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Volumn 6, Issue , 2016, Pages

MicroRNA-223 Attenuates Hypoxia-induced Vascular Remodeling by Targeting RhoB/MLC2 in Pulmonary Arterial Smooth Muscle Cells

Author keywords

[No Author keywords available]

Indexed keywords

CARDIAC MYOSIN; MICRORNA; MIRN223 MICRORNA, HUMAN; MYOSIN LIGHT CHAIN; MYOSIN LIGHT CHAIN 2; RHOB GUANINE NUCLEOTIDE BINDING PROTEIN;

EID: 84964914632     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep24900     Document Type: Article
Times cited : (63)

References (56)
  • 1
    • 77952234421 scopus 로고    scopus 로고
    • Basic science of pulmonary arterial hypertension for clinicians: New concepts and experimental therapies
    • Archer, S. L., Weir, E. K. & Wilkins, M. R. Basic science of pulmonary arterial hypertension for clinicians: new concepts and experimental therapies. Circulation 121, 2045-66 (2010).
    • (2010) Circulation , vol.121 , pp. 2045-2066
    • Archer, S.L.1    Weir, E.K.2    Wilkins, M.R.3
  • 2
    • 2942541475 scopus 로고    scopus 로고
    • Cellular and molecular pathobiology of pulmonary arterial hypertension
    • Humbert, M. et al. Cellular and molecular pathobiology of pulmonary arterial hypertension. J Am Coll Cardiol 43, 13S-24S (2004).
    • (2004) J Am Coll Cardiol , vol.43 , pp. 13S-24S
    • Humbert, M.1
  • 3
    • 84899137231 scopus 로고    scopus 로고
    • Molecular mechanisms of pulmonary arterial remodeling
    • Crosswhite, P. & Sun, Z. Molecular mechanisms of pulmonary arterial remodeling. Mol Med 20, 191-201 (2014).
    • (2014) Mol Med , vol.20 , pp. 191-201
    • Crosswhite, P.1    Sun, Z.2
  • 4
    • 50149083752 scopus 로고    scopus 로고
    • Mammalian Rho GTPases: New insights into their functions fromm vivo studies
    • Heasman, S.J. & Ridley, A. J. Mammalian Rho GTPases: new insights into their functions fromm vivo studies. Nat Rev Mol Cell Biol 9, 690-701(2008).
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 690-701
    • Heasman, S.J.1    Ridley, A.J.2
  • 5
    • 84861589157 scopus 로고    scopus 로고
    • Role of RhoB in the regulation of pulmonary endothelial and smooth muscle cell responses to hypoxia
    • Wojciak-Stothard, B. et al. Role of RhoB in the regulation of pulmonary endothelial and smooth muscle cell responses to hypoxia. Ore Res 110, 1423-34(2012).
    • (2012) Ore Res , vol.110 , pp. 1423-1434
    • Wojciak-Stothard, B.1
  • 6
    • 34247216078 scopus 로고    scopus 로고
    • Oxygen activates the Rho/Rho-kinase pathway and induces RhoB and ROCK-1 expression in human and rabbit ductus arteriosus by increasing mitochondria-derived reactive oxygen species: A newly recognized mechanism for sustaining ductal constriction
    • Kajimoto, H. et al Oxygen activates the Rho/Rho-kinase pathway and induces RhoB and ROCK-1 expression in human and rabbit ductus arteriosus by increasing mitochondria-derived reactive oxygen species: a newly recognized mechanism for sustaining ductal constriction. Circulation 115, 1777-88 (2007).
    • (2007) Circulation , vol.115 , pp. 1777-1788
    • Kajimoto, H.1
  • 7
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • Bartel, D. P. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116, 281-97 (2004).
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 8
    • 84872896723 scopus 로고    scopus 로고
    • MicroRNA control of vascular endothelial growth factor signaling output during vascular development
    • Dang, L. T., Lawson, N. D. & Fish, J. E. MicroRNA control of vascular endothelial growth factor signaling output during vascular development. Arterioscler Thromb Vasc Biol 33, 193-200 (2013).
    • (2013) Arterioscler Thromb Vasc Biol , vol.33 , pp. 193-200
    • Dang, L.T.1    Lawson, N.D.2    Fish, J.E.3
  • 9
    • 46449128469 scopus 로고    scopus 로고
    • SMAD proteins control DROSHA-mediated microRNA maturation
    • Davis, B. N., Hilyard, A. C, Lagna, G. & Hata, A. SMAD proteins control DROSHA-mediated microRNA maturation. Nature 454, 56-61(2008).
