Effects of metronidazole on growth of Gardnerella vaginalis ATCC 14018, probiotic Lactobacillus rhamnosus GR-1 and vaginal isolate Lactobacillus plantarum KCA

Microbial Ecology in Health and Disease

Volumn 20, Issue 1, 2008, Pages 48-52

  Anukam, Kingsley C ^b   Reid, Gregor ^a  

^a LAWSON HEALTH RESEARCH INSTITUTE   (Canada)

^b NONE

Author keywords

Bacterial vaginosis; Gardnerella; Growth; Lactobacillus; Metronidazole

Indexed keywords

METRONIDAZOLE; PROBIOTIC AGENT;

ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIAL SURVIVAL; BACTERIUM ISOLATE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG POTENTIATION; GARDNERELLA VAGINALIS; GROWTH INHIBITION; HUMAN; IN VITRO STUDY; LACTOBACILLUS PLANTARUM; LACTOBACILLUS RHAMNOSUS; NONHUMAN; PRIORITY JOURNAL; TREATMENT PLANNING; VAGINA FLORA; VAGINITIS;

BACTERIA (MICROORGANISMS); GARDNERELLA; GARDNERELLA VAGINALIS; LACTOBACILLUS; LACTOBACILLUS PLANTARUM; LACTOBACILLUS RHAMNOSUS;

EID: 42049120060     PISSN: 0891060X     EISSN: 16512235     Source Type: Journal    
DOI: 10.1080/08910600701837964     Document Type: Article

References (30)

