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Volumn 6, Issue , 2016, Pages

Metformin protects against cisplatin-induced tubular cell apoptosis and acute kidney injury via AMPKα-regulated autophagy induction

Author keywords

[No Author keywords available]

Indexed keywords

AMPK ALPHA1 SUBUNIT, MOUSE; ANTIDIABETIC AGENT; ANTINEOPLASTIC AGENT; CISPLATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; METFORMIN; PROTECTIVE AGENT;

EID: 84964050119     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep23975     Document Type: Article
Times cited : (137)

References (50)
  • 1
    • 0345256652 scopus 로고    scopus 로고
    • Cisplatin: Mode of cytotoxic action and molecular basis of resistance
    • Siddik, Z. H. Cisplatin: mode of cytotoxic action and molecular basis of resistance. Oncogene 22, 7265-79 (2003)
    • (2003) Oncogene , vol.22 , pp. 7265-7279
    • Siddik, Z.H.1
  • 2
    • 84880292198 scopus 로고    scopus 로고
    • Acute kidney injury: An increasing global concern
    • Lameire, N. H. et al. Acute kidney injury: an increasing global concern. Lancet 382, 170-9 (2013)
    • (2013) Lancet , vol.382 , pp. 170-179
    • Lameire, N.H.1
  • 4
    • 0036256227 scopus 로고    scopus 로고
    • Role of apoptosis in the pathogenesis of acute renal failure
    • Bonegio, R., & Lieberthal, W. Role of apoptosis in the pathogenesis of acute renal failure. Curr Opin Nephrol Hypertens 11, 301-8 (2002)
    • (2002) Curr Opin Nephrol Hypertens , vol.11 , pp. 301-308
    • Bonegio, R.1    Lieberthal, W.2
  • 5
    • 42149187768 scopus 로고    scopus 로고
    • Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies
    • Pabla, N., & Dong, Z. Cisplatin nephrotoxicity: mechanisms and renoprotective strategies. Kidney Int 73, 994-1007 (2008)
    • (2008) Kidney Int , vol.73 , pp. 994-1007
    • Pabla, N.1    Dong, Z.2
  • 6
    • 77951657455 scopus 로고    scopus 로고
    • And metallomic strategies for understanding the mode of action of anticancer metallodrugs
    • Gabbiani, C., Magherini, F., Modesti, A., & Messori, L. Proteomic and metallomic strategies for understanding the mode of action of anticancer metallodrugs. Anticancer Agents Med Chem. 10, 324-37 (2010)
    • (2010) Anticancer Agents Med Chem , vol.10 , pp. 324-337
    • Gabbiani, C.1    Magherini, F.2    Modesti, A.3    Proteomic, M.L.4
  • 8
    • 49749120592 scopus 로고    scopus 로고
    • Autophagy is cytoprotective during cisplatin injury of renal proximal tubular cells
    • Periyasamy-Thandavan, S. et al. Autophagy is cytoprotective during cisplatin injury of renal proximal tubular cells. Kidney Int 74, 631-40 (2008)
    • (2008) Kidney Int , vol.74 , pp. 631-640
    • Periyasamy-Thandavan, S.1
  • 9
    • 77749264299 scopus 로고    scopus 로고
    • Autophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemiareperfusion injury
    • Jiang, M., Liu, K., Luo, J., & Dong, Z. Autophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemiareperfusion injury. Am J Pathol. 176, 1181-92 (2010)
    • (2010) Am J Pathol , vol.176 , pp. 1181-1192
    • Jiang, M.1    Liu, K.2    Luo, J.3    Dong, Z.4
  • 10
    • 84862635122 scopus 로고    scopus 로고
    • Autophagy plays a critical role in kidney tubule maintenance, aging and ischemia-reperfusion injury
    • Liu, S. et al. Autophagy plays a critical role in kidney tubule maintenance, aging and ischemia-reperfusion injury. Autophagy 8, 826-37 (2012)
    • (2012) Autophagy , vol.8 , pp. 826-837
    • Liu, S.1
  • 11
    • 79955626606 scopus 로고    scopus 로고
    • Autophagy protects the proximal tubule from degeneration and acute ischemic injury
    • Kimura, T. et al. Autophagy protects the proximal tubule from degeneration and acute ischemic injury. J Am Soc Nephrol. 22, 902-13 (2011)
