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Volumn 25, Issue 6, 2016, Pages 729-734

Alvocidib (flavopiridol) for the treatment of chronic lymphocytic leukemia

Author keywords

Alvocidib; chronic lymphocytic leukemia; cytokine release syndrome; flavopiridol; tumor lysis syndrome

Indexed keywords

FLAVOPIRIDOL; ANTINEOPLASTIC AGENT; CYCLIN DEPENDENT KINASE; FLAVONOID; PIPERIDINE DERIVATIVE; PROTEIN KINASE INHIBITOR;

EID: 84963998098     PISSN: 13543784     EISSN: 17447658     Source Type: Journal    
DOI: 10.1517/13543784.2016.1169273     Document Type: Article
Times cited : (74)

References (49)
  • 1
    • 84933500314 scopus 로고    scopus 로고
    • Outcomes of patients with chronic lymphocytic leukemia and Richter’s transformation after transplantation failure
    • U.Rozovski, O.Benjamini, P.Jain, et al. Outcomes of patients with chronic lymphocytic leukemia and Richter’s transformation after transplantation failure. J Clin Oncol. 2015;33:1557–1563.
    • (2015) J Clin Oncol , vol.33 , pp. 1557-1563
    • Rozovski, U.1    Benjamini, O.2    Jain, P.3
  • 2
    • 84943579968 scopus 로고    scopus 로고
    • Complex karyotype is a stronger predictor than del(17p) for an inferior outcome in relapsed or refractory chronic lymphocytic leukemia patients treated with ibrutinib-based regimens
    • P.A.Thompson, S.M.O’Brien, W.G.Wierda, et al. Complex karyotype is a stronger predictor than del(17p) for an inferior outcome in relapsed or refractory chronic lymphocytic leukemia patients treated with ibrutinib-based regimens. Cancer. 2015;121:3612–3621.
    • (2015) Cancer , vol.121 , pp. 3612-3621
    • Thompson, P.A.1    O’Brien, S.M.2    Wierda, W.G.3
  • 3
    • 84927638285 scopus 로고    scopus 로고
    • Idelalisib: First-in-class PI3K delta inhibitor for the treatment of chronic lymphocytic leukemia, small lymphocytic leukemia, and follicular lymphoma
    • Q.Yang, P.Modi, T.Newcomb, et al. Idelalisib: first-in-class PI3K delta inhibitor for the treatment of chronic lymphocytic leukemia, small lymphocytic leukemia, and follicular lymphoma. Clin Cancer Res. 2015;21:1537–1542.
    • (2015) Clin Cancer Res , vol.21 , pp. 1537-1542
    • Yang, Q.1    Modi, P.2    Newcomb, T.3
  • 4
    • 84959096243 scopus 로고    scopus 로고
    • A phase II randomized trial comparing standard and low dose rituximab combined with alemtuzumab as initial treatment of progress chronic lymphocytic leukemia in older patients: A trial of the ECOG-Acrin Cancer Research Group (E1908)
    • C.S.Zent, X.V.Wang, R.P.Ketterling, et al. A phase II randomized trial comparing standard and low dose rituximab combined with alemtuzumab as initial treatment of progress chronic lymphocytic leukemia in older patients: a trial of the ECOG-Acrin Cancer Research Group (E1908). Am J Hematol. 2016;91:308–312.
    • (2016) Am J Hematol , vol.91 , pp. 308-312
    • Zent, C.S.1    Wang, X.V.2    Ketterling, R.P.3
  • 5
    • 84955484673 scopus 로고    scopus 로고
    • Randomized phase 2 study of obinutuzumab monotherapy in symptomatic, previously untreated chronic lymphocytic leukemia
    • J.C.Byrd, J.Flynn, T.J.Kipps, et al. Randomized phase 2 study of obinutuzumab monotherapy in symptomatic, previously untreated chronic lymphocytic leukemia. Blood. 2016;127:79–86.
    • (2016) Blood , vol.127 , pp. 79-86
    • Byrd, J.C.1    Flynn, J.2    Kipps, T.J.3
  • 6
    • 84929071974 scopus 로고    scopus 로고
    • Ofatumumab for the treatment of chronic lymphocytic leukemia
    • S.Grosicki Ofatumumab for the treatment of chronic lymphocytic leukemia. Expert Rev Hematol. 2015;8:265–272.
