메뉴 건너뛰기




Volumn 46, Issue 1, 2015, Pages 324-332

The effect of organic anion-transporting polypeptides 1B1, 1B3 and 2B1 on the antitumor activity of flavopiridol in breast cancer cells

Author keywords

Breast cancer; Cell cycle inhibition; Cellular uptake; Flavopiridol; OATP; Transport

Indexed keywords

ANTINEOPLASTIC AGENT; FLAVONOID; FLAVOPIRIDOL; ORGANIC ANION TRANSPORTER; PIPERIDINE DERIVATIVE; SLCO1B1 PROTEIN, HUMAN; SLCO1B3 PROTEIN, HUMAN; SLCO2B1 PROTEIN, HUMAN;

EID: 84917707385     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2014.2731     Document Type: Article
Times cited : (11)

References (51)
  • 1
    • 0033568521 scopus 로고    scopus 로고
    • Down-regulation of cyclin D1 by transcriptional repression in MCF-7 human breast carcinoma cells induced by flavopiridol
    • Carlson B, Lahusen T, Singh S, et al: Down-regulation of cyclin D1 by transcriptional repression in MCF-7 human breast carcinoma cells induced by flavopiridol. Cancer Res 59: 4634-4641, 1999.
    • (1999) Cancer Res , vol.59 , pp. 4634-4641
    • Carlson, B.1    Lahusen, T.2    Singh, S.3
  • 2
    • 0029807115 scopus 로고    scopus 로고
    • Flavopiridol (L86 8275; NSC 649890), a new kinase inhibitor for tumor therapy
    • Sedlacek HH, Czech J, Naik R, et al: Flavopiridol (L86 8275; NSC 649890), a new kinase inhibitor for tumor therapy. Int J Oncol 9: 1143-1168, 1996.
    • (1996) Int J Oncol , vol.9 , pp. 1143-1168
    • Sedlacek, H.H.1    Czech, J.2    Naik, R.3
  • 4
    • 0035233239 scopus 로고    scopus 로고
    • Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol
    • Research0041
    • Lam LT, Pickeral OK, Peng AC, et al: Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol. Genome Biol 2: Research0041, 2001.
    • (2001) Genome Biol , vol.2
    • Lam, L.T.1    Pickeral, O.K.2    Peng, A.C.3
  • 5
    • 33749076241 scopus 로고    scopus 로고
    • Sequential combinations of flavopiridol and docetaxel inhibit prostate tumors induce apoptosis and decrease angiogenesis in the Ggamma/T-15 transgenic mouse model of prostate cancer
    • Reiner T, de las Pozas A and Perez-Stable C: Sequential combinations of flavopiridol and docetaxel inhibit prostate tumors, induce apoptosis, and decrease angiogenesis in the Ggamma/T-15 transgenic mouse model of prostate cancer. Prostate 66: 1487-1497, 2006.
    • (2006) Prostate , vol.66 , pp. 1487-1497
    • Reiner, T.1    De Las Pozas, A.2    Perez-Stable, C.3
  • 6
    • 0034887130 scopus 로고    scopus 로고
    • Flavopiridol increases sensitization to gemcitabine in human gastrointestinal cancer cell lines and correlates with down-regulation of ribonucleotide reductase M2 subunit
    • Jung CP, Motwani MV and Schwartz GK: Flavopiridol increases sensitization to gemcitabine in human gastrointestinal cancer cell lines and correlates with down-regulation of ribonucleotide reductase M2 subunit. Clin Cancer Res 7: 2527-2536, 2001.
    • (2001) Clin Cancer Res , vol.7 , pp. 2527-2536
    • Jung, C.P.1    Motwani, M.V.2    Schwartz, G.K.3
  • 7
    • 33846219417 scopus 로고    scopus 로고
    • Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia
    • Byrd JC, Lin TS, Dalton JT, et al: Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia. Blood 109: 399-404, 2007.
    • (2007) Blood , vol.109 , pp. 399-404
    • Byrd, J.C.1    Lin, T.S.2    Dalton, J.T.3
  • 8
    • 63849246351 scopus 로고    scopus 로고
    • Clinical response and pharmacokinetics from a phase 1 study of an active dosing schedule of flavopiridol in relapsed chronic lymphocytic leukemia
    • Phelps MA, Lin TS, Johnson AJ, et al: Clinical response and pharmacokinetics from a phase 1 study of an active dosing schedule of flavopiridol in relapsed chronic lymphocytic leukemia. Blood 113: 2637-2645, 2009.
