Aquaculture as yet another environmental gateway to the development and globalisation of antimicrobial resistance

The Lancet Infectious Diseases

Volumn 16, Issue 7, 2016, Pages e127-e133

  Cabello, Felipe C ^a   Godfrey, Henry P ^a   Buschmann, Alejandro H ^b   Dölz, Humberto J ^c  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b UNIVERSIDAD DE LOS LAGOS   (Chile)

^c UNIVERSIDAD AUSTRAL DE CHILE   (Chile)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; BETA LACTAM ANTIBIOTIC; CHLORAMPHENICOL; DISINFECTANT AGENT; HEAVY METAL; PROBIOTIC AGENT; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SULFONAMIDE; TETRACYCLINE; TRIMETHOPRIM; VACCINE;

ANIMAL HUSBANDRY; ANTIBIOTIC RESISTANCE; AQUACULTURE; AQUATIC ENVIRONMENT; BACTERIAL GENE; BACTERIAL MUTATION; BACTERIOPHAGE; BACTERIUM MUTANT; FISH; FLAVOBACTERIUM; FOOD CONTAMINATION; FRANCISELLA PHILOMIRAGIA; GENETIC RECOMBINATION; GENETIC VARIATION; HORIZONTAL GENE TRANSFER; HUMAN; MARINE SPECIES; MICROBIAL CONTAMINATION; NONHUMAN; PRIORITY JOURNAL; REVIEW; RHODOCOCCUS ERYTHROPOLIS; RISK ASSESSMENT; SHELLFISH; STREPTOCOCCUS; STREPTOCOCCUS AGALACTIAE; VETERINARY MEDICINE; VIBRIO; YERSINIA; ANIMAL; BACTERIAL INFECTIONS; BACTERIUM; DRUG EFFECTS; INTERNATIONAL COOPERATION; PROCEDURES;

ANIMALS; ANTI-BACTERIAL AGENTS; AQUACULTURE; BACTERIA; BACTERIAL INFECTIONS; DRUG RESISTANCE, BACTERIAL; FISHES; HUMANS; INTERNATIONALITY;

EID: 84964328712     PISSN: 14733099     EISSN: 14744457     Source Type: Journal    
DOI: 10.1016/S1473-3099(16)00100-6     Document Type: Review

References (118)

1. Marshall BM, Levy SB Food animals and antimicrobials: impacts on human health. Clin Microbiol Rev 2011, 24:718-733.
2. Finland M Emergence of antibiotic-resistant bacteria. N Engl J Med 1955, 253:1019-1028.
3. Datta N Infectious drug resistance. Br Med Bull 1965, 21:254-259.
4. Anderson ES The ecology of transferable drug resistance in the enterobacteria. Annu Rev Microbiol 1968, 22:131-180.
5. Smith KE, Besser JM, Hedberg CW, et al. Quinolone-resistant Campylobacter jejuni infections in Minnesota, 1992-1998. N Engl J Med 1999, 340:1525-1532. the Investigation Team.
6. Prescott JF History of antimicrobial usage in agriculture. Antimicrobial resistance in bacteria of animal origin 2006, 19-27. ASM Press, Washington, DC. F.M. Aarestrup (Ed.).
7. Smith TC, Male MJ, Harper AL, et al. Methicillin-resistant Staphylococcus aureus (MRSA) strain ST398 is present in midwestern US swine and swine workers. PLoS One 2009, 4:e4258.
8. MacPherson DW, Gushulak BD, Baine WB, et al. Population mobility, globalization, and antimicrobial drug resistance. Emerg Infect Dis 2009, 15:1727-1732.
9. Love DC, Rodman S, Neff RA, Nachman KE Veterinary drug residues in seafood inspected by the European Union, United States, Canada, and Japan from 2000 to 2009. Environ Sci Technol 2011, 45:7232-7240.
10. Bengtsson-Palme J, Angelin M, Huss M, et al. The human gut microbiome as a transporter of antibiotic resistance genes between continents. Antimicrob Agents Chemother 2015, 59:6551-6560.
11. De Lappe N, O'Connor J, Garvey P, McKeown P, Cormican M Ciprofloxacin-resistant Shigella sonnei associated with travel to India. Emerg Infect Dis 2015, 21:894-896.
12. Diana JS, Egna HS, Chopin T, et al. Responsible aquaculture in 2050: valuing local conditions and human innovations will be key to success. Bioscience 2013, 63:255-262.