    • (2015) Expert Rev Hematol , vol.8 , pp. 265-272
    • Grosicki, S.1
  • 7
    • 84947731681 scopus 로고    scopus 로고
    • Cytogenetic prioritization with inclusion of molecular markers predicts outcome in previously untreated patients with chronic lymphocytic leukemia treated with fludarabine or fludarabine plus cyclophosphamide: A long-term follow-up study of the US Intergroup phase III trial E2997
    • D.M.Lucas, A.S.Ruppert, G.Lozanski, et al. Cytogenetic prioritization with inclusion of molecular markers predicts outcome in previously untreated patients with chronic lymphocytic leukemia treated with fludarabine or fludarabine plus cyclophosphamide: a long-term follow-up study of the US Intergroup phase III trial E2997. Leuk Lymphoma. 2015;56:3031–3037.
    • (2015) Leuk Lymphoma , vol.56 , pp. 3031-3037
    • Lucas, D.M.1    Ruppert, A.S.2    Lozanski, G.3
  • 8
    • 85009944675 scopus 로고    scopus 로고
    • Optimal use of bendamustine in hematologic disorders: Treatment recommendations from an international consensus panel-an update
    • B.D.Cheson, W.Brugger, G.Damaj, et al. Optimal use of bendamustine in hematologic disorders: treatment recommendations from an international consensus panel-an update. Leuk Lymphoma. 2015;23:1–17.
    • (2015) Leuk Lymphoma , vol.23 , pp. 1-17
    • Cheson, B.D.1    Brugger, W.2    Damaj, G.3
  • 9
    • 84975170821 scopus 로고    scopus 로고
    • Systematic review of the recent evidence for the efficacy and safety of chlorambucil in the treatment of B-cell malignancies
    • S.Lepretre, C.Dartigeas, P.Feugier, et al. Systematic review of the recent evidence for the efficacy and safety of chlorambucil in the treatment of B-cell malignancies. Leuk Lymphoma. 2015;8:1–14.
    • (2015) Leuk Lymphoma , vol.8 , pp. 1-14
    • Lepretre, S.1    Dartigeas, C.2    Feugier, P.3
  • 10
    • 84952639130 scopus 로고    scopus 로고
    • Lenalidomide in chronic lymphocytic leukemia: The present and future in the era of tyrosine kinase inhibitors
    • • Excellent review of an important drug
    • R.Maffei, E.Colaci, S.Fiorcari, et al. Lenalidomide in chronic lymphocytic leukemia: the present and future in the era of tyrosine kinase inhibitors. Crit Rev Oncol Hematol. 2016;97:291–302.• Excellent review of an important drug.
    • (2016) Crit Rev Oncol Hematol , vol.97 , pp. 291-302
    • Maffei, R.1    Colaci, E.2    Fiorcari, S.3
  • 11
    • 84975181469 scopus 로고    scopus 로고
    • Pitting new treatments for chronic lymphocytic leukemia against old ones: How do they fare?
    • L.Shvidel, A.Berrebi. Pitting new treatments for chronic lymphocytic leukemia against old ones: how do they fare? Expert Rev Hematol. 2015;23:1–10.
    • (2015) Expert Rev Hematol , vol.23 , pp. 1-10
    • Shvidel, L.1    Berrebi, A.2
  • 12
    • 84955491187 scopus 로고    scopus 로고
    • Targeting BCL2 with venetoclax in relapsed chronic lymphocytic leukemia
    • A.W.Roberts, M.S.Davids, J.M.Pagel, et al. Targeting BCL2 with venetoclax in relapsed chronic lymphocytic leukemia. N Engl J Med. 2016;374:311–322.
    • (2016) N Engl J Med , vol.374 , pp. 311-322
    • Roberts, A.W.1    Davids, M.S.2    Pagel, J.M.3
  • 13
    • 84951310166 scopus 로고    scopus 로고
    • Clinical activity of alvocidib (flavopiridol) in acute myeloid leukemia
    • J.F.Zeidner, J.E.Karp. Clinical activity of alvocidib (flavopiridol) in acute myeloid leukemia. Leuk Res. 2015;39:1312–1318.
