Antiproliferative activities of five Chinese medicinal herbs and active compounds in Elephantopus scaber

Natural Product Communications

Volumn 4, Issue 8, 2009, Pages 1025-1030

  Su, Miaoxian ^a   Wu, Xia ^b   Chung, Hau Yin ^a   Li, Yaolan ^b,c   Ye, Wencai ^b,c  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b JINAN UNIVERSITY   (China)

^c Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drug Research   (China)

Author keywords

Antiproliferation; Apoptosis; Chinese medicinal herbs; Deoxyelephantopin; Elephantopus scaber

Indexed keywords

ACETIC ACID ETHYL ESTER; ANTIMITOTIC AGENT; BETULIC ACID; DEOXYELEPHATOPIN; EPIFRIEDELANOL; HERBACEOUS AGENT; ISODEOXYELEPHATOPIN; LUPEOL; LUPEOL ACETATE; LUTEOLIN; PHENOL; SCABERTOPIN; TERPENE; TRICIN; UNCLASSIFIED DRUG; URSOLIC ACID; SESQUITERPENE;

ARTICLE; CANCER CELL CULTURE; CHEMICAL COMPOSITION; CHINESE HERB; CONTROLLED STUDY; ELEPHANTOPUS SCABER; EXTRACTION; FLOW CYTOMETRY; FRACTIONATION; HUMAN; HUMAN CELL; ISOLATION AND PURIFICATION; NASOPHARYNX CARCINOMA; NITROBLUE TETRAZOLIUM TEST; NONHUMAN; PROMYELOCYTIC LEUKEMIA; PROSTATE CARCINOMA; THIN LAYER CHROMATOGRAPHY; ASTERACEAE; BREAST TUMOR; CELL DIVISION; CELL LINE; CELL STRAIN HL 60; CHEMISTRY; CHINESE MEDICINE; DRUG EFFECT; FEMALE; FIBROBLAST; MEDICINAL PLANT; METHODOLOGY; SKIN; TUMOR CELL LINE;

ELEPHANTOPUS SCABER;

ASTERACEAE; BREAST NEOPLASMS; CELL DIVISION; CELL LINE; CELL LINE, TUMOR; CHROMATOGRAPHY, THIN LAYER; FEMALE; FIBROBLASTS; FLOW CYTOMETRY; HL-60 CELLS; HUMANS; MEDICINE, CHINESE TRADITIONAL; PLANTS, MEDICINAL; SESQUITERPENES; SKIN;

EID: 73949153090     PISSN: 1934578X     EISSN: 15559475     Source Type: Journal    
DOI: 10.1177/1934578x0900400802     Document Type: Article

References (18)

1. Balunas MJ, Kinghorn AD. (2005) Drug discovery from medicinal plants. Life Sciences, 78, 431-441.
2. Lee KH. (2004) Current developments in the discovery and design of new drug candidates from plant natural product leads. Journal of Natural Products, 67, 273-283.
3. Cheng JH, Li YB. (1998) Anti-tumor Herbal Medicines and Their Proved Recipes. Jiangxi Science Technology Press, Beijing, China, 732.
4. Zhang YH. (2000) A Collection of Anticancer Chinese Medicines. Jiangsu Science Technology Press, Nanjing, China, 17, 44, 184, and 435.
5. Bo QM, Wu ZY, Shun QS, Bao XS, Mao ZS, Ha SQ, Lu SY, Huang JM. (2002) A Selection of the Illustrated Chinese Anti-cancer Herbal Medicine. Shanghai Science and Technology Literature Press, Shanghai, China, 10.
6. Anonymous. Edited by Jiangsu New Medicine College. (1986) Dictionary of Traditional Chinese Medicine. Shanghai Science and Technology Press, Shanghai, China, 168, 780, 1086 and 1231.
7. Liang Q, Shi G. (2003) Structure elucidation of sesquiterpenoids from Elephantopus scaber using the NOESY technique. Chinese Journal of Magnetic Resonance, 20, 289-295. (Pubitemid 37291823)
8. But PPH, Hon PM, Cao H, Chan TWD, Wu BM, Mak TCW, Che CT. (1997) Sesquiterpene lactones from Elephantopus scaber. Phytochemistry, 44, 113-116.
9. Guo F, Liang Q, Min Z. (2002) Study on flavonoids of Elephantopus scaber. Zhongcaoyao, 33, 303-304.
10. Liang Q, Gong Z, Min Z. (2007) Studies on triterpenes from Elephantopus scaber. Chinese Pharmaceutical Journal, 42, 494-496.
11. Xu G, Liang Q, Gong Z, Yu W, He S, Xi L. (2006) Antitumor activities of the four sesquiterpene lactones from Elephantopus scaber L. Experimental Oncology, 28, 106-109. (Pubitemid 44140260)
12. Zou G, Gao Z, Wang J, Zhang Y, Ding H, Huang J, Chen L, Guo Y, Jiang H, Shen X. (2008) Deoxyelephantopin inhibits cancer cell proliferation and functions as a selective partial agonist against PPARγ. Biochemical Pharmacology, 75, 1381-1392.
13. Fulda S. (2009) Tumor resistance to apoptosis. International Journal of Cancer, 124, 511-515.
14. Hanahan D, Weinberg RA. (2000) The hallmarks of cancer. Cell, 100, 57-70.
15. Fulda S, Debatin KM. (2004) Apoptosis signaling in tumor therapy. Annals of the New York Academy of Sciences, 1028, 150-156.
16. Ichikawa H, Nair MS, Takada Y, Sheeja DBA, Kumar MAS, Oommen OV, Aggarwal BB. (2006) Isodeoxyelephantopin, a novel sesquiterpene lactone, potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis through suppression of nuclear factor-κB (NF-κB) activation and NF-κB-regulated gene expression. Clinical Cancer Research, 12, 5910-5918.
17. Satyajit DS, Zahid L, Alexander IG. (2006) Natural Products Isolation. Humana Press, Totowa, New Jersey, 88-89.
18. Mosmann T. (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. Journal of Immunological Methods, 65, 55-63.