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Volumn 29, Issue 4, 2016, Pages 534-544

In Vitro Developmental Toxicology Screens: A Report on the Progress of the Methodology and Future Applications

Author keywords

[No Author keywords available]

Indexed keywords

DEVELOPMENTAL TOXICITY; EMBRYO CULTURE; EMBRYONIC STEM CELL; EVALUATION STUDY; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; REVIEW; RISK ASSESSMENT; TERATOGENICITY; TOXICOLOGY; ZEBRA FISH; ANIMAL; ANIMAL TESTING ALTERNATIVE; CELL CULTURE TECHNIQUE; DRUG DEVELOPMENT; DRUG EFFECTS; HUMAN; MAMMALIAN EMBRYO; PROCEDURES; TOXICITY TESTING;

EID: 84964683216     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/acs.chemrestox.5b00458     Document Type: Review
Times cited : (25)

References (77)
  • 1
    • 69349104947 scopus 로고    scopus 로고
    • Chemical regulators have overreached
    • Hartung, T. and Rovida, C. (2009) Chemical regulators have overreached Nature 460, 1080-1081 10.1038/4601080a
    • (2009) Nature , vol.460 , pp. 1080-1081
    • Hartung, T.1    Rovida, C.2
  • 2
    • 73949132615 scopus 로고    scopus 로고
    • Re-evaluation of animal numbers and costs for in vivo tests to accomplish REACH legislation requirements for chemicals - A report by the transatlantic think tank for toxicology (t(4))
    • Rovida, C. and Hartung, T. (2009) Re-evaluation of animal numbers and costs for in vivo tests to accomplish REACH legislation requirements for chemicals-a report by the transatlantic think tank for toxicology (t(4)) ALTEX: Alternatives to Animal Experimentation 26, 187-208
    • (2009) ALTEX: Alternatives to Animal Experimentation , vol.26 , pp. 187-208
    • Rovida, C.1    Hartung, T.2
  • 3
    • 77749330006 scopus 로고    scopus 로고
    • FRAME, animal experimentation and the Three Rs: Past, present and future
    • Balls, M. (2009) FRAME, animal experimentation and the Three Rs: past, present and future ATLA, Altern. Lab. Anim. 37, 1-6
    • (2009) ATLA, Altern. Lab. Anim. , vol.37 , pp. 1-6
    • Balls, M.1
  • 6
    • 39349118236 scopus 로고    scopus 로고
    • Toxicology. Transforming environmental health protection
    • Collins, F. S., Gray, G. M., and Bucher, J. R. (2008) Toxicology. Transforming environmental health protection Science 319, 906-907 10.1126/science.1154619
    • (2008) Science , vol.319 , pp. 906-907
    • Collins, F.S.1    Gray, G.M.2    Bucher, J.R.3
  • 7
    • 33845620001 scopus 로고    scopus 로고
    • The ToxCast program for prioritizing toxicity testing of environmental chemicals
    • Dix, D. J., Houck, K. A., Martin, M. T., Richard, A. M., Setzer, R. W., and Kavlock, R. J. (2006) The ToxCast program for prioritizing toxicity testing of environmental chemicals Toxicol. Sci. 95, 5-12 10.1093/toxsci/kfl103
    • (2006) Toxicol. Sci. , vol.95 , pp. 5-12
    • Dix, D.J.1    Houck, K.A.2    Martin, M.T.3    Richard, A.M.4    Setzer, R.W.5    Kavlock, R.J.6
  • 8
    • 37449031428 scopus 로고    scopus 로고
    • Toxicity testing in the 21st century: A vision and a strategy
    • Gibb, S. (2008) Toxicity testing in the 21st century: a vision and a strategy Reprod. Toxicol. 25, 136-138 10.1016/j.reprotox.2007.10.013
    • (2008) Reprod. Toxicol. , vol.25 , pp. 136-138
    • Gibb, S.1
  • 10
    • 77953521553 scopus 로고    scopus 로고
    • In vitro developmental toxicology assays: A review of the state of the science of rodent and zebrafish whole embryo culture and embryonic stem cell assays
    • Augustine-Rauch, K., Zhang, C. X., and Panzica-Kelly, J. M. (2010) In vitro developmental toxicology assays: A review of the state of the science of rodent and zebrafish whole embryo culture and embryonic stem cell assays Birth Defects Res., Part C 90, 87-98 10.1002/bdrc.20175
    • (2010) Birth Defects Res., Part C , vol.90 , pp. 87-98
    • Augustine-Rauch, K.1    Zhang, C.X.2    Panzica-Kelly, J.M.3
  • 11
    • 0017928819 scopus 로고
    • Whole-embryo culture and the study of mammalian embryos during organogenesis
    • New, D. A. (1978) Whole-embryo culture and the study of mammalian embryos during organogenesis Biol. Rev. Cambridge Philos. Soc. 53, 81-122 10.1111/j.1469-185X.1978.tb00993.x
    • (1978) Biol. Rev. Cambridge Philos. Soc. , vol.53 , pp. 81-122
    • New, D.A.1
  • 12
    • 0020359203 scopus 로고
    • Whole embryo culture: A screening technique for teratogens?