    • (2015) Leuk Res , vol.39 , pp. 1312-1318
    • Zeidner, J.F.1    Karp, J.E.2
  • 14
    • 84951567371 scopus 로고    scopus 로고
    • Synergistic anti-tumor efficacy of doxorubicin and flavopiridol in an in vivo hepatocellular carcinoma model
    • M.S.Kwak, S.J.Yu, J.H.Yoon, et al. Synergistic anti-tumor efficacy of doxorubicin and flavopiridol in an in vivo hepatocellular carcinoma model. J Cancer Res Clin Oncol. 2015;141:2037–2045.
    • (2015) J Cancer Res Clin Oncol , vol.141 , pp. 2037-2045
    • Kwak, M.S.1    Yu, S.J.2    Yoon, J.H.3
  • 15
    • 84930241305 scopus 로고    scopus 로고
    • Sequential combination of flavopiridol with taxol synergistically suppresses human ovarian carcinoma growth
    • Y.Song, X.Xin, X.Zhai, et al. Sequential combination of flavopiridol with taxol synergistically suppresses human ovarian carcinoma growth. Arch Gyenocol Obstet. 2015;291:143–150.
    • (2015) Arch Gyenocol Obstet , vol.291 , pp. 143-150
    • Song, Y.1    Xin, X.2    Zhai, X.3
  • 16
    • 84917707385 scopus 로고    scopus 로고
    • The effect of organic anion-transporting polypeptides 1B1, 1B3 and 2B1 on the antitumor activity of flavopiridol in breast cancer cells
    • S.Brenner, J.Riha, B.Giessrigl, et al. The effect of organic anion-transporting polypeptides 1B1, 1B3 and 2B1 on the antitumor activity of flavopiridol in breast cancer cells. Int J Oncol. 2015;46:324–332.
    • (2015) Int J Oncol , vol.46 , pp. 324-332
    • Brenner, S.1    Riha, J.2    Giessrigl, B.3
  • 17
    • 84907189766 scopus 로고    scopus 로고
    • Induced growth inhibition, cell cycle arrest and apoptosis in CD133+/CD44+ prostate cancer stem cells by flavopiridol
    • B.C.Soner, H.Aktug, E.Adikgoz, et al. Induced growth inhibition, cell cycle arrest and apoptosis in CD133+/CD44+ prostate cancer stem cells by flavopiridol. In J Mol Med. 2014;34:1249–1256.
    • (2014) In J Mol Med , vol.34 , pp. 1249-1256
    • Soner, B.C.1    Aktug, H.2    Adikgoz, E.3
  • 18
    • 84907197386 scopus 로고    scopus 로고
    • Antitumor effects of flavopiridol on human uterine leiomyoma in vitro and in a xenograft model
    • H.G.Lee, J.W.Baek, S.J.Shin, et al. Antitumor effects of flavopiridol on human uterine leiomyoma in vitro and in a xenograft model. Reprod Sci. 2014;21:1153–1160.
    • (2014) Reprod Sci , vol.21 , pp. 1153-1160
    • Lee, H.G.1    Baek, J.W.2    Shin, S.J.3
  • 19
    • 84861721783 scopus 로고    scopus 로고
    • Cyclin-dependent kinase inhibition by flavoalkaloids
    • • Excellent review of the mechanism of action of this class of drugs
    • S.K.Jain, S.B.Bharate, R.A.Vishwakarma. Cyclin-dependent kinase inhibition by flavoalkaloids. Mini Rev Med Chem. 2012;12:632–649.• Excellent review of the mechanism of action of this class of drugs.
    • (2012) Mini Rev Med Chem , vol.12 , pp. 632-649
    • Jain, S.K.1    Bharate, S.B.2    Vishwakarma, R.A.3
  • 20
    • 0031670668 scopus 로고    scopus 로고
    • Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms
    • A.M.Senderowicz, D.Headlee, S.F.Stinson, et al. Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms. J Clin Oncol. 1998;16:2986–2999.
    • (1998) J Clin Oncol , vol.16 , pp. 2986-2999
    • Senderowicz, A.M.1    Headlee, D.2    Stinson, S.F.3
  • 21
    • 0032533599 scopus 로고    scopus 로고
    • Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53
    • •• Landmark demonstration of alvocidib activity in CLL
    • J.C.Byrd, C.Shinn, J.K.Waselenko, et al. Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53. Blood. 1998;92:3804–3816.•• Landmark demonstration of alvocidib activity in CLL.
