Deoxyelephantopin impairs growth of cervical carcinoma SiHa cells and induces apoptosis by targeting multiple molecular signaling pathways

Cell Biology and Toxicology

Volumn 30, Issue 6, 2014, Pages 331-343

  Farha, Arakkaveettil Kabeer ^a   Dhanya, Sethumadhavannair Rajalekshmi ^b   Mangalam, Sivasankaran Nair ^b   Geetha, Balakrishnan Sreedevi ^c   Latha, Panickamparambil Gopalakrishnan ^c   Remani, Prathapan ^a  

^a REGIONAL CANCER CENTRE   (India)

^b REGIONAL RESEARCH LABORATORY CSIR   (India)

^c Jawaharlal Nehru Tropical Botanic Garden and Research Institute   (India)

Author keywords

Apoptosis; Deoxyelephantopin; Elephantopus scaber; ROS generation; SiHa cells

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE INHIBITOR 1A; DEOXYELEPHANTOPIN; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; PLANT EXTRACT; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE B; PROTEIN P21; PROTEIN P53; REACTIVE OXYGEN METABOLITE; STAT3 PROTEIN; UNCLASSIFIED DRUG; BAX PROTEIN, HUMAN; BCL2 PROTEIN, HUMAN; BCL2L1 PROTEIN, HUMAN; CASPASE; CCNB1 PROTEIN, HUMAN; CDK1 PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE; LACTONE; PROTEIN BCL X; SESQUITERPENE; STAT3 PROTEIN, HUMAN;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL PROLIFERATION; CERVICAL CANCER CELL LINE; CERVICAL CARCINOMA SIHA CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELEPHANTOPUS SCABER; G2 PHASE CELL CYCLE CHECKPOINT; M PHASE CELL CYCLE CHECKPOINT; MITOCHONDRIAL MEMBRANE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UTERINE CERVIX CARCINOMA; AGONISTS; ANTAGONISTS AND INHIBITORS; ASTERACEAE; CHEMISTRY; DRUG EFFECTS; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; PATHOLOGY; TUMOR CELL LINE; UTERINE CERVIX;

ELEPHANTOPUS SCABER;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; ASTERACEAE; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; CASPASES; CELL LINE, TUMOR; CELL PROLIFERATION; CERVIX UTERI; CYCLIN B1; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASES; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; G2 PHASE CELL CYCLE CHECKPOINTS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LACTONES; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; SESQUITERPENES; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84912088450     PISSN: 07422091     EISSN: 15736822     Source Type: Journal    
DOI: 10.1007/s10565-014-9288-z     Document Type: Article

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