    • Sadler, T. W., Horton, W. E., and Warner, C. W. (1982) Whole embryo culture: a screening technique for teratogens? Teratog., Carcinog., Mutagen. 2, 243-253 10.1002/1520-6866(1990)2:3/4<243::AID-TCM1770020306>3.0.CO;2-U
    • (1982) Teratog., Carcinog., Mutagen. , vol.2 , pp. 243-253
    • Sadler, T.W.1    Horton, W.E.2    Warner, C.W.3
  • 13
    • 77955871792 scopus 로고    scopus 로고
    • The etiology of cleft palate: A 50-year search for mechanistic and molecular understanding
    • Abbott, B. D. (2010) The etiology of cleft palate: a 50-year search for mechanistic and molecular understanding Birth Defects Res., Part B 89, 266-274 10.1002/bdrb.20252
    • (2010) Birth Defects Res., Part B , vol.89 , pp. 266-274
    • Abbott, B.D.1
  • 15
    • 77955873327 scopus 로고    scopus 로고
    • Whole embryo culture: A ″new″ technique that enabled decades of mechanistic discoveries
    • Ellis-Hutchings, R. G. and Carney, E. W. (2010) Whole embryo culture: a ″New″ technique that enabled decades of mechanistic discoveries Birth Defects Res., Part B 89, 304-312 10.1002/bdrb.20263
    • (2010) Birth Defects Res., Part B , vol.89 , pp. 304-312
    • Ellis-Hutchings, R.G.1    Carney, E.W.2
  • 16
    • 0019806298 scopus 로고
    • Quantitation of rat embryonic development in vitro: A morphological scoring system
    • Brown, N. A. and Fabro, S. (1981) Quantitation of rat embryonic development in vitro: a morphological scoring system Teratology 24, 65-78 10.1002/tera.1420240108
    • (1981) Teratology , vol.24 , pp. 65-78
    • Brown, N.A.1    Fabro, S.2
  • 17
    • 0036098620 scopus 로고    scopus 로고
    • The ECVAM international validation study on in vitro embryotoxicity tests: Results of the definitive phase and evaluation of prediction models. European Centre for the Validation of Alternative Methods
    • Genschow, E., Spielmann, H., Scholz, G., Seiler, A., Brown, N., Piersma, A., Brady, M., Clemann, N., Huuskonen, H., Paillard, F., Bremer, S., and Becker, K. (2002) The ECVAM international validation study on in vitro embryotoxicity tests: results of the definitive phase and evaluation of prediction models. European Centre for the Validation of Alternative Methods ATLA, Altern. Lab. Anim. 30, 151-176
    • (2002) ATLA, Altern. Lab. Anim. , vol.30 , pp. 151-176
    • Genschow, E.1    Spielmann, H.2    Scholz, G.3    Seiler, A.4    Brown, N.5    Piersma, A.6    Brady, M.7    Clemann, N.8    Huuskonen, H.9    Paillard, F.10    Bremer, S.11    Becker, K.12
  • 19
    • 79953841352 scopus 로고    scopus 로고
    • Not a walk in the park: The ECVAM whole embryo culture model challenged with pharmaceuticals and attempted improvements with random forest design
    • Thomson, J., Johnson, K., Chapin, R., Stedman, D., Kumpf, S., and Ozolins, T. R. (2011) Not a walk in the park: The ECVAM whole embryo culture model challenged with pharmaceuticals and attempted improvements with random forest design Birth Defects Res., Part B 92, 111-121 10.1002/bdrb.20289
    • (2011) Birth Defects Res., Part B , vol.92 , pp. 111-121
    • Thomson, J.1    Johnson, K.2    Chapin, R.3    Stedman, D.4    Kumpf, S.5    Ozolins, T.R.6
  • 20
    • 84861477230 scopus 로고    scopus 로고
