-
1
-
-
33644847307
-
Select high-risk genetic features predict earlier progression following chemoimmunotherapy with fludarabine and rituximab in chronic lymphocytic leukemia: Justification for risk-adapted therapy
-
Byrd JC, Gribben JG, Peterson BL, et al. Select high-risk genetic features predict earlier progression following chemoimmunotherapy with fludarabine and rituximab in chronic lymphocytic leukemia: Justification for risk-adapted therapy. J Clin Oncol 2006;24:437-443.
-
(2006)
J Clin Oncol
, vol.24
, pp. 437-443
-
-
Byrd, J.C.1
Gribben, J.G.2
Peterson, B.L.3
-
2
-
-
33744482623
-
Immunomodulating drugs for chronic lymphocytic leukaemia
-
Chanan-Khan A, Porter CW. Immunomodulating drugs for chronic lymphocytic leukaemia. Lancet Oncol 2006;7:480-488.
-
(2006)
Lancet Oncol
, vol.7
, pp. 480-488
-
-
Chanan-Khan, A.1
Porter, C.W.2
-
3
-
-
33846219417
-
Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia
-
Byrd J, Lin TS, Dalton JT, et al. Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia. Blood 2007;109:399-404.
-
(2007)
Blood
, vol.109
, pp. 399-404
-
-
Byrd, J.1
Lin, T.S.2
Dalton, J.T.3
-
4
-
-
33947243663
-
Clinical efficacy of lenalidomide in patients with relapsed or refractory chronic lymphocytic leukemia: Results of a phase II study
-
Chanan-Khan A, Miller KC, Musial L, et al. Clinical efficacy of lenalidomide in patients with relapsed or refractory chronic lymphocytic leukemia: Results of a phase II study. J Clin Oncol 2006;24:5343-5349.
-
(2006)
J Clin Oncol
, vol.24
, pp. 5343-5349
-
-
Chanan-Khan, A.1
Miller, K.C.2
Musial, L.3
-
5
-
-
45949100928
-
Lenalidomide induces complete and partial remissions in patients with relapsed and refractory chronic lymphocytic leukemia
-
Ferrajoli A, Lee BN, Schlette EJ, et al. Lenalidomide induces complete and partial remissions in patients with relapsed and refractory chronic lymphocytic leukemia. Blood 2008;111:5291-5297.
-
(2008)
Blood
, vol.111
, pp. 5291-5297
-
-
Ferrajoli, A.1
Lee, B.N.2
Schlette, E.J.3
-
6
-
-
84863115505
-
Final results of a multicenter phase 1 study of lenalidomide in patients with relapased or refractory chronic lymphocytic leukemia
-
Wendtner CM, Hillmen P, Mahadevan D. Final results of a multicenter phase 1 study of lenalidomide in patients with relapased or refractory chronic lymphocytic leukemia. Leuk Lymph 2012;53:417-423.
-
(2012)
Leuk Lymph
, vol.53
, pp. 417-423
-
-
Wendtner, C.M.1
Hillmen, P.2
Mahadevan, D.3
-
7
-
-
33749438404
-
Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion
-
List A, Dewald G, Bennett J, et al. Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion. N Engl J Med 2006;355:1456-1465.
-
(2006)
N Engl J Med
, vol.355
, pp. 1456-1465
-
-
List, A.1
Dewald, G.2
Bennett, J.3
-
8
-
-
34547474047
-
Lenalidomide inhibits the malignant clone and up-regulates the SPARC gene mapping to the commonly deleted region in 5q- syndrome patients
-
Pellagatti A, Jadersten M, Forsblom AM, et al. Lenalidomide inhibits the malignant clone and up-regulates the SPARC gene mapping to the commonly deleted region in 5q- syndrome patients. Proc Natl Acad Sci USA 2007;104:11406-11411.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 11406-11411
-
-
Pellagatti, A.1
Jadersten, M.2
Forsblom, A.M.3
-
9
-
-
33750607347
-
A randomized phase 2 study of lenalidomide therapy for patients with relapsed or relapsed and refractory multiple myeloma
-
Richardson PG, Blood E, Mitsiades CS, et al. A randomized phase 2 study of lenalidomide therapy for patients with relapsed or relapsed and refractory multiple myeloma. Blood 2006;108:3458-3464.