    • (2008) Nature , vol.454 , pp. 56-61
    • Davis, B.N.1    Hilyard, A.C.2    Lagna, G.3    Hata, A.4
  • 10
    • 78649892620 scopus 로고    scopus 로고
    • MicroRNA-21 plays a role in hypoxia-mediated pulmonary artery smooth muscle cell proliferation and migration
    • Sarkar, J. et al MicroRNA-21 plays a role in hypoxia-mediated pulmonary artery smooth muscle cell proliferation and migration. Am J Physiol Lung Cell Mol Physiol 299, L861-71 (2010).
    • (2010) Am J Physiol Lung Cell Mol Physiol , vol.299 , pp. L861-L871
    • Sarkar, J.1
  • 11
    • 79952733132 scopus 로고    scopus 로고
    • Role for MIR-204in human pulmonary arterial hypertension
    • Courboulin, A. et al Role for miR-204in human pulmonary arterial hypertension. J Exp Med 208, 535-48 (2011).
    • (2011) J Exp Med , vol.208 , pp. 535-548
    • Courboulin, A.1
  • 12
    • 79959691239 scopus 로고    scopus 로고
    • MIR-143 and miR-145: Molecular keys to switch the phenotype of vascular smooth muscle cells
    • Rangrez, A. Y., Massy, Z. A., Metzinger-Le Meuth, V. &Metzinger, L. miR-143 and miR-145: molecular keys to switch the phenotype of vascular smooth muscle cells. Circ Cardiovasc Genet 4, 197-205 (2011).
    • (2011) Circ Cardiovasc Genet , vol.4 , pp. 197-205
    • Rangrez, A.Y.1    Massy, Z.A.2    Metzinger-Le Meuth, V.3    Metzinger, L.4
  • 13
    • 68449097267 scopus 로고    scopus 로고
    • MIR-145 and miR-143 regulate smooth muscle cell fate and plasticity
    • Cordes, K. R. et al miR-145 and miR-143 regulate smooth muscle cell fate and plasticity. Nature 460, 705-10 (2009).
    • (2009) Nature , vol.460 , pp. 705-710
    • Cordes, K.R.1
  • 14
    • 84883426400 scopus 로고    scopus 로고
    • MicroRNA-124 suppresses the transactivation of nuclear factor of activated T cells by targeting multiple genes and inhibits the proliferation of pulmonary artery smooth muscle cells
    • Kang, K. et al MicroRNA-124 suppresses the transactivation of nuclear factor of activated T cells by targeting multiple genes and inhibits the proliferation of pulmonary artery smooth muscle cells. J Biol Chem 288, 25414-27 (2013).
    • (2013) J Biol Chem , vol.288 , pp. 25414-25427
    • Kang, K.1
  • 15
    • 84892930632 scopus 로고    scopus 로고
    • MicroRNA-124 controls the proliferative, migratory, and inflammatory phenotype of pulmonary vascular fibroblasts
    • Wang, D. et al MicroRNA-124 controls the proliferative, migratory, and inflammatory phenotype of pulmonary vascular fibroblasts. Circ Res 114, 67-78 (2014).
    • (2014) Circ Res , vol.114 , pp. 67-78
    • Wang, D.1
  • 16
    • 84930179938 scopus 로고    scopus 로고
    • New insights into the pathology of pulmonary hypertension: Implication of themiR-210/ISCUl/2/Fe-S axis
    • Tang, H., Ayon, R. J. &Yuan, J.X. New insights into the pathology of pulmonary hypertension: implication of themiR-210/ISCUl/2/Fe-S axis. EMBO Mol Med 7, 689-91 (2015).
    • (2015) EMBO Mol Med , vol.7 , pp. 689-691
    • Tang, H.1    Ayon, R.J.2    Yuan, J.X.3
  • 17
    • 84924755766 scopus 로고    scopus 로고
    • Loss of microRNA-17 approximately 92 in smooth muscle cells attenuates experimental pulmonary hypertension via induction of PDZ and LIM domain S
    • Chen, T. et al Loss of microRNA-17 approximately 92 in smooth muscle cells attenuates experimental pulmonary hypertension via induction of PDZ and LIM domain S. Am J Respir Crit Care Med 191, 678-92 (2015).
