-
1
-
-
84875953344
-
Dietary (poly)phenolics in human health: Structures, bioavailability, and evidence of protective effects against chronic diseases
-
Del Rio, D. et al. Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases. Antioxid. Redox Signal. 18, 1818-92 (2013).
-
(2013)
Antioxid. Redox Signal
, vol.18
, pp. 1818-1892
-
-
Del Rio, D.1
-
2
-
-
14644438499
-
Grape seed procyanidins improve atherosclerotic risk index and induce liver CYP7A1 and SHP expression in healthy rats
-
Del Bas, J. M. et al. Grape seed procyanidins improve atherosclerotic risk index and induce liver CYP7A1 and SHP expression in healthy rats. FASEB J. 19, 479-81 (2005).
-
(2005)
FASEB J
, vol.19
, pp. 479-481
-
-
Del Bas, J.M.1
-
3
-
-
33748521562
-
Procyanidin Effects on Adipocyte-Related Pathologies
-
Pinent, M. et al. Procyanidin Effects on Adipocyte-Related Pathologies. Crit. Rev. Food Sci. Nutr. 46, 543-550 (2006).
-
(2006)
Crit. Rev. Food Sci. Nutr
, vol.46
, pp. 543-550
-
-
Pinent, M.1
-
4
-
-
70349119490
-
Grape seed proanthocyanidins correct dyslipidemia associated with a high-fat diet in rats and repress genes controlling lipogenesis and VLDL assembling in liver
-
Quesada, H. et al. Grape seed proanthocyanidins correct dyslipidemia associated with a high-fat diet in rats and repress genes controlling lipogenesis and VLDL assembling in liver. Int. J. Obes. (Lond). 33, 1007-12 (2009).
-
(2009)
Int. J. Obes. (Lond)
, vol.33
, pp. 1007-1012
-
-
Quesada, H.1
-
5
-
-
79952538203
-
Modulatory effect of grape-seed procyanidins on local and systemic inflammation in diet-induced obesity rats
-
Terra, X. et al. Modulatory effect of grape-seed procyanidins on local and systemic inflammation in diet-induced obesity rats. J. Nutr. Biochem. 22, 380-7 (2011).
-
(2011)
J. Nutr. Biochem
, vol.22
, pp. 380-387
-
-
Terra, X.1
-
6
-
-
84876181430
-
Low doses of grape seed procyanidins reduce adiposity and improve the plasma lipid profile in hamsters
-
Caimari, A., del Bas, J. M., Crescenti, A. & Arola, L. Low doses of grape seed procyanidins reduce adiposity and improve the plasma lipid profile in hamsters. Int. J. Obes. 37, 576-583 (2012).
-
(2012)
Int. J. Obes
, vol.37
, pp. 576-583
-
-
Caimari, A.1
Del Bas, J.M.2
Crescenti, A.3
Arola, L.4
-
7
-
-
84959085988
-
Acute administration of single oral dose of grape seed polyphenols restores blood pressure in a rat model of metabolic syndrome: Role of nitric oxide and prostacyclin
-
Pons, Z., Margalef, M., Bravo, F. I., Arola-Arnal, A. & Muguerza, B. Acute administration of single oral dose of grape seed polyphenols restores blood pressure in a rat model of metabolic syndrome: role of nitric oxide and prostacyclin. Eur. J. Nutr. 55, 749-58 (2015).
-
(2015)
Eur. J. Nutr
, vol.55
, pp. 749-758
-
-
Pons, Z.1
Margalef, M.2
Bravo, F.I.3
Arola-Arnal, A.4
Muguerza, B.5
-
8
-
-
77954749598
-
Lipogenesis is decreased by grape seed proanthocyanidins according to liver proteomics of rats fed a high fat diet
-
Baiges, I., Palmfeldt, J., Bladé, C., Gregersen, N. & Arola, L. Lipogenesis is decreased by grape seed proanthocyanidins according to liver proteomics of rats fed a high fat diet. Mol. Cell. Proteomics 9, 1499-513 (2010).
-
(2010)
Mol. Cell. Proteomics
, vol.9
, pp. 1499-1513
-
-
Baiges, I.1
Palmfeldt, J.2
Bladé, C.3
Gregersen, N.4
Arola, L.5
-
9
-
-
84908595514
-
Grape seed proanthocyanidin rescues rats from steatosis: A comparative and combination study with metformin
-
Yogalakshmi, B., Sreeja, S., Geetha, R., Radika, M. K. & Anuradha, C. V. Grape seed proanthocyanidin rescues rats from steatosis: a comparative and combination study with metformin. J. Lipids 2013, 153897 (2013).