13. Grigorakis K, Rigos G Aquaculture effects on environmental and public welfare-the case of Mediterranean mariculture. Chemosphere 2011, 85:899-919.
14. Cabello FC, Godfrey HP, Tomova A, et al. Antimicrobial use in aquaculture re-examined: its relevance to antimicrobial resistance and to animal and human health. Environ Microbiol 2013, 15:1917-1942.
15. Rico A, Phu TM, Satapornvanit K, et al. Use of veterinary medicines, feed additives and probiotics in four major internationally traded aquaculture species farmed in Asia. Aquaculture 2013, 412-413:231-243.
16. Cao L, Naylor R, Henriksson P, et al. Global food supply. China's aquaculture and the world's wild fisheries. Science 2015, 347:133-135.
17. Miranda CD, Kehrenberg C, Ulep C, Schwarz S, Roberts MC Diversity of tetracycline resistance genes in bacteria from Chilean salmon farms. Antimicrob Agents Chemother 2003, 47:883-888.
18. Lupo A, Coyne S, Berendonk TU Origin and evolution of antibiotic resistance: the common mechanisms of emergence and spread in water bodies. Front Microbiol 2012, 3:18.
19. Zhao JY, Dang H Coastal seawater bacteria harbor a large reservoir of plasmid-mediated quinolone resistance determinants in Jiaozhou Bay, China. Microb Ecol 2012, 64:187-199.
20. Van Boeckel TP, Brower C, Gilbert M, et al. Global trends in antimicrobial use in food animals. Proc Natl Acad Sci USA 2015, 112:5649-5654.
21. Robinson TP, Wertheim HF, Kakkar M, Kariuki S, Bu D, Price LB Animal production and antimicrobial resistance in the clinic. Lancet 2016, 387:e1-e3.
22. Millanao BA, Barrientos HM, Gómez CC, et al. Injudicious and excessive use of antibiotics: Public health and salmon aquaculture in Chile. Rev Med Chil 2011, 139:107-118. (in English).
23. Romero J, Ringo E, Merrifield DE The gut microbiota of fish. Aquaculture nutrition: gut health, probiotics and prebiotics 2014, 75-100. Wiley-Blackwell, Hoboken, NJ. D.E. Merrifield, E. Ringo (Eds.).
24. Navarrete P, Mardones P, Opazo R, Espejo R, Romero J Oxytetracycline treatment reduces bacterial diversity of intestinal microbiota of Atlantic salmon. J Aquat Anim Health 2008, 20:177-183.
25. Rozas M, Enríquez R Piscirickettsiosis and Piscirickettsia salmonis in fish: a review. J Fish Dis 2014, 37:163-188.
26. Valdes N, Espinoza C, Sanhueza L, Gonzalez A, Corsini G, Tello M Draft genome sequence of the Chilean isolate Aeromonas salmonicida strain CBA100. FEMS Microbiol Lett 2015, 362:fnu062.
27. Henríquez P, Kaiser M, Bohle H, Bustos P, Mancilla M Comprehensive antibiotic susceptibility profiling of Chilean Piscirickettsia salmonis field isolates. J Fish Dis 2015, published online Dec 11. 10.1111/jfd.12427.
28. Read AF, Baigent SJ, Powers C, et al. Imperfect vaccination can enhance the transmission of highly virulent pathogens. PLoS Biol 2015, 13:e1002198.
29. Chen DQ, Yang L, Luo YT, Mao MJ, Lin YP, Wu AW Prevalence and characterization of quinolone resistance in Laribacter hongkongensis from grass carp and Chinese tiger frog. J Med Microbiol 2013, 62:1559-1564.
30. Ryu SH, Park SG, Choi SM, et al. Antimicrobial resistance and resistance genes in Escherichia coli strains isolated from commercial fish and seafood. Int J Food Microbiol 2012, 152:14-18.
31. Iwamoto M, Ayers T, Mahon BE, Swerdlow DL Epidemiology of seafood-associated infections in the United States. Clin Microbiol Rev 2010, 23:399-411.
32. Cabello FC Heavy use of prophylactic antibiotics in aquaculture: a growing problem for human and animal health and for the environment. Environ Microbiol 2006, 8:1137-1144.
33. Björklund H, Bondestam J, Bylund G Residues of oxytetracycline in wild fish and sediments from fish farms. Aquaculture 1990, 86:359-367.