    • Development of a streamlined rat whole embryo culture assay for classifying teratogenic potential of pharmaceutical compounds
    • Zhang, C., Cao, J., Kenyon, J. R., Panzica-Kelly, J. M., Gong, L., and Augustine-Rauch, K. (2012) Development of a streamlined rat whole embryo culture assay for classifying teratogenic potential of pharmaceutical compounds Toxicol. Sci. 127, 535-546 10.1093/toxsci/kfs112
    • (2012) Toxicol. Sci. , vol.127 , pp. 535-546
    • Zhang, C.1    Cao, J.2    Kenyon, J.R.3    Panzica-Kelly, J.M.4    Gong, L.5    Augustine-Rauch, K.6
  • 21
    • 0019452034 scopus 로고
    • Production of clones of homozygous diploid zebra fish (Brachydanio rerio)
    • Streisinger, G., Walker, C., Dower, N., Knauber, D., and Singer, F. (1981) Production of clones of homozygous diploid zebra fish (Brachydanio rerio) Nature 291, 293-296 10.1038/291293a0
    • (1981) Nature , vol.291 , pp. 293-296
    • Streisinger, G.1    Walker, C.2    Dower, N.3    Knauber, D.4    Singer, F.5
  • 22
    • 0023967616 scopus 로고
    • Cell lineage and developmental potential of cells in the zebrafish embryo
    • Kimmel, C. B. and Warga, R. M. (1988) Cell lineage and developmental potential of cells in the zebrafish embryo Trends Genet. 4, 68-74 10.1016/0168-9525(88)90043-1
    • (1988) Trends Genet. , vol.4 , pp. 68-74
    • Kimmel, C.B.1    Warga, R.M.2
  • 23
    • 84928801798 scopus 로고    scopus 로고
    • Zebrafish: A New Companion for Translational Research in Oncology
    • Barriuso, J., Nagaraju, R., and Hurlstone, A. (2015) Zebrafish: A New Companion for Translational Research in Oncology Clin. Cancer Res. 21, 969-975 10.1158/1078-0432.CCR-14-2921
    • (2015) Clin. Cancer Res. , vol.21 , pp. 969-975
    • Barriuso, J.1    Nagaraju, R.2    Hurlstone, A.3
  • 25
    • 84857506740 scopus 로고    scopus 로고
    • Ototoxin-induced cellular damage in neuromasts disrupts lateral line function in larval zebrafish
    • Buck, L. M., Winter, M. J., Redfern, W. S., and Whitfield, T. T. (2012) Ototoxin-induced cellular damage in neuromasts disrupts lateral line function in larval zebrafish Hear. Res. 284, 67-81 10.1016/j.heares.2011.12.001
    • (2012) Hear. Res. , vol.284 , pp. 67-81
    • Buck, L.M.1    Winter, M.J.2    Redfern, W.S.3    Whitfield, T.T.4
  • 26
    • 33644934734 scopus 로고    scopus 로고
    • The zebrafish (Danio rerio): A model system for cranial suture patterning
    • Quarto, N. and Longaker, M. T. (2005) The zebrafish (Danio rerio): a model system for cranial suture patterning Cells Tissues Organs 181, 109-118 10.1159/000091100
    • (2005) Cells Tissues Organs , vol.181 , pp. 109-118
    • Quarto, N.1    Longaker, M.T.2
  • 29
    • 84922858402 scopus 로고    scopus 로고
    • Transgenic fish systems and their application in ecotoxicology
    • Lee, O., Green, J. M., and Tyler, C. R. (2015) Transgenic fish systems and their application in ecotoxicology Crit. Rev. Toxicol. 45, 124-141 10.3109/10408444.2014.965805
    • (2015) Crit. Rev. Toxicol. , vol.45 , pp. 124-141
    • Lee, O.1    Green, J.M.2    Tyler, C.R.3
  • 30
    • 84894231554 scopus 로고    scopus 로고
    • Zebrafish models for assessing developmental and reproductive toxicity
    • He, J. H., Gao, J. M., Huang, C. J., and Li, C. Q. (2014) Zebrafish models for assessing developmental and reproductive toxicity Neurotoxicol. Teratol. 42, 35-42 10.1016/j.ntt.2014.01.006