    • (2009) Blood , vol.113 , pp. 2637-2645
    • Phelps, M.A.1    Lin, T.S.2    Johnson, A.J.3
  • 9
    • 20344368831 scopus 로고    scopus 로고
    • Treatment of relapsed chronic lymphocytic leukemia by 72-hour continuous infusion or 1-hour bolus infusion of flavopiridol: Results from cancer and leukemia group B study 19805
    • Byrd JC, Peterson BL, Gabrilove J, et al: Treatment of relapsed chronic lymphocytic leukemia by 72-hour continuous infusion or 1-hour bolus infusion of flavopiridol: results from cancer and leukemia group B study 19805. Clin Cancer Res 11: 4176-4181, 2005.
    • (2005) Clin Cancer Res , vol.11 , pp. 4176-4181
    • Byrd, J.C.1    Peterson, B.L.2    Gabrilove, J.3
  • 10
    • 73349096649 scopus 로고    scopus 로고
    • Phase II study of flavopiridol in relapsed chronic lymphocytic leukemia demonstrating high response rates in genetically high-risk disease
    • Lin TS, Ruppert AS, Johnson AJ, et al: Phase II study of flavopiridol in relapsed chronic lymphocytic leukemia demonstrating high response rates in genetically high-risk disease. J Clin Oncol 27: 6012-6018, 2009.
    • (2009) J Clin Oncol , vol.27 , pp. 6012-6018
    • Lin, T.S.1    Ruppert, A.S.2    Johnson, A.J.3
  • 11
    • 0035064435 scopus 로고    scopus 로고
    • In vitro glucuronidation of the cyclin-dependent kinase inhibitor flavopiridol by rat and human liver microsomes: Involvement of udpglucuronosyltransferases 1A1 and 1A9
    • Hagenauer B, Salamon A, Thalharmmer T, et al: In vitro glucuronidation of the cyclin-dependent kinase inhibitor flavopiridol by rat and human liver microsomes: involvement of udpglucuronosyltransferases 1A1 and 1A9. Drug Metab Dispos 29: 407-414, 2001.
    • (2001) Drug Metab Dispos , vol.29 , pp. 407-414
    • Hagenauer, B.1    Salamon, A.2    Thalharmmer, T.3
  • 12
    • 0035783264 scopus 로고    scopus 로고
    • UGT1A1 polymorphism predicts irinotecan toxicity: Evolving proof
    • Mani S: UGT1A1 polymorphism predicts irinotecan toxicity: evolving proof. AAPS Pharm Sci 3: 2, 2001.
    • (2001) AAPS Pharm Sci , vol.3 , pp. 2
    • Mani, S.1
  • 13
    • 33746780621 scopus 로고    scopus 로고
    • Pharmacogenetics of uridine diphosphoglucuronosyltransferase (UGT) 1A family members and its role in patient response to irinotecan
    • Nagar S and Blanchard RL: Pharmacogenetics of uridine diphosphoglucuronosyltransferase (UGT) 1A family members and its role in patient response to irinotecan. Drug Metab Rev 38: 393-409, 2006.
    • (2006) Drug Metab Rev , vol.38 , pp. 393-409
    • Nagar, S.1    Blanchard, R.L.2
  • 14
  • 16
    • 0042835753 scopus 로고    scopus 로고
    • Quantitative analysis of breast cancer resistance protein and cellular resistance to flavopiridol in acute leukemia patients
    • Nakanishi T, Karp JE, Tan M, et al: Quantitative analysis of breast cancer resistance protein and cellular resistance to flavopiridol in acute leukemia patients. Clin Cancer Res 9: 3320-3328, 2003.
    • (2003) Clin Cancer Res , vol.9 , pp. 3320-3328
    • Nakanishi, T.1    Karp, J.E.2    Tan, M.3
  • 17
    • 0032503010 scopus 로고    scopus 로고
    • Metabolism of the anticancer drug flavopiridol, a new inhibitor of cyclin dependent kinases, in rat liver
    • Jager W, Zembsch B, Wolschann P, et al: Metabolism of the anticancer drug flavopiridol, a new inhibitor of cyclin dependent kinases, in rat liver. Life Sci 62: 1861-1873, 1998.
