Effect of metformin against cisplatin induced acute renal injury in rats: A biochemical and histoarchitectural evaluation

Experimental and Toxicologic Pathology

Volumn 65, Issue 6, 2013, Pages 933-940

  Sahu, Bidya Dhar ^a   Kuncha, Madhusudana ^a   Putcha, Uday Kumar ^b   Sistla, Ramakrishna ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b NATIONAL INSTITUTE OF NUTRITION   (India)

Author keywords

Apoptosis; Cisplatin; Metformin; Nephrotoxicity; Oxidative stress

Indexed keywords

CASPASE 3; CISPLATIN; CREATININE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; LACTATE DEHYDROGENASE; MALONALDEHYDE; METFORMIN; NITROGEN; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; UREA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMICAL COMPOSITION; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG MECHANISM; ENZYME ACTIVITY; HISTOPATHOLOGY; KIDNEY FUNCTION TEST; KIDNEY INJURY; LIPID PEROXIDATION; MALE; NONHUMAN; RAT; UREA NITROGEN BLOOD LEVEL;

APOPTOSIS; CISPLATIN; METFORMIN; NEPHROTOXICITY; OXIDATIVE STRESS;

ACUTE KIDNEY INJURY; ANIMALS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; ASCORBIC ACID; CISPLATIN; GLUTATHIONE; KIDNEY; KIDNEY FUNCTION TESTS; LIPID PEROXIDATION; MALE; METFORMIN; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES;

RATTUS;

EID: 84880041261     PISSN: 09402993     EISSN: 16181433     Source Type: Journal    
DOI: 10.1016/j.etp.2013.01.007     Document Type: Article

References (36)