    • (2014) Neurotoxicol. Teratol. , vol.42 , pp. 35-42
    • He, J.H.1    Gao, J.M.2    Huang, C.J.3    Li, C.Q.4
  • 35
    • 84936749186 scopus 로고    scopus 로고
    • Optimization and Performance Assessment of the Chorion-Off [Dechorinated] Zebrafish Developmental Toxicity Assay
    • Panzica-Kelly, J. M., Zhang, C. X., and Augustine-Rauch, K. A. (2015) Optimization and Performance Assessment of the Chorion-Off [Dechorinated] Zebrafish Developmental Toxicity Assay Toxicol. Sci. 146, 127-134 10.1093/toxsci/kfv076
    • (2015) Toxicol. Sci. , vol.146 , pp. 127-134
    • Panzica-Kelly, J.M.1    Zhang, C.X.2    Augustine-Rauch, K.A.3
  • 36
    • 84901300483 scopus 로고    scopus 로고
    • Improvement of the evaluation method for teratogenicity using zebrafish embryos
    • Yamashita, A., Inada, H., Chihara, K., Yamada, T., Deguchi, J., and Funabashi, H. (2014) Improvement of the evaluation method for teratogenicity using zebrafish embryos J. Toxicol. Sci. 39, 453-464 10.2131/jts.39.453
    • (2014) J. Toxicol. Sci. , vol.39 , pp. 453-464
    • Yamashita, A.1    Inada, H.2    Chihara, K.3    Yamada, T.4    Deguchi, J.5    Funabashi, H.6
  • 39
    • 45549090693 scopus 로고    scopus 로고
    • Development of a new screening assay to identify proteratogenic substances using zebrafish danio rerio embryo combined with an exogenous mammalian metabolic activation system (mDarT)
    • Busquet, F., Nagel, R., von Landenberg, F., Mueller, S. O., Huebler, N., and Broschard, T. H. (2008) Development of a new screening assay to identify proteratogenic substances using zebrafish danio rerio embryo combined with an exogenous mammalian metabolic activation system (mDarT) Toxicol. Sci. 104, 177-188 10.1093/toxsci/kfn065
    • (2008) Toxicol. Sci. , vol.104 , pp. 177-188
    • Busquet, F.1    Nagel, R.2    Von Landenberg, F.3    Mueller, S.O.4    Huebler, N.5    Broschard, T.H.6
  • 40
    • 8744223170 scopus 로고    scopus 로고
    • Validation of the embryonic stem cell test in the international ECVAM validation study on three in vitro embryotoxicity tests
    • Genschow, E., Spielmann, H., Scholz, G., Pohl, I., Seiler, A., Clemann, N., Bremer, S., and Becker, K. (2004) Validation of the embryonic stem cell test in the international ECVAM validation study on three in vitro embryotoxicity tests ATLA, Altern. Lab. Anim. 32, 209-244
    • (2004) ATLA, Altern. Lab. Anim. , vol.32 , pp. 209-244
    • Genschow, E.1    Spielmann, H.2    Scholz, G.3    Pohl, I.4    Seiler, A.5    Clemann, N.6    Bremer, S.7    Becker, K.8
  • 42
    • 24644513538 scopus 로고    scopus 로고
    • Predicting the risk of developmental toxicity from in vitro assays
    • Spielmann, H. (2005) Predicting the risk of developmental toxicity from in vitro assays Toxicol. Appl. Pharmacol. 207, 375-380 10.1016/j.taap.2005.01.049
    • (2005) Toxicol. Appl. Pharmacol. , vol.207 , pp. 375-380
    • Spielmann, H.1
  • 43
    • 0030917962 scopus 로고    scopus 로고
    • The embryonic stem cell test (EST), an in vitro embryotoxicity test using two permanent mouse cell lines: 3T3 fibroblasts and embryonic stem cells
