Screening of compounds against gardnerella vaginalis biofilms

PLoS ONE

Volumn 11, Issue 4, 2016, Pages

  Gottschick, Cornelia ^a   Szafranski, Szymon P ^a   Kunze, Brigitte ^a   Sztajer, Helena ^a   Masur, Clarissa ^b   Abels, Christoph ^b   Wagner Döbler, Irene ^a  

^a HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^b Dr August Wolff GmbH and Co KG Arzneimittel   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; CETYLPYRIDINIUM SALT; CHLOROCRESOL; METRONIDAZOLE; PHOSPHATIDYLCHOLINE; POLYAMINOPROPYL BIGUANIDE; SODIUM COCOAMPHOACETATE; TOBRAMYCIN SULFATE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL CELL; BACTERIAL VIABILITY; BIOFILM; CONTROLLED STUDY; DRUG EFFECT; DRUG SCREENING; DRUG STRUCTURE; GARDNERELLA VAGINALIS; MICROBIAL BIOMASS; NONHUMAN; BIOLOGICAL MODEL; DRUG EFFECTS; FEMALE; HUMAN; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; VAGINOSIS, BACTERIAL;

ANTI-BACTERIAL AGENTS; BIOFILMS; FEMALE; GARDNERELLA VAGINALIS; HUMANS; MICROBIAL SENSITIVITY TESTS; MODELS, BIOLOGICAL; VAGINOSIS, BACTERIAL;

EID: 84965167515     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0154086     Document Type: Article

References (54)

