Tumour MLH1 promoter region methylation testing is an effective prescreen for lynch syndrome (HNPCC)

Journal of Medical Genetics

Volumn 51, Issue 12, 2014, Pages 789-796

  Newton, K ^a   Jorgensen, N M ^b   Wallace, A J ^b   Buchanan, D D ^c,d,e   Lalloo, F ^b   McMahon, R F T ^a,f   Hill, J ^a   Evans, D G ^b  

^a MANCHESTER ROYAL INFIRMARY   (United Kingdom)

^b MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

^c QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^d UNIVERSITY OF MELBOURNE   (Australia)

^e UNIVERSITY OF MELBOURNE   (Australia)

^f UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

ADULT; ARTICLE; BRAF GENE; CANCER PATIENT; CANCER SCREENING; CODON USAGE; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; DIAGNOSTIC TEST ACCURACY STUDY; DNA EXTRACTION; DNA METHYLATION; GENE IDENTIFICATION; GENE LOSS; GENETIC SCREENING; HEREDITARY NONPOLYPOSIS COLORECTAL CANCER; HUMAN; MAJOR CLINICAL STUDY; MIDDLE AGED; MISMATCH REPAIR; MLH1 GENE; MUTATION RATE; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROMOTER REGION; PYROSEQUENCING; QUANTITATIVE GENETICS; SENSITIVITY AND SPECIFICITY; SOMATIC MUTATION; TUMOR GENE; WILD TYPE;

EID: 84964308687     PISSN: 00222593     EISSN: 14686244     Source Type: Journal    
DOI: 10.1136/jmedgenet-2014-102552     Document Type: Article

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