    • (1998) Life Sci , vol.62 , pp. 1861-1873
    • Jager, W.1    Zembsch, B.2    Wolschann, P.3
  • 18
    • 40049110714 scopus 로고    scopus 로고
    • Carrier-mediated cellular uptake of pharmaceutical drugs: An exception or the rule?
    • D obson PD and Kell DB: Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule? Nat Rev Drug Discov 7: 205-220, 2008.
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 205-220
    • Dobson, P.D.1    Kell, D.B.2
  • 19
    • 48749112588 scopus 로고    scopus 로고
    • Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family
    • Hagenbuch B and Gui C: Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family. Xenobiotica 38: 778-801, 2008.
    • (2008) Xenobiotica , vol.38 , pp. 778-801
    • Hagenbuch, B.1    Gui, C.2
  • 20
    • 0242469240 scopus 로고    scopus 로고
    • Organic anion-transporting polypeptide (OATP) transporter family and drug disposition
    • Kim RB: Organic anion-transporting polypeptide (OATP) transporter family and drug disposition. Eur J Clin Invest 33 (Suppl 2): 1-5, 2003.
    • (2003) Eur J Clin Invest , vol.33 , pp. 1-5
    • Kim, R.B.1
  • 21
    • 0034709561 scopus 로고    scopus 로고
    • Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family
    • Tamai I, Nezu J, Uchino H, et al: Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun 273: 251-260, 2000.
    • (2000) Biochem Biophys Res Commun , vol.273 , pp. 251-260
    • Tamai, I.1    Nezu, J.2    Uchino, H.3
  • 22
    • 34548165578 scopus 로고    scopus 로고
    • Human liver-specific organic anion transporter-2 is a potent prognostic factor for human breast carcinoma
    • Muto M, Onogawa T, Suzuki T, et al: Human liver-specific organic anion transporter-2 is a potent prognostic factor for human breast carcinoma. Cancer Sci 98: 1570-1576, 2007.
    • (2007) Cancer Sci , vol.98 , pp. 1570-1576
    • Muto, M.1    Onogawa, T.2    Suzuki, T.3
  • 23
    • 58149161886 scopus 로고    scopus 로고
    • Altered expression of organic anion transporter polypeptide (OATP) genes in human breast carcinoma
    • Wlcek K, Svoboda M, Thalhammer T, Sellner F, Krupitza G and Jaeger W: Altered expression of organic anion transporter polypeptide (OATP) genes in human breast carcinoma. Cancer Biol Ther 7: 1452-1457, 2008.
    • (2008) Cancer Biol Ther , vol.7 , pp. 1452-1457
    • Wlcek, K.1    Svoboda, M.2    Thalhammer, T.3    Sellner, F.4    Krupitza, G.5    Jaeger, W.6
  • 24
    • 84855869661 scopus 로고    scopus 로고
    • The expression and function of organic anion transporting polypeptides in normal tissues and in cancer
    • Obaidat A, Roth M and Hagenbuch B: The expression and function of organic anion transporting polypeptides in normal tissues and in cancer. Annu Rev Pharmacol Toxicol 52: 135-151, 2012.
    • (2012) Annu Rev Pharmacol Toxicol , vol.52 , pp. 135-151
    • Obaidat, A.1    Roth, M.2    Hagenbuch, B.3
  • 26
    • 0035006408 scopus 로고    scopus 로고
    • LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers
    • Abe T, Unno M, Onogawa T, et al: LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. Gastroenterology 120: 1689-1699, 2001.
    • (2001) Gastroenterology , vol.120 , pp. 1689-1699
    • Abe, T.1    Unno, M.2    Onogawa, T.3
  • 27
    • 20744450287 scopus 로고    scopus 로고
    • Characterization of the organic cation transporter SLC22A16: A doxorubicin importer
    • Okabe M, Unno M, Harigae H, et al: Characterization of the organic cation transporter SLC22A16: a doxorubicin importer. Biochem Biophys Res Commun 333: 754-762, 2005.
    • (2005) Biochem Biophys Res Commun , vol.333 , pp. 754-762
    • Okabe, M.1    Unno, M.2    Harigae, H.3
  • 28
    • 28244486151 scopus 로고    scopus 로고
    • Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2
    • Ciarimboli G, Ludwig T, Lang D, et al: Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2. Am J Pathol 167: 1477-1484, 2005.
