83-94
-
-
Henn, A.1
Lund, S.2
Hedtjarn, M.3
Schrattenholz, A.4
Porzgen, P.5
Leist, M.6
-
22
-
-
77957101431
-
Extracellular ATP is a danger signal activating P2X7 receptor in lung inflammation and fibrosis
-
1:CAS:528:DC%2BC3cXhtlemtrzK 20522787
-
Riteau N, Gasse P, Fauconnier L, Gombault A, Couegnat M, Fick L, Kanellopoulos J, Quesniaux VF, Marchand-Adam S, Crestani B, et al. Extracellular ATP is a danger signal activating P2X7 receptor in lung inflammation and fibrosis. Am J Respir Crit Care Med. 2010;182:774-83.
-
(2010)
Am J Respir Crit Care Med
, vol.182
, pp. 774-783
-
-
Riteau, N.1
Gasse, P.2
Fauconnier, L.3
Gombault, A.4
Couegnat, M.5
Fick, L.6
Kanellopoulos, J.7
Quesniaux, V.F.8
Marchand-Adam, S.9
Crestani, B.10
-
23
-
-
74549184092
-
The NLRP3 inflammasome: A sensor for metabolic danger?
-
1:CAS:528:DC%2BC3cXktlWrsg%3D%3D 20075245
-
Schroder K, Zhou R, Tschopp J. The NLRP3 inflammasome: a sensor for metabolic danger? Science. 2010;327:296-300.
-
(2010)
Science
, vol.327
, pp. 296-300
-
-
Schroder, K.1
Zhou, R.2
Tschopp, J.3
-
24
-
-
78651393239
-
A role for mitochondria in NLRP3 inflammasome activation
-
1:CAS:528:DC%2BC3cXhsV2nsLrE 21124315
-
Zhou R, Yazdi AS, Menu P, Tschopp J. A role for mitochondria in NLRP3 inflammasome activation. Nature. 2011;469:221-5.
-
(2011)
Nature
, vol.469
, pp. 221-225
-
-
Zhou, R.1
Yazdi, A.S.2
Menu, P.3
Tschopp, J.4
-
25
-
-
14044251458
-
Human MicroRNA targets
-
15502875 521178
-
John B, Enright AJ, Aravin A, Tuschl T, Sander C, Marks DS. Human MicroRNA targets. PLoS Biol. 2004;2:e363.
-
(2004)
PLoS Biol
, vol.2
, pp. e363
-
-
John, B.1
Enright, A.J.2
Aravin, A.3
Tuschl, T.4
Sander, C.5
Marks, D.S.6
-
26
-
-
78649686234
-
The role of inflammatory cytokines in cognition and other non-motor symptoms of Parkinson's disease
-
1:CAS:528:DC%2BC3cXhsFyqs7nF 21051678 2987579
-
Menza M, Dobkin RD, Marin H, Mark MH, Gara M, Bienfait K, Dicke A, Kusnekov A. The role of inflammatory cytokines in cognition and other non-motor symptoms of Parkinson's disease. Psychosomatics. 2010;51:474-9.
-
(2010)
Psychosomatics
, vol.51
, pp. 474-479
-
-
Menza, M.1
Dobkin, R.D.2
Marin, H.3
Mark, M.H.4
Gara, M.5
Bienfait, K.6
Dicke, A.7
Kusnekov, A.8
-
27
-
-
84896324370
-
The role of inflammasome in Alzheimer's disease
-
Liu L, Chan C. The role of inflammasome in Alzheimer's disease. Ageing Res Rev. 2014;15C:6-15.
-
(2014)
Ageing Res Rev
, vol.15 C
, pp. 6-15
-
-
Liu, L.1
Chan, C.2
-
28
-
-
84905919293
-
Characterization of porcine NLRP3 inflammasome activation and its upstream mechanism
-
Kim J, Ahn H, Woo HM, Lee E, Lee GS. Characterization of porcine NLRP3 inflammasome activation and its upstream mechanism. Vet Res Commun. 2014.
-
(2014)
Vet Res Commun.
-
-
Kim, J.1
Ahn, H.2
Woo, H.M.3
Lee, E.4
Lee, G.S.5
-
29
-
-
84896544563
-
NLRP3 inflammasome contributes to inflammation after intracerebral hemorrhage
-
1:CAS:528:DC%2BC2cXkvVGgs7w%3D 24273204 4386653
-
Ma Q, Chen S, Hu Q, Feng H, Zhang JH, Tang J. NLRP3 inflammasome contributes to inflammation after intracerebral hemorrhage. Ann Neurol. 2014;75:209-19.
-
(2014)
Ann Neurol
, vol.75
, pp. 209-219
-
-
Ma, Q.1
Chen, S.2
Hu, Q.3
Feng, H.4
Zhang, J.H.5
Tang, J.6
-
30
-
-
84882604061
-
Asbestos and erionite prime and activate the NLRP3 inflammasome that stimulates autocrine cytokine release in human mesothelial cells
-
1:CAS:528:DC%2BC3sXhtlCktb%2FJ 23937860 3751315
-
Hillegass JM, Miller JM, MacPherson MB, Westbom CM, Sayan M, Thompson JK, Macura SL, Perkins TN, Beuschel SL, Alexeeva V, et al. Asbestos and erionite prime and activate the NLRP3 inflammasome that stimulates autocrine cytokine release in human mesothelial cells. Part Fibre Toxicol. 2013;10:39.
