A Developmental Toxicology Assay Platform for Screening Teratogenic Liability of Pharmaceutical Compounds

Birth Defects Research Part B - Developmental and Reproductive Toxicology

Volumn 107, Issue 1, 2016, Pages 4-20

  Augustine Rauch, Karen ^a   Zhang, Cindy X ^a   Panzica Kelly, Julieta M ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Developmental toxicology assays; In vitro; Prediction models; Teratogenic classification; Tiered screens

Indexed keywords

4 AMINOBUTYRIC ACID; 4,4' ISOPROPYLIDENEDIPHENOL; ACEBUTOLOL; ACRYLAMIDE; ANTIFUNGAL AGENT; ASCORBIC ACID; CAMPHOR; CEFOTAXIME; CHEMICAL AGENT; CLOZAPINE; DIPHENHYDRAMINE; DOXYLAMINE; FENFLURAMINE; FLUMAZENIL; FLUOXETINE; FOLINIC ACID; GLIBENCLAMIDE; HYDROCHLOROTHIAZIDE; ISONIAZID; LORATADINE; METFORMIN; METOCLOPRAMIDE; MIRTAZAPINE; NORTRIPTYLINE; OLANZAPINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PHTHALIC ACID DIMETHYL ESTER; SEROTONIN 1A RECEPTOR; TERATOGENIC AGENT; UNINDEXED DRUG; 4 AMINOBUTYRIC ACID RECEPTOR; DRUG; HISTAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOASSAY; CLASSIFICATION; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; EMBRYO; EMBRYO CULTURE; EMBRYONIC STEM CELL; FREQUENCY ANALYSIS; IN VITRO STUDY; MOLECULAR EMBRYONIC STEM CELL ASSAY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SAFETY; SCREENING; SOLUBILITY; TERATOGENICITY; TOXICOLOGY; WHOLE EMBRYO CULTURE ASSAY; ZEBRA FISH; ZEBRAFISH EMBRYO CULTURE ASSAY; ANIMAL; DRUG EFFECTS; EMBRYOLOGY; METABOLISM; MOUSE EMBRYONIC STEM CELL; PRECLINICAL STUDY; PROCEDURES; TOXICITY TESTING;

ANIMALS; DRUG EVALUATION, PRECLINICAL; HISTAMINE; MICE; MOUSE EMBRYONIC STEM CELLS; PHARMACEUTICAL PREPARATIONS; RECEPTORS, GABA; TERATOGENS; TOXICITY TESTS; ZEBRAFISH;

EID: 84959168037     PISSN: 15429733     EISSN: 15429741     Source Type: Journal    
DOI: 10.1002/bdrb.21168     Document Type: Article

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