1. Fredricks DN, Fiedler TL, Marrazzo JM. Molecular identification of bacteria associated with bacterial vaginosis. N Engl J Med. 2005;353:1899-911.
2. Burton JP, Devillard E, Cadieux PA, Hammond JA, Reid G. Detection of Atopobium vaginae in postmenopausal women by cultivation-independent methods warrants further investigation. J Clin Microbiol. 2004;42:1829-31.
3. Ferris DG, Nyirjesy P, Sobel JD, Soper D, Pavletic A, Litaker MS. Over-the-counter antifungal drug misuse associated with patient-diagnosed vulvovaginal candidiasis. Obstet Gynecol. 2002;99:419-25.
4. Allsworth JE, Peipert JF. Prevalence of bacterial vaginosis: 2001-2004 National Health and Nutrition Examination Survey data. Obstet Gynecol. 2007;109:114-20.
5. Sewankambo N, Gray RH, Wawer MJ, Paxton L, McNaim D, Wabwire-Mangen F, et al. HIV-1 infection associated with abnormal vaginal flora morphology and bacterial vaginosis. Lancet. 1997;350:546-50.
6. Koumans EH, Kendrick JS. CDC Bacterial Vaginosis Working Group. Preventing adverse sequelae of bacterial vaginosis: a public health program and research agenda. Sex Transm Dis. 2001;28:292-7.
7. Cherpes TL, Meyn LA, Krohn MA, Lurie JG, Hillier SL. Association between acquisition of herpes simplex virus type 2 in women and bacterial vaginosis. Clin Infect Dis. 2003;37:319-25.
8. Leitich H, Kiss H. Asymptomatic bacterial vaginosis and intermediate flora as risk factors for adverse pregnancy outcome. Best Pract Res Clin Obstet Gynaecol. 2007;21:375-90.
9. McGregor JA, Larson PG. King Holmes, bacterial vaginosis and women and babies. Int J Gynecol Obstet. 1999;67 (Suppl 1):S9-S11.
10. Austin MN, Beigi RH, Meyn LA, Hillier SL. Microbiologic response to treatment of bacterial vaginosis with topical clindamycin or metronidazole. J Clin Microbiol. 2005;43:4492-7.
11. Bradshaw CS, Morton AN, Hocking J, Garland SM, Morris MB, Moss LM, et al. High recurrence rates of bacterial vaginosis over the course of 12 months after oral metronidazole therapy and factors associated with recurrence. J Infect Dis. 2006;193:1478-86.
12. Eschenbach DA. Bacterial vaginosis: resistance, recurrence, and/or reinfection? Clin Infect Dis. 2007;44:220-1.
13. Schwebke JR, Desmond RA. A randomized trial of the duration of therapy with metronidazole plus or minus azithromycin for treatment of symptomatic bacterial vaginosis. Clin Infect Dis. 2007;44:213-9.
14. Thomas KK, Sanchez S, Garcia PJ, Holmes KK. Why do different criteria for 'cure' yield different conclusions in comparing two treatments for bacterial vaginosis? Sex Transm Dis. 2005;32:526-30.
15. Hillier SL, Holmes KK. Bacterial vaginosis. In: Holmes KK, Sparling PF, Mardh P-M, Lemon SM, Stamm WE, Piot P, et al. editors. Sexually transmitted diseases, 3rd edn. New York: McGraw Hill; 1999. p. 563-86.
16. Sobel JD, Ferris D, Schwebke J, Nyirjesy P, Wiesenfeld HC, Peipert J, et al. Suppressive antibacterial therapy with 0.75% metronidazole vaginal gel to prevent recurrent bacterial vaginosis. Am J Obstet Gynecol. 2006;194:1283-9.
17. Anukam KC, Osazuwa EO, Ahonkhai I, Ngwu M, Osemene G, Bruce AW. Augmentation of antimicrobial metronidazole therapy of bacterial vaginosis with oral probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14: randomized, double-blind, placebo controlled trial. Microbes Infect. 2006;8:1450-4.
18. Anukam KC, Osazuwa E. Osemene GI, Ehigiagbe F, Bruce AW, Reid G. Clinical study comparing probiotic Lactobacillus GR-1 and RC-14 with metronidazole vaginal gel to treat symptomatic bacterial vaginosis. Microbes Infect. 2006;8:2772-6.
19. Geshnizgani AM, Onderdonk AB. Defined medium simulating genital tract secretions for growth of vaginal microflora. J Clin Microbiol 1992;1323-6.
20. Simoes JA, Aroutcheva AA, Shott S, Faro S. Effect of metronidazole on the growth of vaginal lactobacilli in vitro. Infect Dis Obstet Gynecol. 2001;9:41-5.
21. Swidsinski A, Mendling W, Loening-Baucke V, Ladhoff A, Swidsinski S, Hale LP, et al. Adherent biofilms in bacterial vaginosis. Obstet Gynecol. 2005;106(5 Pt 1):1013-23.
22. Austin MN, Meyn LA, Hillier SL. Susceptibility of vaginal bacteria to metronidazole and tinidazole. Anaerobe. 2006;12:227-30.
23. Keane FE, Ison CA, Taylor-Robinson D. A longitudinal study of the vaginal flora over a menstrual cycle. Int J STD AIDS. 1997;8:489-94.
24. Nyirjesy P, McIntosh MJ, Gattermeir DJ, Schumacher RJ, Steinmetz JI, Joffrion JL. The effects of intravaginal clindamycin and metronidazole therapy on vaginal lactobacilli in patients with bacterial vaginosis. Am J Obstet Gynecol. 2006;194:1277-82.
25. Saunders S, Bocking A, Challis J, Reid G. Effect of Lactobacillus challenge on Gardnerella vaginalis biofilms. Colloids Surf B Biointerfaces. 2007;55:138-42.
26. Atassi F, Brassart D, Grob P, Graf F, Servin AL. Lactobacillus strains isolated from the vaginal microbiota of healthy women inhibit Prevotella bivia and Gardnerella vaginalis in coculture and cell culture. FEMS Immunol Med Microbiol. 2006;48:424-32.
27. Sethi S, Das A, Sharma M. Inhibition of Gardnerella vaginalis by lactobacilli. Int J Gynaecol Obstet. 2006;93:158-9.
28. Forney LJ, Foster JA, Ledger W. The vaginal flora of healthy women is not always dominated by Lactobacillus species. J Infect Dis. 2006;194:1468-9.
29. Davis B, Glover DD, Larsen B. Analysis of metronidazole penetration into vaginal fluid by reverse-phase high-performance liquid chromatography. Am J Obstet Gynecol. 1984;149:802-3.
30. Decena DC, Co JT, Manalastas RM Jr, Palaypayon EP, Padolina CS, Sison JM, et al. Metronidazole with Lactacyd vaginal gel in bacterial vaginosis. J Obstet Gynaecol Res. 2006;32:243-51.