    • (1998) Blood , vol.92 , pp. 3804-3816
    • Byrd, J.C.1    Shinn, C.2    Waselenko, J.K.3
  • 22
    • 84881399114 scopus 로고    scopus 로고
    • Emerging drug profile: Cyclin-dependent kinase inhibitors
    • J.S.Blachly, J.C.Byrd. Emerging drug profile: cyclin-dependent kinase inhibitors. Leuk Lymphoma. 2013;54:2133–2143.
    • (2013) Leuk Lymphoma , vol.54 , pp. 2133-2143
    • Blachly, J.S.1    Byrd, J.C.2
  • 23
    • 0034935026 scopus 로고    scopus 로고
    • Flavopiridol circumvents Bcl-2 family mediated inhibition of apoptosis and drug resistance in B-cell chronic lymphocytic leukaemia
    • C.Pepper, A.Thomas, T.Hoy, et al. Flavopiridol circumvents Bcl-2 family mediated inhibition of apoptosis and drug resistance in B-cell chronic lymphocytic leukaemia. Br J Haematol. 2001;114:70–77.
    • (2001) Br J Haematol , vol.114 , pp. 70-77
    • Pepper, C.1    Thomas, A.2    Hoy, T.3
  • 24
    • 42449097201 scopus 로고    scopus 로고
    • Flavopiridol causes early mitochondrial damage in chronic lymphocytic leukemia cells with impaired oxygen consumption and mobilization of intracellular calcium
    • S.R.Hussain, D.M.Lucas, A.J.Johnson, et al. Flavopiridol causes early mitochondrial damage in chronic lymphocytic leukemia cells with impaired oxygen consumption and mobilization of intracellular calcium. Blood. 2008;111:3190–3199.
    • (2008) Blood , vol.111 , pp. 3190-3199
    • Hussain, S.R.1    Lucas, D.M.2    Johnson, A.J.3
  • 25
    • 84877323041 scopus 로고    scopus 로고
    • Autophagy and ER stress play an essential role in the mechanism of action and drug resistance of the cyclin-dependent kinase inhibitor flavopiridol
    • E.Mahoney, J.C.Byrd, A.J.Johnson. Autophagy and ER stress play an essential role in the mechanism of action and drug resistance of the cyclin-dependent kinase inhibitor flavopiridol. Autophagy. 2013;9:434–435.
    • (2013) Autophagy , vol.9 , pp. 434-435
    • Mahoney, E.1    Byrd, J.C.2    Johnson, A.J.3
  • 26
    • 84865183563 scopus 로고    scopus 로고
    • ER stress and autophagy: New discoveries in the mechanism of action and drug resistance of the cyclin-dependent kinase inhibitor flavopiridol
    • E.Mahoney, D.M.Lucas, S.V.Gupta, et al. ER stress and autophagy: new discoveries in the mechanism of action and drug resistance of the cyclin-dependent kinase inhibitor flavopiridol. Blood. 2012;120:1262–1273.
    • (2012) Blood , vol.120 , pp. 1262-1273
    • Mahoney, E.1    Lucas, D.M.2    Gupta, S.V.3
  • 27
    • 84992444634 scopus 로고    scopus 로고
    • Structural, conformational and thermodynamic aspects of groove-directed-intercalation of flavopiridol into DNA
    • B.Ray, S.Agarwal, N.Lohani, et al. Structural, conformational and thermodynamic aspects of groove-directed-intercalation of flavopiridol into DNA. J Biomol Struct Dyn. 2016;17:1–18.
    • (2016) J Biomol Struct Dyn , vol.17 , pp. 1-18
    • Ray, B.1    Agarwal, S.2    Lohani, N.3
  • 28
    • 78349231616 scopus 로고    scopus 로고
    • The binding of flavopiridol to blood serum albumin
    • D.Myatt, L.Johnson, S.Baumli, et al. The binding of flavopiridol to blood serum albumin. Chirality. 2010;22(Suppl 1E):E40–43.
    • (2010) Chirality , vol.22 , pp. E40-E43
    • Myatt, D.1    Johnson, L.2    Baumli, S.3
  • 29
    • 78249236222 scopus 로고    scopus 로고
    • Flavopiridol pharmacogenetics: Clinical and functional evidence for the role of SLCO1B1/OATP1B1 in flavopiridol disposition
    • W.Ni, J.Ji, Z.Dai, et al. Flavopiridol pharmacogenetics: clinical and functional evidence for the role of SLCO1B1/OATP1B1 in flavopiridol disposition. PLoS One. 2010;5:e13792.
