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Volumn 6, Issue 4, 2016, Pages 957-971

Whole genome comparison reveals high levels of inbreeding and strain redundancy across the spectrum of commercial wine strains of Saccharomyces cerevisiae

Author keywords

Comparative genomics; Fermentation; Genome sequencing; Industrial yeast

Indexed keywords

BREWING; DOMESTICATION; FUNGAL CELL CULTURE; GENETIC VARIABILITY; GENOME; INBREEDING; MAJOR CLINICAL STUDY; NECK; SACCHAROMYCES CEREVISIAE; WINE; CHEMISTRY; CHROMOSOME; CLASSIFICATION; CLUSTER ANALYSIS; COMPARATIVE GENOMIC HYBRIDIZATION; COPY NUMBER VARIATION; DNA SEQUENCE; FUNGAL GENOME; GENETIC VARIATION; GENETICS; HETEROZYGOTE; ISOLATION AND PURIFICATION; METABOLISM; MICROBIOLOGY; PHYLOGENY;

EID: 84963979598     PISSN: None     EISSN: 21601836     Source Type: Journal    
DOI: 10.1534/g3.115.025692     Document Type: Article
Times cited : (115)

References (45)
  • 1
    • 82255194233 scopus 로고    scopus 로고
    • Whole-genome sequencing of sake yeast Saccharomyces cerevisiae Kyokai no. 7
    • Akao, T., I. Yashiro, A. Hosoyama, H. Kitagaki, H. Horikawa et al., 2011 Whole-genome sequencing of sake yeast Saccharomyces cerevisiae Kyokai no. 7. DNA Res. 18: 423-434.
    • (2011) DNA Res. , vol.18 , pp. 423-434
    • Akao, T.1    Yashiro, I.2    Hosoyama, A.3    Kitagaki, H.4    Horikawa, H.5
  • 2
    • 84901925216 scopus 로고    scopus 로고
    • A Gondwanan imprint on global diversity and domestication of wine and cider yeast Saccharomyces uvarum
    • Almeida, P., C. Gonçalves, S. Teixeira, D. Libkind, M. Bontrager et al., 2014 A Gondwanan imprint on global diversity and domestication of wine and cider yeast Saccharomyces uvarum. Nat. Commun. 5: 4044.
    • (2014) Nat. Commun. , vol.5 , pp. 4044
    • Almeida, P.1    Gonçalves, C.2    Teixeira, S.3    Libkind, D.4    Bontrager, M.5
  • 3
    • 84945452256 scopus 로고    scopus 로고
    • A population genomics insight into the Mediterranean origins of wine yeast domestication
    • Almeida, P., R. Barbosa, P. Zalar, Y. Imanishi, K. Shimizu et al., 2015 A population genomics insight into the Mediterranean origins of wine yeast domestication. Mol. Ecol. 24: 5412-5427.
    • (2015) Mol. Ecol. , vol.24 , pp. 5412-5427
    • Almeida, P.1    Barbosa, R.2    Zalar, P.3    Imanishi, Y.4    Shimizu, K.5
  • 4
    • 33748425414 scopus 로고    scopus 로고
    • Sulfur and adenine metabolisms are linked, and both modulate sulfite resistance in wine yeast
    • Aranda, A., E. Jiménez-Martí, H. Orozco, E. Matallana, and M. Del Olmo, 2006 Sulfur and adenine metabolisms are linked, and both modulate sulfite resistance in wine yeast. J. Agric. Food Chem. 54: 5839-5846.
    • (2006) J. Agric. Food Chem. , vol.54 , pp. 5839-5846
    • Aranda, A.1    Jiménez-Martí, E.2    Orozco, H.3    Matallana, E.4    Del Olmo, M.5
  • 5
    • 73249135142 scopus 로고    scopus 로고
    • Genome structure of a Saccharomyces cerevisiae strain widely used in bioethanol production
    • Argueso, J. L., M. F. Carazzolle, P. A. Mieczkowski, F. M. Duarte, O. V. C. Netto et al., 2009 Genome structure of a Saccharomyces cerevisiae strain widely used in bioethanol production. Genome Res. 19: 2258-2270.
