In vitro mammalian mutagenicity of complex polycyclic aromatic hydrocarbon mixtures in contaminated soils

Environmental Science and Technology

Volumn 49, Issue 3, 2015, Pages 1787-1796

  Lemieux, Christine L ^a   Long, Alexandra S ^a   Lambert, Iain B ^b   Lundstedt, Staffan ^c   Tysklind, Mats ^c   White, Paul A ^a  

^a HEALTH CANADA   (Canada)

^b CARLETON UNIVERSITY   (Canada)

^c UMEÅ UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC COMPOUNDS; AROMATIC HYDROCARBONS; AROMATIZATION; CONTAMINATION; MACHINERY; MAMMALS; METABOLISM; MIXTURES; RISK ASSESSMENT; RISK PERCEPTION; SOIL POLLUTION; SOILS;

AROMATIC FRACTION; ASSESSMENT PROTOCOLS; COMPETITIVE INHIBITION; CONTAMINATED SITES; CONTAMINATED SOILS; MIXTURE COMPONENTS; MUTAGENIC ACTIVITY; NEUTRAL FRACTIONS;

POLYCYCLIC AROMATIC HYDROCARBONS;

AROMATIC HYDROCARBON RECEPTOR; POLYCYCLIC AROMATIC HYDROCARBON;

BIOASSAY; MAMMAL; METABOLISM; MUTAGENICITY; PAH; RISK ASSESSMENT; SOIL POLLUTION;

ANIMAL CELL; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG MIXTURE; FRACTIONATION; IN VITRO STUDY; MAMMAL CELL; METABOLIC CAPACITY; MUTAGENIC ACTIVITY; MUTAGENICITY; NONHUMAN; RISK ASSESSMENT; SOIL POLLUTION;

MAMMALIA; RODENTIA;

EID: 84964197753     PISSN: 0013936X     EISSN: 15205851     Source Type: Journal    
DOI: 10.1021/es504465f     Document Type: Article

References (64)