-
(2013)
Part Fibre Toxicol
, vol.10
, pp. 39
-
-
Hillegass, J.M.1
Miller, J.M.2
MacPherson, M.B.3
Westbom, C.M.4
Sayan, M.5
Thompson, J.K.6
MacUra, S.L.7
Perkins, T.N.8
Beuschel, S.L.9
Alexeeva, V.10
-
31
-
-
80053087484
-
Inflammasome is a central player in the induction of obesity and insulin resistance
-
1:CAS:528:DC%2BC3MXht1Gqt7zL 21876127 3174591
-
Stienstra R, van Diepen JA, Tack CJ, Zaki MH, van de Veerdonk FL, Perera D, Neale GA, Hooiveld GJ, Hijmans A, Vroegrijk I, et al. Inflammasome is a central player in the induction of obesity and insulin resistance. Proc Natl Acad Sci U S A. 2011;108:15324-9.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 15324-15329
-
-
Stienstra, R.1
Van Diepen, J.A.2
Tack, C.J.3
Zaki, M.H.4
Van De Veerdonk, F.L.5
Perera, D.6
Neale, G.A.7
Hooiveld, G.J.8
Hijmans, A.9
Vroegrijk, I.10
-
32
-
-
84896545055
-
Environmental neurotoxic challenge of conditional alpha-synuclein transgenic mice predicts a dopaminergic olfactory-striatal interplay in early PD
-
1:CAS:528:DC%2BC2cXitFCgsLg%3D 24509835 4324760
-
Nuber S, Tadros D, Fields J, Overk CR, Ettle B, Kosberg K, Mante M, Rockenstein E, Trejo M, Masliah E. Environmental neurotoxic challenge of conditional alpha-synuclein transgenic mice predicts a dopaminergic olfactory-striatal interplay in early PD. Acta Neuropathol. 2014;127:477-94.
-
(2014)
Acta Neuropathol
, vol.127
, pp. 477-494
-
-
Nuber, S.1
Tadros, D.2
Fields, J.3
Overk, C.R.4
Ettle, B.5
Kosberg, K.6
Mante, M.7
Rockenstein, E.8
Trejo, M.9
Masliah, E.10
-
33
-
-
44949151157
-
Hypersensitivity of aquaporin 4-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine and astrocytic modulation
-
1:CAS:528:DC%2BD1cXnsF2lsbc%3D 17353068
-
Fan Y, Kong H, Shi X, Sun X, Ding J, Wu J, Hu G. Hypersensitivity of aquaporin 4-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine and astrocytic modulation. Neurobiol Aging. 2008;29:1226-36.
-
(2008)
Neurobiol Aging
, vol.29
, pp. 1226-1236
-
-
Fan, Y.1
Kong, H.2
Shi, X.3
Sun, X.4
Ding, J.5
Wu, J.6
Hu, G.7
-
34
-
-
84863979358
-
The neuroprotection of hydrogen sulfide against MPTP-induced dopaminergic neuron degeneration involves uncoupling protein 2 rather than ATP-sensitive potassium channels
-
1:CAS:528:DC%2BC38XhtVantLvJ 22360462 3392622
-
Lu M, Zhao FF, Tang JJ, Su CJ, Fan Y, Ding JH, Bian JS, Hu G. The neuroprotection of hydrogen sulfide against MPTP-induced dopaminergic neuron degeneration involves uncoupling protein 2 rather than ATP-sensitive potassium channels. Antioxid Redox Signal. 2012;17:849-59.
-
(2012)
Antioxid Redox Signal
, vol.17
, pp. 849-859
-
-
Lu, M.1
Zhao, F.F.2
Tang, J.J.3
Su, C.J.4
Fan, Y.5
Ding, J.H.6
Bian, J.S.7
Hu, G.8
-
35
-
-
77956677763
-
MiR-16 targets the serotonin transporter: A new facet for adaptive responses to antidepressants
-
1:CAS:528:DC%2BC3cXhtFGjtLrP 20847275
-
Baudry A, Mouillet-Richard S, Schneider B, Launay JM, Kellermann O. miR-16 targets the serotonin transporter: a new facet for adaptive responses to antidepressants. Science. 2010;329:1537-41.
-
(2010)
Science
, vol.329
, pp. 1537-1541
-
-
Baudry, A.1
Mouillet-Richard, S.2
Schneider, B.3
Launay, J.M.4
Kellermann, O.5
-
36
-
-
64749115463
-
Gaussia luciferase reporter assay for monitoring biological processes in culture and in vivo
-
1:CAS:528:DC%2BD1MXjvFOqu74%3D 19373229 2692611
-
Tannous BA. Gaussia luciferase reporter assay for monitoring biological processes in culture and in vivo. Nat Protoc. 2009;4:582-91.
-
(2009)
Nat Protoc
, vol.4
, pp. 582-591
-
-
Tannous, B.A.1
|