    • (2009) Genome Res. , vol.19 , pp. 2258-2270
    • Argueso, J.L.1    Carazzolle, M.F.2    Mieczkowski, P.A.3    Duarte, F.M.4    Netto, O.V.C.5
  • 6
    • 79960735137 scopus 로고    scopus 로고
    • Newly generated interspecific wine yeast hybrids introduce flavour and aroma diversity to wines
    • Bellon, J. R., J. M. Eglinton, T. E. Siebert, A. P. Pollnitz, L. Rose et al., 2011 Newly generated interspecific wine yeast hybrids introduce flavour and aroma diversity to wines. Appl. Microbiol. Biotechnol. 91: 603-612.
    • (2011) Appl. Microbiol. Biotechnol. , vol.91 , pp. 603-612
    • Bellon, J.R.1    Eglinton, J.M.2    Siebert, T.E.3    Pollnitz, A.P.4    Rose, L.5
  • 7
    • 84876217555 scopus 로고    scopus 로고
    • Introducing a new breed of wine yeast: interspecific hybridisation between a commercial Saccharomyces cerevisiae wine yeast and Saccharomyces mikatae
    • Bellon, J. R., F. Schmid, D. L. Capone, B. L. Dunn, and P. J. Chambers, 2013 Introducing a new breed of wine yeast: interspecific hybridisation between a commercial Saccharomyces cerevisiae wine yeast and Saccharomyces mikatae. PLoS One 8: e62053.
    • (2013) PLoS One , vol.8
    • Bellon, J.R.1    Schmid, F.2    Capone, D.L.3    Dunn, B.L.4    Chambers, P.J.5
  • 8
    • 84941992703 scopus 로고    scopus 로고
    • Designing and creating Saccharomyces interspecific hybrids for improved, industry relevant, phenotypes
    • Bellon, J. R., F. Yang, M. P. Day, D. L. Inglis, and P. J. Chambers, 2015 Designing and creating Saccharomyces interspecific hybrids for improved, industry relevant, phenotypes. Appl. Microbiol. Biotechnol. 99: 8597-8609.
    • (2015) Appl. Microbiol. Biotechnol. , vol.99 , pp. 8597-8609
    • Bellon, J.R.1    Yang, F.2    Day, M.P.3    Inglis, D.L.4    Chambers, P.J.5
  • 9
    • 84897883016 scopus 로고    scopus 로고
    • A high-definition view of functional genetic variation from natural yeast genomes
    • Bergström, A., J. T. Simpson, F. Salinas, B. Barré, L. Parts et al., 2014 A high-definition view of functional genetic variation from natural yeast genomes. Mol. Biol. Evol. 31: 872-888.
    • (2014) Mol. Biol. Evol. , vol.31 , pp. 872-888
    • Bergström, A.1    Simpson, J.T.2    Salinas, F.3    Barré, B.4    Parts, L.5
  • 10
    • 84905049901 scopus 로고    scopus 로고
    • Trimmomatic: a flexible trimmer for Illumina sequence data
    • Bolger, A. M., M. Lohse, and B. Usadel, 2014 Trimmomatic: a flexible trimmer for Illumina sequence data. Bioinformatics 30: 2114-2120.
    • (2014) Bioinformatics , vol.30 , pp. 2114-2120
    • Bolger, A.M.1    Lohse, M.2    Usadel, B.3
  • 11
    • 79952262678 scopus 로고    scopus 로고
    • Whole-genome comparison reveals novel genetic elements that characterize the genome of industrial strains of Saccharomyces cerevisiae
    • Borneman, A. R., B. A. Desany, D. Riches, J. P. Affourtit, A. H. Forgan et al., 2011 Whole-genome comparison reveals novel genetic elements that characterize the genome of industrial strains of Saccharomyces cerevisiae. PLoS Genet. 7: e1001287.
    • (2011) PLoS Genet. , vol.7
    • Borneman, A.R.1    Desany, B.A.2    Riches, D.3    Affourtit, J.P.4    Forgan, A.H.5
  • 12
    • 84855547158 scopus 로고    scopus 로고
    • The genome sequence of the wine yeast VIN7 reveals an allotriploid hybrid genome with Saccharomyces cerevisiae and Saccharomyces kudriavzevii origins
    • Borneman, A. R., B. A. Desany, D. Riches, J. P. Affourtit, A. H. Forgan et al., 2012 The genome sequence of the wine yeast VIN7 reveals an allotriploid hybrid genome with Saccharomyces cerevisiae and Saccharomyces kudriavzevii origins. FEMS Yeast Res. 12: 88-96.
