A kinetic study of Rhodamine123 pumping by P-glycoprotein

Biochimica et Biophysica Acta - Biomembranes

Volumn 1758, Issue 10, 2006, Pages 1671-1676

  Wang, Yulin ^a   Hao, DaCheng ^a   Stein, Wilfred D ^b   Yang, Ling ^a  

^a DALIAN INSTITUTE OF CHEMICAL PHYSICS   (China)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Fluorescence; Kinetics; Pglycoprotein; Quenching; Resistance; Rhodamine 123

Indexed keywords

GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN 1; RHODAMINE 123; VERAPAMIL;

ARTICLE; CANCER CELL CULTURE; CELL STRAIN K 562; CONTROLLED STUDY; HUMAN; HUMAN CELL; KINETICS; LEUKEMIA CELL LINE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION;

ALGORITHMS; HUMANS; K562 CELLS; KINETICS; P-GLYCOPROTEIN; RHODAMINE 123; VERAPAMIL;

EID: 33749080965     PISSN: 00052736     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamem.2006.06.004     Document Type: Article

References (17)

1. Lin J.H., and Yamazaki M. Role of P-glycoprotein in pharmacokinetics: clinical implications. Clin. Pharmacokinet. 42 (2003) 59-98
2. Loo T.W., Bartlett C.M., and Clarke D.M. Drug binding in human P-glycoprotein causes conformational changes in both nucleotide-binding domains. J. Biol. Chem. 278 (2003) 1575-1578
3. Lee J.-Y., Urbatsch I.L., Senior A.E., and Wilkens S. Projection structure of P-glycoprotein by electron microscopy. J. Biol. Chem. 277 (2002) 40125-40131
4. Dayan G., Baubichon-Cortay H., Jault J.M., Cortay J.C., Deleage G., and Di Pietro A. Recombinant N-terminal nucleotide-binding domain from mouse P-glycoprotein. J. Biol. Chem. 271 (1996) 11652-11658
5. Tamai I., and Safa A.R. Azidopine noncompetitively interacts with vinblastine and cyclosporin A binding to P-glycoprotein in multidrug resistant cells. J. Biol. Chem. 266 (1991) 16796-16800
6. Polli J.W., Wring S.A., Humphreys J.E., Huang L., Morgan J.B., Webster L.O., and Serabjit-Singh C.S. Rational use of in vitro P-glycoprotein assays in drug discovery. J. Pharmacol. Exp. Ther. 299 (2001) 620-628
7. Loetchutinat C., Saengkhae C., Matbuef-Gueye C., and Garnier-Suillerot A. New insights into the P-glycoprotein-mediated effluxes of rhodamines. Eur. J. Biochem. 270 (2003) 476-485
8. Xiao H., Li X., Zou H., Yang L., Yang Y., Wang Y., Wang H., and Le X.C. Immunoassay of P-glycoprotein on single cell by capillary electrophoresis with laser induced fluorescence detection. Anal. Chim. Acta 556 (2006) 340-346
9. Hamilton K.O., Yazdanian M.A., and Audus K.L. Modulation of P-glycoprotein activity in Calu-3 cells using steroids and β-ligands. Int. J. Pharm. 228 (2001) 171-179
10. Loo T.W., Bartlett M.C., and Clarke D.M. Methanethiosulfonate derivatives of rhodamine and verapamil activate human P-glycoprotein at different sites. J. Biol. Chem. 278 (2003) 50136-50141
11. Bruggemann E.P., Currier S.J., Gottesman M.M., and Pastan I. Characterization of the azidopine and vinblastine binding site of P-glycoprotein. J. Biol. Chem. 267 (1992) 21020-21026
12. Loo T.W., Bartlett M.C., and Clarke D.M. Substrate-induced conformational changes in the transmembrane segments of human P-glycoprotein. J. Biol. Chem. 278 (2003) 13603-13606
13. Loo T.W., Bartlett M.C., and Clarke D.M. Simultaneous binding of two different drugs in the binding pocket of the human multidrug resistance P-glycoprotein. J. Biol. Chem. 278 (2003) 39706-39710
14. Urbatsch I.L., Tyndall G.A., Tombline G., and Senior A.E. P-glycoprotein catalytic mechanism: studies of the ADP-vanadate inhibited state. J. Biol. Chem. 278 (2003) 23171-23179
15. Shapiro A.B., and Ling V. Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificities. Eur. J. Biochem. 250 (1997) 130-137
16. Loo T.W., and Clarke D.M. Identification of residues within the drug-binding domain of the human multidrug resistance P-glycoprotein by cysteine-scanning mutagenesis and reaction with dibromobimane. J. Biol. Chem. 275 (2000) 39272-39278
17. Loo T.W., and Clarke D.M. Location of the rhodamine-binding site in the human multidrug resistance P-glycoprotein. J. Biol. Chem. 277 (2002) 44332-44338