Human pluripotent stem cells with distinct X inactivation status show molecular and cellular differences controlled by the X-Linked ELK-1 gene

Cell Reports

Volumn 4, Issue 2, 2013, Pages 262-270

  Bruck, Tal ^a   Yanuka, Ofra ^a   Benvenisty, Nissim ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

OXYGEN; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR ELK 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; AUTOSOME; CELL CULTURE; CELL DIFFERENTIATION; CELL GROWTH; CELL HETEROGENEITY; CELL HYPOXIA; CELL TYPE; CONTROLLED STUDY; ELK 1 GENE; EMBRYO; EPIGENETICS; FEMALE; GENE EXPRESSION; GENE FUNCTION; GENE SILENCING; GENETIC REGULATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPIC VARIATION; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; X CHROMOSOME INACTIVATION; XAXA CELL; XAXI CELL;

ANIMALS; APOPTOSIS; CELL DIFFERENTIATION; DOWN-REGULATION; ETS-DOMAIN PROTEIN ELK-1; FEMALE; GENOMICS; HUMANS; IMMUNOHISTOCHEMISTRY; MICE, INBRED NOD; MICE, SCID; MICROARRAY ANALYSIS; PLURIPOTENT STEM CELLS; POLYMORPHISM, SINGLE NUCLEOTIDE; TRANSCRIPTOME; TRANSFECTION; X CHROMOSOME INACTIVATION;

EID: 84880794883     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2013.06.026     Document Type: Article

References (27)

