Optogenetics for neurodegenerative diseases

International Journal of Physiology, Pathophysiology and Pharmacology

Volumn 8, Issue 1, 2016, Pages 1-8

  Vann, Kiara T ^a   Xiong, Zhi Gang ^a  

^a MOREHOUSE SCHOOL OF MEDICINE   (United States)

Author keywords

Channelrhodopsin; Halorhodopsin; Neurodegenerative diseases; Optogenetics

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; CHANNEL RHODOPSIN 2; NEUROPEPTIDE Y; NITRIC OXIDE; RHODOPSIN; SOMATOSTATIN; UNCLASSIFIED DRUG; VASCULOTROPIN;

ALZHEIMER DISEASE; AUDITORY BRAIN STEM IMPLANT; BRAIN DEPTH STIMULATION; CEREBROVASCULAR ACCIDENT; DEGENERATIVE DISEASE; EPILEPSY; EXCITATORY POSTSYNAPTIC POTENTIAL; HEARING IMPAIRMENT; HUMAN; HUNTINGTON CHOREA; NERVE CONDUCTION; NONHUMAN; OPTOGENETICS; PARKINSON DISEASE; PROTEIN EXPRESSION; RETINOPATHY; REVIEW;

EID: 84965008599     PISSN: None     EISSN: 19448171     Source Type: Journal    
DOI: None     Document Type: Review

References (55)

