Insulin signaling misregulation underlies circadian and cognitive deficits in a Drosophila fragile X model

Molecular Psychiatry

Volumn 22, Issue 8, 2017, Pages 1140-1148

  Monyak, R E ^a   Emerson, D ^a   Schoenfeld, B P ^a,b   Zheng, X ^a   Chambers, D B ^c   Rosenfelt, C ^c   Langer, S ^c   Hinchey, P ^b   Choi, C H ^b,c   McDonald, T V ^b   Bolduc, F V ^c   Sehgal, A ^a   McBride, S M J ^a   Jongens, T A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN LIKE PEPTIDE 2; METFORMIN; PEPTIDE HORMONE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; UNCLASSIFIED DRUG; DROSOPHILA PROTEIN; FMR1 PROTEIN, DROSOPHILA; FRAGILE X MENTAL RETARDATION PROTEIN; INSULIN;

ADULT; AMNESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; DFMR1 GENE; DROSOPHILA; DRUG EFFICACY; ENZYME ACTIVITY; FRAGILE X SYNDROME; GENE; GENE EXPRESSION; LEARNING; LOCOMOTION; LONG TERM MEMORY; MALE; MIDDLE AGED; NERVE CELL PLASTICITY; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SHORT TERM MEMORY; SIGNAL TRANSDUCTION; ANIMAL; BRAIN; COGNITION; COGNITIVE DEFECT; DISEASE MODEL; DROSOPHILA MELANOGASTER; GENETICS; MEMORY; METABOLISM; NERVE CELL; PHYSIOLOGY; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BRAIN; CIRCADIAN RHYTHM; COGNITION; COGNITION DISORDERS; COGNITIVE DYSFUNCTION; DISEASE MODELS, ANIMAL; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; FRAGILE X MENTAL RETARDATION PROTEIN; FRAGILE X SYNDROME; INSULIN; MEMORY; NEURONS; SIGNAL TRANSDUCTION;

EID: 84964409630     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/mp.2016.51     Document Type: Article

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