Structural characterization of a human Fc fragment engineered for lack of effector functions

Acta Crystallographica Section D: Biological Crystallography

Volumn 64, Issue 6, 2008, Pages 700-704

  Oganesyan, Vaheh ^a   Gao, Changshou ^a   Shirinian, Lena ^a   Wu, Herren ^a   Dall'Acqua, William F ^a  

^a MEDIMMUNE   (United States)

Author keywords

Fc fragments

Indexed keywords

COMPLEMENT COMPONENT C1Q; FC RECEPTOR; IMMUNOGLOBULIN FC FRAGMENT; MONOCLONAL ANTIBODY; RECOMBINANT PROTEIN;

ANTIBODY COMBINING SITE; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HUMAN; METABOLISM; PROTEIN CONFORMATION; PROTEIN ENGINEERING; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY;

ANTIBODIES, MONOCLONAL; BINDING SITES, ANTIBODY; COMPLEMENT C1Q; CRYSTALLOGRAPHY, X-RAY; HUMANS; IMMUNOGLOBULIN FC FRAGMENTS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; PROTEIN ENGINEERING; RECEPTORS, IGG; RECOMBINANT PROTEINS;

EID: 45749102844     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S0907444908007877     Document Type: Article

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