1. IARC (International Agency for Research on Cancer). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 92: Some Non-Heteroycyclic Polycyclic Aromatic Hydrocarbons and Some Related Exposures; International Agency for Research on Cancer: Lyon, France, 2010.
2. Machala, M.; Vondráček, J.; Bláha, L.; Ciganek, M.; Neča, J. Aryl hydrocarbon receptor-mediated activity of mutagenic polycyclic aromatic hydrocarbons determined using in vitro reporter gene assay Mutat. Res. 2001, 497 (1-2) 49-62
3. IARC (International Agency for Research on Cancer). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 83: Tobacco Smoke and Involuntary Smoking; International Agency for Research on Cancer: Lyon, France, 2004.
4. Hale, R. C.; Aneiro, K. M. Determination of coal tar and creosote constituents in the aquatic environment J. Chromatogr., A 1997, 774 (1-2) 79-95
5. Haeseler, F.; Blanchet, D.; Druelle, V.; Werner, P.; Vandecasteele, J.-P. Analytical characterization of contaminated soils from former manufactured gas plants Environ. Sci. Technol. 1999, 33 (6) 825-830
6. Ahn, S.; Werner, D.; Luthy, R. Physicochemical characterization of coke-plant soil for the assessment of polycyclic aromatic hydrocarbon availability and the feasibility of phytoremediation Environ. Toxicol. Chem. 2005, 24, 2185-2195
7. Brooks, L. R.; Hughes, T. J.; Claxton, L. D.; Austern, B.; Brenner, R.; Kremer, F. Bioassay-directed fractionation and chemical identification of mutagens in bioremediated soils Environ. Health Perspect. 1998, 106 (Suppl 6) 1435-1440
8. Lemieux, C.; Lambert, I.; Lundstedt, S.; Tysklind, M.; White, P. Mutagenic hazards of complex polycyclic aromatic hydrocarbon mixtures in contaminated soil Environ. Toxicol. Chem. 2008, 27 (4) 978-990
9. Taylor, M. S.; Setzer, R. W.; DeMarini, D. M. Examination of the additivity assumption using the spiral and standard Salmonella assays to evaluate binary combinations of mutagens Mutat. Res. 1995, 335 (1) 1-14
10. White, P. A. The genotoxicity of priority polycyclic aromatic hydrocarbons in complex mixtures Mutat. Res. 2002, 515 (1-2) 85-98
11. Swartz, R.; Schults, D.; Ozretich, R.; Lamberson, J.; Cole, F.; DeWitt, T.; Redmond, M.; Ferraro, S. -PAH: A model to predict the toxicity of polynuclear aromatic hydrocarbons mixtures in field-collected sediments Environ. Toxicol. Chem. 1995, 14, 1977-1987
12. Tarantini, A.; Maitre, A.; Lefebvre, E.; Marques, M.; Marie, C.; Ravanat, J.-L.; Douki, T. Relative contribution of DNA strand breaks and DNA adducts to the genotoxicity of benzo[a]pyrene as a pure compound and in complex mixtures Mutat. Res. 2009, 671 (1-2) 67-75
13. Mahadevan, B.; Keshava, C.; Musafia-Jeknic, T.; Pecaj, A.; Weston, A.; Baird, W. M. Altered gene expression patterns in MCF-7 cells induced by the urban dust particulate complex mixture standard reference material 1649a Cancer Res. 2005, 65 (4) 1251-1258
14. Mahadevan, B.; Marston, C. P.; Luch, A.; Dashwood, W. M.; Brooks, E.; Pereira, C.; Doehmer, J.; Baird, W. M. Competitive inhibition of carcinogen-activating CYP1A1 and CYP1B1 enzymes by a standardized complex mixture of PAH extracted from coal tar Int. J. Cancer 2007, 120 (6) 1161-1168
15. Mahadevan, B.; Marston, C. P.; Dashwood, W. M.; Li, Y.; Pereira, C.; Baird, W. M. Effect of a standardized complex mixture derived from coal tar on the metabolic activation of carcinogenic polycyclic aromatic hydrocarbons in human cells in culture Chem. Res. Toxicol. 2005, 18 (2) 224-31