    • (2011) J Am Soc Nephrol , vol.22 , pp. 902-913
    • Kimura, T.1
  • 12
    • 84855996286 scopus 로고    scopus 로고
    • Autophagy guards against cisplatin-induced acute kidney injury
    • Takahashi, A. et al. Autophagy guards against cisplatin-induced acute kidney injury. Am J Pathol. 180, 517-25 (2012)
    • (2012) Am J Pathol , vol.180 , pp. 517-525
    • Takahashi, A.1
  • 13
    • 84870580153 scopus 로고    scopus 로고
    • Autophagy in proximal tubules protects against acute kidney injury
    • Jiang, M. et al. Autophagy in proximal tubules protects against acute kidney injury. Kidney Int 82, 1271-83 (2012)
    • (2012) Kidney Int , vol.82 , pp. 1271-1283
    • Jiang, M.1
  • 14
    • 84903784412 scopus 로고    scopus 로고
    • Rictor mTORC2 protects against cisplatin-induced tubular cell death and acute kidney injury
    • Li, J. et al. Rictor mTORC2 protects against cisplatin-induced tubular cell death and acute kidney injury. Kidney Int 86, 86-102 (2014)
    • (2014) Kidney Int , vol.86 , pp. 86-102
    • Li, J.1
  • 15
    • 84887070613 scopus 로고    scopus 로고
    • Obesity-mediated autophagy insufficiency exacerbates proteinuria-induced tubulointerstitial lesions
    • Yamahara, K. et al. Obesity-mediated autophagy insufficiency exacerbates proteinuria-induced tubulointerstitial lesions. J Am Soc Nephrol. 24, 1769-81 (2013)
    • (2013) J Am Soc Nephrol , vol.24 , pp. 1769-1781
    • Yamahara, K.1
  • 16
    • 84903957218 scopus 로고    scopus 로고
    • Mtorc1 maintains renal tubular homeostasis and is essential in response to ischemic stress
    • Grahammer, F. et al. mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress. Proc Natl Acad Sci USA 111, E2817-26 (2014)
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. E2817-E2826
    • Grahammer, F.1
  • 17
    • 84893494111 scopus 로고    scopus 로고
    • New autophagy reporter mice reveal dynamics of proximal tubular autophagy
    • Li, L., Wang, Z. V., Hill, J. A., & Lin, F. New autophagy reporter mice reveal dynamics of proximal tubular autophagy. J Am Soc Nephrol 25, 305-15 (2014)
    • (2014) J Am Soc Nephrol , vol.25 , pp. 305-315
    • Li, L.1    Wang, Z.V.2    Hill, J.A.3    Lin, F.4
  • 18
    • 84907545906 scopus 로고    scopus 로고
    • AMPK: Positive and negative regulation, and its role in whole-body energy homeostasis
    • Hardie, D. G. AMPK: positive and negative regulation, and its role in whole-body energy homeostasis. Curr Opin Cell Biol. 33, 1-7 (2015)
    • (2015) Curr Opin Cell Biol , vol.33 , pp. 1-7
    • Hardie, D.G.1
  • 19
    • 80052511813 scopus 로고    scopus 로고
    • The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
    • Mihaylova, M. M., & Shaw, R. J. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol. 13, 1016-23 (2011)
    • (2011) Nat Cell Biol , vol.13 , pp. 1016-1023
    • Mihaylova, M.M.1    Shaw, R.J.2
  • 20
    • 77954964776 scopus 로고    scopus 로고
    • An energetic tale of AMPK-independent effects of metformin
    • Miller, R. A., & Birnbaum, M. J. An energetic tale of AMPK-independent effects of metformin. J Clin Invest 120, 2267-70 (2010)
    • (2010) J Clin Invest , vol.120 , pp. 2267-2270
    • Miller, R.A.1    Birnbaum, M.J.2
  • 21
    • 78650931836 scopus 로고    scopus 로고
    • Metformin activates AMP kinase through inhibition of AMP deaminase
    • Ouyang, J., Parakhia, R. A., & Ochs, R. S. Metformin activates AMP kinase through inhibition of AMP deaminase. J Biol Chem. 286, 1-11 (2011)
    • (2011) J Biol Chem , vol.286 , pp. 1-11
    • Ouyang, J.1    Parakhia, R.A.2    Ochs, R.S.3
  • 22
    • 84881413580 scopus 로고    scopus 로고
    • Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1
    • Tripathi, D. N. et al. Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1. Proc Natl Acad Sci USA 110, E2950-7 (2013)
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. E2950-E2957
    • Tripathi, D.N.1
  • 23
    • 84858782079 scopus 로고    scopus 로고
    • AMPK: A nutrient and energy sensor that maintains energy homeostasis
    • Hardie, D. G., Ross, F. A., & Hawley, S. A. AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol 13, 251-62 (2012)
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 251-262
    • Hardie, D.G.1    Ross, F.A.2    Hawley, S.A.3
  • 24
    • 84922952894 scopus 로고    scopus 로고
    • Beneficial effects of amp-activated protein kinase agonists in kidney ischemia- reperfusion: Autophagy and cellular stress markers
    • Decleves, A. E., Sharma, K., & Satriano, J. Beneficial Effects of AMP-Activated Protein Kinase Agonists in Kidney Ischemia- Reperfusion: Autophagy and Cellular Stress Markers. Nephron Exp Nephrol. (2014)
    • (2014) Nephron Exp Nephrol
    • Decleves, A.E.1    Sharma, K.2    Satriano, J.3
  • 25
    • 65549136655 scopus 로고    scopus 로고
    • Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein
    • He, L. et al. Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein. Cell 137, 635-46 (2009)
    • (2009) Cell , vol.137 , pp. 635-646
    • He, L.1
  • 26
    • 0034641568 scopus 로고    scopus 로고
    • Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): Prospective observational study
    • Stratton, I. M. et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ 321, 405-12 (2000)
    • (2000) BMJ , vol.321 , pp. 405-412
    • Stratton, I.M.1
  • 27
    • 84855603512 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of metformin: An overview
    • Viollet, B. et al. Cellular and molecular mechanisms of metformin: an overview. Clin Sci (Lond) 122, 253-70 (2012)
    • (2012) Clin Sci (Lond , vol.122 , pp. 253-270
    • Viollet, B.1
  • 28
    • 77955517441 scopus 로고    scopus 로고
    • Diabetes and cancer: A consensus report
    • Giovannucci, E. et al. Diabetes and cancer: a consensus report. Diabetes Care 33, 1674-85 (2010)
    • (2010) Diabetes Care , vol.33 , pp. 1674-1685
    • Giovannucci, E.1
  • 29
    • 69549097703 scopus 로고    scopus 로고
    • New users of metformin are at low risk of incident cancer: A cohort study among people with type 2 diabetes
    • Libby, G. et al. New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes. Diabetes Care 32, 1620-5 (2009)
    • (2009) Diabetes Care , vol.32 , pp. 1620-1625
    • Libby, G.1
  • 30
    • 0035082644 scopus 로고    scopus 로고
    • Prevention of pancreatic cancer induction in hamsters by metformin
    • Schneider, M. B. et al. Prevention of pancreatic cancer induction in hamsters by metformin. Gastroenterology 120, 1263-70 (2001)
    • (2001) Gastroenterology , vol.120 , pp. 1263-1270
    • Schneider, M.B.1
  • 31
    • 84928473295 scopus 로고    scopus 로고
    • Metformin suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-+ Leprdb/+ Leprdb mice
    • Ohno, T. et al. Metformin suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-+ Leprdb/+ Leprdb mice. Plos One 10, e0124081 (2015)
    • (2015) Plos One , vol.10 , pp. e0124081
    • Ohno, T.1
  • 32
    • 84874660234 scopus 로고    scopus 로고
    • Metformin decreases hepatocellular carcinoma risk in a dose-dependent manner: Population-based and in vitro studies
    • Chen, H. P. et al. Metformin decreases hepatocellular carcinoma risk in a dose-dependent manner: population-based and in vitro studies. Gut 62, 606-15 (2013)
    • (2013) Gut , vol.62 , pp. 606-615
    • Chen, H.P.1
  • 33