    • (2012) FEMS Yeast Res. , vol.12 , pp. 88-96
    • Borneman, A.R.1    Desany, B.A.2    Riches, D.3    Affourtit, J.P.4    Forgan, A.H.5
  • 13
    • 84874990532 scopus 로고    scopus 로고
    • Comparative genomics: a revolutionary tool for wine yeast strain development
    • Borneman, A. R., I. S. Pretorius, and P. J. Chambers, 2013 Comparative genomics: a revolutionary tool for wine yeast strain development. Curr. Opin. Biotechnol. 24: 192-199.
    • (2013) Curr. Opin. Biotechnol. , vol.24 , pp. 192-199
    • Borneman, A.R.1    Pretorius, I.S.2    Chambers, P.J.3
  • 15
    • 84945289705 scopus 로고    scopus 로고
    • Ecological and genetic barriers differentiate natural populations of Saccharomyces cerevisiae
    • Clowers, K. J., J. Heilberger, J. S. Piotrowski, J. L. Will, and A. P. Gasch, 2015a Ecological and genetic barriers differentiate natural populations of Saccharomyces cerevisiae. Mol. Biol. Evol. 32: 2317-2327.
    • (2015) Mol. Biol. Evol. , vol.32 , pp. 2317-2327
    • Clowers, K.J.1    Heilberger, J.2    Piotrowski, J.S.3    Will, J.L.4    Gasch, A.P.5
  • 16
    • 84948586358 scopus 로고    scopus 로고
    • A unique ecological niche fosters hybridization of oak-tree and vineyard isolates of Saccharomyces cerevisiae
    • Clowers, K. J., J. L. Will, and A. P. Gasch, 2015b A unique ecological niche fosters hybridization of oak-tree and vineyard isolates of Saccharomyces cerevisiae. Mol. Ecol. 24: 5886-5898.
    • (2015) Mol. Ecol. , vol.24 , pp. 5886-5898
    • Clowers, K.J.1    Will, J.L.2    Gasch, A.P.3
  • 17
    • 53549098548 scopus 로고    scopus 로고
    • Reconstruction of the genome origins and evolution of the hybrid lager yeast Saccharomyces pastorianus
    • Dunn, B., and G. Sherlock, 2008 Reconstruction of the genome origins and evolution of the hybrid lager yeast Saccharomyces pastorianus. Genome Res. 18: 1610-1623.
    • (2008) Genome Res. , vol.18 , pp. 1610-1623
    • Dunn, B.1    Sherlock, G.2
  • 18
    • 84860591356 scopus 로고    scopus 로고
    • Analysis of the Saccharomyces cerevisiae pan-genome reveals a pool of copy number variants distributed in diverse yeast strains from differing industrial environments
    • Dunn, B., C. Richter, D. J. Kvitek, T. Pugh, and G. Sherlock, 2012 Analysis of the Saccharomyces cerevisiae pan-genome reveals a pool of copy number variants distributed in diverse yeast strains from differing industrial environments. Genome Res. 22: 908-924.
    • (2012) Genome Res. , vol.22 , pp. 908-924
    • Dunn, B.1    Richter, C.2    Kvitek, D.J.3    Pugh, T.4    Sherlock, G.5
  • 19
    • 4944245629 scopus 로고    scopus 로고
    • Population genetic variation in gene expression is associated with phenotypic variation in Saccharomyces cerevisiae
    • Fay, J. C., H. L. McCullough, P. D. Sniegowski, and M. B. Eisen, 2004 Population genetic variation in gene expression is associated with phenotypic variation in Saccharomyces cerevisiae. Genome Biol. 5: R26.
    • (2004) Genome Biol. , vol.5 , pp. R26
    • Fay, J.C.1    McCullough, H.L.2    Sniegowski, P.D.3    Eisen, M.B.4
  • 20
    • 33645096818 scopus 로고    scopus 로고
    • Evidence for domesticated and wild populations of Saccharomyces cerevisiae
    • Fay, J. C., and J. A. Benavides, 2005 Evidence for domesticated and wild populations of Saccharomyces cerevisiae. PLoS Genet. 1: 66-71.