    • (2015) Am J Respir Crit Care Med , vol.191 , pp. 678-692
    • Chen, T.1
  • 18
    • 84922347131 scopus 로고    scopus 로고
    • AntagoMIR directed against MIR-20a restores functional BMPR2 signalling and prevents vascular remodelling in hypoxia-induced pulmonary hypertension
    • Brock, M. et al. AntagomiR directed against miR-20a restores functional BMPR2 signalling and prevents vascular remodelling in hypoxia-induced pulmonary hypertension. Eur Heart J 35, 3203-11 (2014).
    • (2014) Eur Heart J , vol.35 , pp. 3203-3211
    • Brock, M.1
  • 19
    • 84862777565 scopus 로고    scopus 로고
    • MicroRNA-21 integrates pathogenic signaling to control pulmonary hypertension: Results of a network bioinformatics approach
    • Parikh, V. N. et al. MicroRNA-21 integrates pathogenic signaling to control pulmonary hypertension: results of a network bioinformatics approach. Circulation 125, 1520-32 (2012).
    • (2012) Circulation , vol.125 , pp. 1520-1532
    • Parikh, V.N.1
  • 20
    • 77952346716 scopus 로고    scopus 로고
    • MicroRNA-223 regulates Glut4 expression and cardiomyocyte glucose metabolism
    • Lu, H., Buchan, R. J. & Cook, S. A. MicroRNA-223 regulates Glut4 expression and cardiomyocyte glucose metabolism. Cardiovasc fc 86, 410-20 (2010).
    • (2010) Cardiovasc Fc , vol.86 , pp. 410-420
    • Lu, H.1    Buchan, R.J.2    Cook, S.A.3
  • 21
    • 77957572525 scopus 로고    scopus 로고
    • MIR-223 and miR-142 attenuate hematopoietic cell proliferation, and miR-223 positively regulates miR-142 through LM02 isoforms and CEBP-beta
    • Sun, W et al. miR-223 and miR-142 attenuate hematopoietic cell proliferation, and miR-223 positively regulates miR-142 through LM02 isoforms and CEBP-beta. Cell Res 20, 1158-69 (2010).
    • (2010) Cell Res , vol.20 , pp. 1158-1169
    • Sun, W.1
  • 22
    • 77950076454 scopus 로고    scopus 로고
    • Complexity of MIR-223 regulation by CEBPA in human AML
    • Eyholzer, M. et al. Complexity of miR-223 regulation by CEBPA in human AML. Leuk Res 34, 672-6 (2010).
    • (2010) Leuk Res , vol.34 , pp. 672-676
    • Eyholzer, M.1
  • 23
    • 46249125127 scopus 로고    scopus 로고
    • MicroRNA-223 is commonly repressed in hepatocellular carcinoma and potentiates expression of Stathminl
    • Wong, Q. W. et al. MicroRNA-223 is commonly repressed in hepatocellular carcinoma and potentiates expression of Stathminl. Gastroenterology 135, 257-69 (2008).
    • (2008) Gastroenterology , vol.135 , pp. 257-269
    • Wong, Q.W.1
  • 24
    • 43949136141 scopus 로고    scopus 로고
    • Potential role of MIR-9 andMIR-223 in recurrent ovarian cancer
    • Laios, A. et al. Potential role of miR-9 andmiR-223 in recurrent ovarian cancer. Mol Cancer 7, 35 (2008).
    • (2008) Mol Cancer , vol.7 , pp. 35
    • Laios, A.1
  • 26
    • 70349668311 scopus 로고    scopus 로고
    • Common micro-RNA signature in skeletal muscle damage and regeneration induced by Duchenne muscular dystrophy and acute ischemia
    • Greco, S. et al Common micro-RNA signature in skeletal muscle damage and regeneration induced by Duchenne muscular dystrophy and acute ischemia. FASEB J23, 3335-46 (2009).
    • (2009) FASEB J , vol.23 , pp. 3335-3346
    • Greco, S.1
  • 27
    • 84890433094 scopus 로고    scopus 로고
    • MicroRNA-223 antagonizes angiogenesis by targeting betal integrin and preventing growth factor signaling in endothelial cells
    • Shi, L. et al MicroRNA-223 antagonizes angiogenesis by targeting betal integrin and preventing growth factor signaling in endothelial cells. Circ Res 113, 1320-30(2013).