    • 0034773404 scopus 로고    scopus 로고
    • Role of AMP-Activated protein kinase in mechanism of metformin action
    • Zhou, G. et al. Role of AMP-Activated protein kinase in mechanism of metformin action. J Clin Invest 108, 1167-74 (2001)
    • (2001) J Clin Invest , vol.108 , pp. 1167-1174
    • Zhou, G.1
  • 34
    • 36348950449 scopus 로고    scopus 로고
    • Metformin inhibits mammalian target of rapamycindependent translation initiation in breast cancer cells
    • Dowling, R. J., Zakikhani, M., Fantus, I. G., Pollak, M., & Sonenberg, N. Metformin inhibits mammalian target of rapamycindependent translation initiation in breast cancer cells. Cancer Res 67, 10804-12 (2007)
    • (2007) Cancer Res , vol.67 , pp. 10804-10812
    • Dowling, R.J.1    Zakikhani, M.2    Fantus, I.G.3    Pollak, M.4    Sonenberg, N.5
  • 35
    • 84903530938 scopus 로고    scopus 로고
    • The anti-diabetic drug metformin protects against chemotherapy-induced peripheral neuropathy in a mouse model
    • Mao-Ying, Q. L. et al. The anti-diabetic drug metformin protects against chemotherapy-induced peripheral neuropathy in a mouse model. Plos One 9, e100701 (2014)
    • (2014) Plos One , vol.9 , pp. e100701
    • Mao-Ying, Q.L.1
  • 36
    • 78650677585 scopus 로고    scopus 로고
    • Metformin reduces cisplatin-mediated apoptotic death of cancer cells through AMPK-independent activation of Akt
    • Janjetovic, K. et al. Metformin reduces cisplatin-mediated apoptotic death of cancer cells through AMPK-independent activation of Akt. Eur J Pharmacol. 651, 41-50 (2011)
    • (2011) Eur J Pharmacol , vol.651 , pp. 41-50
    • Janjetovic, K.1
  • 37
    • 77951879150 scopus 로고    scopus 로고
    • Metformin prevents experimental gentamicin-induced nephropathy by a mitochondria-dependent pathway
    • Morales, A. I. et al. Metformin prevents experimental gentamicin-induced nephropathy by a mitochondria-dependent pathway. Kidney Int 77, 861-9 (2010)
    • (2010) Kidney Int , vol.77 , pp. 861-869
    • Morales, A.I.1
  • 38
    • 84880041261 scopus 로고    scopus 로고
    • Effect of metformin against cisplatin induced acute renal injury in rats: A biochemical and histoarchitectural evaluation
    • Sahu, B. D., Kuncha, M., Putcha, U. K., & Sistla, R. Effect of metformin against cisplatin induced acute renal injury in rats: a biochemical and histoarchitectural evaluation. Exp Toxicol Pathol. 65, 933-40 (2013)
    • (2013) Exp Toxicol Pathol , vol.65 , pp. 933-940
    • Sahu, B.D.1    Kuncha, M.2    Putcha, U.K.3    Sistla, R.4
  • 39
    • 0034778721 scopus 로고    scopus 로고
    • Role and regulation of activation of caspases in cisplatin-induced injury to renal tubular epithelial cells
    • Kaushal, G. P., Kaushal, V., Hong, X., & Shah, S. V. Role and regulation of activation of caspases in cisplatin-induced injury to renal tubular epithelial cells. Kidney Int 60, 1726-36 (2001)
    • (2001) Kidney Int , vol.60 , pp. 1726-1736
    • Kaushal, G.P.1    Kaushal, V.2    Hong, X.3    Shah, S.V.4
  • 40
    • 52449107552 scopus 로고    scopus 로고
    • Inflammation in acute kidney injury
    • Kinsey, G. R., Li, L., & Okusa, M. D. Inflammation in acute kidney injury. Nephron Exp Nephrol. 109, e102-7 (2008)
    • (2008) Nephron Exp Nephrol , vol.109 , pp. e102-e107
    • Kinsey, G.R.1    Li, L.2    Okusa, M.D.3
  • 41
    • 84886304307 scopus 로고    scopus 로고
    • Metformin attenuates the exacerbation of the allergic eosinophilic inflammation in high fat-diet-induced obesity in mice
    • Calixto, M. C. et al. Metformin attenuates the exacerbation of the allergic eosinophilic inflammation in high fat-diet-induced obesity in mice. Plos One 8, e76786 (2013)
    • (2013) Plos One , vol.8 , pp. e76786