    • (2005) PLoS Genet. , vol.1 , pp. 66-71
    • Fay, J.C.1    Benavides, J.A.2
  • 22
    • 74549125386 scopus 로고    scopus 로고
    • SeaView version 4: A multiplatform graphical user interface for sequence alignment and phylogenetic tree building
    • Gouy, M., S. Guindon, and O. Gascuel, 2010 SeaView version 4: A multiplatform graphical user interface for sequence alignment and phylogenetic tree building. Mol. Biol. Evol. 27: 221-224.
    • (2010) Mol. Biol. Evol. , vol.27 , pp. 221-224
    • Gouy, M.1    Guindon, S.2    Gascuel, O.3
  • 23
    • 37249016359 scopus 로고    scopus 로고
    • The reacquisition of biotin prototrophy in Saccharomyces cerevisiae involved horizontal gene transfer, gene duplication and gene clustering
    • Hall, C., and F. S. Dietrich, 2007 The reacquisition of biotin prototrophy in Saccharomyces cerevisiae involved horizontal gene transfer, gene duplication and gene clustering. Genetics 177: 2293-2307.
    • (2007) Genetics , vol.177 , pp. 2293-2307
    • Hall, C.1    Dietrich, F.S.2
  • 24
    • 0022370773 scopus 로고
    • Growth of natural yeast flora during the fermentation of inoculated wines
    • Heard, G. M., and G. H. Fleet, 1985 Growth of natural yeast flora during the fermentation of inoculated wines. Appl. Environ. Microbiol. 50: 727-728.
    • (1985) Appl. Environ. Microbiol. , vol.50 , pp. 727-728
    • Heard, G.M.1    Fleet, G.H.2
  • 25
    • 0031779071 scopus 로고    scopus 로고
    • Selective effects of sulfur dioxide and yeast starter culture addition on indigenous yeast populations and sensory characteristics of wine
    • Henick-Kling, T., W. Edinger, P. Daniel, and P. Monk, 1998 Selective effects of sulfur dioxide and yeast starter culture addition on indigenous yeast populations and sensory characteristics of wine. J. Appl. Microbiol. 84: 865-876.
    • (1998) J. Appl. Microbiol. , vol.84 , pp. 865-876
    • Henick-Kling, T.1    Edinger, W.2    Daniel, P.3    Monk, P.4
  • 26
    • 84878462125 scopus 로고    scopus 로고
    • Mixing of vineyard and oak-tree ecotypes of Saccharomyces cerevisiae in North American vineyards
    • Hyma, K. E., and J. C. Fay, 2013 Mixing of vineyard and oak-tree ecotypes of Saccharomyces cerevisiae in North American vineyards. Mol. Ecol. 22: 2917-2930.
    • (2013) Mol. Ecol. , vol.22 , pp. 2917-2930
    • Hyma, K.E.1    Fay, J.C.2
  • 27
    • 84863229597 scopus 로고    scopus 로고
    • VarScan 2: somatic mutation and copy number alteration discovery in cancer by exome sequencing
    • Koboldt, D. C., Q. Zhang, D. E. Larson, D. Shen, M. D. McLellan et al., 2012 VarScan 2: somatic mutation and copy number alteration discovery in cancer by exome sequencing. Genome Res. 22: 568-576.
    • (2012) Genome Res. , vol.22 , pp. 568-576
    • Koboldt, D.C.1    Zhang, Q.2    Larson, D.E.3    Shen, D.4    McLellan, M.D.5
  • 29
    • 80052293238 scopus 로고    scopus 로고
    • Microbe domestication and the identification of the wild genetic stock of lager-brewing yeast
    • Libkind, D., C. T. Hittinger, E. Valério, C. Gonçalves, J. Dover et al., 2011 Microbe domestication and the identification of the wild genetic stock of lager-brewing yeast. Proc. Natl. Acad. Sci. USA 108: 14539-14544.
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 14539-14544
    • Libkind, D.1    Hittinger, C.T.2    Valério, E.3    Gonçalves, C.4    Dover, J.5
  • 30
    • 62649089109 scopus 로고    scopus 로고
    • Population genomics of domestic and wild yeasts
    • Liti, G., D. M. Carter, A. M. Moses, J. Warringer, L. Parts et al., 2009 Population genomics of domestic and wild yeasts. Nature 458: 337-341.