1. Aebi H. Catalase. Methods of enzymatic analysis 1974, 673-677. Academic Press, New York, London. H.U. Bergmeyer (Ed.).
2. Ali B.H., Moundhri M.S. Agents ameliorating or augmenting the nephrotoxicity of cisplatin and other platinum compounds: a review of some recent research. Food and Chemical Toxicology 2006, 44:1173-1183.
3. Asensio-López M.C., Lax A., Pascual-Figal D.A., Valdés M., Sánchez-Más J. Metformin protects against doxorubicin-induced cardiotoxicity: involvement of the adiponectin cardiac system. Free Radical Biology and Medicine 2011, 51:1861-1871.
4. Bhamra G.S., Hausenloy D.J., Davidson S.M., Carr R.D., Paiva M., Wynne A.M., et al. Metformin protects the ischemic heart by the Akt mediated inhibition of mitochondrial permeability transition pore opening. Basic Research in Cardiology 2008, 103:274-284.
5. Bonnefont-Rousselot D., Raji B., Walrand S., Gardes-Albert M., Jore D., Legrand A., et al. An intracellular modulation of free radical production could contribute to the beneficial effects of metformin towards oxidative stress. Metabolism: Clinical and Experimental 2003, 52:586-589.
6. Bowker S.L., Majumdar S.R., Veugelers P., Johnson J.A. Increased cancer-related mortality for patients with type 2 diabetes who use sulfonyl ureas or insulin. Diabetes Care 2006, 29:254-258.
7. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry 1976, 72:248-254.
8. Burger H., Loose W.J., Eechoute K., Verweij J., Mathijssen R.H.J., Wiemer E.A.C. Drug transporters of platinum-based anticancer agents and their clinical significance. Drug Resistance Updates 2011, 14:22-34.
9. Carlberg I., Mannervik B. Glutathione reductase levels in rat brain. Journal of Biological Chemistry 1975, 250:5475-5480.
10. Chakraborty A., Chowdhury S., Bhattacharyya M. Effect of metformin on oxidative stress, nitrosative stress and inflammatory biomarkers in type 2 diabetes patients. Diabetes Research and Clinical Practice 2011, 93:56-62.
11. Ciarimboli G. Role of organic cat ion transporters in drug-induced toxicity. Expert Opinion on Drug Metabolism and Toxicology 2011, 7:159-174.
12. Correia S., Carvalho C., Santos M.S., Seiça R., Oliveira C.R., Moreira P.I. Mechanisms of action of metformin in type 2 diabetes and associated complications: an overview. Mini Reviews in Medicinal Chemistry 2008, 8:1343-1354.
13. Dichtwald S., Weinbroum A.A., Sorkine P., Ekstein M.P., Dahan E. Metformin-associated lactic acidosis following acute kidney injury. Efficacious treatment with continuous renal replacement therapy. Diabetic Medicine 2012, 29:245-250.
14. Ellman Georg L. Tissue sulfahydryl group. Archives of Biochemistry and Biophysics 1959, 82:70-77.
15. Habig W.H., Pabst M.J., Jakoby W.B. Glutathione S-transferases. The first enzymatic step in Mercapturic acid formation. Journal of Biological Chemistry 1974, 249:7130.
16. Hou X., Song J., Li X., Zhang L., Wang X., Chen L., et al. Metformin reduces intracellular reactive oxygen species levels by up regulating expression of the antioxidant thioredoxin via the AMPK-FOXO3 pathway. Biochemical and Biophysical Research Communications 2010, 396:199-205.
17. Janjetovic K., Vucicevic L., Misirkic M., Vilimanovich U., Tovilovic G., Zogovic N., et al. Metformin reduces cisplatin-mediated apoptotic death of cancer cells through AMPK-independent activation of Akt. European Journal of Pharmacology 2011, 651:41-50.
18. Jung M., Hotter G., Viñas J.L., Sola A. Cisplatin up regulates mitochondrial nitric oxide synthase and peroxynitrite formation to promote renal injury. Toxicology and Applied Pharmacology 2009, 234:236-246.
19. Kuhad A., Pilkhwal S., Sharma S., Tirkey N., Chopra K. Effect of curcumin on inflammation and oxidative stress in cisplatin-induced experimental nephrotoxicity. Journal of Agricultural and Food Chemistry 2007, 55:10150-10155.
20. Lee S., Moon S., Kim W., Sung M.J., Kim D.H., Kang K.P., et al. Protective role of L-2-oxothiazolidine-4-carboxylicacid in cisplatin-induced renal injury. Nephrology, Dialysis, Transplantation 2006, 21:2085-2095.
21. Lupi R., Del Guerra S., Fierabracci L.V., Marselli L., Novelli M., Patanè G., et al. Lipotoxicity in human pancreatic islets and the protective effect of metformin. Diabetes 2002, 51:134-137.
22. Morales A.I., Detaille D., Prieto M., Puente A., Briones E., Arevalo M., et al. Metformin prevents experimental gentamicin-induced nephropathy by a mitochondria-dependent pathway. Kidney International 2010, 77:861-869.
23. Nakamura T., Yonezawa A., Hashimoto S., Katsura T., Inui K. Disruption of multi drug and toxin extrusion MATE1 potentiates cisplatin-induced nephrotoxicity. Biochemical Pharmacology 2010, 80:1762-1767.
24. Ohkawa H., Ohishi N., Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical Biochemistry 1979, 95:351-358.
25. Omaye S.T., Turbull T.P., Sauberchich H.C. Selected methods for determination of ascorbic acid in cells, tissues and fluids. Methods in Enzymology 1979, 6:3-11.
26. Paglia D.E., Valentine W.N. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. Journal of Laboratory and Clinical Medicine 1967, 70:158-169.
27. Pan H., Mukhopadhyay P., Rajesh M., Patel V., Mukhopadhyay B., Gao B., et al. Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation and cell death. Journal of Pharmacology and Experimental Therapeutics 2009, 328:708-714.
28. Rattan R., Graham R.P., Maguire J.L., Giri S., Shridhar V. Metformin suppresses ovarian cancer growth and metastasis with enhancement of cisplatin cytotoxicity in vivo. Neoplasia 2011, 13:483-491.
29. Rodrigues M.A.C., Rodrigues J.L., Martins N.M., Barbosa F., Curti C., Santos N.A.G., et al. Carvedilol protects against cisplatin-induced oxidative stress, redox state unbalance and apoptosis in rat kidney mitochondria. Chemico-Biological Interactions 2011, 189:45-51.
30. Saad S.Y., Najja T.A.O., Daba M.H., Al-Rikabi A.C. Inhibition of nitric oxide synthase aggravates cisplatin-induced nephrotoxicity: effect of 2-amino-4-methylpyridine. Chemotherapy 2000, 48:309-315.
31. Sahu B.D., Reddy K.K.R., Putcha U.K., Kuncha M., Naidu V.G.M., Sistla R. Carnosic acid attenuates renal injury in an experimental model of rat cisplatin-induced nephrotoxicity. Food and Chemical Toxicology 2011, 49:3090-3097.
32. Saleh S., El-Demerdash E. Protective effects of L-arginine against cisplatin-induced renal oxidative stress and toxicity: role of nitric oxide. Basic and Clinical Pharmacology and Toxicology 2005, 97:91-97.
33. Santos N.A.G., Catão C.S., Martins N.M., Curti C., Bianchi M.L.P., Santos A.C. Cisplatin-induced nephrotoxicity is associated with oxidative stress, redox state unbalance, impairment of energetic metabolism and apoptosis in rat kidney mitochondria. Archives of Toxicology 2007, 81:495-504.
34. Tsuda M., Terada T., Ueba M., Sato T., Masuda S., Katsura T., et al. Involvement of human multidrug and toxin extrusion1 in the drug interaction between cimetidine and metformin in renal epithelial cells. Journal of Pharmacology and Experimental Therapeutics 2009, 329:185-191.
35. Viollet B., Guigass B., Garcia N.S., Leclerc J., Foretz M., Andreelli F. Cellular and molecular mechanisms of metformin: an overview. Clinical Science 2012, 122:253-270.
36. Yuan H., Li L., Zheng W., Wan J., Ge P., Li H., et al. Antidiabetic drug metformin alleviates endotoxin-induced fulminant liver injury in mice. International Immunopharmacology 2012, 12:682-688.