1. Nagel G, Ollig D, Fuhrmann M, Kateriya S, Musti AM, Bamberg E, Hegemann P. Channelrhodopsin-1: a light-gated proton channel in green algae. Science 2002; 296: 2395-2398.
2. Boyden ES, Zhang F, Bamberg E, Nagel G and Deisseroth K. Millisecond-timescale, genetically targeted optical control of neural activity. Nat Neurosci 2005; 8: 1263-1268.
3. Ishizuka T, Kakuda M, Araki R and Yawo H. Kinetic evaluation of photosensitivity in genetically engineered neurons expressing green algae light-gated channels. Neurosci Res 2006; 54: 85-94.
4. Lanyi JK and Oesterhelt D. Identification of the retinal-binding protein in halorhodopsin. J Biol Chem 1982; 257: 2674-2677.
5. Schobert B and Lanyi JK. Halorhodopsin is a light-driven chloride pump. J Biol Chem 1982; 257: 10306-10313.
6. Gradinaru V, Mogri M, Thompson KR, Henderson JM and Deisseroth K. Optical deconstruction of parkinsonian neural circuitry. Science 2009; 324: 354-359.
7. Kim JH, Auerbach JM, Rodriguez-Gomez JA, Velasco I, Gavin D, Lumelsky N, Lee SH, Nguyen J, Sanchez-Pernaute R, Bankiewicz K and McKay R. Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson’s disease. Nature 2002; 418: 50-56.
8. Brederlau A, Correia AS, Anisimov SV, Elmi M, Paul G, Roybon L, Morizane A, Bergquist F, Riebe I, Nannmark U, Carta M, Hanse E, Takahashi J, Sasai Y, Funa K, Brundin P, Eriksson PS and Li JY. Transplantation of human embryonic stem cell-derived cells to a rat model of Parkinson’s disease: effect of in vitro differentiation on graft survival and teratoma formation. Stem Cells 2006; 24: 1433-1440.
9. Ben-Hur T, Idelson M, Khaner H, Pera M, Reinhartz E, Itzik A and Reubinoff BE. Transplantation of human embryonic stem cell-derived neural progenitors improves behavioral deficit in Parkinsonian rats. Stem Cells 2004; 22: 1246-1255.
10. Steinbeck JA, Choi SJ, Mrejeru A, Ganat Y, Deisseroth K, Sulzer D, Mosharov EV and Studer L. Optogenetics enables functional analysis of human embryonic stem cell-derived grafts in a Parkinson’s disease model. Nat Biotechnol 2015; 33: 204-209.
11. Kriks S, Shim JW, Piao J, Ganat YM, Wakeman DR, Xie Z, Carrillo-Reid L, Auyeung G, Antonacci C, Buch A, Yang L, Beal MF, Surmeier DJ, Kordower JH, Tabar V and Studer L. Dopamine neurons derived from human ES cells efficient ly engraft in animal models of Parkinson’s disease. Nature 2011; 480: 547-551.
12. Kirkeby A, Grealish S, Wolf DA, Nelander J, Wood J, Lundblad M, Lindvall O and Parmar M. Generation of regionally specified neural progenitors and functional neurons from human embryonic stem cells under defined conditions. Cell Rep 2012; 1: 703-714.
13. Roy NS, Cleren C, Singh SK, Yang L, Beal MF and Goldman SA. Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes. Nat Med 2006; 12: 1259-1268.
14. Cepeda C, Galvan L, Holley SM, Rao SP, Andre VM, Botelho EP, Chen JY, Watson JB, Deisseroth K and Levine MS. Multiple Sources of Striatal Inhibition Are Differentially Affected in Huntingtons Disease Mouse Models. J Neurosci 2013; 33: 7393-7406.
15. Cepeda C, Andre VM, Yamazaki I, Wu N, Kleiman-Weiner M and Levine MS. Differential electrophysiological properties of dopamine D1 and D2 receptor-containing striatal medium-sized spiny neurons. Eur J Neurosci 2008; 27: 671-682.
16. Andre VM, Cepeda C, Fisher YE, Huynh M, Bardakjian N, Singh S, Yang XW and Levine MS. Differential electrophysiological changes in striatal output neurons in Huntington’s disease. J Neurosci 2011; 31: 1170-1182.
17. Andre VM, Fisher YE and Levine MS. Altered Balance of Activity in the Striatal Direct and Indirect Pathways in Mouse Models of Huntington’s Disease. Front Syst Neurosci 2011; 5: 46.
18. Andre VM, Cepeda C, Fisher YE, Huynh M, Bardakjian N, Singh S, Yang XW and Levine MS. Differential electrophysiological changes in striatal output neurons in Huntington’s disease. J Neurosci 2011; 31: 1170-1182.
