Dynamic conformational switching in the chemokine ligand is essential for G-protein-coupled receptor activation

Biochemical Journal

Volumn 456, Issue 2, 2013, Pages 241-251

  Joseph, Prem Raj B ^a   Sawant, Kirti V ^a   Isley, Angela ^b   Pedroza, Mesias ^a   Garofalo, Roberto P ^a   Richardson, Ricardo M ^b   Rajarathnam, Krishna ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b NORTH CAROLINA CENTRAL UNIVERSITY   (United States)

Author keywords

Chemokine; Conformational ensemble; G proteincoupled receptor; Long range coupling; Signalling

Indexed keywords

CHEMOKINE; G PROTEIN COUPLED RECEPTOR; GLYCINE; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE; PROLINE; RADIOLIGAND;

ARTICLE; CALCIUM MOBILIZATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; FEMALE; GENE SWITCHING; LOSS OF FUNCTION MUTATION; MOLECULAR CLONING; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ORGANOGENESIS; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; RECEPTOR AFFINITY; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; SIMULATION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; CALCIUM SIGNALING; CELL LINE; CONSERVED SEQUENCE; FEMALE; INTERLEUKIN-8; LIGANDS; MICE; MICE, INBRED BALB C; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; NEUTROPHILS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTORS, INTERLEUKIN-8A; RECEPTORS, INTERLEUKIN-8B;

EID: 84887415994     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20130148     Document Type: Article

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