    • (2013) Circ Res , vol.113 , pp. 1320-1330
    • Shi, L.1
  • 28
    • 2942574709 scopus 로고    scopus 로고
    • Pathologic assessment of vasculopathies in pulmonary hypertension
    • Pietra, G. G. et al Pathologic assessment of vasculopathies in pulmonary hypertension. J Am Coll Cardiol 43, 25S-32S (2004).
    • (2004) J Am Coll Cardiol , vol.43 , pp. 25S-32S
    • Pietra, G.G.1
  • 29
    • 71949117652 scopus 로고    scopus 로고
    • Hypoxia promotes human pulmonary artery smooth muscle cell proliferation through induction of arginase
    • Chen, B., Calvert, A. E., Cui, H. & Nelin, L. D. Hypoxia promotes human pulmonary artery smooth muscle cell proliferation through induction of arginase. Am J Physiol Lung Cell Mol Physiol 297, L1151-9 (2009).
    • (2009) Am J Physiol Lung Cell Mol Physiol , vol.297 , pp. L1151-L1159
    • Chen, B.1    Calvert, A.E.2    Cui, H.3    Nelin, L.D.4
  • 30
    • 0034698841 scopus 로고    scopus 로고
    • Distinct roles of ROCK (Rho-kinase) and MLCK in spatial regulation of MLC phosphorylation for assembly of stress fibers and focal adhesions in 3T3 fibroblasts
    • Totsukawa, G. et al Distinct roles of ROCK (Rho-kinase) and MLCK in spatial regulation of MLC phosphorylation for assembly of stress fibers and focal adhesions in 3T3 fibroblasts. J. Cell Biol 150, 797-806 (2000).
    • (2000) J. Cell Biol , vol.150 , pp. 797-806
    • Totsukawa, G.1
  • 31
    • 84887622487 scopus 로고    scopus 로고
    • Hypoxia modulates the expression of leucine zipper-positive MYPTl and its interaction with protein kinase G and Rho kinases in pulmonary arterial smooth muscle cells
    • Singh, D. K., Sarkar, J., Raghavan, A., Reddy, S. P. & Raj, J. U. Hypoxia modulates the expression of leucine zipper-positive MYPTl and its interaction with protein kinase G and Rho kinases in pulmonary arterial smooth muscle cells. Pulm Circ 1, 487-98 (2011).
    • (2011) Pulm Circ , vol.1 , pp. 487-498
    • Singh, D.K.1    Sarkar, J.2    Raghavan, A.3    Reddy, S.P.4    Raj, J.U.5
  • 33
    • 77954161288 scopus 로고    scopus 로고
    • Circulating microRNA: A novel potential biomarker for early diagnosis of acute myocardial infarction in humans
    • Wang, G. K. et al Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans. Eur Heart J31, 659-66 (2010).
    • (2010) Eur Heart J , vol.31 , pp. 659-666
    • Wang, G.K.1
  • 34
    • 84878140094 scopus 로고    scopus 로고
    • Circulating miRNAs as potential marker for pulmonary hypertension
    • Wei, C. et al Circulating miRNAs as potential marker for pulmonary hypertension. PLos One 8, e64396 (2013).
    • (2013) PLos One , vol.8 , pp. e64396
    • Wei, C.1
  • 35
    • 79952761947 scopus 로고    scopus 로고
    • Hypoxic pulmonary vasoconstriction: Mechanisms of oxygen-sen sing
    • Evans, A. M., Hardie, D. G., Peers, C. & Mahmoud, A. Hypoxic pulmonary vasoconstriction: mechanisms of oxygen-sen sing. Curr Opin Anaesthesiol24, 13-20 (2011).
    • (2011) Curr Opin Anaesthesiol , vol.24 , pp. 13-20
    • Evans, A.M.1    Hardie, D.G.2    Peers, C.3    Mahmoud, A.4
  • 36
    • 84894896486 scopus 로고    scopus 로고
    • Hypoxamirs in Pulmonary Hypertension: Breathing New Life into Pulmonary Vascular Research
    • Hale, A. E., White, K. & Chan, S. Y. Hypoxamirs in Pulmonary Hypertension: Breathing New Life into Pulmonary Vascular Research. Cardiovasc Diagn Ther 2, 200-212 (2012).