34. Fortt ZA, Cabello CF, Buschmann RA Residues of tetracycline and quinolones in wild fish living around a salmon aquaculture center in Chile. Rev Chilena Infectol 2007, 24:14-18. (in English).
35. Blaser MJ The microbiome revolution. J Clin Invest 2014, 124:4162-4165.
36. Seiler C, Berendonk TU Heavy metal driven co-selection of antibiotic resistance in soil and water bodies impacted by agriculture and aquaculture. Front Microbiol 2012, 3:399.
37. Pal C, Bengtsson-Palme J, Kristiansson E, Larsson DG Co-occurrence of resistance genes to antibiotics, biocides and metals reveals novel insights into their co-selection potential. BMC Genomics 2015, 16:964.
38. Lin CK Prawn culture in Taiwan: what went wrong. World Aquacult Soc 1989, 20:19-20.
39. Sørum H Antibiotic resistance associated with veterinary drug use in fish farms. Improving farmed fish quality and safety 2008, 157-182. Woodhead Publishing, Cambridge, UK. Ø. Lie (Ed.).
40. Sinnott R Fish farming and feed companies. The handbook of salmon 2002, 105-185. Springer Praxis Publishing, Chichester. S.M. Stead, L. Laird (Eds.).
41. Beveridge MCM Cage aquaculture 2004, Blackwell Publishing, Oxford. 3rd edn.
42. Samuelsen OB, Torsvik V, Ervik A Long-range changes in oxytetracycline concentration and bacterial resistance toward oxytetracycline in a fish farm sediment after medication. Sci Total Environ 1992, 114:25-36.
43. Hektoen H, Berge JA, Hormazabal V, Yndestad M Persistence of antibacterial agents in marine sediments. Aquaculture 1995, 133:175-184.
44. Smith P Is sediment deposition the dominant fate of oxytetracycline used in marine salmonid farms: a review of available evidence. Aquaculture 1996, 146:157-169.
45. Coyne R, Smith P, Moriarty C The fate of oxytetracycline in the marine environment of a salmon cage farm. Mar Environ Health Ser 2001, 3:1-24.
46. Björklund HV, Råbergh CMJ, Bylund G Residues of oxolinic acid and oxytetracycline in fish and sediments from fish farms. Aquaculture 1991, 97:85-96.
47. Stock I, Wiedemann B Natural antibiotic susceptibilities of Edwardsiella tarda, E ictaluri, and E hoshinae. Antimicrob Agents Chemother 2001, 45:2245-2255.
48. Smith P, Hiney M Towards setting breakpoints for oxolinic acid susceptibility of Aeromonas salmonicida using distribution of data generated by standard test protocols. Aquaculture 2005, 250:22-26.
49. Tello A, Austin B, Telfer TC Selective pressure of antibiotic pollution on bacteria of importance to public health. Environ Health Perspect 2012, 120:1100-1106.
50. Bengtsson-Palme J, Larsson DG Concentrations of antibiotics predicted to select for resistant bacteria: proposed limits for environmental regulation. Environ Int 2016, 86:140-149.
51. Kümmerer K, al-Ahmad A, Mersch-Sundermann V Biodegradability of some antibiotics, elimination of the genotoxicity and affection of wastewater bacteria in a simple test. Chemosphere 2000, 40:701-710.
52. Buschmann AH, Tomova A, López A, et al. Salmon aquaculture and antimicrobial resistance in the marine environment. PLoS One 2012, 7:e42724.
53. Ding C, He J Effect of antibiotics in the environment on microbial populations. Appl Microbiol Biotechnol 2010, 87:925-941.
54. Durso LM, Miller DN, Wienhold BJ Distribution and quantification of antibiotic resistant genes and bacteria across agricultural and non-agricultural metagenomes. PLoS One 2012, 7:e48325.
55. Poirel L, Cattoir V, Nordmann P Plasmid-mediated quinolone resistance: interactions between human, animal, and environmental ecologies. Front Microbiol 2012, 3:24.
56. Aedo S, Ivanova L, Tomova A, Cabello FC Plasmid-related quinolone resistance determinants in epidemic Vibrio parahaemolyticus, uropathogenic Escherichia coli, and marine bacteria from an aquaculture area in Chile. Microb Ecol 2014, 68:324-328.