16. Courter, L. A.; Musafia-Jeknic, T.; Fischer, K.; Bildfell, R.; Giovanini, J.; Pereira, C.; Baird, W. M. Urban dust particulate matter alters PAH-induced carcinogenesis by inhibition of CYP1A1 and CYP1B1 Toxicol. Sci. 2007, 95 (1) 63-73
17. Courter, L. A.; Pereira, C.; Baird, W. M. Diesel exhaust influences carcinogenic PAH-induced genotoxicity and gene expression in human breast epithelial cells in culture Mutat. Res. 2007, 625 (1-2) 72-82
18. Courter, L. A.; Luch, A.; Musafia-Jeknic, T.; Arlt, V. M.; Fischer, K.; Bildfell, R.; Pereira, C.; Phillips, D. H.; Poirier, M. C.; Baird, W. M. The influence of diesel exhaust on polycyclic aromatic hydrocarbon-induced DNA damage, gene expression, and tumor initiation in Sencar mice in vivo Cancer Lett. 2008, 265 (1) 135-147
19. Binková, B.; Šrám, R. J. The genotoxic effect of carcinogenic PAHs, their artificial and environmental mixtures (EOM) on human diploid lung fibroblasts Mutat. Res. 2004, 547 (1-2) 109-121
20. USEPA (United States Environmental Protection Agency). Guidelines for the Health Risk Assessment of Chemical Mixtures, EPA/630/R-98/002; United States Environmental Protection Agency: Washington, DC, 1986.
21. USEPA (United States Environmental Protection Agency). Supplementary Guidance for Conducting Health Risk Assessment of Chemical Mixtures, EPA/630/R-00/002; United States Environmental Protection Agency: Washington, DC, 2000.
22. NRC (National Research Council). Complex Mixtures. Methods for In Vivo Toxicity Testing; National Academy Press: Washington, DC, 1988.
23. Teuschler, L.; Klaunig, J.; Carney, E.; Chambers, J.; Conolly, R.; Gennings, C.; Giesy, J.; Hertzberg, R.; Klaassen, C.; Kodell, R.; Paustenbach, D.; Yang, R.; Bucher, J.; Bus, J.; Farland, W.; Foran, J.; Goodman, J.; Lamb, S.; Mason, A.; Parrish, R.; Thompson, C. Support of science-based decisions concerning the evaluation of the toxicology of mixtures: A new beginning Regul. Toxicol. Pharmacol. 2002, 36 (1) 34-39
24. Health Canada. Federal Contaminated Site Risk Assessment Program. Part I: Guidance on Human Health Preliminary Quantitative Risk Assessment (PQRA); Health Canada: Ottawa, Ontario. 2004.
25. Keith, L. H.; Telliard, W. A. Priority pollutants I-A perspective view Environ. Sci. Technol. 1979, 13 (4) 416-423
26. Boström, C.; Gerde, P.; Hanberg, A.; Jernström, B.; Johansson, C.; Kyrklund, T.; Rannug, A.; Törnqvist, M.; Victorin, K.; Westerholm, R. Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient air Environ. Health Perspect. 2002, 110 (SUPPL. 3) 451-488
27. Lemieux, C.; Long, A.; Lambert, I.; Lundstedt, S.; Tysklind, M.; White, P. Cancer risk assessment of complex polycyclic aromatic hydrocarbon mixtures in contaminated soils: Use of a mutagenic potency ratio approach Environ. Sci. Technol. 2014, 10.1021/es504465f
28. OECD (Organization for Economic Cooperation and Development). OECD Guideline for the Testing of Chemicals. Test Guideline 488, Transgenic Rodent Somatic and Germ Cell Gene Mutation Assay; Organization for Economic Cooperation and Development: Paris, France, 2011.
29. White, P. A.; Douglas, G. R.; Gingerich, J.; Parfett, C.; Shwed, P.; Seligy, V.; Soper, L.; Berndt, L.; Bayley, J.; Wagner, S.; Pound, K.; Blakey, D. Development and characterization of a stable epithelial cell line from MutaMouse lung Environ. Mol. Mutagen. 2003, 42 (3) 166-184
30. Berndt-Weis, M.; Kauri, L. M.; Williams, A.; White, P.; Douglas, G.; Yauk, C. Global transcriptional characterization of a mouse pulmonary epithelial cell line for use in genetic toxicology Toxicol. In Vitro 2009, 23 (5) 816-833