    • (2010) PLoS One , vol.5
    • Ni, W.1    Ji, J.2    Dai, Z.3
  • 30
    • 84934444471 scopus 로고    scopus 로고
    • Interactions of cyclin-dependent kinase inhibitors AT-7519, flavopiridol and SNS-032 with ABCB1, ABCG2 and ABCC1 transporters and their potential to overcome multidrug resistance in vitro
    • D.Cihalova, F.Staud, M.Ceckova. Interactions of cyclin-dependent kinase inhibitors AT-7519, flavopiridol and SNS-032 with ABCB1, ABCG2 and ABCC1 transporters and their potential to overcome multidrug resistance in vitro. Cancer Chemother Pharmacol. 2015;76:105–116.
    • (2015) Cancer Chemother Pharmacol , vol.76 , pp. 105-116
    • Cihalova, D.1    Staud, F.2    Ceckova, M.3
  • 31
    • 77952393660 scopus 로고    scopus 로고
    • Kinetic analysis of the cooperation of p-glycoprotein (P- gp/Abeb1) and breast cancer resistance protein (Berp/Abeg2) in limiting the brain and testis penetration of erlotinib, flavopiridol, and mitoxantrone
    • H.Kodaira, H.Kusuhara, J.Ushiki, et al. Kinetic analysis of the cooperation of p-glycoprotein (P- gp/Abeb1) and breast cancer resistance protein (Berp/Abeg2) in limiting the brain and testis penetration of erlotinib, flavopiridol, and mitoxantrone. J Pharmacol and Exptl Therapeutics. 2010;333:788–796.
    • (2010) J Pharmacol and Exptl Therapeutics , vol.333 , pp. 788-796
    • Kodaira, H.1    Kusuhara, H.2    Ushiki, J.3
  • 32
    • 33846219417 scopus 로고    scopus 로고
    • Flaavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia
    • •• Important demonstration of the importance of scheduling
    • J.C.Byrd, T.S.Lin, J.T.Dalton, et al. Flaavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia. Blood. 2007;109:399–404.•• Important demonstration of the importance of scheduling.
    • (2007) Blood , vol.109 , pp. 399-404
    • Byrd, J.C.1    Lin, T.S.2    Dalton, J.T.3
  • 33
    • 63849246351 scopus 로고    scopus 로고
    • Clinical response and pharmacokinetics from a phase 1 study of an active dosing schedule of flavopiridol in relapsed chronic lymphocytic leukemia
    • M.A.Phelps, T.S.Lin, A.J.Johnson, et al. Clinical response and pharmacokinetics from a phase 1 study of an active dosing schedule of flavopiridol in relapsed chronic lymphocytic leukemia. Blood. 2009;113:2637–2645.
    • (2009) Blood , vol.113 , pp. 2637-2645
    • Phelps, M.A.1    Lin, T.S.2    Johnson, A.J.3
  • 34
    • 84883557418 scopus 로고    scopus 로고
    • Cyclophosphamide, alvocidib (flavopiridol), and rituximab, a novel feasible chemoimmunotherapy regimen for patients with high-risk chronic lymphocytic leukemia
    • D.M.Stephens, A.S.Ruppert, K.Maddocks, et al. Cyclophosphamide, alvocidib (flavopiridol), and rituximab, a novel feasible chemoimmunotherapy regimen for patients with high-risk chronic lymphocytic leukemia. Leuk Res. 2013;37:1195–1199.
    • (2013) Leuk Res , vol.37 , pp. 1195-1199
    • Stephens, D.M.1    Ruppert, A.S.2    Maddocks, K.3
  • 35
    • 84925348918 scopus 로고    scopus 로고
    • Reduced occurrence of tumor flare with flavopiridol followed by combine flavopiridol and lenalidomide in patients with relapsed chronic lymphocytic leukemia (CLL)
    • K.Maddocks, L.Wei, D.Rozewski, et al. Reduced occurrence of tumor flare with flavopiridol followed by combine flavopiridol and lenalidomide in patients with relapsed chronic lymphocytic leukemia (CLL). Am J Hematol. 2015;90:327–333.
