Multiple glycosaminoglycan-binding epitopes of monocyte chemoattractant protein-3/CCL7 enable it to function as a non-oligomerizing chemokine

Journal of Biological Chemistry

Volumn 289, Issue 21, 2014, Pages 14896-14912

  Salanga, Catherina L ^a   Dyer, Douglas P ^a   Kiselar, Janna G ^b   Gupta, Sayan ^b,c   Chance, Mark R ^b,c   Handel, Tracy M ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b Center for Proteomics and Bioinformatics   (United States)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BODY FLUIDS; CELL MEMBRANES; EPITOPES; OLIGOMERIZATION; PEPTIDES; SURFACE PLASMON RESONANCE;

CHEMOATTRACTANTS; DIRECTIONAL SIGNALS; GLYCOSAMINOGLYCANS; HEPARAN SULFATES; HIGH AFFINITY BINDING; HYDROXYL RADICAL FOOTPRINTING; LARGE CLUSTERS; STRUCTURAL BASIS;

OLIGOMERS;

GLYCOSAMINOGLYCAN; MONOCYTE CHEMOTACTIC PROTEIN 3;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; BIOTINYLATION; CELL SURFACE; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; MOLECULAR RECOGNITION; NONHUMAN; OLIGOMERIZATION; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CROSS LINKING; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN MOTIF; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; SURFACE PLASMON RESONANCE; TANDEM MASS SPECTROMETRY;

CCL2; CCL7; CHEMOKINES; GLYCOSAMINOGLYCAN; HYDROXY RADICAL FOOTPRINTING; MASS SPECTROMETRY (MS); STRUCTURAL BIOLOGY; SURFACE PLASMON RESONANCE (SPR);

AMINO ACID SEQUENCE; BINDING SITES; CELL LINE; CHEMOKINE CCL2; CHEMOKINE CCL7; ELECTROPHORESIS, POLYACRYLAMIDE GEL; EPITOPES; GLYCOSAMINOGLYCANS; HUMANS; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SURFACE PLASMON RESONANCE;

EID: 84901450371     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.547737     Document Type: Article

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