-
(2013)
J. Lipids
, vol.2013
-
-
Yogalakshmi, B.1
Sreeja, S.2
Geetha, R.3
Radika, M.K.4
Anuradha, C.V.5
-
10
-
-
84897083367
-
Grape seed proanthocyanidin extract improves the hepatic glutathione metabolism in obese Zucker rats
-
Fernández-Iglesias, A. et al. Grape seed proanthocyanidin extract improves the hepatic glutathione metabolism in obese Zucker rats. Mol. Nutr. Food Res. 58, 727-37 (2014).
-
(2014)
Mol. Nutr. Food Res
, vol.58
, pp. 727-737
-
-
Fernández-Iglesias, A.1
-
11
-
-
68149123902
-
Dietary procyanidins enhance transcriptional activity of bile acid-activated FXR in vitro and reduce triglyceridemia in vivo in a FXR-dependent manner
-
Del Bas, J. M. et al. Dietary procyanidins enhance transcriptional activity of bile acid-activated FXR in vitro and reduce triglyceridemia in vivo in a FXR-dependent manner. Mol. Nutr. Food Res. 53, 805-14 (2009).
-
(2009)
Mol. Nutr. Food Res
, vol.53
, pp. 805-814
-
-
Del Bas, J.M.1
-
12
-
-
84892538136
-
Chronic supplementation of proanthocyanidins reduces postprandial lipemia and liver MIR-33a and MIR-122 levels in a dose-dependent manner in healthy rats
-
Baselga-Escudero, L. et al. Chronic supplementation of proanthocyanidins reduces postprandial lipemia and liver miR-33a and miR-122 levels in a dose-dependent manner in healthy rats. J. Nutr. Biochem. 25, 151-6 (2014).
-
(2014)
J. Nutr. Biochem
, vol.25
, pp. 151-156
-
-
Baselga-Escudero, L.1
-
13
-
-
84893225831
-
Resveratrol and EGCG bind directly and distinctively to MIR-33a and MIR-122 and modulate divergently their levels in hepatic cells
-
Baselga-Escudero, L. et al. Resveratrol and EGCG bind directly and distinctively to miR-33a and miR-122 and modulate divergently their levels in hepatic cells. Nucleic Acids Res. 42, 882-92 (2014).
-
(2014)
Nucleic Acids Res
, vol.42
, pp. 882-892
-
-
Baselga-Escudero, L.1
-
14
-
-
84887981047
-
Epigenetic and disease targets by polyphenols
-
Pan, M.-H., Lai, C.-S., Wu, J.-C. & Ho, C.-T. Epigenetic and disease targets by polyphenols. Curr. Pharm. Des. 19, 6156-85 (2013).
-
(2013)
Curr. Pharm. des
, vol.19
, pp. 6156-6185
-
-
Pan, M.-H.1
Lai, C.-S.2
Wu, J.-C.3
Ho, C.-T.4
-
15
-
-
84858790233
-
Metabolomics: The apogee of the omics trilogy
-
Patti, G. J., Yanes, O. & Siuzdak, G. Innovation: Metabolomics: the apogee of the omics trilogy. Nat. Rev. Mol. Cell Biol. 13, 263-9 (2012).
-
(2012)
Nat. Rev. Mol. Cell Biol
, vol.13
, pp. 263-269
-
-
Patti, G.J.1
Yanes, O.2
Innovation, S.G.3
-
16
-
-
77952013674
-
Metabolomic assessment of the effect of dietary cholesterol in the progressive development of fatty liver disease
-
Vinaixa, M. et al. Metabolomic assessment of the effect of dietary cholesterol in the progressive development of fatty liver disease. J. Proteome Res. 9, 2527-38 (2010).
-
(2010)
J. Proteome Res
, vol.9
, pp. 2527-2538
-
-
Vinaixa, M.1
-
17
-
-
67649424750
-
Metabolic phenotyping of genetically modified mice: An NMR metabonomic approach
-
Rull, A. et al. Metabolic phenotyping of genetically modified mice: An NMR metabonomic approach. Biochimie 91, 1053-7 (2009).