-
(2006)
Blood
, vol.108
, pp. 3458-3464
-
-
Richardson, P.G.1
Blood, E.2
Mitsiades, C.S.3
-
10
-
-
84887030194
-
Long-term follow-up of lenalidomide in relapsed/refractory mantle cell lymphoma: Subset analysis of the NHL-003 study
-
Zinzani PL, Vose JM, Czuczman MS, et al. Long-term follow-up of lenalidomide in relapsed/refractory mantle cell lymphoma: Subset analysis of the NHL-003 study. Ann Oncol 2013;24:2892-2897.
-
(2013)
Ann Oncol
, vol.24
, pp. 2892-2897
-
-
Zinzani, P.L.1
Vose, J.M.2
Czuczman, M.S.3
-
11
-
-
33745961875
-
Enhancement of ligand-dependent activation of human natural killer T cells by lenalidomide: Therapeutic implications
-
Chang DH, Liu N, Klimek V, et al. Enhancement of ligand-dependent activation of human natural killer T cells by lenalidomide: Therapeutic implications. Blood 2006;108:618-621.
-
(2006)
Blood
, vol.108
, pp. 618-621
-
-
Chang, D.H.1
Liu, N.2
Klimek, V.3
-
12
-
-
34547925624
-
Combination therapy targeting the tumor microenvironment is effective in a model of human ocular melanoma
-
Mangiameli DP, Blansfield JA, Kachaia S, et al. Combination therapy targeting the tumor microenvironment is effective in a model of human ocular melanoma. J Transl Med 2007;5:38.
-
(2007)
J Transl Med
, vol.5
, pp. 38
-
-
Mangiameli, D.P.1
Blansfield, J.A.2
Kachaia, S.3
-
13
-
-
36849024949
-
Immunomodulatory drugs stimulate natural killer-cell function, alter cytokine production by dendritic cells, and inhibit angiogenesis enhancing the anti-tumour activity of rituximab in vivo
-
Reddy N, Hernandez-Illizaliturri FJ, Deeb G, et al. Immunomodulatory drugs stimulate natural killer-cell function, alter cytokine production by dendritic cells, and inhibit angiogenesis enhancing the anti-tumour activity of rituximab in vivo. Br J Haematol 2008;140:36-45.
-
(2008)
Br J Haematol
, vol.140
, pp. 36-45
-
-
Reddy, N.1
Hernandez-Illizaliturri, F.J.2
Deeb, G.3
-
14
-
-
0033168605
-
Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-alpha
-
Corral LG, Haslett PA, Muller GW, et al. Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-alpha. J Immunol 1999;163:380-386.
-
(1999)
J Immunol
, vol.163
, pp. 380-386
-
-
Corral, L.G.1
Haslett, P.A.2
Muller, G.W.3
-
15
-
-
70349150560
-
Lenalidomide-induced upregulation of CD80 on tumor cells correlates with T-cell activation, the rapid onset of a cytokine release syndrome and leukemic cell clearance in chronic lymphocytic leukemia
-
Aue G, Njuguna N, Tian X, et al. Lenalidomide-induced upregulation of CD80 on tumor cells correlates with T-cell activation, the rapid onset of a cytokine release syndrome and leukemic cell clearance in chronic lymphocytic leukemia. Haematologica 2009;94:1266-1273.
-
(2009)
Haematologica
, vol.94
, pp. 1266-1273
-
-
Aue, G.1
Njuguna, N.2
Tian, X.3
-
16
-
-
45149115902
-
Higher doses of lenalidomide are associated with unacceptable toxicity including life-threatening tumor flare in patients with chronic lymphocytic leukemia
-
Andritsos LA, Johnson AJ, Lozanski G, et al. Higher doses of lenalidomide are associated with unacceptable toxicity including life-threatening tumor flare in patients with chronic lymphocytic leukemia. J Clin Oncol 2008;26:2519-2525.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2519-2525
-
-
Andritsos, L.A.1
Johnson, A.J.2
Lozanski, G.3
-
17
-
-
79955515528
-
Tumor flare reaction associated with lenalidomide treatment in patients with chronic lymphocytic leukemia predicts clinical response
-
Chanan-Khan A, Miller KC, Lawrence D, et al. Tumor flare reaction associated with lenalidomide treatment in patients with chronic lymphocytic leukemia predicts clinical response. Cancer 2011;117:2127-2135.