57. Rhodes G, Huys G, Swings J, et al. Distribution of oxytetracycline resistance plasmids between aeromonads in hospital and aquaculture environments: implication of Tn1721 in dissemination of the tetracycline resistance determinant tet A. Appl Environ Microbiol 2000, 66:3883-3890.
58. McIntosh D, Cunningham M, Ji B, et al. Transferable, multiple antibiotic and mercury resistance in Atlantic Canadian isolates of Aeromonas salmonicida subsp. salmonicida is associated with carriage of an IncA/C plasmid similar to the Salmonella enterica plasmid pSN254. J Antimicrob Chemother 2008, 61:1221-1228.
59. Wozniak RA, Fouts DE, Spagnoletti M, et al. Comparative ICE genomics: insights into the evolution of the SXT/R391 family of ICEs. PLoS Genet 2009, 5:e1000786.
60. Domingues S, Harms K, Fricke WF, Johnsen PJ, da Silva GJ, Nielsen KM Natural transformation facilitates transfer of transposons, integrons and gene cassettes between bacterial species. PLoS Pathog 2012, 8:e1002837.
61. García-Aljaro C, Riera-Heredia J, Blanch AR Antimicrobial resistance and presence of the SXT mobile element in Vibrio spp isolated from aquaculture facilities. New Microbiol 2014, 37:339-346.
62. Tomova A, Ivanova L, Buschmann AH, et al. Antimicrobial resistance genes in marine bacteria and human uropathogenic Escherichia coli from a region of intensive aquaculture. Environ Microbiol Rep 2015, 7:803-809.
63. Nonaka L, Maruyama F, Suzuki S, Masuda M Novel macrolide-resistance genes, mef(C) and mph(G), carried by plasmids from Vibrio and Photobacterium isolated from sediment and seawater of a coastal aquaculture site. Lett Appl Microbiol 2015, 61:1-6.
64. Roberts MC The evolution of antibiotic-resistant microbes in foods and host ecosystems. Food-borne microbes: shaping the host ecosystem 2009, 213-229. ASM Press, Washington, DC. L.A. Jaykus, H.H. Wang, L.S. Schlesinger (Eds.).
65. Welch TJ, Fricke WF, McDermott PF, et al. Multiple antimicrobial resistance in plague: an emerging public health risk. PLoS One 2007, 2:e309.
66. Del Castillo CS, Hikima J, Jang HB, et al. Comparative sequence analysis of a multidrug-resistant plasmid from Aeromonas hydrophila. Antimicrob Agents Chemother 2013, 57:120-129.
67. Welch TJ, Evenhuis J, White DG, et al. IncA/C plasmid-mediated florfenicol resistance in the catfish pathogen Edwardsiella ictaluri. Antimicrob Agents Chemother 2009, 53:845-846.
68. Fricke WF, Welch TJ, McDermott PF, et al. Comparative genomics of the IncA/C multidrug resistance plasmid family. J Bacteriol 2009, 191:4750-4757.
69. Sørum H, L'Abée-Lund TM, Solberg A, Wold A Integron-containing IncU R plasmids pRAS1 and pAr-32 from the fish pathogen Aeromonas salmonicida. Antimicrob Agents Chemother 2003, 47:1285-1290.
70. Silva J, Zemelman R, Mandoca MA, Henríquez M, Merino C, González C Antibiotic-resistant gram negative bacilli isolated from sea water and shellfish. Possible epidemiological implications. Rev Latinoam Microbiol 1987, 29:165-169.
71. Beaber JW, Hochhut B, Waldor MK SOS response promotes horizontal dissemination of antibiotic resistance genes. Nature 2004, 427:72-74.
72. Baharoglu Z, Bikard D, Mazel D Conjugative DNA transfer induces the bacterial SOS response and promotes antibiotic resistance development through integron activation. PLoS Genet 2010, 6:e1001165.
73. Blázquez J, Couce A, Rodríguez-Beltrán J, Rodríguez-Rojas A Antimicrobials as promoters of genetic variation. Curr Opin Microbiol 2012, 15:561-569.
74. Bernier SP, Surette MG Concentration-dependent activity of antibiotics in natural environments. Front Microbiol 2013, 4:20.
75. Cantas L, Midtlyng PJ, Sørum H Impact of antibiotic treatments on the expression of the R plasmid tra genes and on the host innate immune activity during pRAS1 bearing Aeromonas hydrophila infection in zebrafish (Danio rerio). BMC Microbiol 2012, 12:37.