    • Spielmann, H., Pohl, I., Doring, B., Liebsch, M., and Moldenhauer, F. (1997) The embryonic stem cell test (EST), an in vitro embryotoxicity test using two permanent mouse cell lines: 3T3 fibroblasts and embryonic stem cells In Vitro Toxicol. 10, 119-127
    • (1997) Vitro Toxicol. , vol.10 , pp. 119-127
    • Spielmann, H.1    Pohl, I.2    Doring, B.3    Liebsch, M.4    Moldenhauer, F.5
  • 45
    • 0032856081 scopus 로고    scopus 로고
    • The Relative Semi-quantification of mRNA Expression as a Useful Toxicological Endpoint for the Identification of Embryotoxic/Teratogenic Substances
    • Bigot, K., de Lange, J., Archer, G., Clothier, R., and Bremer, S. (1999) The Relative Semi-quantification of mRNA Expression as a Useful Toxicological Endpoint for the Identification of Embryotoxic/Teratogenic Substances Toxicol. In Vitro 13, 619-623 10.1016/S0887-2333(99)00027-2
    • (1999) Toxicol. in Vitro , vol.13 , pp. 619-623
    • Bigot, K.1    De Lange, J.2    Archer, G.3    Clothier, R.4    Bremer, S.5
  • 46
    • 64349114023 scopus 로고    scopus 로고
    • Embryonic stem cell test remastered: Comparison between the validated EST and the new molecular FACS-EST for assessing developmental toxicity in vitro
    • Buesen, R., Genschow, E., Slawik, B., Visan, A., Spielmann, H., Luch, A., and Seiler, A. (2009) Embryonic stem cell test remastered: comparison between the validated EST and the new molecular FACS-EST for assessing developmental toxicity in vitro Toxicol. Sci. 108, 389-400 10.1093/toxsci/kfp012
    • (2009) Toxicol. Sci. , vol.108 , pp. 389-400
    • Buesen, R.1    Genschow, E.2    Slawik, B.3    Visan, A.4    Spielmann, H.5    Luch, A.6    Seiler, A.7
  • 47
    • 80053476385 scopus 로고    scopus 로고
    • Shortening and Improving the Embryonic Stem Cell Test through the Use of Gene Biomarkers of Differentiation
    • Romero, A. C., Vilanova, E., and Sogorb, M. A. (2011) Shortening and Improving the Embryonic Stem Cell Test through the Use of Gene Biomarkers of Differentiation J. Toxicol. 2011, 286034 10.1155/2011/286034
    • (2011) J. Toxicol. , vol.2011
    • Romero, A.C.1    Vilanova, E.2    Sogorb, M.A.3
  • 48
    • 1542618024 scopus 로고    scopus 로고
    • Improvement of an in vitro stem cell assay for developmental toxicity: The use of molecular endpoints in the embryonic stem cell test
    • Seiler, A., Visan, A., Buesen, R., Genschow, E., and Spielmann, H. (2004) Improvement of an in vitro stem cell assay for developmental toxicity: the use of molecular endpoints in the embryonic stem cell test Reprod. Toxicol. 18, 231-240 10.1016/j.reprotox.2003.10.015
    • (2004) Reprod. Toxicol. , vol.18 , pp. 231-240
    • Seiler, A.1    Visan, A.2    Buesen, R.3    Genschow, E.4    Spielmann, H.5
  • 49
    • 0036043939 scopus 로고    scopus 로고
    • Improving the embryonic stem cell test (EST) by establishing molecular endpoints of tissue specific development using murine embryonic stem cells (D3 cells)
    • Seiler, A., Visan, A., Pohl, I., Genschow, E., Buesen, R., and Spielmann, H. (2002) [Improving the embryonic stem cell test (EST) by establishing molecular endpoints of tissue specific development using murine embryonic stem cells (D3 cells)] ALTEX: Alternatives to Animal Experimentation 19, 55-63
    • (2002) ALTEX: Alternatives to Animal Experimentation , vol.19 , pp. 55-63