    • (2005) Am J Pathol , vol.167 , pp. 1477-1484
    • Ciarimboli, G.1    Ludwig, T.2    Lang, D.3
  • 29
    • 33751168746 scopus 로고    scopus 로고
    • Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and multidrug and toxin extrusion family)
    • Yonezawa A, Masuda S, Yokoo S, Katsura T and Inui K: Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and multidrug and toxin extrusion family). J Pharmacol Exp Ther 319: 879-886, 2006.
    • (2006) J Pharmacol Exp Ther , vol.319 , pp. 879-886
    • Yonezawa, A.1    Masuda, S.2    Yokoo, S.3    Katsura, T.4    Inui, K.5
  • 30
    • 33749037182 scopus 로고    scopus 로고
    • Organic cation transporters are determinants of oxaliplatin cytotoxicity
    • Zhang S, Lovejoy KS, Shima JE, et al: Organic cation transporters are determinants of oxaliplatin cytotoxicity. Cancer Res 66: 8847-8857, 2006.
    • (2006) Cancer Res , vol.66 , pp. 8847-8857
    • Zhang, S.1    Lovejoy, K.S.2    Shima, J.E.3
  • 31
    • 80052675543 scopus 로고    scopus 로고
    • Expression of organic anion-transporting polypeptides 1B1 and 1B3 in ovarian cancer cells: Relevance for paclitaxel transport
    • Svoboda M, Wlcek K, Taferner B, et al: Expression of organic anion-transporting polypeptides 1B1 and 1B3 in ovarian cancer cells: relevance for paclitaxel transport. Biomed Pharmacother 65: 417-426, 2011.
    • (2011) Biomed Pharmacother , vol.65 , pp. 417-426
    • Svoboda, M.1    Wlcek, K.2    Taferner, B.3
  • 32
    • 54049145153 scopus 로고    scopus 로고
    • Profiling SLCO and SLC22 genes in the NCI-60 cancer cell lines to identify drug uptake transporters
    • Okabe M, Szakacs G, Reimers MA, et al: Profiling SLCO and SLC22 genes in the NCI-60 cancer cell lines to identify drug uptake transporters. Mol Cancer Ther 7: 3081-3091, 2008.
    • (2008) Mol Cancer Ther , vol.7 , pp. 3081-3091
    • Okabe, M.1    Szakacs, G.2    Reimers, M.A.3
  • 33
    • 78249236222 scopus 로고    scopus 로고
    • Flavopiridol pharmacogenetics: Clinical and functional evidence for the role of SLCO1B1/OATP1B1 in flavopiridol disposition
    • Ni W, Ji J, Dai Z, et al: Flavopiridol pharmacogenetics: clinical and functional evidence for the role of SLCO1B1/OATP1B1 in flavopiridol disposition. PLoS One 5: e13792, 2010.
    • (2010) PLoS One , vol.5 , pp. e13792
    • Ni, W.1    Ji, J.2    Dai, Z.3
  • 34
    • 41149140202 scopus 로고    scopus 로고
    • Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3
    • Gui C, Miao Y, Thompson L, et al: Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3. Eur J Pharmacol 584: 57-65, 2008.
    • (2008) Eur J Pharmacol , vol.584 , pp. 57-65
    • Gui, C.1    Miao, Y.2    Thompson, L.3
  • 35
    • 34547212999 scopus 로고    scopus 로고
    • Bosentan is a substrate of human OATP1B1 and OATP1B3: Inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin, and sildenafil
    • Treiber A, Schneiter R, Hausler S and Stieger B: Bosentan is a substrate of human OATP1B1 and OATP1B3: inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin, and sildenafil. Drug Metab Dispos 35: 1400-1407, 2007.
    • (2007) Drug Metab Dispos , vol.35 , pp. 1400-1407
    • Treiber, A.1    Schneiter, R.2    Hausler, S.3    Stieger, B.4
  • 37
    • 39149104669 scopus 로고    scopus 로고
    • Metabolism of resveratrol in breast cancer cell lines: Impact of sulfotransferase 1A1 expression on cell growth inhibition
    • Murias M, Miksits M, Aust S, et al: Metabolism of resveratrol in breast cancer cell lines: impact of sulfotransferase 1A1 expression on cell growth inhibition. Cancer Lett 261: 172-182, 2008.
