Quantitative evaluation of CpG island methylation in hyperplastic polyps

Modern Pathology

Volumn 23, Issue 1, 2010, Pages 151-156

  Vaughn, Cecily P ^a   Wilson, Andrew R ^a   Samowitz, Wade S ^a,b  

^a ARUP INSTITUTE FOR CLINICAL AND EXPERIMENTAL PATHOLOGY   (United States)

^b ARUP LABORATORIES   (United States)

Author keywords

CpG island methylator phenotype; Hyperplastic polyp; MLH1; Promoter methylation

Indexed keywords

B RAF KINASE; PROTEIN MLH1;

ARTICLE; CLINICAL ARTICLE; COLON CANCER; COLON POLYP; CPG ISLAND; GENE MUTATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; METHYLATION; MICROSATELLITE MARKER; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; COLONIC NEOPLASMS; COLONIC POLYPS; CPG ISLANDS; DNA METHYLATION; HUMANS; HYPERPLASIA; IMMUNOHISTOCHEMISTRY; NUCLEAR PROTEINS; PRECANCEROUS CONDITIONS; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS B-RAF; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 73949134204     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2009.150     Document Type: Article

References (28)

1. Jass JR. Pathogenesis of colorectal cancer. Surg Clin North Am 2002;82:891-904.
2. Hawkins NJ, Ward RL. Sporadic colorectal cancers with microsatellite instability and their possible origin in hyperplastic polyps and serrated adenomas. J Natl Cancer Inst 2001;93:1307-1313.
3. Smyrk TC. Colon cancer connections. Cancer syndrome meets molecular biology meets histopathology. Am J Pathol 1994;145:1-6.
4. Samowitz WS, Albertsen H, Herrick J, et al. Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer. Gastro-enterology 2005;129:837-845.
5. Weisenberger DJ, Siegmund KD, Campan M, et al. CpG island methylator phenotype underlies sporadic mi-crosatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nat Genet 2006;38:787-793.
6. Miyakura Y, Sugano K, Konishi F, et al. Extensive methylation of hMLH1 promoter region predominates in proximal colon cancer with microsatellite instability. Gastroenterology 2001;121:1300-1309.
7. Kim YH, Kakar S, Cun L, et al. Distinct CpG island methylation profiles and BRAF mutation status in serrated and adenomatous colorectal polyps. Int J Cancer 2008;123:2587-2593.
8. O'Brien MJ, Yang S, Clebanoff JL, et al. Hyperplastic (serrated) polyps of the colorectum: relationship of CpG island methylator phenotype and K-ras mutation to location and histologic subtype. Am J Surg Pathol 2004;28:423-434.
9. O'Brien MJ, Yang S, Mack C, et al. Comparison of microsatellite instability, CpG island methylation phenotype, BRAF and KRAS status in serrated polyps and traditional adenomas indicates separate pathways to distinct colorectal carcinoma end points. Am J Surg Pathol 2006;30:1491-1501.
10. Velho S, Moutinho C, Cirnes L, et al. BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: primary or secondary genetic events in color-ectal carcinogenesis? BMC Cancer 2008;8:255.
11. Yang S, Farraye FA, Mack C, et al. BRAF and KRAS Mutations in hyperplastic polyps and serrated adenomas of the colorectum: relationship to histology and CpG island methylation status. Am J Surg Pathol 2004;28:1452-1459.
12. Sheridan TB, Fenton H, Lewin MR, et al. Sessile serrated adenomas with low-and high-grade dysplasia and early carcinomas: an immunohistochemical study of serrated lesions 'caught in the act'. Am J Clin Pathol 2006;126:564-571.
13. Eads CA, Danenberg KD, Kawakami K, et al. Methy-Light: a high-throughput assay to measure DNA methylation. Nucleic Acids Res 2000;28:E32.
14. Eads CA, Lord RV, Wickramasinghe K, et al. Epigenetic patterns in the progression of esophageal adenocarci-noma. Cancer Res 2001;61:3410-3418.
15. Ogino S, Kawasaki T, Brahmandam M, et al. Precision and performance characteristics of bisulfite conversion and real-time PCR (MethyLight) for quantitative DNA methylation analysis. J Mol Diagn 2006;8:209-217.
16. Widschwendter M, Siegmund KD, Muller HM, et al. Association of breast cancer DNA methylation profiles with hormone receptor status and response to tamox-ifen. Cancer Res 2004;64:3807-3813.
17. Ogino S, Nosho K, Kirkner GJ, et al. CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer. Gut 2009;58:90-96.
18. Torlakovic E, Skovlund E, Snover DC, et al. Morphologic reappraisal of serrated colorectal polyps. Am J Surg Pathol 2003;27:65-81.
19. Ferrandez A, Pho L, Solomon C, et al. An evidence-based, multidisciplinary approach to the clinical considerations, management, and surveillance of adrenal lesions in familial adenomatous polyposis: report of three cases. Dis Colon Rectum 2006;49: 1781-1790.
20. Spirio LN, Samowitz W, Robertson J, et al. Alleles of APC modulate the frequency and classes of mutations that lead to colon polyps. Nat Genet 1998;20:385-388.
21. Tripp SR, Gedge FEH, Lyon E, et al. Microsatellite instability testing by immunohistochemistry: initial evaluation of hereditary nonpolyposis colon cancer and potential prognostic and therapeutic information. J Histotechnol 2004;27:169-172.
22. Herman JG, Graff JR, Myohanen S, et al. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA 1996;93:9821-9826.
23. Ogino S, Cantor M, Kawasaki T, et al. CpG island methylator phenotype (CIMP) of colorectal cancer is best characterised by quantitative DNA methylation analysis and prospective cohort studies. Gut 2006;55:1000-1006. (Pubitemid 43962613)
24. McGivern A, Wynter CV, Whitehall VL, et al. Promoter hypermethylation frequency and BRAF mutations distinguish hereditary non-polyposis colon cancer from sporadic MSI-H colon cancer. Fam Cancer 2004;3:101-107.
25. Halvarsson B, Lindblom A, Johansson L, et al. Loss of mismatch repair protein immunostaining in colorectal adenomas from patients with hereditary nonpolyposis colorectal cancer. Mod Pathol 2005;18:1095-1101.
26. Rijcken FE, Hollema H, Kleibeuker JH. Proximal adenomas in hereditary non-polyposis colorectal cancer are prone to rapid malignant transformation. Gut 2002;50:382-386.
27. Farris AB, Misdraji J, Srivastava A, et al. Sessile serrated adenoma: challenging discrimination from other serrated colonic polyps. Am J Surg Pathol 2008; 32:30-35.
28. Goldstein NS. Serrated pathway and APC (conven-tional)-type colorectal polyps: molecular-morphologic correlations, genetic pathways, and implications for classification. Am J Clin Pathol 2006;125:146-153.