    • (2012) Cardiovasc Diagn Ther , vol.2 , pp. 200-212
    • Hale, A.E.1    White, K.2    Chan, S.Y.3
  • 37
    • 77950878463 scopus 로고    scopus 로고
    • Dynamic changes in lung microRNA profiles during the development of pulmonary hypertension due to chronic hypoxia andmonocrotaline
    • Caruso, P. et al Dynamic changes in lung microRNA profiles during the development of pulmonary hypertension due to chronic hypoxia andmonocrotaline. Arten'osder Thromb Vase Biol 30, 716-23 (2010).
    • (2010) Arten'Osder Thromb Vase Biol , vol.30 , pp. 716-723
    • Caruso, P.1
  • 38
    • 84867636675 scopus 로고    scopus 로고
    • Inorganic phosphate accelerates the migration of vascular smooth muscle cells: Evidence for the involvement of MIR-223
    • Rangrez, A. Y. et al. Inorganic phosphate accelerates the migration of vascular smooth muscle cells: evidence for the involvement of miR-223. PLos One 7, e47807 (2012).
    • (2012) PLos One , vol.7 , pp. e47807
    • Rangrez, A.Y.1
  • 39
    • 84894382202 scopus 로고    scopus 로고
    • Role for DNA damage signaling in pulmonary arterial hypertension
    • Meloche, J. et al. Role for DNA damage signaling in pulmonary arterial hypertension. Circulation 129, 786-97 (2014).
    • (2014) Circulation , vol.129 , pp. 786-797
    • Meloche, J.1
  • 40
    • 84941671128 scopus 로고    scopus 로고
    • MIR-223 Reverses Experimental Pulmonary Arterial Hypertension
    • 00149
    • Meloche, J. et al. MiR-223 Reverses Experimental Pulmonary Arterial Hypertension. Am J Physiol Cell Physiol, ajpcell 00149 2015 (2015).
    • (2015) Am J Physiol Cell Physiol, Ajpcell , pp. 2015
    • Meloche, J.1
  • 42
    • 0033039738 scopus 로고    scopus 로고
    • Rho controls actin cytoskeletal assembly in renal epithelial cells during ATP depletion and recovery
    • Raman, N. & Atkinson, S. J. Rho controls actin cytoskeletal assembly in renal epithelial cells during ATP depletion and recovery. Am J Physiol 276, C1312-24 (1999).
    • (1999) Am J Physiol , vol.276 , pp. C1312-C1324
    • Raman, N.1    Atkinson, S.J.2
  • 43
    • 65649146486 scopus 로고    scopus 로고
    • Signaling through Rho GTPase pathway as viable drug target
    • Lu, Q., Longo, E M., Zhou, H., Massa, S. M. & Chen, Y H. Signaling through Rho GTPase pathway as viable drug target. Curr Med Chem 16, 1355-65 (2009).
    • (2009) Curr Med Chem , vol.16 , pp. 1355-1365
    • Lu, Q.1    Longo, E.M.2    Zhou, H.3    Massa, S.M.4    Chen, Y.H.5
  • 44
    • 70449709345 scopus 로고    scopus 로고
    • Plasma MIR-208 as a biomarker of myocardial injury
    • Ji, X. et al. Plasma miR-208 as a biomarker of myocardial injury. Clin Chem 55, 1944-9 (2009).
    • (2009) Clin Chem , vol.55 , pp. 1944-1949
    • Ji, X.1
  • 45
    • 65849322883 scopus 로고    scopus 로고
    • Down-regulation of MIR-92 in human plasma is a novel marker for acute leukemia patients
    • Tanaka, M. et al. Down-regulation of miR-92 in human plasma is a novel marker for acute leukemia patients. PLos One 4, e5532 (2009).
    • (2009) PLos One , vol.4 , pp. e5532
    • Tanaka, M.1
  • 46
    • 84862777377 scopus 로고    scopus 로고
    • Y Secreted microRNAs: A new form of intercellular communication
    • Chen, X., Liang, H., Zhang, J., Zen, K. & Zhang, C. Y Secreted microRNAs: a new form of intercellular communication. Trends Cell Biol22, 125-32(2012).
    • (2012) Trends Cell Biol , vol.22 , pp. 125-132
    • Chen, X.1    Liang, H.2    Zhang, J.3    Zen, K.4    Zhang, C.5
  • 47
    • 48749122914 scopus 로고    scopus 로고
    • Circulating microRNAs as stable blood-based markers for cancer detection
    • Mitchell, P. S. et al. Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci USA 105, 10513-8(2008).
