CXCL1/MGSA Is a novel glycosaminoglycan (GAG)-binding chemokine: Structural evidence for two distinct non-overlapping binding domains

Journal of Biological Chemistry

Volumn 291, Issue 8, 2016, Pages 4247-4255

  Sepuru, Krishna Mohan ^a   Rajarathnam, Krishna ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BINS; CHEMICAL ACTIVATION; DIMERS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POLYPEPTIDES;

CANCER PROGRESSION; CONCENTRATION GRADIENTS; GLYCOSAMINOGLYCANS; MICROBIAL KILLING; RECEPTOR ACTIVATION; RECEPTOR BINDING; STRUCTURAL EVIDENCE; SULFATED GLYCOSAMINOGLYCANS;

BINDING SITES;

ARGININE; CXCL1 CHEMOKINE; DIMER; GLYCOSAMINOGLYCAN; HEPARIN OLIGOSACCHARIDE; INTERLEUKIN 8; LIGAND; LYSINE; MONOMER; OLIGOSACCHARIDE; UNCLASSIFIED DRUG; CXCL1 PROTEIN, HUMAN; GLUCOSAMINOGLYCANS; IL8 PROTEIN, HUMAN; PROTEIN BINDING;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL MIGRATION; MOLECULAR DOCKING; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTON NUCLEAR MAGNETIC RESONANCE; RECEPTOR BINDING; STRUCTURE ANALYSIS; CHEMISTRY; GENETICS; HUMAN; METABOLISM; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE; PROTEIN TERTIARY STRUCTURE;

CHEMOKINE CXCL1; GLYCOSAMINOGLYCANS; HUMANS; INTERLEUKIN-8; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY;

EID: 84964515173     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.697888     Document Type: Article

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