19. Kawaguchi Y, Wilson CJ, Augood SJ and Emson PC. Striatal interneurones: chemical, physiological and morphological characterization. Trends Neurosci 1995; 18: 527-535.
20. Deckel AW. Nitric oxide and nitric oxide synthase in Huntington’s disease. J Neurosci Res 2001; 64: 99-107.
21. Galarraga E, Vilchis C, Tkatch T, Salgado H, Tecuapetla F, Perez-Rosello T, Perez-Garci E, Hernandez-Echeagaray E, Surmeier DJ and Bargas J. Somatostatinergic modulation of firing pattern and calcium-activated potassium currents in medium spiny neostriatal neurons. Neuroscience 2007; 146: 537-554.
22. Wahab A, Albus K, Gabriel S and Heinemann U. In search of models of pharmacoresistant epilepsy. Epilepsia 2010; 51 Suppl 3: 154-159.
23. Tonnesen J, Sorensen AT, Deisseroth K, Lundberg C and Kokaia M. Optogenetic control of epileptiform activity. Proc Natl Acad Sci U S A 2009; 106: 12162-12167.
24. Paz JT, Davidson TJ, Frechette ES, Delord B, Parada I, Peng K, Deisseroth K and Huguenard JR. Closed-loop optogenetic control of thalamus as a tool for interrupting seizures after cortical injury. Nat Neurosci 2013; 16: 64-70.
25. Ji ZG and Wang H. Optogenetic control of astrocytes: Is it possible to treat astrocyte-related epilepsy? Brain Research Bulletin 2015; 110: 20-25.
26. Sukhotinsky I, Chan AM, Ahmed OJ, Rao VR, Gradinaru V, Ramakrishnan C, Deisseroth K, Majewska AK and Cash SS. Optogenetic delay of status epilepticus onset in an in vivo rodent epilepsy model. PLoS One 2013; 8: e62013
27. Soper C, Wicker E, Kulick CV, N’Gouemo P and Forcelli PA. Optogenetic activation of superior colliculus neurons suppresses seizures originating in diverse brain networks. Neurobiol Dis 2016; 87: 102-115.
28. Selkoe D, Mandelkow E and Holtzman D. Deciphering Alzheimer disease. Cold Spring Harb Perspect Med 2012; 2: a011460
29. Kamenetz F, Tomita T, Hsieh H, Seabrook G, Borchelt D, Iwatsubo T, Sisodia S and Malinow R. APP Processing and Synaptic Function. Neuron 37: 925-937.
30. Cirrito JR, Kang JE, Lee J, Stewart FR, Verges DK, Silverio LM, Bu G, Mennerick S and Holtzman DM. Endocytosis is required for synaptic activity-dependent release of amyloidbeta in vivo. Neuron 2008; 58: 42-51.
31. Cirrito JR, Yamada KA, Finn MB, Sloviter RS, Bales KR, May PC, Schoepp DD, Paul SM, Mennerick S and Holtzman DM. Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo. Neuron 2005; 48: 913-922.
32. Yamamoto K, Tanei Z, Hashimoto T, Wakabayashi T, Okuno H, Naka Y, Yizhar O, Fenno LE, Fukayama M, Bito H, Cirrito JR, Holtzman DM, Deisseroth K and Iwatsubo T. Chronic optogenetic activation augments abeta pathology in a mouse model of Alzheimer disease. Cell Rep 2015; 11: 859-865.
33. Cheng MY, Wang EH, Woodson WJ, Wang S, Sun G, Lee AG, Arac A, Fenno LE, Deisseroth K and Steinberg GK. Optogenetic neuronal stimulation promotes functional recovery after stroke. Proc Natl Acad Sci U S A 2014; 111: 12913-12918.
34. Cheng MY, Wang EH and Steinberg GK. Optogenetic Approaches to Study Stroke Recovery. ACS Chem Neurosci 2014; 5: 1144-1145.
35. Congdon N, O’Colmain B, Klaver CC, Klein R, Muñoz B, Friedman DS, Kempen J, Taylor HR, Mitchell P; Eye Diseases Prevalence Research Group. CAuses and prevalence of visual impairment among adults in the united states. Arch Ophthalmol 2004; 122: 477-485.
36. Hamel C. Retinitis pigmentosa. Orphanet J Rare Dis 2006; 1: 40-40.
37. Agarwal A, Rhoades WR, Hanout M, Soliman MK, Sarwar S, Sadiq MA, Sepah YJ, Do DV and Nguyen QD. Management of neovascular agerelated macular degeneration: current stateof-the-art care for optimizing visual outcomes and therapies in development. Clin Ophthalmol 2015; 9: 1001-1015.
38. Bi A, Cui J, Ma YP, Olshevskaya E, Pu M, Dizhoor AM and Pan ZH. Ectopic expression of a microbial-type rhodopsin restores visual responses in mice with photoreceptor degeneration. Neuron 2006; 50: 23-33.
39. Tomita H, Sugano E, Yawo H, Ishizuka T, Isago H, Narikawa S, Kugler S and Tamai M. Restoration of visual response in aged dystrophic RCS rats using AAV-mediated channelopsin-2 gene transfer. Invest Ophthalmol Vis Sci 2007; 48: 3821-3826.
