Biodegradability of some antibiotics, elimination of the genotoxicity and affection of wastewater bacteria in a simple test

Chemosphere

Volumn 40, Issue 7, 2000, Pages 701-710

  Kummerer K ^a   Al Ahmad, A ^a   Mersch Sundermann, V ^b  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Biodegradability; Ciprofloxacin; Closed bottle test; Genotoxicity; Metronidazole; Ofloxacin; SOS chromotest

Indexed keywords

ANTIBIOTIC AGENT; CIPROFLOXACIN; DRUG METABOLITE; METRONIDAZOLE; OFLOXACIN;

ARTICLE; BACTERIAL GROWTH; BACTERIUM; BIODEGRADATION; COLONY FORMING UNIT; EFFLUENT; ENVIRONMENTAL IMPACT ASSESSMENT; GENOTOXICITY; GROWTH INHIBITION; HEALTH HAZARD; HOSPITAL WASTE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PSEUDOMONAS PUTIDA; WASTE WATER;

ANTI-BACTERIAL AGENTS; BACTERIA; BIODEGRADATION, ENVIRONMENTAL; CELL DIVISION; HUMANS; INHIBITORY CONCENTRATION 50; MICROBIAL SENSITIVITY TESTS; MUTAGENICITY TESTS; OXYGEN; PSEUDOMONAS PUTIDA; SEWAGE; SOS RESPONSE (GENETICS); TOXICITY TESTS; WASTE DISPOSAL, FLUID;

BACTERIA (MICROORGANISMS); PSEUDOMONAS; PSEUDOMONAS PUTIDA;

EID: 0043049381     PISSN: 00456535     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0045-6535(99)00439-7     Document Type: Article

References (46)