76. Jackson RW, Johnson LJ, Clarke SR, Arnold DL Bacterial pathogen evolution: breaking news. Trends Genet 2011, 27:32-40.
77. Srinivasiah S, Bhavsar J, Thapar K, Liles M, Schoenfeld T, Wommack KE Phages across the biosphere: contrasts of viruses in soil and aquatic environments. Res Microbiol 2008, 159:349-357.
78. Balcázar JL, Subirats J, Borrego CM The role of biofilms as environmental reservoirs of antibiotic resistance. Front Microbiol 2015, 6:1216.
79. Taylor NG, Verner-Jeffreys DW, Baker-Austin C Aquatic systems: maintaining, mixing and mobilising antimicrobial resistance?. Trends Ecol Evol 2011, 26:278-284.
80. Heuer H, Schmitt H, Smalla K Antibiotic resistance gene spread due to manure application on agricultural fields. Curr Opin Microbiol 2011, 14:236-243.
81. Jechalke S, Heuer H, Siemens J, Amelung W, Smalla K Fate and effects of veterinary antibiotics in soil. Trends Microbiol 2014, 22:536-545.
82. Aoki T, Egusa S, Watanabe T Detection of R + bacteria in cultured marine fish, yellowtails (Seriola quinqueradiata). Jpn J Microbiol 1973, 17:7-12.
83. Nakajima T, Suzuki M, Harada K, Inoue M, Mitsuhashi S Transmission of R plasmids in Vibrio anguillarum to Vibrio cholerae. Microbiol Immunol 1983, 27:195-198.
84. Sørum H Mobile drug resistance genes among fish bacteria. APMIS Suppl 1998, 84:74-76.
85. Shah SQ, Cabello FC, L'Abée-Lund TM, et al. Antimicrobial resistance and antimicrobial resistance genes in marine bacteria from salmon aquaculture and non-aquaculture sites. Environ Microbiol 2014, 16:1310-1320.
86. Hatosy SM, Martiny AC The ocean as a global reservoir of antibiotic resistance genes. Appl Environ Microbiol 2015, 81:7593-7599.
87. Telke AA, Rolain JM Functional genomics to discover antibiotic resistance genes: the paradigm of resistance to colistin mediated by ethanolamine phosphotransferase in Shewanella algae MARS 14. Int J Antimicrob Agents 2015, 46:648-652.
88. Mian GF, Godoy DT, Leal CA, Yuhara TY, Costa GM, Figueiredo HC Aspects of the natural history and virulence of S agalactiae infection in Nile tilapia. Vet Microbiol 2009, 136:180-183.
89. Avendaño-Herrera R, Balboa S, Castro N, et al. Comparative polyphasic characterization of Streptococcus phocae strains with different host origin and description of the subspecies Streptococcus phocae subsp. salmonis subsp. nov. Int J Syst Evol Microbiol 2014, 64:1775-1781.
90. Kämpfer P, Lodders N, Martin K, Avendaño-Herrera R Flavobacterium chilense sp nov and Flavobacterium araucananum sp nov, isolated from farmed salmonid fish. Int J Syst Evol Microbiol 2012, 62:1402-1408.
91. Olsen AB, Birkbeck TH, Nilsen HK, et al. Vaccine-associated systemic Rhodococcus erythropolis infection in farmed atlantic salmon Salmo salar. Dis Aquat Organ 2006, 72:9-17.
92. Mikalsen J, Olsen AB, Tengs T, Colquhoun DJ Francisella philomiragia subsp noatunensis subsp nov, isolated from farmed Atlantic cod (Gadus morhua L). Int J Syst Evol Microbiol 2007, 57:1960-1965.
93. Baba H, Nada T, Ohkusu K, Ezaki T, Hasegawa Y, Paterson DL First case of bloodstream infection caused by Rhodococcus erythropolis. J Clin Microbiol 2009, 47:2667-2669.
94. Wenger JD, Hollis DG, Weaver RE, et al. Infection caused by Francisella philomiragia (formerly Yersinia philomiragia). A newly recognized human pathogen. Ann Intern Med 1989, 110:888-892.
95. Friis-Møller A, Lemming LE, Valerius NH, Bruun B Problems in identification of Francisella philomiragia associated with fatal bacteremia in a patient with chronic granulomatous disease. J Clin Microbiol 2004, 42:1840-1842.
