Metabolomics analysis of soy hydrolysates for the identification of productivity markers of mammalian cells for manufacturing therapeutic proteins

Biotechnology Progress

Volumn 31, Issue 2, 2015, Pages 522-531

  Richardson, Jason ^a   Shah, Bhavana ^a   Bondarenko, Pavel V ^a   Bhebe, Prince ^a   Zhang, Zhongqi ^a   Nicklaus, Michele ^a   Kombe, Maua C ^a  

^a AMGEN INC   (United States)

Author keywords

CHO cells; Mass spectrometry; Metabolomics; Ornithine; Peptone; Soy hydrolysate

Indexed keywords

ANIMAL CELL CULTURE; ANTIBODIES; CELL PROLIFERATION; DATA HANDLING; MAMMALS; MASS SPECTROMETRY; METABOLITES; PEPTIDES; PRODUCTIVITY; RECOMBINANT PROTEINS;

CHO CELL; METABOLOMICS; ORNITHINE; PEPTONE; SOY HYDROLYSATE;

AMINO ACIDS;

BACTERIA (MICROORGANISMS); CRICETULUS GRISEUS; MAMMALIA;

BIOLOGICAL MARKER; PROTEIN HYDROLYSATE; RECOMBINANT PROTEIN; SOYBEAN PROTEIN;

ANIMAL; BIOREACTOR; CELL SURVIVAL; CHO CELL LINE; CRICETULUS; HAMSTER; MASS SPECTROMETRY; METABOLISM; METABOLOME; METABOLOMICS; PHYSIOLOGY; PRINCIPAL COMPONENT ANALYSIS; PROCEDURES;

ANIMALS; BIOMARKERS; BIOREACTORS; CELL SURVIVAL; CHO CELLS; CRICETINAE; CRICETULUS; MASS SPECTROMETRY; METABOLOME; METABOLOMICS; PRINCIPAL COMPONENT ANALYSIS; PROTEIN HYDROLYSATES; RECOMBINANT PROTEINS; SOYBEAN PROTEINS;

EID: 84928215104     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.2050     Document Type: Article

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