    • Seiler, A.1    Visan, A.2    Pohl, I.3    Genschow, E.4    Buesen, R.5    Spielmann, H.6
  • 51
    • 77954364273 scopus 로고    scopus 로고
    • Monitoring developmental toxicity in the embryonic stem cell test using differential gene expression of differentiation-related genes
    • van Dartel, D. A., Pennings, J. L., de la Fonteyne, L. J., van Herwijnen, M. H., van Delft, J. H., van Schooten, F. J., and Piersma, A. H. (2010) Monitoring developmental toxicity in the embryonic stem cell test using differential gene expression of differentiation-related genes Toxicol. Sci. 116, 130-139 10.1093/toxsci/kfq127
    • (2010) Toxicol. Sci. , vol.116 , pp. 130-139
    • Van Dartel, D.A.1    Pennings, J.L.2    De La Fonteyne, L.J.3    Van Herwijnen, M.H.4    Van Delft, J.H.5    Van Schooten, F.J.6    Piersma, A.H.7
  • 52
    • 62549124073 scopus 로고    scopus 로고
    • Early gene expression changes during embryonic stem cell differentiation into cardiomyocytes and their modulation by monobutyl phthalate
    • van Dartel, D. A., Pennings, J. L., Hendriksen, P. J., van Schooten, F. J., and Piersma, A. H. (2009) Early gene expression changes during embryonic stem cell differentiation into cardiomyocytes and their modulation by monobutyl phthalate Reprod. Toxicol. 27, 93-102 10.1016/j.reprotox.2008.12.009
    • (2009) Reprod. Toxicol. , vol.27 , pp. 93-102
    • Van Dartel, D.A.1    Pennings, J.L.2    Hendriksen, P.J.3    Van Schooten, F.J.4    Piersma, A.H.5
  • 53
    • 77049106803 scopus 로고    scopus 로고
    • Transcriptomics-based identification of developmental toxicants through their interference with cardiomyocyte differentiation of embryonic stem cells
    • van Dartel, D. A., Pennings, J. L., van Schooten, F. J., and Piersma, A. H. (2010) Transcriptomics-based identification of developmental toxicants through their interference with cardiomyocyte differentiation of embryonic stem cells Toxicol. Appl. Pharmacol. 243, 420-428 10.1016/j.taap.2009.12.021
    • (2010) Toxicol. Appl. Pharmacol. , vol.243 , pp. 420-428
    • Van Dartel, D.A.1    Pennings, J.L.2    Van Schooten, F.J.3    Piersma, A.H.4
  • 54
    • 0842264755 scopus 로고    scopus 로고
    • Molecular multiple endpoint embryonic stem cell test - A possible approach to test for the teratogenic potential of compounds
    • zur Nieden, N. I., Kempka, G., and Ahr, H. J. (2004) Molecular multiple endpoint embryonic stem cell test - a possible approach to test for the teratogenic potential of compounds Toxicol. Appl. Pharmacol. 194, 257-269 10.1016/j.taap.2003.09.019
    • (2004) Toxicol. Appl. Pharmacol. , vol.194 , pp. 257-269
    • Zur Nieden, N.I.1    Kempka, G.2    Ahr, H.J.3
  • 58
  • 59
    • 11144223157 scopus 로고    scopus 로고
    • Conserved and divergent paths that regulate self-renewal in mouse and human embryonic stem cells
    • Rao, M. (2004) Conserved and divergent paths that regulate self-renewal in mouse and human embryonic stem cells Dev. Biol. 275, 269-286 10.1016/j.ydbio.2004.08.013
    • (2004) Dev. Biol. , vol.275 , pp. 269-286
    • Rao, M.1
  • 60
    • 0141993704 scopus 로고    scopus 로고
    • A gene-coexpression network for global discovery of conserved genetic modules