    • (2008) Cancer Lett , vol.261 , pp. 172-182
    • Murias, M.1    Miksits, M.2    Aust, S.3
  • 38
    • 84907481602 scopus 로고    scopus 로고
    • Resveratrol and its major sulfated conjugates are substrates of organic anion transporting polypeptides (OATPs) impact on growth of ZR-75-1 breast cancer cells
    • Riha J, Brenner S, Bohmdorfer M, et al: Resveratrol and its major sulfated conjugates are substrates of organic anion transporting polypeptides (OATPs): impact on growth of ZR-75-1 breast cancer cells. Mol Nutr Food Res 58: 1830-1842, 2014.
    • (2014) Mol Nutr Food Res , vol.58 , pp. 1830-1842
    • Riha, J.1    Brenner, S.2    Bohmdorfer, M.3
  • 39
    • 0025860171 scopus 로고
    • Production of analytical quantities of recombinant proteins in Chinese hamster ovary cells using sodium butyrate to elevate gene expression
    • Palermo DP, DeGraaf ME, Marotti KR, Rehberg E and Post LE: Production of analytical quantities of recombinant proteins in Chinese hamster ovary cells using sodium butyrate to elevate gene expression. J Biotechnol 19: 35-47, 1991.
    • (1991) J Biotechnol , vol.19 , pp. 35-47
    • Palermo, D.P.1    Degraaf, M.E.2    Marotti, K.R.3    Rehberg, E.4    Post, L.E.5
  • 40
    • 84861767292 scopus 로고    scopus 로고
    • An apolar extract of Critonia morifolia inhibits c-Myc, cyclin D1, Cdc25A, Cdc25B, Cdc25C and Akt and induces apoptosis
    • Unger C, Popescu R, Giessrigl B, et al: An apolar extract of Critonia morifolia inhibits c-Myc, cyclin D1, Cdc25A, Cdc25B, Cdc25C and Akt and induces apoptosis. Int J Oncol 40: 2131-2139, 2012.
    • (2012) Int J Oncol , vol.40 , pp. 2131-2139
    • Unger, C.1    Popescu, R.2    Giessrigl, B.3
  • 41
    • 0036293982 scopus 로고    scopus 로고
    • Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver
    • Vavricka SR, Van Montfoort J, Ha HR, Meier PJ and Fattinger K: Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver. Hepatology 36: 164-172, 2002.
    • (2002) Hepatology , vol.36 , pp. 164-172
    • Vavricka, S.R.1    Van Montfoort, J.2    Ha, H.R.3    Meier, P.J.4    Fattinger, K.5
  • 42
    • 77149153424 scopus 로고    scopus 로고
    • Interaction of HIV protease inhibitors with OATP1B1, 1B3, and 2B1
    • Annaert P, Ye ZW, Stieger B and Augustijns P: Interaction of HIV protease inhibitors with OATP1B1, 1B3, and 2B1. Xenobiotica 40: 163-176, 2010.
    • (2010) Xenobiotica , vol.40 , pp. 163-176
    • Annaert, P.1    Ye, Z.W.2    Stieger, B.3    Augustijns, P.4
  • 43
    • 84874825923 scopus 로고    scopus 로고
    • A pharmacokinetic/pharmacodynamic model of tumor lysis syndrome in chronic lymphocytic leukemia patients treated with flavopiridol
    • Ji J, Mould DR, Blum KA, et al: A pharmacokinetic/pharmacodynamic model of tumor lysis syndrome in chronic lymphocytic leukemia patients treated with flavopiridol. Clin Cancer Res 19: 1269-1280, 2013.
    • (2013) Clin Cancer Res , vol.19 , pp. 1269-1280
    • Ji, J.1    Mould, D.R.2    Blum, K.A.3
  • 44
    • 84864122633 scopus 로고    scopus 로고
    • Carrier-mediated transport of quercetin conjugates: Involvement of organic anion transporters and organic anion transporting polypeptides
    • Wong CC, Akiyama Y, Abe T, Lippiat JD, Orfila C and Williamson G: Carrier-mediated transport of quercetin conjugates: involvement of organic anion transporters and organic anion transporting polypeptides. Biochem Pharmacol 84: 564-570, 2012.
