Phospholipid-driven differences determine the action of the synthetic antimicrobial peptide OP-145 on Gram-positive bacterial and mammalian membrane model systems

Biochimica et Biophysica Acta - Biomembranes

Volumn 1848, Issue 10, 2015, Pages 2437-2447

  Malanovic, Nermina ^a,b   Leber, Regina ^a   Schmuck, Maria ^b,c   Kriechbaum, Manfred ^d   Cordfunke, Robert A ^e   Drijfhout, Jan W ^e   De Breij, Anna ^e   Nibbering, Peter H ^e   Kolb, Dagmar ^f   Lohner, Karl ^a,b  

^a UNIVERSITY OF GRAZ   (Austria)

^b BIOTECHMED GRAZ   (Austria)

^c GRAZ UNIVERSITY OF TECHNOLOGY   (Austria)

^d GRAZ UNIVERSITY OF TECHNOLOGY   (Austria)

^e LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^f MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

Antibacterial activity; Cytotoxicity; Lipoteichoic acid; Membrane biophysics; Membrane mimics; Peptidoglycan

Indexed keywords

CALCIUM; LIPOSOME; LIPOTEICHOIC ACID; OP 145; PEPTIDOGLYCAN; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLGLYCEROL; PHOSPHOLIPID; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; ANTIMICROBIAL CATIONIC PEPTIDE; LIPID BILAYER;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL CELL WALL; BACTERIAL STRAIN; BINDING AFFINITY; CELL PERMEABILIZATION; CIRCULAR DICHROISM; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG CYTOTOXICITY; DRUG STRUCTURE; ENZYME ACTIVITY; FIBROBLAST; FLUORESCENCE SPECTROSCOPY; GRAM POSITIVE BACTERIUM; HEMOLYSIS; HUMAN; HUMAN CELL; LIPID BILAYER; MAMMAL CELL; MEMBRANE MODEL; NORMAL HUMAN; OPTICAL DENSITY; PHASE TRANSITION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; RADIATION SCATTERING; STAPHYLOCOCCUS AUREUS; SUPERNATANT; THERMODYNAMICS; TRANSMISSION ELECTRON MICROSCOPY; CELL MEMBRANE PERMEABILITY; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; METABOLISM; PHYSIOLOGY;

BACTERIA (MICROORGANISMS); MAMMALIA; POSIBACTERIA; STAPHYLOCOCCUS AUREUS;

ANTI-BACTERIAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; CELL MEMBRANE PERMEABILITY; CELL SURVIVAL; HUMANS; LIPID BILAYERS; PHOSPHOLIPIDS; STAPHYLOCOCCUS AUREUS;

EID: 84939215415     PISSN: 00052736     EISSN: 18792642     Source Type: Journal    
DOI: 10.1016/j.bbamem.2015.07.010     Document Type: Article

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