31. Lundstedt, S.; van Bavel, B.; Haglund, P.; Tysklind, M.; Oberg, L. Pressurised liquid extraction of polycyclic aromatic hydrocarbons from contaminated soils J. Chromatogr., A 2000, 883 (1-2) 151-162
32. Lundstedt, S.; Haglund, P.; Oberg, L. Degradation and formation of polycyclic aromatic compounds during bioslurry treatment of an aged gasworks soil Environ. Toxicol. Chem. 2003, 22 (7) 1413-1420
33. Lundstedt, S.; Haglund, P.; Oberg, L. Simultaneous extraction and fractionation of polycyclic aromatic hydrocarbons and their oxygenated derivatives in soil using selective pressurized liquid extraction Anal. Chem. 2006, 78 (9) 2993-3000
34. - plasmids Nucl. Acid. Res. 1992, 20 (12) 3254
35. Neter, J.; Wasserman, W.; Kutner, M. Applied Linear Statistical Models. Regression, Analysis of Variance, and Experimental Designs; Richard D. Irwin, Inc.: Boston, MA, 1990.
36. Hannigan, M. P.; Cass, G. R.; Penman, B. W.; Crespi, C. L.; Lafleur, A. L.; Busby, W. F., Jr.; Thilly, W. G.; Simoneit, B. R. T. Bioassay-directed chemical analysis of Los Angeles airborne particulate matter using a human cell mutagenicity assay Environ. Sci. Technol. 1998, 32 (22) 3502-3514
37. Hannigan, M. P.; Cass, G. R.; Penman, B. W.; Crespi, C. L.; Lafleur, A. L.; Busby, W. F., Jr.; Thilly, W. G. Human cell mutagens in Los Angeles air Environ. Sci. Technol. 1997, 31 (2) 438-447
38. Lewtas, J. Evaluation of the mutagenicity and carcinogenicity of motor vehicle emissions in short-term bioassays Environ. Health Perspect. 1983, 47, 141-152
39. DeMarini, D. M.; Brimer, P. A.; Hsie, A. W. Cytotoxicity and mutagenicity of coal oils in the CHO/HGPRT assay. Environ Mutagen. 1984, 6 (4) 517-527
40. Pohren, R. D. S.; Rocha, J. A. V.; Leal, K. A.; Vargas, V. M. F. Soil mutagenicity as a strategy to evaluate environmental and health risks in a contaminated area Environ. Int. 2012, 44 (1) 40-52
41. Hughes, T. J.; Claxton, L. D.; Brooks, L.; Warren, S.; Brenner, R.; Kremer, F. Genotoxicity of bioremediated soils from the Reilly Tar site, St. Louis Park, Minnesota Environ. Health Perspect. 1998, 106 (Suppl 6) 1427-1433
42. IARC (International Agency for Research on Cancer). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 32, Polynuclear Aromatic Compounds, Part 1, Chemical, Environmental and Experimental Data; International Agency for Research on Cancer: Lyons, France, 1983.
43. Maertens, R. M.; Bailey, J.; White, P. A. The mutagenic hazards of settled house dust: A review Mutat. Res. 2004, 567 (2-3) 401-425
44. Durant, J. L.; Busby, W. F., Jr; Lafleur, A. L.; Penman, B. W.; Crespi, C. L. Human cell mutagenicity of oxygenated, nitrated and unsubstituted polycyclic aromatic hydrocarbons associated with urban aerosols Mutat. Res. 1996, 371 (3-4) 123-157
45. Audebert, M.; Zeman, F.; Beaudoin, R.; Péry, A.; Cravedi, J.-P. Comparative potency approach based on H2AX assay for estimating the genotoxicity of polycyclic aromatic hydrocarbons Toxicol. Appl. Pharmacol. 2012, 260 (1) 58-64
46. Lundstedt, S.; White, P. A.; Lemieux, C. L.; Lynes, K. D.; Lambert, I. B.; Oberg, L.; Haglund, P.; Tysklind, M. Sources, fate, and toxic hazards of oxygenated polycyclic aromatic hydrocarbons (PAHs) at PAH-contaminated sites Ambio 2007, 36 (6) 475-485
47. Møller, M.; Hagen, I.; Ramdahl, T. Mutagenicity of polycyclic aromatic compounds (PAC) identified in source emissions and ambient air Mutat. Res. 1985, 157 (2-3) 149-56
48. Chen, G.; Gingerich, J.; Soper, L.; Douglas, G. R.; White, P. A. Tissue-specific metabolic activation and mutagenicity of 3-nitrobenzanthrone in MutaMouse Environ. Mol. Mutagen. 2008, 49 (8) 602-613