    • (2009) Nature , vol.458 , pp. 337-341
    • Liti, G.1    Carter, D.M.2    Moses, A.M.3    Warringer, J.4    Parts, L.5
  • 31
    • 84873036642 scopus 로고    scopus 로고
    • High quality de novo sequencing and assembly of the Saccharomyces arboricolus genome
    • Liti, G., A. N. Nguyen Ba, M. Blythe, C. A. Müller, A. Bergström et al., 2013 High quality de novo sequencing and assembly of the Saccharomyces arboricolus genome. BMC Genomics 14: 69.
    • (2013) BMC Genomics , vol.14 , pp. 69
    • Liti, G.1    Nguyen Ba, A.N.2    Blythe, M.3    Müller, C.A.4    Bergström, A.5
  • 32
    • 0028558805 scopus 로고
    • Genome renewal: a new phenomenon revealed from a genetic study of 43 strains of Saccharomyces cerevisiae derived from natural fermentation of grape musts
    • Mortimer, R. K., P. Romano, G. Suzzi, and M. Polsinelli, 1994 Genome renewal: a new phenomenon revealed from a genetic study of 43 strains of Saccharomyces cerevisiae derived from natural fermentation of grape musts. Yeast 10: 1543-1552.
    • (1994) Yeast , vol.10 , pp. 1543-1552
    • Mortimer, R.K.1    Romano, P.2    Suzzi, G.3    Polsinelli, M.4
  • 33
    • 67649602562 scopus 로고    scopus 로고
    • Genome sequence of the lager brewing yeast, an interspecies hybrid
    • Nakao, Y., T. Kanamori, T. Itoh, Y. Kodama, S. Rainieri et al., 2009 Genome sequence of the lager brewing yeast, an interspecies hybrid. DNA Res. 16: 115-129.
    • (2009) DNA Res. , vol.16 , pp. 115-129
    • Nakao, Y.1    Kanamori, T.2    Itoh, T.3    Kodama, Y.4    Rainieri, S.5
  • 34
    • 28044456330 scopus 로고    scopus 로고
    • Molecular genetic study of introgression between Saccharomyces bayanus and S. cerevisiae
    • Naumova, E. S., G. I. Naumov, I. Masneuf-Pomarède, M. Aigle, and D. Dubourdieu, 2005 Molecular genetic study of introgression between Saccharomyces bayanus and S. cerevisiae. Yeast 22: 1099-1115.
    • (2005) Yeast , vol.22 , pp. 1099-1115
    • Naumova, E.S.1    Naumov, G.I.2    Masneuf-Pomarède, I.3    Aigle, M.4    Dubourdieu, D.5
  • 35
    • 0029053524 scopus 로고
    • RTM1: a member of a new family of telomeric repeated genes in yeast
    • Ness, F., and M. Aigle, 1995 RTM1: a member of a new family of telomeric repeated genes in yeast. Genetics 140: 945-956.
    • (1995) Genetics , vol.140 , pp. 945-956
    • Ness, F.1    Aigle, M.2
  • 36
    • 70349515584 scopus 로고    scopus 로고
    • Eukaryoteto-eukaryote gene transfer events revealed by the genome sequence of the wine yeast Saccharomyces cerevisiae EC1118
    • Novo, M., F. Bigey, E. Beyne, V. Galeote, F. Gavory et al., 2009 Eukaryoteto-eukaryote gene transfer events revealed by the genome sequence of the wine yeast Saccharomyces cerevisiae EC1118. Proc. Natl. Acad. Sci. USA 106: 16333-16338.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 16333-16338
    • Novo, M.1    Bigey, F.2    Beyne, E.3    Galeote, V.4    Gavory, F.5
  • 37
    • 84926476162 scopus 로고    scopus 로고
    • Molecular and enological characterization of a natural Saccharomyces uvarum and Saccharomyces cerevisiae hybrid
    • Pérez-Torrado, R., S. S. González, M. Combina, E. Barrio, and A. Querol, 2015 Molecular and enological characterization of a natural Saccharomyces uvarum and Saccharomyces cerevisiae hybrid. Int. J. Food Microbiol. 204: 101-110.
    • (2015) Int. J. Food Microbiol. , vol.204 , pp. 101-110
    • Pérez-Torrado, R.1    González, S.S.2    Combina, M.3    Barrio, E.4    Querol, A.5
  • 38
    • 0029931717 scopus 로고    scopus 로고
    • A putative cyclic peptide efflux pump encoded by the TOXA gene of the plant-pathogenic fungus Cochliobolus carbonum
    • Pitkin, J. W., D. G. Panaccione, and J. D. Walton, 1996 A putative cyclic peptide efflux pump encoded by the TOXA gene of the plant-pathogenic fungus Cochliobolus carbonum. Microbiology 142(Pt 6): 1557-1565.
