Salubrinal-mediated upregulation of eIF2α phosphorylation increases doxorubicin sensitivity in MCF-7/ADR cells

Molecules and Cells

Volumn 39, Issue 2, 2016, Pages 129-135

  Jeon, Yong Joon ^a   Kim, Jin Hyun ^a   Shin, Jong Il ^a   Jeong, Mini ^a   Cho, Jaewook ^a   Lee, Kyungho ^a  

^a Konkuk University   (South Korea)

Author keywords

Doxorubicin resistance; eIF2 phosphorylation; ER stress; GADD34; MCF 7 ADR cells

Indexed keywords

DEOXYRIBONUCLEOPROTEIN; DOXORUBICIN; GROWTH ARREST AND DNA DAMAGE 34; INITIATION FACTOR 2ALPHA; SALUBRINAL; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIBIOTIC; CINNAMIC ACID DERIVATIVE; INITIATION FACTOR 2; PHOSPHOPROTEIN PHOSPHATASE 1; PPP1R15A PROTEIN, HUMAN; THIOUREA;

APOPTOSIS; ARTICLE; BREAST CANCER CELL LINE; CANCER SUSCEPTIBILITY; CELL VIABILITY; CONTROLLED STUDY; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; UPREGULATION; AGONISTS; ANALOGS AND DERIVATIVES; CELL SURVIVAL; DRUG EFFECTS; DRUG POTENTIATION; DRUG RESISTANCE; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; MCF-7 CELL LINE; METABOLISM; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TUMOR CELL LINE;

ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; CINNAMATES; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; DRUG SYNERGISM; EUKARYOTIC INITIATION FACTOR-2; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MCF-7 CELLS; PHOSPHORYLATION; PROTEIN PHOSPHATASE 1; SIGNAL TRANSDUCTION; THIOUREA; TRANSCRIPTIONAL ACTIVATION;

EID: 84965133966     PISSN: 10168478     EISSN: 02191032     Source Type: Journal    
DOI: 10.14348/molcells.2016.2243     Document Type: Article

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