1. Donlan RM. Biofilms: Microbial life on surfaces. Emerg Infect Dis 2002 Sep; 8(9):881-90. PMID: 12194761.
2. Gupta P, Sarkar S, Das B, Bhattacharjee S, Tribedi P. Biofilm, pathogenesis and prevention- A journey to break the wall: A review. Arch Microbiol 2015 Sep 16.
3. Parasion S, Kwiatek M, Gryko R, Mizak L, Malm A. Bacteriophages as an alternative strategy for fighting biofilm development. Pol J Microbiol 2014; 63(2):137-45. PMID: 25115107.
4. Wu H, Moser C, Wang HZ, Hoiby N, Song ZJ. Strategies for combating bacterial biofilm infections. Int J Oral Sci 2015 Mar; 7(1):1-7. doi: 10.1038/ijos.2014.65 PMID: 25504208.
5. Allsworth JE, Peipert JF. Prevalence of bacterial vaginosis: 2001-2004 National Health and Nutrition Examination Survey data. Obstet Gynecol 2007 Jan; 109(1):114-20. PMID: 17197596.
6. Bradshaw CS, Walker J, Fairley CK, Chen MY, Tabrizi SN, Donovan B, et al. Prevalent and incident bacterial vaginosis are associated with sexual and contraceptive behaviours in young Australian women. PLoS One 2013; 8(3):e57688. doi: 10.1371/journal.pone.0057688 PMID: 23472099.
7. Chico RM, Mayaud P, Ariti C, Mabey D, Ronsmans C, Chandramohan D. Prevalence of malaria and sexually transmitted and reproductive tract infections in pregnancy in sub-Saharan Africa: A systematic review. JAMA 2012 May 16; 307(19):2079-86. doi: 10.1001/jama.2012.3428 PMID: 22665107.
8. Ravel J, Gajer P, Abdo Z, Schneider GM, Koenig SS, McCulle SL, et al. Vaginal microbiome of reproductive- Age women. Proc Natl Acad Sci U S A 2011 Mar 15; 108 Suppl 1:4680-7. doi: 10.1073/pnas. 1002611107 PMID: 20534435.
9. Muzny CA, Schwebke JR. Biofilms: An Underappreciated Mechanism of Treatment Failure and Recurrence in Vaginal Infections. Clin Infect Dis 2015 Aug 15; 61(4):601-6. doi: 10.1093/cid/civ353 PMID: 25935553.
10. Onderdonk AB, Delaney ML, Fichorova RN. The Human Microbiome during Bacterial Vaginosis. Clin Microbiol Rev 2016 Apr; 29(2):223-38. doi: 10.1128/CMR.00075-15 PMID: 26864580.
11. Nunn KL, Wang YY, Harit D, Humphrys MS, Ma B, Cone R, et al. Enhanced Trapping of HIV-1 by Human Cervicovaginal Mucus Is Associated with Lactobacillus crispatus-Dominant Microbiota. MBio 2015; 6(5).
12. Amsel R, Totten PA, Spiegel CA, Chen KC, Eschenbach D, Holmes KK. Nonspecific vaginitis. Diagnostic criteria and microbial and epidemiologic associations. Am J Med 1983 Jan; 74(1):14-22. PMID: 6600371.
13. Kenyon CR, Osbak K. Recent progress in understanding the epidemiology of bacterial vaginosis. Curr Opin Obstet Gynecol 2014 Dec; 26(6):448-54. PMID: 25304606 Compounds against Gardnerella Biofilms PLOS.
14. Palmeira-de-Oliveira R, Palmeira-de-Oliveira A, Martinez-de-Oliveira J. New strategies for local treatment of vaginal infections. Adv Drug Deliv Rev 2015 Sep 15; 92:105-22. doi: 10.1016/j.addr.2015.06. 008 PMID: 26144995.
15. Swidsinski A, Mendling W, Loening-Baucke V, Ladhoff A, Swidsinski S, Hale LP, et al. Adherent biofilms in bacterial vaginosis. Obstet Gynecol 2005 Nov; 106(5 Pt 1):1013-23. PMID: 16260520.
16. Hardy L, Jespers V, Dahchour N, Mwambarangwe L, Musengamana V, Vaneechoutte M, et al. Unravelling the Bacterial Vaginosis-Associated Biofilm: A Multiplex Gardnerella vaginalis and Atopobium vaginae Fluorescence In Situ Hybridization Assay Using Peptide Nucleic Acid Probes. PLoS One 2015; 10(8):e0136658. doi: 10.1371/journal.pone.0136658 PMID: 26305575.
17. Machado A, Cerca N. Influence of Biofilm Formation by Gardnerella vaginalis and Other Anaerobes on Bacterial Vaginosis. J Infect Dis 2015 Jun 16.
18. Machado D, Castro J, Palmeira-de-Oliveira A, Martinez-de-Oliveira J, Cerca N. Bacterial Vaginosis Biofilms: Challenges to Current Therapies and Emerging Solutions. Front Microbiol 2015; 6:1528. doi: 10. 3389/fmicb.2015.01528 PMID: 26834706.
19. Patterson JL, Stull-Lane A, Girerd PH, Jefferson KK. Analysis of adherence, biofilm formation and cytotoxicity suggests a greater virulence potential of Gardnerella vaginalis relative to other bacterial-vaginosis- Associated anaerobes. Microbiology 2010 Feb; 156(Pt 2):392-9. doi: 10.1099/mic.0.034280-0 PMID: 19910411.
