NEAT1 is required for survival of breast cancer cells through FUS and miR-548

Gene Regulation and Systems Biology

Volumn 10, Issue , 2016, Pages 11-17

  Ke, Hao ^a,b   Zhao, Limin ^a,b   Feng, Xu ^a,c   Xu, Haibo ^a,b   Zou, Li ^a,b   Yang, Qin ^a,b   Su, Xiaosan ^d   Peng, Lingtao ^e   Jiao, Baowei ^a,b  

^a KUNMING INSTITUTE OF ZOOLOGY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c KUNMING UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^d First Hospital of Kunming   (China)

^e UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Cell apoptosis; FUS; LncRNA; MiR 548ar 3p; NEAT1

Indexed keywords

FUSED IN SARCOMA PROTEIN; LONG UNTRANSLATED RNA; MICRORNA; MICRORNA 548; NUCLEAR PARASPECKLE ASSEMBLY TRANSCRIPT 1; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BIOINFORMATICS; BREAST CANCER CELL LINE; CANCER INHIBITION; CELL SURVIVAL; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; GENE EXPRESSION; GENE OVEREXPRESSION; GENE SILENCING; GENETIC REGULATION; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; PROTEIN RNA BINDING;

EID: 84964899697     PISSN: None     EISSN: 11776250     Source Type: Journal    
DOI: 10.4137/GRSB.S29414     Document Type: Article

References (37)