96. Woodford N, Turton JF, Livermore DM Multiresistant Gram-negative bacteria: the role of high-risk clones in the dissemination of antibiotic resistance. FEMS Microbiol Rev 2011, 35:736-755.
97. Angulo F Use of antimicrobial agents in aquaculture: potential for public health impact 1999, 1-5. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, Atlanta.
98. Cantas L, Shah SQ, Cavaco LM, et al. A brief multi-disciplinary review on antimicrobial resistance in medicine and its linkage to the global environmental microbiota. Front Microbiol 2013, 4:96.
99. Aarestrup FM, Wegener HC, Collignon P Resistance in bacteria of the food chain: epidemiology and control strategies. Expert Rev Anti Infect Ther 2008, 6:733-750.
100. Le Hello S, Hendriksen RS, Doublet B, et al. International spread of an epidemic population of Salmonella enterica serotype Kentucky ST198 resistant to ciprofloxacin. J Infect Dis 2011, 204:675-684.
101. Liu YY, Wang Y, Walsh TR, et al. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infect Dis 2016, 16:161-168.
102. Hasman H, Hammerum AM, Hansen F, et al. Detection of mcr-1 encoding plasmid-mediated colistin-resistant Escherichia coli isolates from human bloodstream infection and imported chicken meat, Denmark 2015. Eurosurveill 2015, 20. PII:30085.
103. Gelband H, Laxminarayan R Tackling antimicrobial resistance at global and local scales. Trends Microbiol 2015, 23:524-526.
104. Årdal C, Outterson K, Hoffman SJ, et al. International cooperation to improve access to and sustain effectiveness of antimicrobials. Lancet 2016, 387:296-307.
105. Burridge L, Weis JS, Cabello F, Pizarro J, Bostick K Chemical use in salmon aquaculture: a review of current practices and possible environmental effects. Aquaculture 2010, 306:7-23.
106. Integrated annual and sustainability report 2014 Cermaq, (accessed Dec 20, 2015). http://report2014.cermaq.com/sustainability/our-performance.
107. Graham JP, Leibler JH, Price LB, et al. The animal-human interface and infectious disease in industrial food animal production: rethinking biosecurity and biocontainment. Public Health Rep 2008, 123:282-299.
108. Conrad PA, Meek LA, Dumit J Operationalizing a One Health approach to global health challenges. Comp Immunol Microbiol Infect Dis 2013, 36:211-216.
109. Gormaz JG, Fry JP, Erazo M, Love DC Public health perspectives on aquaculture. Curr Environ Health Rep 2014, 1:227-238.
110. Asche F, Hansen H, Tveterås R, Tveterås S The salmon disease crisis in Chile. Mar Resour Econ 2010, 24:405-411.
111. Bravo S, Midtlyng PJ The use of fish vaccines in the Chilean salmon industry 1999-2003. Aquaculture 2007, 270:36-42.
112. Midtlyng PJ, Grave K, Horsberg TE What has been done to minimize the use of antibacterial and antiparasitic drugs in Norwegian aquaculture?. Aquacult Res 2011, 42:28-41.
113. Christiansen RH, Dalsgaard I, Middelboe M, Lauritsen AH, Madsen L Detection and quantification of Flavobacterium psychrophilum-specific bacteriophages in vivo in rainbow trout upon oral administration: implications for disease control in aquaculture. Appl Environ Microbiol 2014, 80:7683-7693.
114. Martínez-Porchas M, Vargas-Albores F Microbial metagenomics in aquaculture, a potential tool for a deeper insight into the activity. Rev Aquaculture 2015, 7:1-15.
115. Aarestrup FM The livestock reservoir for antimicrobial resistance: a personal view on changing patterns of risks, effects of interventions and the way forward. Philos Trans R Soc Lond B Biol Sci 2015, 370:20140085.
116. Chantziaras I, Boyen F, Callens B, Dewulf J Correlation between veterinary antimicrobial use and antimicrobial resistance in food-producing animals: a report on seven countries. J Antimicrob Chemother 2014, 69:827-834.
117. Done HY, Venkatesan AK, Halden RU Does the recent growth of aquaculture create antibiotic resistance threats different from those associated with land animal production in agriculture?. AAPS J 2015, 17:513-524.
118. Fauci AS, Marston D The perpetual challenge of antimicrobial resistance. JAMA 2014, 311:1853-1854.