Solution NMR characterization of chemokine CXCL8/IL-8 monomer and dimer binding to glycosaminoglycans: Structural plasticity mediates differential binding interactions

Biochemical Journal

Volumn 472, Issue 1, 2015, Pages 121-133

  Joseph, Prem Raj B ^a,b   Mosier, Philip D ^b   Desai, Umesh R ^b   Rajarathnam, Krishna ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Chemokine; Glycosaminoglycan (GAG); Heparin; Nuclear magnetic resonance (NMR); Structural plasticity; Structure function study

Indexed keywords

DIMER; GLUCOSAMINE; GLYCOSAMINOGLYCAN; HEPARIN; INTERLEUKIN 8; MONOMER; OLIGOSACCHARIDE; IL8 PROTEIN, HUMAN; PROTEIN BINDING; SOLUTION AND SOLUBILITY;

ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; MOLECULAR DOCKING; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STRUCTURE; WILD TYPE; AMINO ACID SEQUENCE; CHEMISTRY; GENETICS; HUMAN; KINETICS; METABOLISM; MOLECULAR DYNAMICS; MOLECULAR GENETICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROCEDURES; PROTEIN MULTIMERIZATION; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; SOLUTION AND SOLUBILITY;

AMINO ACID SEQUENCE; BINDING SITES; GLYCOSAMINOGLYCANS; HEPARIN; HUMANS; INTERLEUKIN-8; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR DOCKING SIMULATION; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; OLIGOSACCHARIDES; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SOLUTIONS;

EID: 84945917798     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20150059     Document Type: Article

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