-
(2009)
Biochimie
, vol.91
, pp. 1053-1057
-
-
Rull, A.1
-
18
-
-
84896761468
-
Rosiglitazone and fenofibrate exacerbate liver steatosis in a mouse model of obesity and hyperlipidemia. A transcriptomic and metabolomic study
-
Rull, A. et al. Rosiglitazone and fenofibrate exacerbate liver steatosis in a mouse model of obesity and hyperlipidemia. A transcriptomic and metabolomic study. J. Proteome Res. 13, 1731-43 (2014).
-
(2014)
J. Proteome Res
, vol.13
, pp. 1731-1743
-
-
Rull, A.1
-
19
-
-
68149164116
-
Challenging homeostasis to define biomarkers for nutrition related health
-
van Ommen, B., Keijer, J., Heil, S. G. & Kaput, J. Challenging homeostasis to define biomarkers for nutrition related health. Mol. Nutr. Food Res. 53, 795-804 (2009).
-
(2009)
Mol. Nutr. Food Res
, vol.53
, pp. 795-804
-
-
Van Ommen, B.1
Keijer, J.2
Heil, S.G.3
Kaput, J.4
-
20
-
-
41849128523
-
The FoxO code
-
Calnan, D. R. & Brunet, A. The FoxO code. Oncogene 27, 2276-88 (2008).
-
(2008)
Oncogene
, vol.27
, pp. 2276-2288
-
-
Calnan, D.R.1
Brunet, A.2
-
21
-
-
33244486764
-
Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells
-
Bordone, L. et al. Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. PLoS Biol. 4, e31 (2006).
-
(2006)
PLoS Biol
, vol.4
, pp. e31
-
-
Bordone, L.1
-
23
-
-
84937522438
-
NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus
-
Cantó, C., Menzies, K. J. & Auwerx, J. NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus. Cell Metab. 22, 31-53 (2015).
-
(2015)
Cell Metab
, vol.22
, pp. 31-53
-
-
Cantó, C.1
Menzies, K.J.2
Auwerx, J.3
-
24
-
-
77249156847
-
Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle
-
Cantó, C. et al. Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle. Cell Metab. 11, 213-9 (2010).
-
(2010)
Cell Metab
, vol.11
, pp. 213-219
-
-
Cantó, C.1
-
25
-
-
46249100836
-
Tissue-specific regulation of SIRT1 by calorie restriction
-
Chen, D. et al. Tissue-specific regulation of SIRT1 by calorie restriction. Genes Dev. 22, 1753-7 (2008).
-
(2008)
Genes Dev
, vol.22
, pp. 1753-1757
-
-
Chen, D.1
-
26
-
-
79957557182
-
Dissecting systemic control of metabolism and aging in the NAD World: The importance of SIRT1 and NAMPT-mediated NAD biosynthesis
-
Imai, S. Dissecting systemic control of metabolism and aging in the NAD World: the importance of SIRT1 and NAMPT-mediated NAD biosynthesis. FEBS Lett. 585, 1657-62 (2011).
-
(2011)
FEBS Lett
, vol.585
, pp. 1657-1662
-
-
Imai, S.1
-
27
-
-
84912572145
-
Metabolic profiling of alternative NAD biosynthetic routes in mouse tissues
-
Mori, V. et al. Metabolic profiling of alternative NAD biosynthetic routes in mouse tissues. PLos One 9, e113939 (2014).
-
(2014)
PLos One
, vol.9
-
-
Mori, V.1
-
28
-
-
0037160097
-
Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1
-
Bitterman, K. J., Anderson, R. M., Cohen, H. Y., Latorre-Esteves, M. & Sinclair, D. A. Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1. J. Biol. Chem. 277, 45099-107 (2002).
-
(2002)
J. Biol. Chem
, vol.277
, pp. 45099-45107
-
-
Bitterman, K.J.1
Anderson, R.M.2
Cohen, H.Y.3
Latorre-Esteves, M.4
Sinclair, D.A.5
-
29
-
-
79953752384
-
PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation
-
Bai, P. et al. PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation. Cell Metab. 13, 461-8 (2011).
-
(2011)
Cell Metab
, vol.13
, pp. 461-468
-
-
Bai, P.1
-
30
-
-
36049038217
-
The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet-induced obesity
-
Barbosa, M. T. P. et al. The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet-induced obesity. FASEB J. 21, 3629-39 (2007).
