Cytotoxic Effect of p-Coumaric Acid on Neuroblastoma, N2a Cell via Generation of Reactive Oxygen Species Leading to Dysfunction of Mitochondria Inducing Apoptosis and Autophagy

Molecular Neurobiology

Volumn 51, Issue 1, 2015, Pages 119-130

  Shailasree, S ^a   Venkataramana, M ^b   Niranjana, S R ^a   Prakash, H S ^a  

^a UNIVERSITY OF MYSORE   (India)

^b BHARATHIAR UNIVERSITY   (India)

Author keywords

Apoptosis; Autophagy; Caspase 8; LC3 II; Neuroblastoma N2a cells; p Coumaric acid; p53

Indexed keywords

4-COUMARIC ACID; BIOLOGICAL MARKER; CASPASE 8; COUMARIC ACID; CYTOCHROME C; DRUG TOXICITY; GLUTATHIONE; MAP1LC3 PROTEIN, MOUSE; MESSENGER RNA; MICROTUBULE ASSOCIATED PROTEIN; PARA COUMARIC ACID; PROTEIN P53; REACTIVE OXYGEN METABOLITE;

ANIMAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL LEVEL; CELL SHAPE; CELL STRUCTURE; CHEMISTRY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG EFFECTS; ENZYME RELEASE; ENZYMOLOGY; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENETICS; MEMBRANE POTENTIAL; METABOLISM; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; NEUROBLASTOMA; NEUROBLASTOMA CELL; NONHUMAN; PATHOLOGY; TUMOR CELL LINE; UPREGULATION;

ANIMALS; APOPTOSIS; AUTOPHAGY; BIOLOGICAL MARKERS; CASPASE 8; CELL LINE, TUMOR; CELL SHAPE; CHEMISTRY; COUMARIC ACIDS; CYTOCHROMES C; DRUG EFFECTS; ENZYMOLOGY; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETICS; GLUTATHIONE; MEMBRANE POTENTIAL, MITOCHONDRIAL; METABOLISM; MICE; MICROTUBULE-ASSOCIATED PROTEINS; MITOCHONDRIA; NEUROBLASTOMA; PATHOLOGY; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; TOXICITY; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 84964237311     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-014-8700-2     Document Type: Article

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