    • (2015) Am J Hematol , vol.90 , pp. 327-333
    • Maddocks, K.1    Wei, L.2    Rozewski, D.3
  • 36
    • 20344368831 scopus 로고    scopus 로고
    • Treatment of relapsed chronic lymphocytic leukemia by 72-hour continuous infusion or 1-hour bolus infusion of flavopiridol: Results from Cancer and Leukemia Group B study 19805
    • J.C.Byrd, B.L.Peterson, J.Gabrilove, et al. Treatment of relapsed chronic lymphocytic leukemia by 72-hour continuous infusion or 1-hour bolus infusion of flavopiridol: results from Cancer and Leukemia Group B study 19805. Clin Cancer Res. 2005;11:4176–4181.
    • (2005) Clin Cancer Res , vol.11 , pp. 4176-4181
    • Byrd, J.C.1    Peterson, B.L.2    Gabrilove, J.3
  • 37
    • 73349096649 scopus 로고    scopus 로고
    • Phase II study of flavopiridol in relapsed chronic lymphocytic leukemia demonstrating high response rates in genetically high-risk disease
    • •• A major Phase II study
    • T.S.Lin, A.S.Ruppert, A.J.Johnson, et al. Phase II study of flavopiridol in relapsed chronic lymphocytic leukemia demonstrating high response rates in genetically high-risk disease. J Clin Oncol. 2009;27:6012–6018.•• A major Phase II study.
    • (2009) J Clin Oncol , vol.27 , pp. 6012-6018
    • Lin, T.S.1    Ruppert, A.S.2    Johnson, A.J.3
  • 38
    • 0037317194 scopus 로고    scopus 로고
    • Flavopiridol-related proinflammatory syndrome is associated with induction of interleukin-6
    • R.A.Messmann, C.D.Ulmann, T.Lahusen, et al. Flavopiridol-related proinflammatory syndrome is associated with induction of interleukin-6. Clin Cancer Res. 2003;9:562–570.
    • (2003) Clin Cancer Res , vol.9 , pp. 562-570
    • Messmann, R.A.1    Ulmann, C.D.2    Lahusen, T.3
  • 39
    • 84928089301 scopus 로고    scopus 로고
    • Final results of EFC6663: A multicenter, international, phase 2 study of alvocidib for patients with fludarabine-refractory chronic lymphocytic leukemia
    • M.C.Lanasa, L.Andritsos, J.R.Brown, et al. Final results of EFC6663: a multicenter, international, phase 2 study of alvocidib for patients with fludarabine-refractory chronic lymphocytic leukemia. Leuk Res. 2015;39:495–500.
    • (2015) Leuk Res , vol.39 , pp. 495-500
    • Lanasa, M.C.1    Andritsos, L.2    Brown, J.R.3
  • 40
    • 85018232770 scopus 로고    scopus 로고
    • Randomized multicenter phase II study of flavopiridol (alvocidib), cytarabine, and mitoxantrone (FLAM) versus cytarabine/daunorubicin (7+3) in newly diagnosed acute myeloid leukemia
    • J.F.Zeidner, M.C.Foster, A.L.Blackford, et al. Randomized multicenter phase II study of flavopiridol (alvocidib), cytarabine, and mitoxantrone (FLAM) versus cytarabine/daunorubicin (7+3) in newly diagnosed acute myeloid leukemia. Haematologica. 2015;100:1172–1179.
    • (2015) Haematologica , vol.100 , pp. 1172-1179
    • Zeidner, J.F.1    Foster, M.C.2    Blackford, A.L.3
  • 41
    • 80052478669 scopus 로고    scopus 로고
    • Risk factors for tumor lysis syndrome in patients with chronic lymphocytic leukemia treated with the cyclin-dependent kinase inhibitor, flavopiridol
    • K.A.Blum, A.S.Ruppert, J.A.Woyach, et al. Risk factors for tumor lysis syndrome in patients with chronic lymphocytic leukemia treated with the cyclin-dependent kinase inhibitor, flavopiridol. Leukemia. 2011;25:1444–1451.
    • (2011) Leukemia , vol.25 , pp. 1444-1451
    • Blum, K.A.1    Ruppert, A.S.2    Woyach, J.A.3
  • 42
    • 84874825923 scopus 로고    scopus 로고
    • A pharmacokinetic/pharmacodynamic model of tumor lysis syndrome in chronic lymphocytic leukemia patients treated with flavopiridol
    • •• An important toxicity study
    • J.Ji, D.R.Mould, K.A.Blum, et al. A pharmacokinetic/pharmacodynamic model of tumor lysis syndrome in chronic lymphocytic leukemia patients treated with flavopiridol. Clin Cancer Res. 2013;19:1269–1280.•• An important toxicity study.