1. Wright MW, Bruford EA. Naming ‘junk’: human non-protein coding RNA (ncRNA) gene nomenclature. Hum Genomics. 2011;5(2):90–8.
2. DeOcesano-Pereira C, Amaral MS, Parreira KS, et al. Long non-coding RNA INXS is a critical mediator of BCL-XS induced apoptosis. Nucleic Acids Res. 2014;42(13):8343–55.
3. Yang G, Lu X, Yuan L. LncRNA: a link between RNA and cancer. Biochim Biophys Acta. 2014;1839(11):1097–109.
4. Richards EJ, Zhang G, Li Z-P, et al. Long non-coding RNAs regulated by TGFβ: lncRNA-HIT mediated TGFβ-induced epithelial to mesenchymal transition in mammary epithelia. J Biol Chem. 2015;290(11):6857–67.
5. Derrien T, Johnson R, Bussotti G, et al. The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expres­sion. Genome Res. 2012;22(9):1775–89.
6. Kallen AN, Zhou X-B, Xu J, et al. The imprinted H19 lncRNA antagonizes let-7 microRNAs. Mol Cell. 2013;52(1):101–12.
7. Zhao J, Sun BK, Erwin JA, Song J-J, Lee JT. Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome. Science. 2008;322(5902):750–6.
8. Nakagawa S, Shimada M, Yanaka K, et al. The lncRNA Neat1 is required for corpus luteum formation and the establishment of pregnancy in a subpopulation of mice. Development. 2014;141(23):4618–27.
9. Gremlich S, Damnon F, Reymondin D, et al. The long non-coding RNA NEAT1 is increased in IUGR placentas, leading to potential new hypotheses of IUGR origin/development. Placenta. 2014;35(1):44–9.
10. Standaert L, Adriaens C, Radaelli E, et al. The long noncoding RNA Neat1 is required for mammary gland development and lactation. RNA. 2014;20(12):1844–9.
11. Imamura K, Imamachi N, Akizuki G, et al. Long noncoding RNA NEAT1-dependent SFPQ relocation from promoter region to paraspeckle mediates IL8 expression upon immune stimuli. Mol Cell. 2014;53(3):393–406.
12. Zeng C, Xu Y, Xu L, et al. Inhibition of long non-coding RNA NEAT1 impairs myeloid differentiation in acute promyelocytic leukemia cells. BMC Cancer. 2014;14(1):693.
13. Chakravarty D, Sboner A, Nair SS, et al. The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer. Nat Commun. 2014;5:5383.
14. Cooper DR, Carter G, Li P, Patel R, Watson JE, Patel NA. Long non-coding RNA NEAT1 associates with SRp40 to temporally regulate PPARγ2 splicing during adi­pogenesis in 3T3-L1 Cells. Genes. 2014;5(4):1050–63.
15. Hirose T, Virnicchi G, Tanigawa A, et al. NEAT1 long noncoding RNA regulates transcription via protein sequestration within subnuclear bodies. Mol Biol Cell. 2014;25(1):169–83.
16. Hu B, Ying X, Wang J, et al. Identification of a tumor-suppressive human-spe­cific microRNA within the FHIT tumor-suppressor gene. Cancer Res. 2014;74(8):2283–94.
17. Zhang Q, Chen C-Y, Yedavalli VS, Jeang K-T. NEAT1 long noncoding RNA and paraspeckle bodies modulate HIV-1 posttranscriptional expression. MBio. 2013;4(1):e596–12.
18. Choudhry H, Albukhari A, Morotti M, et al. Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival. Oncogene. 2014;34(34):4546.
19. Kwiatkowski TJ Jr, Bosco DA, Leclerc AL, et al. Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis. Science. 2009;323(5918):1205–8.
20. Lagier-Tourenne C, Polymenidou M, Cleveland DW. TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration. Hum Mol Genet. 2010;19(R1):R46–64.
21. Nishimoto Y, Nakagawa S, Hirose T, et al. The long non-coding RNA nuclear-enriched abundant transcript 1_2 induces paraspeckle formation in the motor neu­ron during the early phase of amyotrophic lateral sclerosis. Mol Brain. 2013;6:31.
22. Neumann M, Sampathu DM, Kwong LK, et al. Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science. 2006;314(5796):130–3.
23. Polymenidou M, Lagier-Tourenne C, Hutt KR, et al. Long pre-mRNA deple­tion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43. Nat Neurosci. 2011;14(4):459–68.
24. Sephton CF, Cenik B, Cenik BK, Herz J, Yu G. TDP-43 in central nervous sys­tem development and function: clues to TDP-43-associated neurodegeneration. Biol Chem. 2012;393(7):589–94.
25. Parker SJ, Meyerowitz J, James JL, et al. Endogenous TDP-43 localized to stress granules can subsequently form protein aggregates. Neurochem Int. 2012;60(4):415–24.
26. Lagier-Tourenne C, Polymenidou M, Hutt KR, et al. Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs. Nat Neurosci. 2012;15(11):1488–97.
27. Kruger J, Rehmsmeier M. RNAhybrid: microRNA target prediction easy, fast and flexible. Nucleic Acids Res. 2006;34:W451–4. doi: (2006).10.1093.
28. Ricci EP, Kucukural A, Cenik C, et al. Staufen1 senses overall transcript sec­ondary structure to regulate translation. Nat Struct Mol Biol. 2014;21(1):26–35.
29. Tollervey JR, Curk T, Rogelj B, et al. Characterizing the RNA targets and posi­tion-dependent splicing regulation by TDP-43. Nat Neurosci. 2011;14(4):452–8.
30. Jackson TC, Du L, Janesko-Feldman K, et al. The nuclear splicing factor RNA binding motif 5 promotes caspase activation in human neuronal cells, and increases after traumatic brain injury in mice. J Cereb Blood Flow Metab. 2015;35(4):655–66.
31. Vo DT, Abdelmohsen K, Martindale JL, et al. The oncogenic RNA-binding protein Musashi1 is regulated by HuR via mRNA translation and stability in glioblastoma cells. Mol Cancer Res. 2012;10(1):143–55.
32. Scoumanne A, Cho SJ, Zhang J, Chen X. The cyclin-dependent kinase inhibitor p21 is regulated by RNA-binding protein PCBP4 via mRNA stability. Nucleic Acids Res. 2011;39(1):213–24.
33. Wang F, Yuan JH, Wang SB, et al. Oncofetal long noncoding RNA PVT1 pro­motes proliferation and stem cell-like property of hepatocellular carcinoma cells by stabilizing NOP2. Hepatology. 2014;60(4):1278–90.
34. Johnson SM, Grosshans H, Shingara J, et al. RAS is regulated by the let-7 microRNA family. Cell. 2005;120(5):635–47.
35. Cimmino A, Calin GA, Fabbri M, et al. miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci U S A. 2005;102(39):13944–49.
36. Kong W, He L, Coppola M, et al. MicroRNA-155 regulates cell survival, growth, and chemosensitivity by targeting FOXO3a in breast cancer. J Biol Chem. 2010;285(23):17869–79.
37. Yang CH, Pfeffer SR, Sims M, et al. The oncogenic microRNA-21 inhibits the tumor suppressive activity of FBXO11 to promote tumorigenesis. J Biol Chem. 2015;290(10):6037–46.