-
(2011)
Cancer
, vol.117
, pp. 2127-2135
-
-
Chanan-Khan, A.1
Miller, K.C.2
Lawrence, D.3
-
18
-
-
0034661538
-
Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate anti-apoptosis proteins in B-cell chronic lymphocytic leukemia
-
Kitada S, Zapata J, Andreef M, Reed J. Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate anti-apoptosis proteins in B-cell chronic lymphocytic leukemia. Blood 2000;96:393-397.
-
(2000)
Blood
, vol.96
, pp. 393-397
-
-
Kitada, S.1
Zapata, J.2
Andreef, M.3
Reed, J.4
-
19
-
-
0037446980
-
The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process
-
Yu C, Rahmani M, Dai Y, et al. The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process. Cancer Res 2003;63:1822-1833.
-
(2003)
Cancer Res
, vol.63
, pp. 1822-1833
-
-
Yu, C.1
Rahmani, M.2
Dai, Y.3
-
20
-
-
1042278138
-
Flavopiridol inhibits NF-{kappa}B activation induced by various carcinogens and inflammatory agents through inhibition of I{kappa}B{alpha} kinase and p65 phosphorylation: Abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9
-
Takada Y, Aggarwal BB. Flavopiridol inhibits NF-{kappa}B activation induced by various carcinogens and inflammatory agents through inhibition of I{kappa}B{alpha} kinase and p65 phosphorylation: Abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9. J Biol Chem 2004;279:4750-4759.
-
(2004)
J Biol Chem
, vol.279
, pp. 4750-4759
-
-
Takada, Y.1
Aggarwal, B.B.2
-
22
-
-
0033231301
-
Flavopiridol, a protein kinase inhibitor, down-regulates hypoxic induction of vascular endothelial growth factor expression in human monocytes
-
Melillo G, Sausville EA, Cloud K, Lahusen T, Varesio L, Senderowicz AM. Flavopiridol, a protein kinase inhibitor, down-regulates hypoxic induction of vascular endothelial growth factor expression in human monocytes. Cancer Res 1999;59:5433-5437.
-
(1999)
Cancer Res
, vol.59
, pp. 5433-5437
-
-
Melillo, G.1
Sausville, E.A.2
Cloud, K.3
Lahusen, T.4
Varesio, L.5
Senderowicz, A.M.6
-
23
-
-
13944277105
-
A dynamic equilibrium between CDKs and PP2A modulates phosphorylation of pRB, p107 and p130
-
Garriga J, Javaraman AL, Limon A, et al. A dynamic equilibrium between CDKs and PP2A modulates phosphorylation of pRB, p107 and p130. Cell Cycle 2004;3:1320-1330.
-
(2004)
Cell Cycle
, vol.3
, pp. 1320-1330
-
-
Garriga, J.1
Javaraman, A.L.2
Limon, A.3
-
24
-
-
0031963058
-
Early induction of apoptosis in hematopoietic cell lines after exposure to flavopiridol
-
Parker BW, Kaur G, Nieves-Neira W, et al. Early induction of apoptosis in hematopoietic cell lines after exposure to flavopiridol. Blood 1998;91:458-465.
-
(1998)
Blood
, vol.91
, pp. 458-465
-
-
Parker, B.W.1
Kaur, G.2
Nieves-Neira, W.3
-
25
-
-
0036450831
-
Phase I clinical and pharmacokinetic trial of the cyclin-dependent kinase inhibitor flavopiridol
-
Thomas JP, Tutsch KD, Cleary JF, et al. Phase I clinical and pharmacokinetic trial of the cyclin-dependent kinase inhibitor flavopiridol. Cancer Chemother Pharmacol 2002;50:465-472.
-
(2002)
Cancer Chemother Pharmacol
, vol.50
, pp. 465-472
-
-
Thomas, J.P.1
Tutsch, K.D.2
Cleary, J.F.3
-
26
-
-
0036240601
-
Seventy-two hour continuous infusion flavopiridol in relapsed and refractory mantle cell lymphoma
-
Lin TS, Howard OM, Neuberg DS, et al. Seventy-two hour continuous infusion flavopiridol in relapsed and refractory mantle cell lymphoma. Leuk Lymph 2002;43:793-797.
