Germline hypermethylation of MLH1 and EPCAM deletions are a frequent cause of Lynch syndrome

Genes Chromosomes and Cancer

Volumn 48, Issue 8, 2009, Pages 737-744

  Niessen, Renée C ^a   Hofstra, Robert M W ^a   Westers, Helga ^a   Ligtenberg, Marjolijn J L ^b   Kooi, Krista ^a   Jager, Paul O J ^a   De Groote, Marloes L ^a   Dijkhuizen, Trijnie ^a   Olderode Berends, Maran J W ^a   Hollema, Harry ^a   Kleibeuker, Jan H ^a   Sijmons, Rolf H ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

3' UNTRANSLATED REGION; ARTICLE; CANCER PATIENT; COLORECTAL CANCER; CONTROLLED STUDY; DNA METHYLATION; DUODENUM CANCER; ENDOMETRIUM CANCER; EPCAM GENE; FAMILIAL CANCER; FEMALE; GENE DELETION; GENE MUTATION; GENE SILENCING; GENETIC TRANSCRIPTION; GERM LINE; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE INSTABILITY; MLH1 GENE; MSH2 GENE; MSH6 GENE; ONCOGENE; PRIORITY JOURNAL; PROMOTER REGION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANTIGENS, NEOPLASM; CELL ADHESION MOLECULES; COHORT STUDIES; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; DNA METHYLATION; DNA-BINDING PROTEINS; FEMALE; GENE DELETION; GERM-LINE MUTATION; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MUTATION; MUTS HOMOLOG 2 PROTEIN; NUCLEAR PROTEINS; PROMOTER REGIONS, GENETIC;

EID: 67650383819     PISSN: 10452257     EISSN: 10982264     Source Type: Journal    
DOI: 10.1002/gcc.20678     Document Type: Article

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