Female human pluripotent stem cells rapidly lose X chromosome inactivation marks and progress to a skewed methylation pattern during culture

Molecular Human Reproduction

Volumn 22, Issue 4, 2016, Pages 285-298

  Geens, M ^a   Seriola, A ^a,b,c   Barbe L ^a   Santalo, J ^b   Veiga, A ^c   Dee K ^a   Van Haute, L ^a,d   Sermon, K ^a   Spits, C ^a  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c CENTER OF REGENERATIVE MEDICINE IN BARCELONA   (Spain)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Differentiation; Histone marks; Human pluripotent stem cells; Long term culture; Skewed methylation; X chromosome inactivation; XIST

Indexed keywords

HISTONE H3; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; X INACTIVE SPECIFIC TRANSCRIPT; BIOLOGICAL MARKER; HISTONE; LONG UNTRANSLATED RNA; XIST NON-CODING RNA;

ALLELE; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CHROMOSOME ABERRATION; CONTROLLED STUDY; DNA METHYLATION; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; INHERITANCE; MALE; MOUSE; NONHUMAN; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; STEM CELL CULTURE; X CHROMOSOME; X CHROMOSOME INACTIVATION; CELL LINE; CYTOLOGY; DNA SEQUENCE; GENETIC EPIGENESIS; GENETICS; METABOLISM; PRIMARY CELL CULTURE;

BIOMARKERS; CELL DIFFERENTIATION; CELL LINE; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; HISTONES; HUMANS; INHERITANCE PATTERNS; MALE; PLURIPOTENT STEM CELLS; PRIMARY CELL CULTURE; RNA, LONG NONCODING; SEQUENCE ANALYSIS, DNA; X CHROMOSOME INACTIVATION;

EID: 84964600747     PISSN: 13609947     EISSN: 14602407     Source Type: Journal    
DOI: 10.1093/molehr/gaw004     Document Type: Article

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