    • (2013) Clin Cancer Res , vol.19 , pp. 1269-1280
    • Ji, J.1    Mould, D.R.2    Blum, K.A.3
  • 43
    • 0346007919 scopus 로고    scopus 로고
    • Successful labor in the course of chronic lymphocytic leukemia (CLL) and management of CLL during pregnancy with leukaphersis
    • R.Ali, F.Ozkalemkaş, V.Ozkocaman, et al. Successful labor in the course of chronic lymphocytic leukemia (CLL) and management of CLL during pregnancy with leukaphersis. Ann Hematol. 2004;83:61–63.
    • (2004) Ann Hematol , vol.83 , pp. 61-63
    • Ali, R.1    Ozkalemkaş, F.2    Ozkocaman, V.3
  • 44
    • 84959464986 scopus 로고    scopus 로고
    • Tumor lysis syndrome in the era of novel and targeted agents in patients with hematologic malignancies: A systematic review
    • S.C.Howard, S.Trifilio, T.K.Gregory, et al. Tumor lysis syndrome in the era of novel and targeted agents in patients with hematologic malignancies: a systematic review. Ann Hematol. 2016;95:563–573.
    • (2016) Ann Hematol , vol.95 , pp. 563-573
    • Howard, S.C.1    Trifilio, S.2    Gregory, T.K.3
  • 45
    • 0028578249 scopus 로고
    • Objective response of multiple myeloma to cyclosporine A
    • P.H.Wiernik, J.P.Dutcher, A.N.Leaf, et al. Objective response of multiple myeloma to cyclosporine A. Leuk Lymphoma. 1994;16:167–170.
    • (1994) Leuk Lymphoma , vol.16 , pp. 167-170
    • Wiernik, P.H.1    Dutcher, J.P.2    Leaf, A.N.3
  • 46
    • 84925228691 scopus 로고    scopus 로고
    • Addition of interleukin-6 inhibition with tocilizumab to standard graft-versus-host disease prophylaxis after allogeneic stem-cell transplantation: A phase 1/2 trial
    • G.A.Kennedy, A.Varelias, S.Vuckovic, et al. Addition of interleukin-6 inhibition with tocilizumab to standard graft-versus-host disease prophylaxis after allogeneic stem-cell transplantation: a phase 1/2 trial. Lancet Oncol. 2014;15:1451–1459.
    • (2014) Lancet Oncol , vol.15 , pp. 1451-1459
    • Kennedy, G.A.1    Varelias, A.2    Vuckovic, S.3
  • 47
    • 57049134722 scopus 로고    scopus 로고
    • A novel liposomal formulation of flavopiridol
    • X.Yang, X.Zhao, M.A.Phelps, et al. A novel liposomal formulation of flavopiridol. Int J Pharm. 2009;365:170–174.
    • (2009) Int J Pharm , vol.365 , pp. 170-174
    • Yang, X.1    Zhao, X.2    Phelps, M.A.3
  • 48
    • 84862017961 scopus 로고    scopus 로고
    • Outcome of patients with relapsed or refractory chronic lymphocytic leukemia treated with flavopiridol: Impact of genetic features
    • J.A.Woyach, G.Lozanski, A.S.Ruppert, et al. Outcome of patients with relapsed or refractory chronic lymphocytic leukemia treated with flavopiridol: impact of genetic features. Leukemia. 2012;26:1442–1444.
    • (2012) Leukemia , vol.26 , pp. 1442-1444
    • Woyach, J.A.1    Lozanski, G.2    Ruppert, A.S.3
  • 49
    • 84863393289 scopus 로고    scopus 로고
    • Flavopiridol treatment of patients aged 70 or older with refractory or relapsed chronic lymphocytic leukemia is a feasible and active therapeutic approach
    • D.M.Stephens, A.S.Ruppert, K.Blum, et al. Flavopiridol treatment of patients aged 70 or older with refractory or relapsed chronic lymphocytic leukemia is a feasible and active therapeutic approach. Haematologica. 2012;97:423–427.
    • (2012) Haematologica , vol.97 , pp. 423-427
    • Stephens, D.M.1    Ruppert, A.S.2    Blum, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.