20. Swidsinski A, Mendling W, Loening-Baucke V, Swidsinski S, Dorffel Y, Scholze J, et al. An adherent Gardnerella vaginalis biofilm persists on the vaginal epithelium after standard therapy with oral metronidazole. Am J Obstet Gynecol 2008 Jan; 198(1):97-6. PMID: 18005928.
21. Bradshaw CS, Morton AN, Hocking J, Garland SM, Morris MB, Moss LM, et al. High recurrence rates of bacterial vaginosis over the course of 12 months after oral metronidazole therapy and factors associated with recurrence. J Infect Dis 2006 Jun 1; 193(11):1478-86. PMID: 16652274.
22. Swidsinski A, Loening-Baucke V, Swidsinski S, Verstraelen H. Polymicrobial Gardnerella biofilm resists repeated intravaginal antiseptic treatment in a subset of women with bacterial vaginosis: A preliminary report. Arch Gynecol Obstet 2015Mar; 291(3):605-9. doi: 10.1007/s00404-014-3484-1 PMID: 25245669.
23. Strandberg KL, Peterson ML, Lin YC, Pack MC, Chase DJ, Schlievert PM. Glycerol monolaurate inhibits Candida and Gardnerella vaginalis in vitro and in vivo but not Lactobacillus. Antimicrob Agents Chemother 2010 Feb; 54(2):597-601. doi: 10.1128/AAC.01151-09 PMID: 20008774.
24. Hooven TA, Randis TM, Hymes SR, Rampersaud R, Ratner AJ. Retrocyclin inhibits Gardnerella vaginalis biofilm formation and toxin activity. J Antimicrob Chemother 2012 Dec; 67(12):2870-2. doi: 10. 1093/jac/dks305 PMID: 22855857.
25. Braga PC, Dal SM, Culici M, Spallino A. Inhibitory activity of thymol on native and mature Gardnerella vaginalis biofilms: in vitro study. Arzneimittelforschung 2010; 60(11):675-81. doi: 10.1055/s-0031- 1296346 PMID: 21175040.
26. Hymes SR, Randis TM, Sun TY, Ratner AJ. DNase inhibits Gardnerella vaginalis biofilms in vitro and in vivo. J Infect Dis 2013 May 15; 207(10):1491-7. doi: 10.1093/infdis/jit047 PMID: 23431033.
27. Algburi A, Volski A, Chikindas ML. Natural antimicrobials subtilosin and lauramide arginine ethyl ester (LAE) synergize with conventional antibiotics clindamycin and metronidazole against biofilms of Gardnerella vaginalis but not against biofilms of healthy vaginal lactobacilli. Pathog Dis 2015 Apr 2.
28. Reichman O, Akins R, Sobel JD. Boric acid addition to suppressive antimicrobial therapy for recurrent bacterial vaginosis. Sex Transm Dis 2009 Nov; 36(11):732-4. PMID: 19704395.
29. McMillan A, Dell M, Zellar MP, Cribby S, Martz S, Hong E, et al. Disruption of urogenital biofilms by lactobacilli. Colloids Surf B Biointerfaces 2011 Aug 1; 86(1):58-64. doi: 10.1016/j.colsurfb.2011.03.016 PMID: 21497071.
30. Mastromarino P, Vitali B, Mosca L. Bacterial vaginosis: A review on clinical trials with probiotics. New Microbiol 2013 Jul; 36(3):229-38. PMID: 23912864.
31. Price KE, Orazi G, Ruoff KL, Hebert WP, O'Toole GA, Mastoridis P. Mannitol Does Not Enhance Tobramycin Killing of Pseudomonas aeruginosa in a Cystic Fibrosis Model System of Biofilm Formation. PLoS One 2015; 10(10):e0141192. doi: 10.1371/journal.pone.0141192 PMID: 26506004.
32. Ebeling W, Hennrich N, Klockow M, Metz H, Orth HD, Lang H. Proteinase K from Tritirachium album Limber. Eur J Biochem 1974 Aug 15; 47(1):91-7. PMID: 4373242.
33. McKenzie HA, White FH Jr. Lysozyme and alpha-lactalbumin: structure, function, and interrelationships. Adv Protein Chem 1991; 41:173-315. PMID: 2069076.
34. Malanovic N, Leber R, Schmuck M, Kriechbaum M, Cordfunke RA, Drijfhout JW, et al. Phospholipiddriven differences determine the action of the synthetic antimicrobial peptide OP-145 on Gram-positive bacterial and mammalian membrane model systems. Biochim Biophys Acta 2015 Oct; 1848(10 Pt A):2437-47. doi: 10.1016/j.bbamem.2015.07.010 PMID: 26210299.
35. McDonnell G, Russell AD. Antiseptics and disinfectants: Activity, action, and resistance. Clin Microbiol Rev 1999 Jan; 12(1):147-79. PMID: 9880479.
36. Abdelwahab NS, Ali NW, Abdelkawy M, Emam AA. Validated RP-HPLC and TLC-densitometric methods for analysis of ternary mixture of cetylpyridinium chloride, chlorocresol and lidocaine in oral antiseptic formulation. J Chromatogr Sci 2015 Sep 12.
37. Mankodi S, Bauroth K, Witt JJ, Bsoul S, He T, Gibb R, et al. A 6-month clinical trial to study the effects of a cetylpyridinium chloride mouthrinse on gingivitis and plaque. Am J Dent 2005 Jul; 18 Spec No:9A- 14A. PMID: 16178130.