40. Tomita H, Sugano E, Isago H, Hiroi T, Wang Z, Ohta E and Tamai M. Channelrhodopsin-2 gene transduced into retinal ganglion cells restores functional vision in genetically blind rats. Exp Eye Res 2010; 90: 429-436.
41. Tomita H, Sugano E, Fukazawa Y, Isago H, Sugiyama Y, Hiroi T, Ishizuka T, Mushiake H, Kato M, Hirabayashi M, Shigemoto R, Yawo H and Tamai M. Visual properties of transgenic rats harboring the channelrhodopsin-2 gene regulated by the thy-1.2 promoter. PLoS One 2009; 4: e7679.
42. Doroudchi MM, Greenberg KP, Liu J, Silka KA, Boyden ES, Lockridge JA, Arman AC, Janani R, Boye SE, Boye SL, Gordon GM, Matteo BC, Sampath AP, Hauswirth WW and Horsager A. Virally delivered channelrhodopsin-2 safely and effectively restores visual function in multiple mouse models of blindness. Mol Ther 2011; 19: 1220-1229.
43. Thyagarajan S, van WM, Lehmann K, Lowel S, Feng G and Wassle H. Visual function in mice with photoreceptor degeneration and transgenic expression of channelrhodopsin 2 in ganglion cells. J Neurosci 2010; 30: 8745-8758.
44. Lagali PS, Balya D, Awatramani GB, Munch TA, Kim DS, Busskamp V, Cepko CL and Roska B. Light-activated channels targeted to ON bipolar cells restore visual function in retinal degeneration. Nat Neurosci 2008; 11: 667-675.
45. Busskamp V, Duebel J, Balya D, Fradot M, Viney TJ, Siegert S, Groner AC, Cabuy E, Forster V, Seeliger M, Biel M, Humphries P, Paques M, Mohand-Said S, Trono D, Deisseroth K, Sahel JA, Picaud S and Roska B. Genetic reactivation of cone photoreceptors restores visual responses in retinitis pigmentosa. Science 2010; 329: 413-417.
46. Nirenberg S and Pandarinath C. Retinal prosthetic strategy with the capacity to restore normal vision. Proc Natl Acad Sci U S A 2012; 109: 15012-15017.
47. van WM, Pielecka-Fortuna J, Lowel S and Kleinlogel S. Restoring the ON Switch in Blind Retinas: Opto-mGluR6, a Next-Generation, Cell-Tailored Optogenetic Tool. PLoS Biol 2015; 13: e1002143
48. Colletti V, Carner M, Miorelli V, Guida M, Colletti L and Fiorino F. Auditory Brainstem Implant (ABI): New Frontiers in Adults and Children. Otolaryngol Head Neck Surg 2005; 133: 126-138.
49. Hight AE, Kozin ED, Darrow K, Lehmann A, Boyden E, Brown MC and Lee DJ. Superior temporal resolution of Chronos versus channelrhodopsin-2 in an optogenetic model of the auditory brainstem implant. Hear Res 2015; 322: 235-241.
50. Shimano T, Fyk-Kolodziej B, Mirza N, Asako M, Tomoda K, Bledsoe S, Pan ZH, Molitor S and Holt AG. Assessment of the AAV-mediated expression of channelrhodopsin-2 and halorhodopsin in brainstem neurons mediating auditory signaling. Brain Res 2013; 1511: 138-152.
51. Hernandez VH, Gehrt A, Jing Z, Hoch G, Jeschke M, Strenzke N and Moser T. Optogenetic stimulation of the auditory nerve. J Vis Exp 2014; e52069.
52. Hernandez VH, Gehrt A, Reuter K, Jing Z, Jeschke M, Mendoza SA, Hoch G, Bartels M, Vogt G, Garnham CW, Yawo H, Fukazawa Y, Augustine GJ, Bamberg E, Kugler S, Salditt T, de HL, Strenzke N and Moser T. Optogenetic stimulation of the auditory pathway. J Clin Invest 2014; 124: 1114-1129.
53. Darrow KN, Slama MC, Kozin ED, Owoc M, Hancock K, Kempfle J, Edge A, Lacour S, Boyden E, Polley D, Brown MC and Lee DJ. Optogenetic stimulation of the cochlear nucleus using channelrhodopsin-2 evokes activity in the central auditory pathways. Brain Res 2015; 1599: 44-56.
54. Zhang F, Wang LP, Boyden ES and Deisseroth K. Channelrhodopsin-2 and optical control of excitable cells. Nat Methods 2006; 3: 785-792.
55. Klapoetke NC, Murata Y, Kim SS, Pulver SR, Birdsey-Benson A, Cho YK, Morimoto TK, Chuong AS, Carpenter EJ, Tian Z, Wang J, Xie Y, Yan Z, Zhang Y, Chow BY, Surek B, Melkonian M, Jayaraman V, Constantine-Paton M, Wong GK and Boyden ES. Independent optical excitation of distinct neural populations. Nat Methods 2014; 11: 338-346.