Early onset MSI-H colon cancer with MLH1 promoter methylation, is there a genetic predisposition?

BMC Cancer

Volumn 10, Issue , 2010, Pages

  van Roon, Eddy H J ^a   van Puijenbroek, Marjo ^a   Middeldorp, Anneke ^a   van Eijk, Ronald ^a   de Meijer, Emile J ^a   Erasmus, Dianhdra ^a   Wouters, Kim A D ^b   van Engeland, Manon ^b   Oosting, Jan ^a   Hes, Frederik J ^a   Tops, Carli M J ^a   van Wezel, Tom ^a   Boer, Judith M ^a   Morreau, Hans ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; B RAF KINASE; DNA; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; GUANINE; K RAS PROTEIN; PROTEIN GADD45A; PROTEIN MLH1; TUMOR MARKER; UNCLASSIFIED DRUG; BRAF PROTEIN, HUMAN; CELL CYCLE PROTEIN; GADD45A PROTEIN, HUMAN; KRAS PROTEIN, HUMAN; MLH1 PROTEIN, HUMAN; NUCLEAR PROTEIN; ONCOPROTEIN; RAS PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ADULT; ARTICLE; CLINICAL ARTICLE; COHORT ANALYSIS; COLON CANCER; CONTROLLED STUDY; CPG ISLAND; FEMALE; GENE DOSAGE; GENE FREQUENCY; GENE LOCUS; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETIC VARIABILITY; GERM LINE; GROUPS BY AGE; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; HUMAN TISSUE; MICROSATELLITE INSTABILITY; MUTATIONAL ANALYSIS; ONSET AGE; PROMOTER REGION; PROTEIN METHYLATION; SINGLE NUCLEOTIDE POLYMORPHISM; SOMATIC MUTATION; AGE; AGED; CASE CONTROL STUDY; CHI SQUARE DISTRIBUTION; COLON TUMOR; DNA METHYLATION; DNA MICROARRAY; GENETIC POLYMORPHISM; GENETICS; MIDDLE AGED; MISMATCH REPAIR; MUTATION; NUCLEOTIDE SEQUENCE; RISK FACTOR;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; CELL CYCLE PROTEINS; CHI-SQUARE DISTRIBUTION; COLONIC NEOPLASMS; CPG ISLANDS; DNA METHYLATION; DNA MISMATCH REPAIR; DNA MUTATIONAL ANALYSIS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LOSS OF HETEROZYGOSITY; MICROSATELLITE INSTABILITY; MIDDLE AGED; MUTATION; NUCLEAR PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS B-RAF; RAS PROTEINS; RISK FACTORS;

EID: 77951844096     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-10-180     Document Type: Article

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