38. Ansorg R, Rath PM, Fabry W. Inhibition of the anti-staphylococcal activity of the antiseptic polihexanide by mucin. Arzneimittelforschung 2003; 53(5):368-71. PMID: 12854364.
39. Burger RM, Franco RJ, Drlica K. Killing acanthamoebae with polyaminopropyl biguanide: quantitation and kinetics. Antimicrob Agents Chemother 1994 Apr; 38(4):886-8. PMID: 8031066.
40. Kumon H, Hashimoto H, Nishimura M, Monden K, Ono N. Catheter- Associated urinary tract infections: impact of catheter materials on their management. Int J Antimicrob Agents 2001 Apr; 17(4):311-6. PMID: 11295414.
41. Goossens A, Bruze M, Gruvberger B, Gielen K, Stoskute L. Contact allergy to sodium cocoamphoacetate present in an eye make-up remover. Contact Dermatitis 2006 Nov; 55(5):302-4. PMID: 17026699.
42. Patrone V, Campana R, Vittoria E, Baffone W. In vitro synergistic activities of essential oils and surfactants in combination with cosmetic preservatives against Pseudomonas aeruginosa and Staphylococcus aureus. Curr Microbiol 2010 Apr; 60(4):237-41. doi: 10.1007/s00284-009-9531-7 PMID: 19921329.
43. Machado D, Palmeira-de-Oliveira A, Cerca N. Optimization of culture conditions for Gardnerella vaginalis biofilm formation. J Microbiol Methods 2015 Nov; 118:143-6. doi: 10.1016/j.mimet.2015.09.007 PMID: 26381661.
44. Fredricks DN, Fiedler TL, Marrazzo JM. Molecular identification of bacteria associated with bacterial vaginosis. N Engl J Med 2005 Nov 3; 353(18):1899-911. PMID: 16267321.
45. Fredricks DN, Fiedler TL, Thomas KK, Oakley BB, Marrazzo JM. Targeted PCR for detection of vaginal bacteria associated with bacterial vaginosis. J Clin Microbiol 2007 Oct; 45(10):3270-6. PMID: 17687006.
46. Twin J, Bradshaw CS, Garland SM, Fairley CK, Fethers K, Tabrizi SN. The potential of metatranscriptomics for identifying screening targets for bacterial vaginosis. PLoS One 2013; 8(9):e76892. doi: 10. 1371/journal.pone.0076892 PMID: 24086764.
47. Verhelst R, Verstraelen H, Claeys G, Verschraegen G, Delanghe J, Van SL, et al. Cloning of 16S rRNA genes amplified from normal and disturbed vaginal microflora suggests a strong association between Atopobium vaginae, Gardnerella vaginalis and bacterial vaginosis. BMC Microbiol 2004 Apr 21; 4:16. PMID: 15102329.
48. Castro J, Alves P, Sousa C, Cereija T, Franca A, Jefferson KK, et al. Using an in-vitro biofilm model to assess the virulence potential of bacterial vaginosis or non-bacterial vaginosis Gardnerella vaginalis isolates. Sci Rep 2015; 5:11640. doi: 10.1038/srep11640 PMID: 26113465.
49. Shipitsyna E, Roos A, Datcu R, Hallen A, Fredlund H, Jensen JS, et al. Composition of the vaginal microbiota in women of reproductive age-sensitive and specific molecular diagnosis of bacterial vaginosis is possible PLoS One 2013; 8(4):e60670. doi: 10.1371/journal.pone.0060670 PMID: 23585843.
50. Sheiness D, Dix K, Watanabe S, Hillier SL. High levels of Gardnerella vaginalis detected with an oligonucleotide probe combined with elevated pH as a diagnostic indicator of bacterial vaginosis. J Clin Microbiol 1992 Mar; 30(3):642-8. PMID: 1372621.
51. Stute P, May TW, Masur C, Schmidts-Winkler IM. Efficacy and safety of non-hormonal remedies for vaginal dryness: open, prospective, randomized trial. Climacteric 2015; 18(4):582-9. doi: 10.3109/13697137.2015.1036854 PMID: 25845406.
52. Anukam KC, Reid G. Effects of metronidazole on growth of Gardnerella vaginalis ATCC 14018, probiotic Lactobacillus rhamnosus GR-1 and vaginal isolate Lactobacillus plantarum KCA. Microbial Ecology in Health and Disease; Vol 20, No 1 (2008).
53. Menard JP, Fenollar F, Henry M, Bretelle F, Raoult D. Molecular quantification of Gardnerella vaginalis and Atopobium vaginae loads to predict bacterial vaginosis. Clin Infect Dis 2008 Jul 1; 47(1):33-43. doi: 10.1086/588661 PMID: 18513147.
54. Swidsinski A, Dorffel Y, Loening-Baucke V, Schilling J, Mendling W. Response of Gardnerella vaginalis biofilm to 5 days of moxifloxacin treatment. FEMS Immunol Med Microbiol 2011 Feb; 61(1):41-6. doi: 10.1111/j.1574-695X.2010.00743.x PMID: 20955467.