1. Al-Ahmad, A., Daschner, F.D., Kümmerer, K., 1999. Biodegradability of cefotiam ciprofloxacin meropenem penicillin G and sulfametohoxazole and inhibition of waste water bacteria. Arch. Environ. Contam. Toxicol., 37, 158-163.
2. Ashby J., Morrod R.S. Detection of human carcinogens. Nature. 352:1991;185-186.
3. Ashby J., Tennant R.W. Chemical structure, Salmonella mutagenicity and extent of carcinogenicity as indicators of genotoxic carcinogenesis among 222 chemicals tested in rodents by the US NCI/NTP. Mut. Res. 204:1988;17-115.
4. 14C-ciprofloxacin in an aquatic model ecosystem. Bayer PF-Report 3539, 29 July.
5. Brözel V.S., Cloete T.E. Evaluation of nutrient agars for the enumeration of viable aerobic heterotrophs in cooling water. Wat. Res. 26:1992;1111-1117.
6. Burhenne J., Ludwig M., Nikoloudis P., Spiteller M. Photolytic degradation of fluoroquinolone carboxylic acids in aqueous solution. Primary photoproducts and half-lives. ESPR-Environ. Sci. Pollut. Res. 4:1997a;10-15.
7. Burhenne J., Ludwig M., Spiteller M. Photolytic degradation of fluoroquinolone carboxylic acids in aqueous solution Isolation and structural elucidation of polar photometabolites. ESPR-Environ. Sci. Pollut. Res. 4:1997b;61-71.
8. Erbe, T., Kümmerer, K., Daschner, F., 1997. Eintrag von Antibiotika in die aquatische Umwelt: Mengen, erwartete Konzentrationen und zu erwartende Effekte. Studie im Auftrag der Forschungskommission des Universitätsklinikms Freiburg, Freiburg.
9. EU, 1995. Assessment of potential risks to the environment posed by medical products for human use (excluding products containing live genetically modified organisms. Direction General III, No. 5504/94 Draft 6, version 4, Brussels, 5 January.
10. Gerding, D.N., Peterson, L.R., Hughes, C.E., Bamberger, D.M., Larson, T.A., 1991. Extravascular antimicrobial distribution and the respective blood concentrations in human. In V. Lorian (Ed.), Antibiotics in Laboratory Medicine (3rd ed.). Baltimore, pp. 880-961.
11. Halling-Sørensen B., Nors Nielsen S., Lanzky P.F., Ingerslev F., Holten Lützhøft H.C., Jørgensen S.E. Occurrence fate and effects of pharmaceutical substances in the environment - a review. Chemosphere. 36:1998;357-393.
12. Hartmann A., Golet E.M., Gartiser S., Alder A.C., Koller T., Widmer R. Primary DNA damage but not mutagenicity correlates with ciprofloxacin concentrations in German hospital waste waters. Arch. Environ. Contam. Toxicol. 36:1999;115-119.
13. Helma C., Mersch-Sundermann V., Houk V.S., Kassie F., Schulte-Hermann R., Knasmüller S. Comparative evaluation of four bacterial assays for the detection of genotoxic effects in water samples. Environ. Sci. Technol. 30:1996;897-907.
14. Hiraishi A. Respiratory quinone profiles as tools for identifying different bacterial populations in activated sludge. J. Gen. Appl. Microbiol. 34:1988;39-56.
15. Hirsch R., Ternes T., Haberer K., Kratz K.L. Occurrence of antibiotics in the aquatic environment. Sci. Tot. Environ. 225:1999;109-118.
16. Hübener B., Dornberger K., Zielke R., Gräfe U. Microbial degradation of cyclosporin A. UWSF-Z. Umweltchem. Ökotox. 4:1992;227-230.
17. ISO, 1990. Water quality - determination of dissolved oxygen. ISO 5814. In: German standard methods for the examination of water, waste water and sludge - VCH Verlagsgesellschaft, Weinheim, New York.
18. ISO, 1995. Water quality - Pseudomonas growth inhibition test. ISO 17 012, 1995. In: German standard methods for the examination of water, waste water and sludge - 1995. VCH Verlagsgesellschaft, Weinheim, New York.
19. Kümmerer, K., 1998. Eintrag von Pharmaka, Diagnostika und Desinfektionsmitteln aus Krankenhäusern in die aquatische Umwelt. Habilitationschrift Medizinische Fakultät der Universität Freiburg.
20. Kümmerer, K., 1999. Drugs, diagnostic agents and disinfectants in waste water and water-a review. Wat. Sci. Technol., accepted for publication.
21. Kümmerer, K., Al-Ahmad, A., 1999. Monitoring bacterial shift in biodegradability testing of the quaternary Ammonium compound benzalkonium chloride using bacterial quinone profiles. Chemosphere, submitted.
