Establishment of a molecular embryonic stem cell developmental toxicity assay

Toxicological Sciences

Volumn 131, Issue 2, 2013, Pages 447-457

  Panzica Kelly, Julieta M ^a   Brannen, Kimberly C ^a,b   Ma, Yan ^a   Zhang, Cindy X ^a   Flint, Oliver P ^a   Lehman McKeeman, Lois D ^a   Augustine Rauch, Karen A ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b CHARLES RIVER LABORATORIES   (United States)

Author keywords

Developmental toxicity screen; Embryonic stem cell test; Embryotoxicity screen; High throughput; In vitro teratogenicity; Molecular endpoints

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; ACEBUTOLOL; ACRYLAMIDE; ASCORBIC ACID; CAMPHOR; CD34 ANTIGEN; CEFOTAXIME; CHEMOKINE RECEPTOR CXCR4; CLOZAPINE; DIPHENHYDRAMINE; DOXYLAMINE; FENFLURAMINE; FIBROBLAST GROWTH FACTOR 5; FIBROBLAST GROWTH FACTOR 8; FLUMAZENIL; FLUOXETINE; FOLINIC ACID; GLIBENCLAMIDE; HEPATOCYTE NUCLEAR FACTOR 3BETA; HYDROCHLOROTHIAZIDE; ISONIAZID; LORATADINE; METFORMIN; PHTHALIC ACID DIMETHYL ESTER; TERATOGENIC AGENT; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR LHX1; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX17; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ADHESION; CELL ASSAY; CELL DIFFERENTIATION; CELL GROWTH; CELL MATURATION; CONTROLLED STUDY; CYTOTOXICITY; DECISION TREE; EMBRYO; EMBRYO DEVELOPMENT; EMBRYOID BODY; EMBRYONIC STEM CELL; GENE CONTROL; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE TARGETING; IC 50; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; PREDICTIVE VALUE; STATISTICAL SIGNIFICANCE; TERATOGEN TESTING; TERATOGENICITY; TRANSCRIPTION REGULATION;

ANIMALS; CELL DIFFERENTIATION; CELL LINE; DNA, COMPLEMENTARY; EMBRYONIC STEM CELLS; INHIBITORY CONCENTRATION 50; MICE; MODELS, THEORETICAL; POLYMERASE CHAIN REACTION; TERATOGENS;

EID: 84873830846     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfs293     Document Type: Article

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