-
(2007)
FASEB J
, vol.21
, pp. 3629-3639
-
-
Barbosa, M.T.P.1
-
31
-
-
0242496900
-
Transcriptional coactivation of nuclear factor-kappaB-dependent gene expression by p300 is regulated by poly(ADP)-ribose polymerase-1
-
Hassa, P. O., Buerki, C., Lombardi, C., Imhof, R. & Hottiger, M. O. Transcriptional coactivation of nuclear factor-kappaB-dependent gene expression by p300 is regulated by poly(ADP)-ribose polymerase-1. J. Biol. Chem. 278, 45145-53 (2003).
-
(2003)
J. Biol. Chem
, vol.278
, pp. 45145-45153
-
-
Hassa, P.O.1
Buerki, C.2
Lombardi, C.3
Imhof, R.4
Hottiger, M.O.5
-
32
-
-
3242719545
-
Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase
-
Yeung, F. et al. Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J. 23, 2369-80 (2004).
-
(2004)
EMBO J
, vol.23
, pp. 2369-2380
-
-
Yeung, F.1
-
33
-
-
67651210858
-
SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1
-
Rajamohan, S. B. et al. SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1. Mol. Cell. Biol. 29, 4116-29 (2009).
-
(2009)
Mol. Cell. Biol
, vol.29
, pp. 4116-4129
-
-
Rajamohan, S.B.1
-
34
-
-
33751072349
-
Resveratrol improves health and survival of mice on a high-calorie diet
-
Baur, J. A. et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444, 337-42 (2006).
-
(2006)
Nature
, vol.444
, pp. 337-342
-
-
Baur, J.A.1
-
35
-
-
20444431507
-
Substrate-specific activation of sirtuins by resveratrol
-
Kaeberlein, M. et al. Substrate-specific activation of sirtuins by resveratrol. J. Biol. Chem. 280, 17038-45 (2005).
-
(2005)
J. Biol. Chem
, vol.280
, pp. 17038-17045
-
-
Kaeberlein, M.1
-
36
-
-
77950246109
-
SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1
-
Pacholec, M. et al. SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. J. Biol. Chem. 285, 8340-51 (2010).
-
(2010)
J. Biol. Chem
, vol.285
, pp. 8340-8351
-
-
Pacholec, M.1
-
37
-
-
70350524083
-
Resveratrol is not a direct activator of SIRT1 enzyme activity
-
Beher, D. et al. Resveratrol is not a direct activator of SIRT1 enzyme activity. Chem. Biol. Drug Des. 74, 619-24 (2009).
-
(2009)
Chem. Biol. Drug des
, vol.74
, pp. 619-624
-
-
Beher, D.1
-
38
-
-
33646550204
-
SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis
-
Vaquero, A. et al. SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis. Genes Dev. 20, 1256-61 (2006).
-
(2006)
Genes Dev
, vol.20
, pp. 1256-1261
-
-
Vaquero, A.1
-
39
-
-
37549002891
-
Mammalian Sir2 Homolog SIRT3 Regulates Global Mitochondrial Lysine Acetylation
-
Lombard, D. B. et al. Mammalian Sir2 Homolog SIRT3 Regulates Global Mitochondrial Lysine Acetylation. Mol. Cell. Biol. 27, 8807-8814 (2007).
-
(2007)
Mol. Cell. Biol
, vol.27
, pp. 8807-8814
-
-
Lombard, D.B.1
-
40
-
-
84895127938
-
SIRT1 metabolic actions: Integrating recent advances from mouse models
-
Boutant, M. & Cantó, C. SIRT1 metabolic actions: Integrating recent advances from mouse models. Mol. Metab. 3, 5-18 (2014).
-
(2014)
Mol. Metab
, vol.3
, pp. 5-18
-
-
Boutant, M.1
Cantó, C.2
-
41
-
-
77954515012
-
Lack of SIRT1 (Mammalian Sirtuin 1) activity leads to liver steatosis in the SIRT1+ /- mice: A role of lipid mobilization and inflammation
-
Xu, F. et al. Lack of SIRT1 (Mammalian Sirtuin 1) activity leads to liver steatosis in the SIRT1+ /- mice: a role of lipid mobilization and inflammation. Endocrinology 151, 2504-14 (2010).
-
(2010)
Endocrinology
, vol.151
, pp. 2504-2514
-
-
Xu, F.1
-
42
-
-
63449112017
-
Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation
-
Purushotham, A. et al. Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. Cell Metab. 9, 327-38 (2009).