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 10513-10518
    • Mitchell, P.S.1
  • 48
    • 77957259803 scopus 로고    scopus 로고
    • Plasma microRNA profiling reveals loss of endothelial MIR-126 and other microRNAs in type 2 diabetes
    • Zampetaki, A. et al. Plasma microRNA profiling reveals loss of endothelial miR-126 and other microRNAs in type 2 diabetes. Circ Res 107, 810-7 (2010).
    • (2010) Circ Res , vol.107 , pp. 810-817
    • Zampetaki, A.1
  • 49
    • 84863971529 scopus 로고    scopus 로고
    • Prospective study on circulating MicroRNAs and risk of myocardial infarction
    • Zampetaki, A. et al. Prospective study on circulating MicroRNAs and risk of myocardial infarction. J Am Coll Cardiol 60, 290-9 (2012).
    • (2012) J Am Coll Cardiol , vol.60 , pp. 290-299
    • Zampetaki, A.1
  • 50
    • 84902381640 scopus 로고    scopus 로고
    • Decreased circulating microRNA-223 level predicts high on-treatment platelet reactivity in patients with troponin-negative non-ST elevation acute coronary syndrome
    • Zhang, Y Y et al. Decreased circulating microRNA-223 level predicts high on-treatment platelet reactivity in patients with troponin-negative non-ST elevation acute coronary syndrome. J. Thromb Thrombolysis 38, 65-72 (2013).
    • (2013) J. Thromb Thrombolysis , vol.38 , pp. 65-72
    • Zhang, Y.Y.1
  • 51
    • 79251574405 scopus 로고    scopus 로고
    • Gender differences in plasma biomarker levels in a cohort of COPD patients: A pilot study
    • de Torres, J. P. et al. Gender differences in plasma biomarker levels in a cohort of COPD patients: a pilot study. PLos One 6, e 16021 (2011).
    • (2011) PLos One , vol.6 , pp. e16021
    • De Torres, J.P.1
  • 52
    • 84955216808 scopus 로고    scopus 로고
    • Human lung microRNA profiling in pulmonary arterial hypertension secondary to congenital heart defect
    • Ma, K. et al. Human lung microRNA profiling in pulmonary arterial hypertension secondary to congenital heart defect. Pediatr Pulmonol 80, 1214-23 (2015).
    • (2015) Pediatr Pulmonol , vol.80 , pp. 1214-1223
    • Ma, K.1
  • 53
    • 84869008360 scopus 로고    scopus 로고
    • A novel real-time PCR assay of microRNAs using S-Poly(T), a specific oligo(dT) reverse transcription primer with excellent sensitivity and specificity
    • Kang, K. et al. A novel real-time PCR assay of microRNAs using S-Poly(T), a specific oligo(dT) reverse transcription primer with excellent sensitivity and specificity. PLoS One 7, e48536 (2012).
    • (2012) PLoS One , vol.7 , pp. e48536
    • Kang, K.1
  • 54
    • 84944224284 scopus 로고    scopus 로고
    • An improved method for detecting circulating microRNAs with S-Poly(T) Plus real-time PCR
    • Niu, Y et al. An improved method for detecting circulating microRNAs with S-Poly(T) Plus real-time PCR. Sci Rep 5, 15100 (2015).
    • (2015) Sci Rep , vol.5 , pp. 15100
    • Niu, Y.1
  • 55
    • 84867716694 scopus 로고    scopus 로고
    • MIR-210 has an antiapoptotic effect in pulmonary artery smooth muscle cells during hypoxia
    • Gou, D. et al. miR-210 has an antiapoptotic effect in pulmonary artery smooth muscle cells during hypoxia. Am J Physiol Lung Cell Mol Physiol 303, 1682-91 (2012).
    • (2012) Am J Physiol Lung Cell Mol Physiol , vol.303 , pp. 1682-1691
    • Gou, D.1
  • 56
    • 1642525097 scopus 로고    scopus 로고
    • Functional analysis of the role of hypoxia-inducible factor 1 in the pathogenesis of hypoxic pulmonary hypertension
    • Shimoda, L. A. & Semenza, G. L. Functional analysis of the role of hypoxia-inducible factor 1 in the pathogenesis of hypoxic pulmonary hypertension. Methods Enzymol 381, 121-9 (2004).
    • (2004) Methods Enzymol , vol.381 , pp. 121-129
    • Shimoda, L.A.1    Semenza, G.L.2


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