Efficient molecular screening of Lynch syndrome by specific 3′ promoter methylation of the MLH1 or BRAF mutation in colorectal cancer with high-frequency microsatellite instability

Oncology Reports

Volumn 21, Issue 6, 2009, Pages 1577-1583

  Nakagawa, Hitoshi ^a   Nagasaka, Takeshi ^a   Cullings, Harry M ^b   Notohara, Kenji ^c   Hoshijima, Naoko ^a   Young, Joanne ^d   Lynch, Henry T ^e   Tanaka, Noriaki ^a   Matsubara, Nagahide ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b RADIATION EFFECTS RESEARCH FOUNDATION   (Japan)

^c KURASHIKI CENTRAL HOSPITAL   (Japan)

^d QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^e CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

BRAF; Lynch syndrome; Methylation; Microsatellite instability; MLH1

Indexed keywords

B RAF KINASE; BISULFITE; MISMATCH REPAIR PROTEIN; PROTEIN MLH1; BRAF PROTEIN, HUMAN; MLH1 PROTEIN, HUMAN; NUCLEAR PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ADULT; AGED; ARTICLE; CLINICAL ARTICLE; COLORECTAL CANCER; CONTROLLED STUDY; CPG ISLAND; FAMILIAL CANCER; FEMALE; GENE EXPRESSION; GENE MUTATION; GENE SEQUENCE; GENE SILENCING; GENETIC SCREENING; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MICROSATELLITE INSTABILITY; MISMATCH REPAIR; MOLECULAR GENETICS; MUTATIONAL ANALYSIS; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; RNA METHYLATION; SENSITIVITY AND SPECIFICITY; CHEMISTRY; COLORECTAL TUMOR; DNA METHYLATION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; METHODOLOGY; MUTATION; NUCLEOTIDE SEQUENCE; PREDICTION AND FORECASTING;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; CPG ISLANDS; DNA METHYLATION; DNA MUTATIONAL ANALYSIS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC SCREENING; HUMANS; IMMUNOHISTOCHEMISTRY; MICROSATELLITE INSTABILITY; MUTATION; NUCLEAR PROTEINS; PREDICTIVE VALUE OF TESTS; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS B-RAF; SENSITIVITY AND SPECIFICITY;

EID: 67650000219     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or_00000390     Document Type: Article

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