    • Calixto, M.C.1
  • 42
    • 84927724643 scopus 로고    scopus 로고
    • Autophagy in acute kidney injury and repair
    • He, L., Livingston, M. J., & Dong, Z. Autophagy in acute kidney injury and repair. Nephron Clin Pract. 127, 56-60 (2014)
    • (2014) Nephron Clin Pract , vol.127 , pp. 56-60
    • He, L.1    Livingston, M.J.2    Dong, Z.3
  • 43
    • 77951217000 scopus 로고    scopus 로고
    • Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class i and III phosphoinositide 3-kinase
    • Wu, Y. T. et al. Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase. J Biol Chem. 285, 10850-61 (2010)
    • (2010) J Biol Chem , vol.285 , pp. 10850-10861
    • Wu, Y.T.1
  • 44
    • 79959385996 scopus 로고    scopus 로고
    • Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 mice
    • Xie, Z. et al. Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 mice. Diabetes 60, 1770-8 (2011)
    • (2011) Diabetes , vol.60 , pp. 1770-1778
    • Xie, Z.1
  • 45
    • 84937512689 scopus 로고    scopus 로고
    • Metformin in patients with advanced pancreatic cancer: A double-blind, randomised, placebo-controlled phase 2 trial
    • Kordes, S. et al. Metformin in patients with advanced pancreatic cancer: a double-blind, randomised, placebo-controlled phase 2 trial. Lancet Oncol. 16, 839-47 (2015)
    • (2015) Lancet Oncol , vol.16 , pp. 839-847
    • Kordes, S.1
  • 46
    • 84924279764 scopus 로고    scopus 로고
    • Gastric cancer Metformin improves survival and recurrence rate in patients with diabetes and gastric cancer
    • Greenhill, C. Gastric cancer. Metformin improves survival and recurrence rate in patients with diabetes and gastric cancer. Nat Rev Gastroenterol Hepatol. 12, 124 (2015)
    • (2015) Nat Rev Gastroenterol Hepatol , vol.12 , pp. 124
    • Greenhill, C.1
  • 47
    • 84922874622 scopus 로고    scopus 로고
    • Survival of patients with stage IV lung cancer with diabetes treated with metformin
    • Lin, J. J. et al. Survival of patients with stage IV lung cancer with diabetes treated with metformin. Am J Respir Crit Care Med. 191, 448-54 (2015)
    • (2015) Am J Respir Crit Care Med , vol.191 , pp. 448-454
    • Lin, J.J.1
  • 48
    • 84886557970 scopus 로고    scopus 로고
    • Metformin use and all-cause and prostate cancer-specific mortality among men with diabetes
    • Margel, D. et al. Metformin use and all-cause and prostate cancer-specific mortality among men with diabetes. J Clin Oncol. 31, 3069-75 (2013)
    • (2013) J Clin Oncol , vol.31 , pp. 3069-3075
    • Margel, D.1
  • 49
    • 84883168731 scopus 로고    scopus 로고
    • Metformin enhances cisplatin cytotoxicity by suppressing signal transducer and activator of transcription-3 activity independently of the liver kinase B1-AMP-Activated protein kinase pathway
    • Lin, C. C. et al. Metformin enhances cisplatin cytotoxicity by suppressing signal transducer and activator of transcription-3 activity independently of the liver kinase B1-AMP-Activated protein kinase pathway. Am J Respir Cell Mol Biol. 49, 241-50 (2013)
    • (2013) Am J Respir Cell Mol Biol , vol.49 , pp. 241-250
    • Lin, C.C.1
  • 50
    • 79955834631 scopus 로고    scopus 로고
    • Metformin suppresses ovarian cancer growth and metastasis with enhancement of cisplatin cytotoxicity in vivo
    • Rattan, R., Graham, R. P., Maguire, J. L., Giri, S., & Shridhar, V. Metformin suppresses ovarian cancer growth and metastasis with enhancement of cisplatin cytotoxicity in vivo. Neoplasia 13, 483-91 (2011)
    • (2011) Neoplasia , vol.13 , pp. 483-491
    • Rattan, R.1    Graham, R.P.2    Maguire, J.L.3    Giri, S.4    Shridhar, V.5


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