Effects of Polyoxyethylene Alkyl Ethers on the Intestinal Transport and Absorption of Rhodamine 123: A P-glycoprotein Substrate by in Vitro and in Vivo Studies

Journal of Pharmaceutical Sciences

Volumn 105, Issue 4, 2016, Pages 1526-1534

  Zhao, Wanting ^a   Uehera, Sachiyo ^a   Tanaka, Keiichiro ^a   Tadokoro, Shuhei ^a   Kusamori, Kosuke ^a   Katsumi, Hidemasa ^a   Sakane, Toshiyasu ^a   Yamamoto, Akira ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

intestinal absorption; P glycoprotein; pharmaceutical excipient; polyoxyethylene alkyl ether; rhodamine 123

Indexed keywords

6 CARBOXYFLUORESCEIN; BL 9EX; BRIJ 72; BRIJ 92; BRIJ 97; CETOMACROGOL; LACTATE DEHYDROGENASE; MULTIDRUG RESISTANCE PROTEIN; POLYOXYETHYLENE ALKYL ETHER; POLYOXYETHYLENE OLEYL ETHER; POLYOXYETHYLENE STEARYL ETHER; RHODAMINE 110; RHODAMINE 123; UNCLASSIFIED DRUG; MACROGOL DERIVATIVE; SANONIC SS-90; SURFACTANT;

ANALYTIC METHOD; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CACO 2 CELL LINE; CONTROLLED STUDY; DIFFUSION CHAMBER; DRUG BLOOD LEVEL; ENZYME ACTIVITY; IN SITU LOOP METHOD; IN VITRO STUDY; IN VIVO STUDY; INTESTINE ABSORPTION; INTESTINE INJURY; MALE; NONHUMAN; PROTEIN SECRETION; RAT; ANIMAL; CACO-2 CELL LINE; DRUG EFFECTS; HUMAN; METABOLISM; WISTAR RAT;

ANIMALS; CACO-2 CELLS; HUMANS; INTESTINAL ABSORPTION; MALE; P-GLYCOPROTEINS; POLYETHYLENE GLYCOLS; RATS, WISTAR; RHODAMINE 123; SURFACE-ACTIVE AGENTS;

EID: 84964469215     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1016/j.xphs.2016.01.020     Document Type: Article

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