1. Amps K., Andrews P.W., Anyfantis G., Armstrong L., Avery S., Baharvand H., Baker J., Baker D., Munoz M.B., Beil S., et al. Screening ethnically diverse human embryonic stem cells identifies a chromosome 20minimal amplicon conferring growth advantage. Nat. Biotechnol. 2011, 29:1132-1144. International Stem Cell Initiative.
2. Anguera M.C., Sadreyev R., Zhang Z., Szanto A., Payer B., Sheridan S.D., Kwok S., Haggarty S.J., Sur M., Alvarez J., et al. Molecular signatures of human induced pluripotent stem cells highlight sex differences and cancer genes. Cell Stem Cell 2012, 11:75-90.
3. Barrett L.E., Van Bockstaele E.J., Sul J.Y., Takano H., Haydon P.G., Eberwine J.H. Elk-1 associates with the mitochondrial permeability transition pore complex in neurons. Proc. Natl. Acad. Sci. USA 2006, 103:5155-5160.
4. Bode A.M., Dong Z. The functional contrariety of JNK. Mol. Carcinog. 2007, 46:591-598.
5. Boros J., Donaldson I.J., O'Donnell A., Odrowaz Z.A., Zeef L., Lupien M., Meyer C.A., Liu X.S., Brown M., Sharrocks A.D. Elucidation of the ELK1 target gene network reveals a role in the coordinate regulation of core components of the gene regulation machinery. Genome Res. 2009, 19:1963-1973.
6. Bruck T., Benvenisty N. Meta-analysis of the heterogeneity of Xchromosome inactivation in human pluripotent stem cells. Stem Cell Res. (Amst.) 2011, 6:187-193.
7. Dvash T., Lavon N., Fan G. Variations of X chromosome inactivation occur in early passages of female human embryonic stem cells. PLoS ONE 2010, 5:e11330.
8. Fan G., Tran J. X chromosome inactivation in human and mouse pluripotent stem cells. Hum. Genet. 2011, 130:217-222.
9. Greer Card D.A., Sierant M.L., Davey S. Rad9A is required for G2 decatenation checkpoint and to prevent endoreduplication in response to topoisomerase II inhibition. J.Biol. Chem. 2010, 285:15653-15661.
10. Hanna J., Cheng A.W., Saha K., Kim J., Lengner C.J., Soldner F., Cassady J.P., Muffat J., Carey B.W., Jaenisch R. Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs. Proc. Natl. Acad. Sci. USA 2010, 107:9222-9227.
11. Huang W., Sherman B.T., Tan Q., Kir J., Liu D., Bryant D., Guo Y., Stephens R., Baseler M.W., Lane H.C., Lempicki R.A. DAVID Bioinformatics Resources: expanded annotation database and novel algorithms to better extract biology from large gene lists. Nucleic Acids Res. 2007, 35(Web Server issue):W169-W175.
12. Leeb M., Wutz A. Mechanistic concepts in X inactivation underlying dosage compensation in mammals. Heredity (Edinb.) 2010, 105:64-70.
13. Lengner C.J., Gimelbrant A.A., Erwin J.A., Cheng A.W., Guenther M.G., Welstead G.G., Alagappan R., Frampton G.M., Xu P., Muffat J., et al. Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations. Cell 2010, 141:872-883.
14. Lyon M.F. Sex chromatin and gene action in the mammalian X-chromosome. Am. J. Hum. Genet. 1962, 14:135-148.
15. Maherali N., Sridharan R., Xie W., Utikal J., Eminli S., Arnold K., Stadtfeld M., Yachechko R., Tchieu J., Jaenisch R., et al. Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. Cell Stem Cell 2007, 1:55-70.
16. Mekhoubad S., Bock C., de Boer A.S., Kiskinis E., Meissner A., Eggan K. Erosion of dosage compensation impacts human iPSC disease modeling. Cell Stem Cell 2012, 10:595-609.
17. Navarro P., Chambers I., Karwacki-Neisius V., Chureau C., Morey C., Rougeulle C., Avner P. Molecular coupling of Xist regulation and pluripotency. Science 2008, 321:1693-1695.
18. Nazor K.L., Altun G., Lynch C., Tran H., Harness J.V., Slavin I., Garitaonandia I., Müller F.J., Wang Y.C., Boscolo F.S., et al. Recurrent variations in DNA methylation in human pluripotent stem cells and their differentiated derivatives. Cell Stem Cell 2012, 10:620-634.
19. Rieger A.M., Nelson K.L., Konowalchuk J.D., Barreda D.R. Modified annexin V/propidium iodide apoptosis assay for accurate assessment of cell death. J.Vis. Exp. 2011, Published online April 24, 2011. 10.3791/2597.
20. Sabapathy K., Wagner E.F. JNK2: a negative regulator of cellular proliferation. Cell Cycle 2004, 3:1520-1523.
21. Shao N., Chai Y., Cui J.Q., Wang N., Aysola K., Reddy E.S., Rao V.N. Induction of apoptosis by Elk-1 and deltaElk-1 proteins. Oncogene 1998, 17:527-532.
22. Sharrocks A.D. Complexities in ETS-domain transcription factor function and regulation: lessons from the TCF (ternary complex factor) subfamily. The Colworth Medal Lecture. Biochem. Soc. Trans. 2002, 30:1-9.
23. Silva S.S., Rowntree R.K., Mekhoubad S., Lee J.T. X-chromosome inactivation and epigenetic fluidity in human embryonic stem cells. Proc. Natl. Acad. Sci. USA 2008, 105:4820-4825.
24. Tchieu J., Kuoy E., Chin M.H., Trinh H., Patterson M., Sherman S.P., Aimiuwu O., Lindgren A., Hakimian S., Zack J.A., et al. Female human iPSCs retain an inactive X chromosome. Cell Stem Cell 2010, 7:329-342.
25. Tomoda K., Takahashi K., Leung K., Okada A., Narita M., Yamada N.A., Eilertson K.E., Tsang P., Baba S., White M.P., et al. Derivation conditions impact X-inactivation status in female human induced pluripotent stem cells. Cell Stem Cell 2012, 11:91-99.
26. Ulitsky I., Maron-Katz A., Shavit S., Sagir D., Linhart C., Elkon R., Tanay A., Sharan R., Shiloh Y., Shamir R. Expander: from expression microarrays to networks and functions. Nat. Protoc. 2010, 5:303-322.
27. Xu P., Davis R.J. c-Jun NH2-terminal kinase is required for lineage-specific differentiation but not stem cell self-renewal. Mol. Cell. Biol. 2010, 30:1329-1340.