22. Kümmerer K., Al-Ahmad A., Steger-Hartmann T. Epirubicin hydrochloride in the aquatic environment - biodegradation and bacterial toxicity. Umweltmed. Forsch. Prax. 1:1996a;133-137.
23. Kümmerer K., Eitel A., Braun U., Hubner P., Daschner F., Mascart G., Milandri M., Reinthaler F., Verhuef J. Analysis of benzalkoniumchloride in the effluent from European hospitals by solid-phase extraction and HPLC with post-column ion-pairing for fluorescence detection. J. Chromatogr. A. 774:1997b;281-286.
24. Kümmerer K., Helmers E. Hospital effluents as a source for platinum in the environment. Sci. Total Environ. 193:1997;179-184.
25. Kümmerer K., Helmers E., Hubner P., Mascart G., Milandri M., Reinthaler F., Zwakenberg M. European hospitals as a source for platinum in the environment: emissions with effluents-concentrations, amounts and comparison with other sources. Sci. Total Environ. 225:1998;155-165.
26. Kümmerer K., Steger-Hartmann T., Baranyai A., Bürhaus I. Evaluation of the biological degradation of the antineoplastics cyclophosphamide and ifosfamide with the Closed Bottle Test OECD 301 D. Zbl. Hyg. 198:1996b;215-225.
27. Kümmerer K, Steger-Hartmann T., Meyer M. Biodegradability of the anti-tumour agent ifosfamide and its occurrence in hospital effluents and sewage. Wat. Res. 31:1997a;2705-2710.
28. Lanzky P.F., Halling-Sørensen B. The toxic effect of the antibiotic metronidazole on aquatic organisms. Chemosphere. 35:1997;2553-2561.
29. Lowry O.H., Rosebrough N.J., Farr A.L, Randall R.J. Protein measurement with the folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
30. Martens R., Wetzstein H.G., Zadrazil F., Capelari M., Hoffmann P., Schmeer M. Degradation of the fluoroquinolone enrofloxacin by wood-rotting fungi. Appl. Environ. Microbiol. 62:1996;4206-4209.
31. Marengo J.R., Kok R.A., Velagaleti R., Stamm J.M. Aerobic degradation of 14C-sarafloxacin hydrochloride in soil. Environ. Toxicol. Chem. 16:1997;462-471.
32. Mersch-Sundermann V., Hauff K.-H., Braun P., Lu W., Hof H. DNA damage caused by antibiotic drugs: Quinolones. Intern. J. Oncol. 5:1994a;855-859.
33. Mersch-Sundermann V., Kevekordes S., Mochayedi S. Sources of variability on the Escherichia coli PQ37 genotoxicity assay. Mut. Res. 252:1991;51-60.
34. Mersch-Sundermann V, Klopman G., Rosenkranz H.S. Chemical structure and genotoxicity: structure-activity studies of the SOS chromotest. Mut. Res. 340:1996;81-91.
35. Mersch-Sundermann V., Schneider U., Klopman G., Rosenkranz H.S. SOS-induction in E.coli and Salmonella mutagenicity: a comparison using 330 compounds. Mutagenesis. 9:1994b;205-224.
36. Mersch-Sundermann V., Wintermann F., Kern S. Influence of S9-mix composition on the SOS response in Escherichia coli PQ37. Mut. Res. 291:1993;53-60.
37. Nyholm N. The European system of standardized legal tests for assessing the biodegradability of chemicals. Environ. Toxicol. Chem. 10:1991;1237-1246.
38. OECD, 1992. Guidelines for Testing of Chemicals. 301 D Closed Bottle Test Adopted by the Council on 17 July 1992. Paris.
39. Quillardet P., Hofnung M. The SOS chromotest a colorimetric bacterial assay for genotoxins. procedures. Mut. Res. 147:1985;65-78.
40. Richardson M.L., Bowron J.M. The fate of pharmaceutical chemicals in the aquatic environment. J. Pharm. Pharmacol. 37:1985;1-12.
41. Rosenkranz, H.S., Mersch-Sundermann, V., Klopman, G., 1999. Salmonella mutagenicity and SOS chromotest: evidence of mechanistic differences. Mut. Res., in press.
42. Simon C., Stille W. Antibiotikatherapie in Klinik und 8. 1993;Auflage, Schlattauer, Stuttgart New York.
43. Stan H.-J., Heberer T., Linkerhägner M. Vorkommen von Clofibrinsäure im Gewässersystem-ist der humanmedizinische Gebrauch Urasche für die Kontamination von Oberflächen-, Grund- und Trinkwasser. Vom Wasser. 83:1994;57-68.
44. Stumpf M., Ternes T.A., Haberer K., Seel P. Determination of pharmaceuticals in sewage plants and river water. Vom Wasser. 86:1996;291-303.
45. van Ginkel C.G., Stroh C.A. A simple method to prolong the Closed Bottle Test for the determination of the inherent biodegradability. Ecotox. Environ. Safety. 24:1992;319-327.
46. Weerasinghe C.A., Towner D. Aerobic biodegradation of virginiamycin in soil. Environ. Toxicol. Chem. 16:1997;1873-1876.