    • Stuart, J. M., Segal, E., Koller, D., and Kim, S. K. (2003) A gene-coexpression network for global discovery of conserved genetic modules Science 302, 249-255 10.1126/science.1087447
    • (2003) Science , vol.302 , pp. 249-255
    • Stuart, J.M.1    Segal, E.2    Koller, D.3    Kim, S.K.4
  • 61
    • 33845212541 scopus 로고    scopus 로고
    • Cross-species transcriptional profiles establish a functional portrait of embryonic stem cells
    • Sun, Y., Li, H., Liu, Y., Shin, S., Mattson, M. P., Rao, M. S., and Zhan, M. (2007) Cross-species transcriptional profiles establish a functional portrait of embryonic stem cells Genomics 89, 22-35 10.1016/j.ygeno.2006.09.010
    • (2007) Genomics , vol.89 , pp. 22-35
    • Sun, Y.1    Li, H.2    Liu, Y.3    Shin, S.4    Mattson, M.P.5    Rao, M.S.6    Zhan, M.7
  • 62
    • 34547116839 scopus 로고    scopus 로고
    • Defining embryonic stem cell identity using differentiation-related microRNAs and their potential targets
    • Chen, C., Ridzon, D., Lee, C. T., Blake, J., Sun, Y., and Strauss, W. M. (2007) Defining embryonic stem cell identity using differentiation-related microRNAs and their potential targets Mamm. Genome 18, 316-327 10.1007/s00335-007-9032-6
    • (2007) Mamm. Genome , vol.18 , pp. 316-327
    • Chen, C.1    Ridzon, D.2    Lee, C.T.3    Blake, J.4    Sun, Y.5    Strauss, W.M.6
  • 64
    • 84905113858 scopus 로고    scopus 로고
    • ESNATS conference - The use of human embryonic stem cells for novel toxicity testing approaches
    • Rovida, C., Vivier, M., Garthoff, B., and Hescheler, J. (2014) ESNATS conference-the use of human embryonic stem cells for novel toxicity testing approaches ATLA, Altern. Lab. Anim. 42, 97-113
    • (2014) ATLA, Altern. Lab. Anim. , vol.42 , pp. 97-113
    • Rovida, C.1    Vivier, M.2    Garthoff, B.3    Hescheler, J.4
  • 65
    • 37249044261 scopus 로고    scopus 로고
    • First steps in establishing a developmental toxicity test method based on human embryonic stem cells
    • Adler, S., Pellizzer, C., Hareng, L., Hartung, T., and Bremer, S. (2008) First steps in establishing a developmental toxicity test method based on human embryonic stem cells Toxicol. In Vitro 22, 200-211 10.1016/j.tiv.2007.07.013
    • (2008) Toxicol. in Vitro , vol.22 , pp. 200-211
    • Adler, S.1    Pellizzer, C.2    Hareng, L.3    Hartung, T.4    Bremer, S.5
  • 66
    • 84893731185 scopus 로고    scopus 로고
    • Assessment of Developmental Toxicants using Human Embryonic Stem Cells
    • Hong, E. J. and Jeung, E. B. (2013) Assessment of Developmental Toxicants using Human Embryonic Stem Cells Toxicol. Res. 29, 221-227 10.5487/TR.2013.29.4.221
    • (2013) Toxicol. Res. , vol.29 , pp. 221-227
    • Hong, E.J.1    Jeung, E.B.2
  • 67
  • 70
    • 77956260872 scopus 로고    scopus 로고
    • Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells
    • Guenther, M. G., Frampton, G. M., Soldner, F., Hockemeyer, D., Mitalipova, M., Jaenisch, R., and Young, R. A. (2010) Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells Cell Stem Cell 7, 249-257 10.1016/j.stem.2010.06.015
    • (2010) Cell Stem Cell , vol.7 , pp. 249-257
    • Guenther, M.G.1    Frampton, G.M.2    Soldner, F.3    Hockemeyer, D.4    Mitalipova, M.5    Jaenisch, R.6    Young, R.A.7
  • 71
    • 70349445082 scopus 로고    scopus 로고
