Proanthocyanidins modulate microRNA expression in human HepG2 cells

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Arola Arnal, Anna ^a,b   Bladé, Cinta ^a  

^a UNIVERSITAT ROVIRA I VIRGILI   (Spain)

^b Centre Tecnologic de Nutrició i Salut CTNS   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

COCOA EXTRACT; EPIGALLOCATECHIN GALLATE; GRAPE SEED EXTRACT; MICRORNA; MICRORNA 1224 3P; MICRORNA 197; MICRORNA 30B; MICRORNA 532 3P; PLANT EXTRACT; PROANTHOCYANIDIN DERIVATIVE; UNCLASSIFIED DRUG; CATECHIN; DRUG DERIVATIVE; INSULIN; PROANTHOCYANIDIN; TRANSCRIPTOME;

ARTICLE; CACAO; CELL STRAIN HEPG2; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; HUMAN; HUMAN CELL; MICROARRAY ANALYSIS; POLYMERASE CHAIN REACTION; TEA; BIOLOGY; DRUG EFFECT; GENETICS; INFLAMMATION; LIPID METABOLISM; LIVER CELL; METABOLISM; OXIDATIVE STRESS; REPRODUCIBILITY; SIGNAL TRANSDUCTION;

THEOBROMA CACAO; VITACEAE;

CATECHIN; COMPUTATIONAL BIOLOGY; HEP G2 CELLS; HEPATOCYTES; HUMANS; INFLAMMATION; INSULIN; LIPID METABOLISM; MICRORNAS; OXIDATIVE STRESS; PROANTHOCYANIDINS; REPRODUCIBILITY OF RESULTS; SIGNAL TRANSDUCTION; TRANSCRIPTOME;

EID: 80053607424     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0025982     Document Type: Article

References (37)

