Expression profile of Caenorhabditis elegans mutant for the Werner syndrome gene ortholog reveals the impact of vitamin C on development to increase life span

BMC Genomics

Volumn 15, Issue 1, 2014, Pages

  Dallaire, Alexandra ^a   Proulx, Sophie ^a   Simard, Martin J ^a   Lebel, Michel ^a  

^a University Laval   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; MESSENGER RNA; TRANSCRIPTOME;

ANATOMICAL CONCEPTS; ARTICLE; BINDING SITE; CAENORHABDITIS ELEGANS; CARBOHYDRATE METABOLISM; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOWN REGULATION; GENE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE MUTATION; GENETIC ANALYSIS; LIFESPAN; LIPID METABOLISM; LOCOMOTION; MORPHOGENESIS; NONHUMAN; OXIDATION REDUCTION REACTION; PROTEIN DEGRADATION; PROTEIN DOMAIN; RNA SEQUENCE; UPREGULATION; WRN 1 GENE; ANIMAL; DRUG EFFECTS; GENETICS; GROWTH, DEVELOPMENT AND AGING; LONGEVITY; METABOLISM; MUTATION; PHYSIOLOGY; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; WERNER SYNDROME;

ANIMALS; ASCORBIC ACID; CAENORHABDITIS ELEGANS; LONGEVITY; MUTATION; RNA, MESSENGER; SEQUENCE ANALYSIS, RNA; SEQUENCE HOMOLOGY, NUCLEIC ACID; TRANSCRIPTOME; WERNER SYNDROME;

EID: 84964313819     PISSN: None     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/1471-2164-15-940     Document Type: Article

References (43)