49. Park, J.; Ball, L. M.; Richardson, S. D.; Zhu, H.; Aitken, M. D. Oxidative mutagenicity of polar fractions from polycyclic aromatic hydrocarbon-contaminated soils Environ. Toxicol. Chem. 2008, 27 (11) 2207-2215
50. Higley, E.; Grund, S.; Jones, P. D.; Schulze, T.; Seiler, T.-B.; Lübcke-von Varel, U.; Brack, W.; Wölz, J.; Zielke, H.; Giesy, J. P.; Hollert, H.; Hecker, M. Endocrine disrupting, mutagenic, and teratogenic effects of upper Danube River sediments using effect-directed analysis Environ. Toxicol. Chem. 2012, 31 (5) 1053-1062
51. Lübcke-von Varel, U.; Bataineh, M.; Lohrmann, S.; Löffler, I.; Schulze, T.; Flückiger-Isler, S.; Neca, J.; Machala, M.; Brack, W. Identification and quantitative confirmation of dinitropyrenes and 3-nitrobenzanthrone as major mutagens in contaminated sediments Environ. Int. 2012, 44 (1) 31-39
52. Lübcke-von Varel, U.; Machala, M.; Ciganek, M.; Neca, J.; Pencikova, K.; Palkova, L.; Vondracek, J.; Löffler, I.; Streck, G.; Reifferscheid, G.; Flückiger-Isler, S.; Weiss, J. M.; Lamoree, M.; Brack, W. Polar compounds dominate in vitro effects of sediment extracts Environ. Sci. Technol. 2011, 45 (6) 2384-2390
53. Brack, W. Effect-directed analysis: A promising tool for the identification of organic toxicants in complex mixtures? Anal. Bioanal. Chem. 2003, 377 (3) 397-407
54. Brack, W.; Klamer, H. J.; Lopez de Alda, M.; Barcelo, D. Effect-directed analysis of key toxicants in European river basins a review. Environ Sci. Pollut. Res. Int. 2007, 14 (1) 30-8
55. Brack, W.; Schmitt-Jansen, M.; MacHala, M.; Brix, R.; Barceló, D.; Schymanski, E.; Streck, G.; Schulze, T. How to confirm identified toxicants in effect-directed analysis Anal. Bioanal. Chem. 2008, 390 (8) 1959-1973
56. Nagaraj, N. S.; Beckers, S.; Mensah, J. K.; Waigel, S.; Vigneswaran, N.; Zacharias, W. Cigarette smoke condensate induces cytochromes P450 and aldo-keto reductases in oral cancer cells Toxicol. Lett. 2006, 165 (2) 182-194
57. Park, J.-H.; Troxel, A. B.; Harvey, R. G.; Penning, T. M. Polycyclic aromatic hydrocarbon (PAH) o-quinones produced by the aldo-keto-reductases (AKRs) generate abasic sites, oxidized pyrimidines, and 8-Oxo-dGuo via reactive oxygen species Chem. Res. Toxicol. 2006, 19 (5) 719-728
58. Hermann, M. Synergistic effects of individual polycyclic aromatic hydrocarbons on the mutagenicity of their mixtures Mutat. Res. 1981, 90, 399-409
59. Jacob, J.; Schmoldt, A.; Grimmer, G. Influence of monooxygenase inducers on the metabolic profile of phenanthrene in rat liver microsomes Toxicology 1982, 25 (4) 333-343
60. Jerina, D. M.; Daly, J. W.; Witkop, B.; Zaltzman-Nirenberg, P.; Udenfriend, S. 1,2-Naphthalene oxide as an intermediate in the microsomal hydroxylation of naphthalene Biochemistry 1970, 9 (1) 147-156
61. Shimada, T.; Guengerich, F. P. Inhibition of human cytochrome P450 1A1-, 1A2-, and 1B1-mediated activation of procarcinogens to genotoxic metabolites by polycyclic aromatic hydrocarbons Chem. Res. Toxicol. 2006, 19 (2) 288-294
62. Sen, B.; Mahadevan, B.; DeMarini, D. M. Transcriptional responses to complex mixtures-A review Mutat. Res. 2007, 636 (1-3) 144-177
63. Bi, X.; Slater, D. M.; Ohmori, H.; Vaziri, C. DNA polymerase κ is specifically required for recovery from the benzo[a]pyrene-dihydrodiol epoxide (BPDE)-induced S-phase checkpoint J. Biol. Chem. 2005, 280 (23) 22343-22355
64. Mahadevan, B.; Keshava, C.; Musafia-Jeknic, T.; Pecaj, A.; Weston, A.; Baird, W. M. Altered gene expression patterns in MCF-7 cells induced by the urban dust particulate complex mixture standard reference material 1649a Cancer Res. 2005, 65 (4) 1251-1258