1. Bartel DP, (2009) MicroRNAs: Target Recognition and Regulatory Functions. Cell 136: 215-233.
2. Lim LP, Lau NC, Garrett-Engele P, Grimson A, Schelter JM, et al. (2005) Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature 433: 769-773.
3. Pillai RS, Bhattacharyya SN, Filipowicz W, (2007) Repression of protein synthesis by miRNAs: how many mechanisms? Trends Cell Biol 17: 118-126.
4. Lewis BP, Burge CB, Bartel DP, (2005) Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets. Cell 120: 15-20.
5. Krutzfeldt J, Rajewsky N, Braich R, Rajeev KG, Tuschl T, et al. (2005) Silencing of microRNAs in vivo with/'antagomirs/'. Nature 438: 685-689.
6. Krützfeldt J, Stoffel M, (2006) MicroRNAs: A new class of regulatory genes affecting metabolism. Cell Metabolism 4: 9-12.
7. Esau CC, Monia BP, (2007) Therapeutic potential for microRNAs. Adv Drug Deliv Rev 59: 101-114.
8. Alvarez-Garcia I, Miska EA, (2005) MicroRNA functions in animal development and human disease. Development 132: 4653-4662.
9. Chiba Y, Hijikata T, (2010) MicroRNAs and Their Therapeutic Potential for Human Diseases: Preface. J Pharmacol-Sci 114: 262-263.
10. Qin S, Zhang C, (2011) MicroRNAs in vascular disease. J Cardiovasc Pharmacol 57: 8-12.
11. Farazi TA, Spitzer JI, Morozov P, Tuschl T, (2011) miRNAs in human cancer. J Pathol 223: 102-115.
12. Chen J, Xu X, (2010) Diet, epigenetic, and cancer prevention. Adv Genet 71: 237-255.
13. Link A, Balaguer F, Goel A, (2010) Cancer chemoprevention by dietary polyphenols: Promising role for epigenetics. Biochem Pharmacol 80: 1771-1792.
14. Tsang WP, Kwok TT, (2010) Epigallocatechin gallate up-regulation of miR-16 and induction of apoptosis in human cancer cells. J Nutr Biochem 21: 140-146.
15. Crozier A, Jaganath IB, Clifford MN, (2009) Dietary phenolics: chemistry, bioavailability and effects on health. Nat Prod Rep 26: 1001-1043.
16. USDA website. USDA database for the flavonoid content of selected foods. Available: http://www.nal.usda.gov/fnic/foodcomp/Data/Flav/flav.pdf. Accessed 2011 June 10.
17. Serrano J, Puupponen-Pimiä R, Dauer A, Aura A-M, Saura-Calixto F, (2009) Tannins: Current knowledge of food sources, intake, bioavailability and biological effects. Mol Nutr Food Res 53: S310-S329.
18. Bladé C, Arola L, Salvadó M-J, (2010) Hypolipidemic effects of proanthocyanidins and their underlying biochemical and molecular mechanisms. Mol Nutr Food Res 54: 37-59.
19. Nandakumar V, Singh T, Katiyar S, (2008) Multi-targeted prevention and therapy of cancer by proanthocyanidins. Cancer Lett 269: 378-387.
20. Serra A, Macià A, Romero M-P, Valls J, Bladé C, et al. (2010) Bioavailability of procyanidin dimers and trimers and matrix food effects in in vitro and in vivo models. Br J Nutr 103: 944-952.
21. Ortega Nd, Romero M-P, Macia A, Reguant J, Angles N, et al. (2008) Obtention and Characterization of Phenolic Extracts from Different Cocoa Sources. J Agric Food Chem 56: 9621-9627.
22. Nakai M, Fukui Y, Asami S, Toyoda-Ono Y, Iwashita T, et al. (2005) Inhibitory Effects of Oolong Tea Polyphenols on Pancreatic Lipase in Vitro. J Agric Food Chem 53: 4593-4598.
23. Kobayashi M, Ichitani M, Suzuki Y, Unno T, Sugawara T, et al. (2009) Black-Tea Polyphenols Suppress Postprandial Hypertriacylglycerolemia by Suppressing Lymphatic Transport of Dietary Fat in Rats. J Agric Food Chem 57: 7131-7136.
24. Iglesias J, Pazos M, Lois S, Medina I, (2010) Contribution of Galloylation and Polymerization to the Antioxidant Activity of Polyphenols in Fish Lipid Systems. J Agric Food Chem 58: 7423-7431.
25. García-Ramírez B, Fernandez-Larrea J, Salvadó M, Ardèvol A, Arola L, et al. (2006) Tetramethylated dimeric procyanidins are detected in rat plasma and liver early after oral administration of synthetic oligomeric procyanidins. J Agric Food Chem 54: 2543-2551.
26. Del Bas JM, Fernandez-Larrea J, Blay M, Ardevol A, Salvado MJ, et al. (2005) Grape seed procyanidins improve atherosclerotic risk index and induce liver CYP7A1 and SHP expression in healthy rats. FASEB J 19: 479-481.
27. De Bruyne T, Pieters L, Deelstra H, Vlietinck AJ, (1999) Condensed vegetable tannins: Biodiversity in structure and biological activities. Biochem Syst Ecol 27: 445-459.
28. Counet C, Collin S, (2003) Effect of the Number of Flavanol Units on the Antioxidant Activity of Procyanidin Fractions Isolated from Chocolate. J Agric Food Chem 51: 6816-6822.
29. Montagut G, Isabel B, Josep V, Ximena T, M dBJ, et al. (2009) A trimer plus a dimer-gallate reproduce the bioactivity described for an extract of grape seed procyanidins. Food Chem 116: 265-270.
30. Montagut G, Onnockx S, Vaqué M, Bladé C, Blay M, et al. (2010) Oligomers of grape-seed procyanidin extract activate the insulin receptor and key targets of the insulin signaling pathway differently from insulin. J Nutr Biochem 21: 476-481.
31. Terra X, Palozza P, Fernandez-Larrea J, Ardevol A, Blade C, et al. (2011) Procyanidin dimer B1 and trimer C1 impair inflammatory response signalling in human monocytes. Free Radic Res 45: 611-619.
32. Terra X, Pallarés V, Ardèvol A, Bladé C, Fernández-Larrea J, et al. (2011) Modulatory effect of grape-seed procyanidins on local and systemic inflammation in diet-induced obesity rats. J Nutr Biochem 22: 380-387.
33. Puiggros F, Llopiz N, Ardevol A, Blade C, Arola L, et al. (2005) Grape Seed Procyanidins Prevent Oxidative Injury by Modulating the Expression of Antioxidant Enzyme Systems. J Agric Food Chem 53: 6080-6086.
34. Bas JMD, Ricketts ML, Baiges I, Quesada H, Ardevol A, et al. (2008) Dietary procyanidins lower triglyceride levels signaling through the nuclear receptor small heterodimer partner. Mol Nutr Food Res 52: 1172-1181.
35. Bas JMD, Ricketts M-L, Vaqué M, Sala E, Quesada H, et al. (2009) Dietary procyanidins enhance transcriptional activity of bile acid-activated FXR in vitro and reduce triglyceridemia in vivo in a FXR-dependent manner. Mol Nutr Food Res 53: 805-814.
36. Moore KJ, Rayner KJ, Suarez Y, Fernandez-Hernando C, (2011) The Role of MicroRNAs in Cholesterol Efflux and Hepatic Lipid Metabolism. doi:10.1146/annurev-nutr-081810-160756. Ann Rev Nutr 31.
37. Dorn C, Riener M, Kirovski G, MSaugspier, Steib K, et al. (2010) Expression of fatty acid synthase in nonalcoholic fatty liver disease. Int J Clin Exp Pathol 3: 505-514.