-
(2009)
Cell Metab
, vol.9
, pp. 327-338
-
-
Purushotham, A.1
-
43
-
-
79955661493
-
Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver
-
Li, Y. et al. Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver. FASEB J. 25, 1664-79 (2011).
-
(2011)
FASEB J
, vol.25
, pp. 1664-1679
-
-
Li, Y.1
-
44
-
-
40449086665
-
Dose translation from animal to human studies revisited
-
Reagan-Shaw, S., Nihal, M. & Ahmad, N. Dose translation from animal to human studies revisited. FASEB J. 22, 659-61 (2008).
-
(2008)
FASEB J
, vol.22
, pp. 659-661
-
-
Reagan-Shaw, S.1
Nihal, M.2
Ahmad, N.3
-
45
-
-
84873926187
-
Low-molecular procyanidin rich grape seed extract exerts antihypertensive effect in males spontaneously hypertensive rats
-
Quiñones, M. et al. Low-molecular procyanidin rich grape seed extract exerts antihypertensive effect in males spontaneously hypertensive rats. Food Res. Int. 51, 587-595 (2013).
-
(2013)
Food Res. Int
, vol.51
, pp. 587-595
-
-
Quiñones, M.1
-
46
-
-
23744497733
-
Grape seed procyanidins prevent oxidative injury by modulating the expression of antioxidant enzyme systems
-
Puiggros, F. et al. Grape seed procyanidins prevent oxidative injury by modulating the expression of antioxidant enzyme systems. J. Agric. Food Chem. 53, 6080-6 (2005).
-
(2005)
J. Agric. Food Chem
, vol.53
, pp. 6080-6086
-
-
Puiggros, F.1
-
47
-
-
80053607424
-
Proanthocyanidins modulate microRNA expression in human HepG2 cells
-
Arola-Arnal, A. & Bladé, C. Proanthocyanidins modulate microRNA expression in human HepG2 cells. PLos One 6, e25982 (2011).
-
(2011)
PLos One
, vol.6
-
-
Arola-Arnal, A.1
Bladé, C.2
-
48
-
-
38149029234
-
Grape seed procyanidins inhibit the expression of metallothione in genes in human HepG2 cells
-
Quesada, I. M. et al. Grape seed procyanidins inhibit the expression of metallothione in genes in human HepG2 cells. Genes Nutr. 2, 105-109 (2007).
-
(2007)
Genes Nutr
, vol.2
, pp. 105-109
-
-
Quesada, I.M.1
-
49
-
-
84922496642
-
Dietary proanthocyanidins modulate the rhythm of BMAL1 expression and induce RORα transactivation in HepG2 cells
-
Ribas-Latre, A., Del Bas, J. M., Baselga-Escudero, L., Casanova, E., Arola-Arnal, A., Salvadó, M. J. & Bladé, C. L. A. Dietary proanthocyanidins modulate the rhythm of BMAL1 expression and induce RORα transactivation in HepG2 cells. J. Funct. Foods 13, 336-344 (2015).
-
(2015)
J. Funct. Foods
, vol.13
, pp. 336-344
-
-
Ribas-Latre, A.1
Del Bas, J.M.2
Baselga-Escudero, L.3
Casanova, E.4
Arola-Arnal, A.5
Salvadó, M.J.6
Bladé, C.L.A.7
-
50
-
-
0035710746
-
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
-
Livak, K. J. & Schmittgen, T. D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25, 402-8 (2001).
-
(2001)
Methods
, vol.25
, pp. 402-408
-
-
Livak, K.J.1
Schmittgen, T.D.2
-
51
-
-
84862891482
-
SIRT1 modulates MAPK pathways in ischemic-reperfused cardiomyocytes
-
Becatti, M. et al. SIRT1 modulates MAPK pathways in ischemic-reperfused cardiomyocytes. Cell. Mol. Life Sci. 69, 2245-60 (2012).
-
(2012)
Cell. Mol. Life Sci
, vol.69
, pp. 2245-2260
-
-
Becatti, M.1
-
52
-
-
70449158340
-
A simple method for the isolation and purification of total lipides from animal tissues
-
Folch, J., Lees, M. & Sloane Stanley, G. H. A simple method for the isolation and purification of total lipides from animal tissues. J. Biol. Chem. 226, 497-509 (1957).
-
(1957)
J. Biol. Chem
, vol.226
, pp. 497-509
-
-
Folch, J.1
Lees, M.2
Sloane Stanley, G.H.3
|