    • Transcriptional signature and memory retention of human-induced pluripotent stem cells
    • Marchetto, M. C., Yeo, G. W., Kainohana, O., Marsala, M., Gage, F. H., and Muotri, A. R. (2009) Transcriptional signature and memory retention of human-induced pluripotent stem cells PLoS One 4, e7076 10.1371/journal.pone.0007076
    • (2009) PLoS One , vol.4
    • Marchetto, M.C.1    Yeo, G.W.2    Kainohana, O.3    Marsala, M.4    Gage, F.H.5    Muotri, A.R.6
  • 73
    • 79952201403 scopus 로고    scopus 로고
    • That which must not, can not be. A reply to the EChA and EDF responses to the REACH analysis of animal use and costs
    • Hartung, T. and Rovida, C. (2009) That which must not, can not be... A reply to the EChA and EDF responses to the REACH analysis of animal use and costs ALTEX: Alternatives to Animal Experimentation 26, 307-311
    • (2009) ALTEX: Alternatives to Animal Experimentation , vol.26 , pp. 307-311
    • Hartung, T.1    Rovida, C.2
  • 74
    • 84907176470 scopus 로고    scopus 로고
    • An integrated approach for detecting embryotoxicity and developmental toxicity of environmental contaminants using in vitro alternative methods
    • Sogorb, M. A., Pamies, D., de Lapuente, J., Estevan, C., Estevez, J., and Vilanova, E. (2014) An integrated approach for detecting embryotoxicity and developmental toxicity of environmental contaminants using in vitro alternative methods Toxicol. Lett. 230, 356-367 10.1016/j.toxlet.2014.01.037
    • (2014) Toxicol. Lett. , vol.230 , pp. 356-367
    • Sogorb, M.A.1    Pamies, D.2    De Lapuente, J.3    Estevan, C.4    Estevez, J.5    Vilanova, E.6
  • 75
    • 84959168037 scopus 로고    scopus 로고
    • A developmental toxicology platform for screening teratogenic liability of pharmaceutical compounds
    • Augustine-Rauch, K., Zhang, C. X., and Panzica-Kelly, J. M. (2016) A developmental toxicology platform for screening teratogenic liability of pharmaceutical compounds Birth Defects Res., Part B 1-17 10.1002/bdrb.21168
    • (2016) Birth Defects Res., Part B , pp. 1-17
    • Augustine-Rauch, K.1    Zhang, C.X.2    Panzica-Kelly, J.M.3
  • 76
    • 84964597857 scopus 로고    scopus 로고
    • ICH Safety Guideline, International Conference on Harmonisation, Geneva, Switzerland
    • (2005) Detection of Toxicity to Reproduction for Medical Products & Toxicity to Male Fertility S5(R2), ICH Safety Guideline, International Conference on Harmonisation, Geneva, Switzerland. http://www.ich.org/products/guidelines/safety/safety-single/article/detection-of-toxicity-to-reproduction-for-medicinal-products-toxicity-to-male-fertility.html.
    • (2005) Detection of Toxicity to Reproduction for Medical Products & Toxicity to Male Fertility S5(R2)
  • 77
    • 78650200526 scopus 로고    scopus 로고
    • A dysmorphology score system for assessing embryo abnormalities in rat whole embryo culture
    • Zhang, C. X., Danberry, T., Jacobs, M. A., and Augustine-Rauch, K. (2010) A dysmorphology score system for assessing embryo abnormalities in rat whole embryo culture Birth Defects Res., Part B 89, 485-492 10.1002/bdrb.20262
    • (2010) Birth Defects Res., Part B , vol.89 , pp. 485-492
    • Zhang, C.X.1    Danberry, T.2    Jacobs, M.A.3    Augustine-Rauch, K.4


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