1. Epstein CJ, Martin GM, Schultz AL, Motulsky AG: Werner's syndrome a review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process. Medicine (Baltimore) 1966, 45(3):177-221.
2. Salk D: Werner's syndrome: a review of recent research with an analysis of connective tissue metabolism, growth control of cultured cells, and chromosomal aberrations. Hum Genet 1982, 62(1):1-5.
3. Yu CE, Oshima J, Fu YH, Wijsman EM, Hisama F, Alisch R, Matthews S, Nakura J, Miki T, Ouais S, Martin GM, Mulligan J, Schellenberg GD: Positional cloning of the Werner's syndrome gene. Science 1996, 272(5259):258-262.
4. Ozgenc A, Loeb LA: Current advances in unraveling the function of the Werner syndrome protein. Mutat Res 2005, 577(1-2):237-251.
5. Kamath-Loeb AS, Shen JC, Loeb LA, Fry M: Werner syndrome protein. II. Characterization of the integral 3'-> 5' DNA exonuclease. J Biol Chem 1998, 273(51):34145-34150.
6. Huang S, Beresten S, Li B, Oshima J, Ellis NA, Campisi J: Characterization of the human and mouse WRN 3'-> 5' exonuclease. Nucleic Acids Res 2000, 28(12):2396-2405.
7. Balajee AS, Machwe A, May A, Gray MD, Oshima J, Martin GM, Nehlin JO, Brosh R, Orren DK, Bohr VA: The Werner syndrome protein is involved in RNA polymerase II transcription. Mol Biol Cell 1999, 10(8):2655-2668.
8. Cooper MP, Machwe A, Orren DK, Brosh RM, Ramsden D, Bohr VA: Ku complex interacts with and stimulates the Werner protein. Genes Dev 2000, 14(8):907-912.
9. Shen JC, Loeb LA: The Werner syndrome gene: the molecular basis of RecQ helicase-deficiency diseases. Trends Genet 2000, 16(5):213-220.
10. Saintigny Y, Makienko K, Swanson C, Emond MJ, Monnat RJ Jr: Homologous recombination resolution defect in werner syndrome. Mol Cell Biol 2002, 22(20):6971-6978.
11. Crabbe L, Verdun RE, Haggblom CI, Karlseder J: Defective telomere lagging strand synthesis in cells lacking WRN helicase activity. Science 2004, 306(5703):1951-1953.
12. Lebel M, Leder P: A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity. Proc Natl Acad Sci U S A 1998, 95(22):13097-13102.
13. Lebel M, Cardiff RD, Leder P: Tumorigenic effect of nonfunctional p53 or p21 in mice mutant in the Werner syndrome helicase. Cancer Res 2001, 61(5):1816-1819.
14. Massip L, Garand C, Turaga RV, Deschenes F, Thorin E, Lebel M: Increased insulin, triglycerides, reactive oxygen species, and cardiac fibrosis in mice with a mutation in the helicase domain of the Werner syndrome gene homologue. Exp Gerontol 2006, 41(2):157-168.
15. Lebel M, Lavoie J, Gaudreault I, Bronsard M, Drouin R: Genetic cooperation between the Werner syndrome protein and poly(ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice. Am J Pathol 2003, 162(5):1559-1569.
16. Massip L, Garand C, Paquet ER, Cogger VC, O'Reilly JN, Tworek L, Hatherell A, Taylor CG, Thorin E, Zahradka P, Le Couteur DG, Lebel M: Vitamin C restores healthy aging in a mouse model for Werner syndrome. FASEB J 2010, 24(1):158-172.
17. Lee JS, Chu IS, Mikaelyan A, Calvisi DF, Heo J, Reddy JK, Thorgeirsson SS: Application of comparative functional genomics to identify best-fit mouse models to study human cancer. Nat Genet 2004, 36(12):1306-1311.
18. Hyun M, Bohr VA, Ahn B: Biochemical characterization of the WRN-1 RecQ helicase of Caenorhabditis elegans. Biochemistry 2008, 47(28):7583-7593.
19. Dallaire A, Garand C, Paquel ER, Mitchell SJ, de Cabo R, Simard MJ, Lebel M: Down regulation of miR-124 in both Werner syndrome DNA helicase mutant mice and mutant Caenorhabditis elegans wrn-1 reveals the importance of this microRNA in accelerated aging. Aging 2012, 4(9):636-647.
20. Mortazavi A, Williams BA, McCue K, Schaeffer L, Wold B: Mapping and quantifying mammalian transcriptomes by RNA-Seq. Nat Methods 2008, 5(7):621-628.
21. Wang Z, Gerstein M, Snyder M: RNA-Seq: a revolutionary tool for transcriptomics. Nat Rev Genet 2009, 10(1):57-63.
22. Marioni JC, Mason CE, Mane SM, Stephens M, Gilad Y: RNA-seq: an assessment of technical reproducibility and comparison with gene expression arrays. Genome Res 2008, 18(9):1509-1517.
23. Hawkins RD, Hon GC, Ren B: Next-generation genomics: an integrative approach. Nat Rev Genet 2010, 11(7):476-486.
24. Hallegger M, Llorian M, Smith CW: Alternative splicing: global insights. FEBS J 2010, 277(4):856-866.
25. Huang J, Lemire BD: Mutations in the C. elegans succinate dehydrogenase iron-sulfur subunit promote superoxide generation and premature aging. J Mol Biol 2009, 387(3):559-569.
26. Gatewood BK, Bucher EA: The mup-4 locus in Caenorhabditis elegans is essential for hypodermal integrity, organismal morphogenesis and embryonic body wall muscle position. Genetics 1997, 146(1):165-183.
27. Niu W, Lu ZJ, Zhong M, Sarov M, Murray JI, Brdlik CM, Janette J, Chen C, Alves P, Preston E, Slightham C, Jiang L, Hyman AA, Kim SK, Waterston RH, Gerstein M, Snyder M, Reinke V: Diverse transcription factor binding features revealed by genome-wide ChIP-seq in C. elegans. Genome Res 2011, 21(2):245-254.
28. Salser SJ, Kenyon C: A C. elegans Hox gene switches on, off, on and off again to regulate proliferation, differentiation and morphogenesis. Development 1996, 122(5):1651-1661.
29. Zhao X, Yang Y, Fitch DH, Herman MA: TLP-1 is an asymmetric cell fate determinant that responds to Wnt signals and controls male tail tip morphogenesis in C. elegans. Development 2002, 129(6):1497-1508.
30. Noble T, Stieglitz J, Srinivasan S: An integrated serotonin and octopamine neuronal circuit directs the release of an endocrine signal to control C. elegans body fat. Cell Metab 2013, 18(5):672-684.
31. Panowski SH, Wolff S, Aguilaniu H, Durieux J, Dillin A: PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans. Nature 2007, 447(7144):550-555.
32. Sheaffer KL, Updike DL, Mango SE: The Target of Rapamycin pathway antagonizes pha-4/FoxA to control development and aging. Current Biology: CB 2008, 18(18):1355-1364.
33. Lee SJ, Yook JS, Han SM, Koo HS: A Werner syndrome protein homolog affects C. elegans development, growth rate, life span and sensitivity to DNA damage by acting at a DNA damage checkpoint. Development 2004, 131(11):2565-2575.
34. Turaga RV, Paquet ER, Sild M, Vignard J, Garand C, Johnson FB, Masson JY, Lebel M: The Werner syndrome protein affects the expression of genes involved in adipogenesis and inflammation in addition to cell cycle and DNA damage responses. Cell Cycle 2009, 8(13):2080-2092.
35. Verelst W, Asard H: A phylogenetic study of cytochrome b561 proteins. Genome Biol 2003, 4(6):R38.
36. Myllyharju J: Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets. Ann Med 2008, 40(6):402-417.
37. Brenner S: The genetics of Caenorhabditis elegans. Genetics 1974, 77(1):71-94.
38. Bates DJ, Li N, Liang R, Sarojini H, An J, Masternak MM, Bartke A, Wang E: MicroRNA regulation in Ames dwarf mouse liver may contribute to delayed aging. Aging Cell 2010, 9(1):1-18.
39. Bosse GD, Ruegger S, Ow MC, Vasquez-Rifo A, Rondeau EL, Ambros VR, Grosshans H, Simard MJ: The decapping scavenger enzyme DCS-1 controls microRNA levels in Caenorhabditis elegans. Mol Cell 2013, 50(2):281-287.
40. Edgar R, Domrachev M, Lash AE: Gene expression omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res 2002, 30(1):207-210.
41. Trapnell C, Roberts A, Goff L, Pertea G, Kim D, Kelley DR, Pimentel H, Salzberg SL, Rinn JL, Pachter L: Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks. Nat Protoc 2012, 7(3):562-578.
42. Anders S, Reyes A, Huber W: Detecting differential usage of exons from RNA-seq data. Genome Res 2012, 22(10):2008-2017.
43. Dennis G Jr, Sherman BT, Hosack DA, Yang J, Gao W, Lane HC, Lempicki RA: DAVID: database for annotation, visualization, and integrated discovery. Genome Biol 2003, 4(5):3.