    • (2012) Biochem Pharmacol , vol.84 , pp. 564-570
    • Wong, C.C.1    Akiyama, Y.2    Abe, T.3    Lippiat, J.D.4    Orfila, C.5    Williamson, G.6
  • 45
    • 58149161886 scopus 로고    scopus 로고
    • Altered expression of organic anion transporter polypeptide (OATP) genes in human breast carcinoma
    • Wlcek K, Svoboda M, Thalhammer T, Sellner F, Krupitza G and Jaeger W: Altered expression of organic anion transporter polypeptide (OATP) genes in human breast carcinoma. Cancer Biol Ther 7: 1450-1455, 2008.
    • (2008) Cancer Biol Ther , vol.7 , pp. 1450-1455
    • Wlcek, K.1    Svoboda, M.2    Thalhammer, T.3    Sellner, F.4    Krupitza, G.5    Jaeger, W.6
  • 46
    • 0029665778 scopus 로고    scopus 로고
    • Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells
    • Carlson BA, Dubay MM, Sausville EA, Brizuela L and Worland PJ: Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells. Cancer Res 56: 2973-2978, 1996.
    • (1996) Cancer Res , vol.56 , pp. 2973-2978
    • Carlson, B.A.1    Dubay, M.M.2    Sausville, E.A.3    Brizuela, L.4    Worland, P.J.5
  • 47
    • 84892154553 scopus 로고    scopus 로고
    • Effects of alvocidib and carboplatin on ovarian cancer cells in vitro
    • Baumann KH, Kim H, Rinke J, Plaum T, Wagner U and Reinartz S: Effects of alvocidib and carboplatin on ovarian cancer cells in vitro. Exp Oncol 35: 168-173, 2013.
    • (2013) Exp Oncol , vol.35 , pp. 168-173
    • Baumann, K.H.1    Kim, H.2    Rinke, J.3    Plaum, T.4    Wagner, U.5    Reinartz, S.6
  • 48
    • 84890334739 scopus 로고    scopus 로고
    • Tumor-specific expression of organic anion-transporting polypeptides: Transporters as novel targets for cancer therapy
    • Buxhofer-Ausch V, Secky L, Wlcek K, et al: Tumor-specific expression of organic anion-transporting polypeptides: transporters as novel targets for cancer therapy. J Drug Deliv 2013: 863539, 2013.
    • (2013) J Drug Deliv , vol.2013 , pp. 863539
    • Buxhofer-Ausch, V.1    Secky, L.2    Wlcek, K.3
  • 49
    • 34247390725 scopus 로고    scopus 로고
    • The influence of macrolide antibiotics on the uptake of organic anions and drugs mediated by OATP1B1 and OATP1B3
    • Seithel A, Eberl S, Singer K, et al: The influence of macrolide antibiotics on the uptake of organic anions and drugs mediated by OATP1B1 and OATP1B3. Drug Metab Dispos 35: 779-786, 2007.
    • (2007) Drug Metab Dispos , vol.35 , pp. 779-786
    • Seithel, A.1    Eberl, S.2    Singer, K.3
  • 50
    • 41549168190 scopus 로고    scopus 로고
    • Investigation of the inhibitory effects of various drugs on the hepatic uptake of fexofenadine in humans
    • Matsushima S, Maeda K, Ishiguro N, Igarashi T and Sugiyama Y: Investigation of the inhibitory effects of various drugs on the hepatic uptake of fexofenadine in humans. Drug Metab Dispos 36: 663-669, 2008.
    • (2008) Drug Metab Dispos , vol.36 , pp. 663-669
    • Matsushima, S.1    Maeda, K.2    Ishiguro, N.3    Igarashi, T.4    Sugiyama, Y.5
  • 51
    • 27544453625 scopus 로고    scopus 로고
    • Flavonoids as a novel class of human organic anion-transporting polypeptide OATP1B1 (OATP-C) modulators
    • Wang X, Wolkoff AW and Morris ME: Flavonoids as a novel class of human organic anion-transporting polypeptide OATP1B1 (OATP-C) modulators. Drug Metab Dispos 33: 1666-1672, 2005.
    • (2005) Drug Metab Dispos , vol.33 , pp. 1666-1672
    • Wang, X.1    Wolkoff, A.W.2    Morris, M.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.