-
(2002)
Leuk Lymph
, vol.43
, pp. 793-797
-
-
Lin, T.S.1
Howard, O.M.2
Neuberg, D.S.3
-
27
-
-
20344382459
-
Flavopiridol administered as a 24-hour continuous infusion in chronic lymphocytic leukemia lacks clinical activity
-
Flinn IW, Byrd JC, Bartlett N, et al. Flavopiridol administered as a 24-hour continuous infusion in chronic lymphocytic leukemia lacks clinical activity. Leuk Res 2005;29:1253-1257.
-
(2005)
Leuk Res
, vol.29
, pp. 1253-1257
-
-
Flinn, I.W.1
Byrd, J.C.2
Bartlett, N.3
-
28
-
-
20344368831
-
Treatment of relapsed chronic lymphocytic leukemia by 72-hour continuous infusion or 1-hourbolus infusion of flavopiridol: Results from cancer and leukemia group B study 19805
-
Byrd JC, Peterson BL, Gabrilove J, et al. Treatment of relapsed chronic lymphocytic leukemia by 72-hour continuous infusion or 1-hourbolus infusion of flavopiridol: Results from cancer and leukemia group B study 19805. Clin Cancer Res 2005;11:4176-4181.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 4176-4181
-
-
Byrd, J.C.1
Peterson, B.L.2
Gabrilove, J.3
-
29
-
-
63849246351
-
Clinical response and pharmacokinetics from a phase I study of an active dosing schedule of flavopiridol in relapsed chronic lymphocytic leukemia
-
Phelps MA, Lin TS, Johnson AJ, et al. Clinical response and pharmacokinetics from a phase I study of an active dosing schedule of flavopiridol in relapsed chronic lymphocytic leukemia. Blood 2009;113:2637-2645.
-
(2009)
Blood
, vol.113
, pp. 2637-2645
-
-
Phelps, M.A.1
Lin, T.S.2
Johnson, A.J.3
-
30
-
-
80052478669
-
Risk factors for tumor lysis syndrome in patients wtih chronic lymphocytic leukemia treated with the cyclin-dependent kinase inhibitor, flavopiridol
-
Blum KA, Ruppert AS, Woyach JA, et al. Risk factors for tumor lysis syndrome in patients wtih chronic lymphocytic leukemia treated with the cyclin-dependent kinase inhibitor, flavopiridol. Leukemia 2011;1444-1451.
-
(2011)
Leukemia
, pp. 1444-1451
-
-
Blum, K.A.1
Ruppert, A.S.2
Woyach, J.A.3
-
31
-
-
84874825923
-
A pharmacokinetic/pharmacodynamic model of tumor lysis syndrome in chronic lymphoctyic leukemia patients treated with flavopiridol
-
Ji J, Mould DR, Blum KA, et al. A pharmacokinetic/pharmacodynamic model of tumor lysis syndrome in chronic lymphoctyic leukemia patients treated with flavopiridol. Clin Cancer Res 2013;19:1269-1280.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 1269-1280
-
-
Ji, J.1
Mould, D.R.2
Blum, K.A.3
-
32
-
-
73349096649
-
Phase II study of flavopiridol in relapsed chronic lymphocytic leukemia demonstrating high response rates in genetically High-risk disease
-
Lin TL, Ruppert AS, Johnson AJ, et al. Phase II study of flavopiridol in relapsed chronic lymphocytic leukemia demonstrating high response rates in genetically High-risk disease. J Clin Oncol 2009;27:6012-6018.
-
(2009)
J Clin Oncol
, vol.27
, pp. 6012-6018
-
-
Lin, T.L.1
Ruppert, A.S.2
Johnson, A.J.3
-
33
-
-
42449097201
-
Flavopiridol causes early mitochondrial damage in chronic lymphocytic leukemia cells with impaired oxygen consumption and mobilizaiton of intracellular calcium
-
Hussain SR, Lucas DM, Johsnon AJ, et al. Flavopiridol causes early mitochondrial damage in chronic lymphocytic leukemia cells with impaired oxygen consumption and mobilizaiton of intracellular calcium. Blood 2008;111:3190-3199.