    • (1996) Microbiology , vol.142 , pp. 1557-1565
    • Pitkin, J.W.1    Panaccione, D.G.2    Walton, J.D.3
  • 39
    • 79955792126 scopus 로고    scopus 로고
    • The yeast IRC7 gene encodes a b-lyase responsible for production of the varietal thiol 4-mercapto-4-methylpentan-2-one in wine
    • Roncoroni, M., M. Santiago, D. O. Hooks, S. Moroney, M. J. Harsch et al., 2011 The yeast IRC7 gene encodes a b-lyase responsible for production of the varietal thiol 4-mercapto-4-methylpentan-2-one in wine. Food Microbiol. 28: 926-935.
    • (2011) Food Microbiol. , vol.28 , pp. 926-935
    • Roncoroni, M.1    Santiago, M.2    Hooks, D.O.3    Moroney, S.4    Harsch, M.J.5
  • 40
    • 84883006832 scopus 로고    scopus 로고
    • The awesome power of yeast evolutionary genetics: new genome sequences and strain resources for the Saccharomyces sensu stricto genus
    • Scannell, D. R., O. A. Zill, A. Rokas, C. Payen, M. J. Dunham et al., 2011 The awesome power of yeast evolutionary genetics: new genome sequences and strain resources for the Saccharomyces sensu stricto genus. G3 (Bethesda) 1: 11-25.
    • (2011) G3 (Bethesda) , vol.1 , pp. 11-25
    • Scannell, D.R.1    Zill, O.A.2    Rokas, A.3    Payen, C.4    Dunham, M.J.5
  • 41
    • 79960739573 scopus 로고    scopus 로고
    • Impacts of variations in elemental nutrient concentration of Chardonnay musts on Saccharomyces cerevisiae fermentation kinetics and wine composition
    • Schmidt, S. A., S. Dillon, R. Kolouchova, P. A. Henschke, and P. J. Chambers, 2011 Impacts of variations in elemental nutrient concentration of Chardonnay musts on Saccharomyces cerevisiae fermentation kinetics and wine composition. Appl. Microbiol. Biotechnol. 91: 365-375.
    • (2011) Appl. Microbiol. Biotechnol. , vol.91 , pp. 365-375
    • Schmidt, S.A.1    Dillon, S.2    Kolouchova, R.3    Henschke, P.A.4    Chambers, P.J.5
  • 42
    • 0035834639 scopus 로고    scopus 로고
    • A novel acetyltransferase found in Saccharomyces cerevisiae Sigma1278b that detoxifies a proline analogue, azetidine-2-carboxylic acid
    • Shichiri, M., C. Hoshikawa, S. Nakamori, and H. Takagi, 2001 A novel acetyltransferase found in Saccharomyces cerevisiae Sigma1278b that detoxifies a proline analogue, azetidine-2-carboxylic acid. J. Biol. Chem. 276: 41998-42002.
    • (2001) J. Biol. Chem. , vol.276 , pp. 41998-42002
    • Shichiri, M.1    Hoshikawa, C.2    Nakamori, S.3    Takagi, H.4
  • 43
    • 79952420028 scopus 로고    scopus 로고
    • Bread, beer and wine: yeast domestication in the Saccharomyces sensu stricto complex
    • Sicard, D., and J.-L. Legras, 2011 Bread, beer and wine: yeast domestication in the Saccharomyces sensu stricto complex. C. R. Biol. 334: 229-236.
    • (2011) C. R. Biol. , vol.334 , pp. 229-236
    • Sicard, D.1    Legras, J.-L.2
  • 44
    • 84883698933 scopus 로고    scopus 로고
    • Integrative phenomics reveals insight into the structure of phenotypic diversity in budding yeast
    • Skelly, D. A., G. E. Merrihew, M. Riffle, C. F. Connelly, E. O. Kerr et al., 2013 Integrative phenomics reveals insight into the structure of phenotypic diversity in budding yeast. Genome Res. 23: 1496-1504.
    • (2013) Genome Res. , vol.23 , pp. 1496-1504
    • Skelly, D.A.1    Merrihew, G.E.2    Riffle, M.3    Connelly, C.F.4    Kerr, E.O.5


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