-
(2008)
Blood
, vol.111
, pp. 3190-3199
-
-
Hussain, S.R.1
Lucas, D.M.2
Johsnon, A.J.3
-
35
-
-
84890484192
-
BH3 profiling discriminates response to cytarabbine-based treatement of acute myelogenous leukemia
-
Pierceall WE, Lornblau SM, Carlson NE, et al. BH3 profiling discriminates response to cytarabbine-based treatement of acute myelogenous leukemia. Mol Can Ther 2013;12:2940-2949.
-
(2013)
Mol Can Ther
, vol.12
, pp. 2940-2949
-
-
Pierceall, W.E.1
Lornblau, S.M.2
Carlson, N.E.3
-
36
-
-
84905699339
-
BCL-2 family proteins as 5-Azacytidine-sensitizing targes and determinates of response in myeloid malignancies
-
Bogenberger JM, Kornblau SM, Pierceall WE, et al. BCL-2 family proteins as 5-Azacytidine-sensitizing targes and determinates of response in myeloid malignancies. Leukemia 2014;28:1657-1665.
-
(2014)
Leukemia
, vol.28
, pp. 1657-1665
-
-
Bogenberger, J.M.1
Kornblau, S.M.2
Pierceall, W.E.3
-
37
-
-
84867490138
-
Relative mitochondrial priming of myeloblasts and normal HSCs determines chemotherapeutic success in AML
-
Vo TT, Ryan J, Carrasco R, et al. Relative mitochondrial priming of myeloblasts and normal HSCs determines chemotherapeutic success in AML. Cell 2012;151:344-355.
-
(2012)
Cell
, vol.151
, pp. 344-355
-
-
Vo, T.T.1
Ryan, J.2
Carrasco, R.3
-
38
-
-
82255192310
-
Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy
-
Ni Chonghaile T, Sarosiek KA, Bo TT, et al. Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy. Science 2011;334:1129-1133.
-
(2011)
Science
, vol.334
, pp. 1129-1133
-
-
Ni Chonghaile, T.1
Sarosiek, K.A.2
Bo, T.T.3
-
39
-
-
45149100665
-
Guidelines for the diagnosiis and treatment of chronic lymphocytic leukemia: A report from the international workshop on chronic lymphocytic leukemai updating the national cancer Institute-working group 1996 guidelines
-
Hallek M, Cheson BD, Catovsky D, et al. Guidelines for the diagnosiis and treatment of chronic lymphocytic leukemia: A report from the international workshop on chronic lymphocytic leukemai updating the national cancer Institute-working group 1996 guidelines. Blood 2008;111:5445-5456.
-
(2008)
Blood
, vol.111
, pp. 5445-5456
-
-
Hallek, M.1
Cheson, B.D.2
Catovsky, D.3
-
40
-
-
55349093022
-
Development and validation of a highly sensitive liquid chrmoatography/mass spectrometry method for simultaneous quantification of lenalidomide and flavopiridol in human plasma
-
Liu Q, Farley KL, Johnson AJ. Development and validation of a highly sensitive liquid chrmoatography/mass spectrometry method for simultaneous quantification of lenalidomide and flavopiridol in human plasma. Drug Monit 2008;30:620-627.
-
(2008)
Drug Monit
, vol.30
, pp. 620-627
-
-
Liu, Q.1
Farley, K.L.2
Johnson, A.J.3
-
41
-
-
78249236222
-
Flavopiridol pharmacogenetics: Clinical and functional evidence for the role of SLCO1B1/OATP1B1 in flavopiridol disposition
-
Ni W, Ji J, Dai Z, et al. Flavopiridol pharmacogenetics: Clinical and functional evidence for the role of SLCO1B1/OATP1B1 in flavopiridol disposition. PloS One 2010;5:e13792
-
(2010)
PloS One
, vol.5
, pp. e13792
-
-
Ni, W.1
Ji, J.2
Dai, Z.3
-
42
-
-
36148973115
-
Pharmacokinetics of lenalidomide in subjects with various degrees of renal impairment and in subjects of hemodialysis
-
479120
-
Chen N, Lau H, Kong L, et al. Pharmacokinetics of lenalidomide in subjects with various degrees of renal impairment and in subjects of hemodialysis. J Clin Pharmacol 2007;479120:1466-1475.
-
(2007)
J Clin Pharmacol
, pp. 1466-1475
-
-
Chen, N.1
Lau, H.2
Kong, L.3
|